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https://www.readbyqxmd.com/read/28340443/quantitative-eeg-abnormalities-in-major-depressive-disorder-with-basal-ganglia-stroke-with-lesions-in-different-hemispheres
#1
Chunfang Wang, Yuanyuan Chen, Ying Zhang, Jin Chen, Xiaojing Ding, Dong Ming, Jingang Du
BACKGROUND: This study aimed to examine the aberrant EEG oscillation in major depressive subjects with basal ganglia stroke with lesions in different hemispheres. METHODS: Resting EEG of 16 electrodes in 58 stroke subjects, 26 of whom had poststroke depression (13 with left-hemisphere lesion and 13 with right) and 32 of whom did not (18 with left lesion and 14 with right), was recorded to obtain spectral power analysis for several frequency bands. Multiple analysis of variance and receiver operating characteristic (ROC) curves were used to identify differences between poststroke depression (PSD) and poststroke non-depression (PSND), treating the different lesion hemispheres separately...
February 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28339441/the-role-of-the-ligamentum-flavum-area-as-a-morphological-parameter-of-lumbar-central-spinal-stenosis
#2
Young Uk Kim, Jun Young Park, Doo Hwan Kim, Myung-Hwan Karm, Jae-Young Lee, Jee In Yoo, Sung Won Chon, Jeong Hun Suh
BACKGROUND: Hypertrophy of the ligamentum flavum (LF) has been considered as a major cause of lumbar central spinal stenosis (LCSS). Previous studies have found that ligamentum flavum thickness (LFT) is correlated with aging, disc degeneration, and lumbar spinal stenosis. However, hypertrophy is different from thickness. Thus, to evaluate hypertrophy of the whole LF, we devised a new morphological parameter, called the ligamentum flavum area (LFA). OBJECTIVES: We hypothesized that the LFA is a key morphologic parameter in the diagnosis of LCSS...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339285/is-the-necrosis-wall-adc-ratio-useful-for-the-differentiation-of-benign-and-malignant-breast-lesions
#3
Irmak Durur-Subasi, Afak Durur-Karakaya, Adem Karaman, Mehmet Seker, Elif Demirci, Fatih Alper
OBJECTIVES: To determine whether the necrosis/wall apparent diffusion coefficient (ADC) ratio is useful for the malignant-benign differentiation of necrotic breast lesions. METHODS: Breast magnetic resonance imaging (MRI) was performed using a 3T system. In this retrospective study, calculation of the necrosis/wall ADC ratio was based on ADC values measured from the necrosis and from the wall of malignant and benign breast lesions by diffusion-weighted imaging (DWI)...
March 24, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28339045/identification-of-circulating-long-non-coding-rna%C3%A2-gas5-as-a-potential-biomarker-for-non-small-cell-lung-cancer-diagnosisnon-small-cell-lung-cancer-long-non-coding-rna-plasma-gas5-biomarker
#4
Qian Tan, Jiangcheng Zuo, Shili Qiu, Yalan Yu, Hu Zhou, Nandi Li, Hui Wang, Chunzi Liang, Mingxia Yu, Jiancheng Tu
Non-small cell lung cancer (NSCLC) is one of the most malignant cancers in the world. Early diagnosis of NSCLC has become especially important for patient treatment and prognosis. Increasing evidence suggest that long non-coding RNA GAS5 plays vital roles in cancer proliferation and differentiation in NSCLC. However, its clinical value in the diagnosis of NSCLC is unclear. The objective of this study was to evaluate the importance of circulating GAS5 as a biomarker for NSCLC diagnosis. In our study, quantitative real-time PCR (QRT-PCR) was applied to detect the GAS5 expression level in 80 pairs of cancer tissues and 57 pairs of plasma samples of NSCLC patients...
March 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28338787/total-and-fetal-circulating-cell-free-dna-angiogenic-and-antiangiogenic-factors-in-preeclampsia-and-hellp-syndrome
#5
Rocío Muñoz-Hernández, Pablo Medrano-Campillo, Maria L Miranda, Hada C Macher, Jose Manuel Praena-Fernández, Antonio J Vallejo-Vaz, María J Dominguez-Simeon, Rafael Moreno-Luna, Pablo Stiefel
BACKGROUND: Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by hypertension and proteinuria. The HELLP syndrome is the most severe form of PE. The aim of the present study was to determine different potential biomarkers that may help us perform an early diagnosis of the disease, assess on the severity of the disease, and/or predict maternal or fetal adverse outcomes. METHODS: We measured serum levels of total and fetal circulating cell-free DNA (cfDNA), soluble endoglin, soluble form of vascular endothelial growth factor receptor, and placental growth factor in a healthy control group of pregnant women (n = 26), patients with mild (n = 37) and severe PE (n = 25), and patients with HELLP syndrome (n = 16)...
February 25, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28338303/what-is-the-quickest-scoring-system-to-predict-percutaneous-nephrolithotomy-outcomes-a-comparative-study-among-s-t-o-n-e-score-guy-s-stone-score-and-croes-nomogram
#6
Fabio C Vicentini, Felipe R Serzedello, Kay Thomas, Giovanni S Marchini, Fabio C M Torricelli, Miguel Srougi, Eduardo Mazzucchi
OBJECTIVE: To compare the application time and the capacity of the nomograms to predict the success of Guy's Stone Score (GSS), S.T.O.N.E. Nephrolithometry (STONE) and Clinical Research Office of the Endourological Society nephrolithometric nomogram (CROES) of percutaneous nephrolithotomy (PCNL), evaluating the most efficient one for clinical use. MATERIALS AND METHODS: We studied 48 patients who underwent PCNL by the same surgeon between 2010 and 2011. We calculated GSS, STONE and CROES based on preoperative non-contrast computed tomography (CT) images and clinical data...
March 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28338236/hsa-mir-3199-2-and-hsa-mir-1293-as-novel-prognostic-biomarkers-of-papillary-renal-cell-carcinoma-by-cox-ratio-risk-regression-model-screening
#7
Wen Luo, Lei Wang, Mao-Hua Luo, Yu-Zhu Huang, Hua Yang, Yu Zhou, Hong-Tao Jia, Xiu-Xin Wang
Papillary renal cell carcinoma(PRCC) is the second most common and aggressive renal cell carcinoma. Identification of novel microRNA biomarkers could be beneficial for the diagnosis and prognosis of PRCCpatients.We aimed to screen differentially expressed miRNAs that can act as prognostic factors and to predict the survival of PRCC patients. High-throughput data of miRNAs of 274 PRCC samples were downloaded from TCGA(The Cancer Genome Atlas) dataset and interested miRNAs were identified. Hierarchical clustering and principal component analysis (PCA) were performed on these miRNAs...
March 24, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28338188/implication-of-peripheral-blood-mirna-124-in-predicting-acute-myocardial-infarction
#8
M-L Guo, L-L Guo, Y-Q Weng
OBJECTIVE: This study aimed to determine the expression of miR-124 in the patients with acute myocardial infarction (AMI) and elucidated the role of miR-124 on early diagnosis of AMI. PATIENTS AND METHODS: A total of 90 AMI patients were recruited, along with 45 healthy individuals as the control group. Blood samples were collected at different time points (0 h at admission, 6 h, 12 h and 24 h of disease onset). Real-time PCR was used to test miRNA-124 level. ELISA was used to test serum troponin (cTnI) and creatine kinase-MB isoenzyme (CK-MB) levels...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28338166/-preoperative-assessment-value-of-spectral-ct-quantitative-parameters-in-lymph-node-metastasis-of-gastric-cancer
#9
Yaru Chai, Jianbo Gao, Jingjing Xing, Peijie Lyu, Pan Liang, Xiaohua Chen
OBJECTIVE: To investigate the preoperative assessment value of spectral CT quantitative parameters in lymph node metastasis of gastric cancer. METHODS: From December 2013 to June 2015, clinical and image data of 86 patients with gastric cancer confirmed by gastroscope pathology undergoing preoperative enhanced CT were prospectively collected. Enhanced CT included nonenhanced CT of conventional 120 kVp mode, arterial phase (AP) and venous phase (VP) with GSI mode on Discover GSI CT scanner...
March 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28337993/evaluation-of-5-novel-protein-biomarkers-for-the-rapid-diagnosis-of-pulmonary-and-extra-pulmonary-tuberculosis-preliminary-results
#10
Amit Singh, Anil Kumar Gupta, Krishnamoorthy Gopinath, Pawan Sharma, Sarman Singh
Improved methods are required for the early and accurate diagnosis of tuberculosis, especially in the patients with smear-negative disease. Several biomarkers have been tried but most have shown poor sensitivity or specificity. In present study we aimed to evaluate the diagnostic utility of five novel antigens identified earlier by us. This is an initial study conducted on 250 subjects. The five recombinant antigens, named as rSS1 (Rv2145c), rSS2 (Rv0164), rSS3 (Rv1437), rSS4 (Rv1827) and rSS5 (Rv2970c), were expressed in pQE-30 expression vector, purified and their sero-diagnostic efficacy was evaluated in an unblinded manner using dot-blot and ELISA methods...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337742/post-cardiac-arrest-level-of-free-plasma-dna-and-dna-histone-complexes
#11
A N Jeppesen, A-M Hvas, A M Grejs, C H V Duez, B S Sorensen, H Kirkegaard
BACKGROUND: Plasma DNA-histone complexes and total free-plasma DNA have the potential to quantify the ischaemia-reperfusion damages occurring after cardiac arrest. Furthermore, DNA-histone complexes may have the potential of being a target for future treatment. The aim was to examine if plasma DNA-histone complexes and the levels of total free-plasma DNA were elevated in post-cardiac arrest patients compared with healthy individuals, and to examine if these biomarkers were capable of predicting mortality...
March 23, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28337725/comparison-of-diagnostic-performance-of-four-software-packages-for-phase-dyssynchrony-analysis-in-gated-myocardial-perfusion-spect
#12
Koichi Okuda, Kenichi Nakajima, Shinro Matsuo, Soichiro Kashiwaya, Hiroto Yoneyama, Takayuki Shibutani, Masahisa Onoguchi, Mitsumasa Hashimoto, Seigo Kinuya
BACKGROUND: Phase analysis of gated myocardial perfusion single-photon emission computed tomography (SPECT) for assessment of left ventricular (LV) dyssynchrony was investigated using the following dedicated software packages: Corridor4DM (4DM), cardioREPO (cREPO), Emory Cardiac Toolbox (ECTb), and quantitative gated SPECT (QGS). The purpose of this study was to evaluate the normal values of 95% histogram bandwidth, phase standard deviation (SD), and entropy and to compare the diagnostic performance of the four software packages...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28337521/evaluating-histologic-differentiation-of-hepatitis-b-virus-related-hepatocellular-carcinoma-using-intravoxel-incoherent-motion-and-afp-levels-alone-and-in-combination
#13
Qungang Shan, Jingbiao Chen, Tianhui Zhang, Ronghua Yan, Jun Wu, Yunhong Shu, Zhuang Kang, Bingjun He, Zhongping Zhang, Jin Wang
PURPOSE: To evaluate histologic differentiation of hepatitis B virus (HBV)-related hepatocellular carcinomas (HCCs) using apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM)-derived metrics and to compare findings with alpha-fetoprotein (AFP) levels alone and in combination. MATERIALS AND METHOD: One hundred and six chronic HBV-related HCC patients who underwent IVIM diffusion-weighted magnetic resonance imaging with eleven b values were enrolled...
March 24, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28337388/the-clinical-significance-of-anti-mitotic-spindle-apparatus-antibody-msa-and-anti-centromere-antibody-aca-detected-in-patients-with-small-cell-lung-cancer-sclc
#14
Liming Tan, Yuhong Zhang, Yongqing Jiang, Hua Li, Juanjuan Chen, Feng Ming, Waimei Wang, Jianlin Yu, Tingting Zeng, Yongjian Tian, Yang Wu
PURPOSE: The project is aimed to detect anti-mitotic spindle apparatus antibody (MSA) and anti-centromere antibody (ACA) and explore the clinical value for the diagnosis of small cell lung cancer (SCLC), providing clinical evidence for molecular studies of SCLC. METHODS: 93 SCLC patients, 208 patients with other cancers and 50 healthy controls were enrolled in this study. MSA antibodies were detected by enzyme linked immunosorbent assay (ELISA). MSA, ACA and anti nuclear antibodies (ANA) were examined by indirect immuno-fluorescence (IIF)...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28336963/radiological-and-clinical-features-associated-with-epidermal-growth-factor-receptor-mutation-status-of-exon-19-and-21-in-lung-adenocarcinoma
#15
Zhang Shi, Xuan Zheng, Ruifeng Shi, Changen Song, Runhong Yang, Qianwen Zhang, Xinrui Wang, Jianping Lu, Yongwei Yu, Qi Liu, Tao Jiang
The exon 19 and 21 in Epidermal Growth Factor Receptor (EGFR) mutation are the most common subtype of lung adenocarcinoma, and the strongest predictive biomarker for progression-free survival and tumor response. Although some studies have shown differences in radiological features between cases with and without EFGR mutations, they lacked necessary stratification. This article is to evaluate the association of CT features between the wild type and the subtype (exon 19 and 21) of EGFR mutations in patients with lung adenocarcinoma...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28336681/accuracy-and-reliability-of-stroke-diagnosis-in-the-pediatric-emergency-department
#16
Mark T Mackay, Adriana Yock-Corrales, Leonid Churilov, Paul Monagle, Geoffrey A Donnan, Franz E Babl
BACKGROUND AND PURPOSE: Access to acute stroke interventions in the emergency department (ED) relies on correct clinical diagnosis. Our aims were to determine the accuracy and reliability of pediatric ED physician diagnosis of childhood stroke and other conditions presenting with brain attack symptoms. METHODS: Prospective study of consecutive children aged 1 month to 18 years presenting to the ED from June 2009 to December 2010 with focal neurological deficits...
March 23, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28335998/point-shear-wave-elastography-to-evaluate-and-monitor-changing-portal-venous-pressure-in-patients-with-decompensated-cirrhosis
#17
Hao Han, Jian Yang, Yu-Zheng Zhuge, Ming Zhang, Min Wu
This study evaluated whether the stiffness of the liver and spleen, measured using the point shear wave elastography (pSWE) technique, correlates with portal venous pressure (PVP) and whether the result extends to estimate the diminishing change in PVP (ΔPVP) in patients with decompensated cirrhosis. We evaluated the data of 67 prospectively enrolled patients who underwent both transjugular intrahepatic portosystemic shunt (TIPS) and pSWE. The stiffness of liver and spleen were evaluated by measuring shear wave velocity (SWV) to determine the statistical correlation with PVP...
March 20, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28335796/predicting-dementia-using-socio-demographic-characteristics-and-the-free-and-cued-selective-reminding-test-in-the-general-population
#18
Thibault Mura, Marieta Baramova, Audrey Gabelle, Sylvaine Artero, Jean-François Dartigues, Hélène Amieva, Claudine Berr
BACKGROUND: Our study aimed to determine whether the consideration of socio-demographic features improves the prediction of Alzheimer's dementia (AD) at 5 years when using the Free and Cued Selective Reminding Test (FCSRT) in the general older population. METHODS: Our analyses focused on 2558 subjects from the prospective Three-City Study, a cohort of community-dwelling individuals aged 65 years and over, with FCSRT scores. Four "residual scores" and "risk scores" were built that included the FCSRT scores and socio-demographic variables...
March 23, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28335787/risk-factors-of-atherosclerotic-tissue-types-in-single-vessel-and-intermediate-coronary-lesions-a-cross-sectional-study
#19
Xianjin Wang, Qun Chen, Yu Xu, Yanqing Wang, Yang Yang, Ming Gu, Haihua Xu, Yanfang Zhao
BACKGROUND: Few data exist that correlate lesion-related risk factors such as conventional cardiovascular risks or lipoprotein-associated phospholipase A2 (Lp-PLA2) with tissue types within atherosclerotic plaques in patients with single-vessel and intermediate coronary lesions. METHODS: One hundred and ninety-two patients with single-vessel and intermediate coronary lesions were enrolled in a cross-sectional study and divided into two groups: stable angina pectoris (SAP) and acute coronary syndrome (ACS) groups...
March 23, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28335662/performance-of-computed-tomography-angiography-to-determine-anterograde-and-collateral-blood-flow-status-in-patients-with-symptomatic-middle-cerebral-artery-stenosis
#20
Baixue Jia, David S Liebeskind, Ligang Song, Xiaotong Xu, Xuan Sun, Lian Liu, Bo Wang, Zhongrong Miao
Background The purpose of this study was to determine the performance of computed tomography angiography (CTA) by using a scoring system to predict anterograde and collateral blood flow status in patients with symptomatic middle cerebral artery (MCA) stenosis with use of conventional angiography as standard reference. Methods We retrospectively identified all consecutive patients with unilateral symptomatic MCA stenosis in our center who underwent conventional angiography and CTA within 1 month. The anterograde and collateral blood flow (AnCo) scoring system consisted of anterograde score (AnS) and collateral score (CoS)...
January 1, 2017: Interventional Neuroradiology
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