Costanza Tripiciano, Paola Zangari, Mauro Montanari, Giovanna Leone, Laura Massella, Lucia Garaboldi, Michela Massoud, Stefano Lancellotti, Luisa Strocchio, Emma Concetta Manno, Paolo Palma, Tiziana Corsetti, Matteo Luciani
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy caused by a severely reduced activity of the von Willebrand factor-cleaving protease ADAMTS13. Over 95% of TTPs are acquired, due to autoantibody inhibitors. In children, acquired TTP is a very rare, life-threatening disease. To date, no consensus exists on the treatment strategy of pediatric TTP. We report the cases of two pediatric patients with a diagnosis of TTP, successfully treated with a combination of various therapeutic approaches...
2021: Frontiers in Pediatrics