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https://www.readbyqxmd.com/read/29356164/tracking-actinic-keratosis-of-face-and-scalp-treated-with-0-015-ingenol-mebutate-to-identify-clinical-and-dermoscopic-predictors-of-treatment-response
#1
R Pampena, E Benati, S Borsari, C Bombonato, M Lombardi, M Raucci, M Mirra, A Lallas, Z Apalla, I Papadimitriou, E Moscarella, A Kyrgidis, G Argenziano, G Pellacani, C Longo
BACKGROUND: Ingenol mebutate (IngMeb) 0.015% gel is an approved field treatment option for non-hyperkeratotic non-hypertrophic actinic keratosis (AKs) of face and scalp. Efficacy of IngMeb has been assessed only on a clinical ground, in the majority of studies. Dermoscopy is a pivotal tool for the diagnosis of AK, while its role in evaluating the response to non-surgical therapies for AK has not been fully defined. OBJECTIVES: Our study aims to determine if some dermoscopic features of AK of the face and scalp areas, may independently predict the response to IngMeb therapy...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29355898/in-vivo-dermoscopic-and-confocal-microscopy-multi-step-algorithm-to-detect-in-situ-melanomas
#2
S Borsari, R Pampena, E Benati, C Bombonato, K Athanassios, E Moscarella, A Lallas, G Argenziano, G Pellacani, C Longo
BACKGROUND: Although several dermoscopic features of in situ melanoma (MIS) have been identified, data on confocal features for MIS are still lacking. OBJECTIVES: To identify RCM (reflectance confocal microscopy) features of MIS and to develop a diagnostic score for MIS while combining dermoscopy and RCM. METHODS: 120 MIS and 213 nevi (test set) were retrospectively analysed to assess the presence of dermoscopic and RCM criteria. Facial and acral lesions have been excluded...
January 21, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29353053/conditional-inactivation-of-npy1r-gene-in-mice-induces-behavioural-inflexibility-and-orbitofrontal-cortex-hyperactivity-that-are-reversed-by-escitalopram
#3
Angela Longo, Melissa Fadda, Claudio Brasso, Paolo Mele, Paola Palanza, Ishira Nanavaty, Ilaria Bertocchi, Alessandra Oberto, Carola Eva
Cognitive flexibility is the ability to rapidly adapt established patterns of behaviour in the face of changing circumstance and depends critically on the orbitofrontal cortex (OFC). Impaired flexibility also results from altered serotonin transmission in the OFC. The Y1 (Y1R) and Y5 (Y5R) receptors for neuropeptide Y (NPY) colocalize in several brain regions and have overlapping functions in regulating cognition and emotional behaviour. The targeted disruption of gene encoding Y1R (Npy1r gene) in Y5R containing neurons (Npy1rY5R-/- mice) increases anxiety-like behaviour and spatial reference memory...
January 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29352638/the-evaluation-of-the-hydrophilic-hydrophobic-interactions-and-their-effect-in-water-methanol-solutions-a-study-in-terms-of-the-thermodynamic-state-functions-in-the-frame-of-the-transition-state-theory
#4
Francesco Mallamace, Carmelo Corsaro, Sveva Longo, Sow-Hsin Chen, Domenico Mallamace
Aqueous solutions of amphiphilic molecules are characterized by the competition between hydrophilic and hydrophobic interactions. These interactions have a different energetic dependence with the temperature. Whereas hydrophilic interactions have been well characterized, a complete theory for the hydrophobic ones is still lacking as well as the comprehension of the effect that the solvent exerts on the solute and vice versa. In this paper from the measured relaxation time, we evaluated the thermodynamic state functions of water-methanol solutions in the frame of the transition state theory...
January 11, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29350402/effectiveness-and-safety-of-original-and-generic-sofosbuvir-for-the-treatment-of-chronic-hepatitis-c-a-real-world-study
#5
Sebastián Marciano, Leila Haddad, María Virginia Reggiardo, Mirta Peralta, Cecilia Vistarini, Mónica Marino, Valeria Inés Descalzi, Claudia D'Amico, Sebastián Figueroa Escuti, Luis Alejandro Gaite, Roberto Pérez Ravier, Cristina Longo, Silvia Mabel Borzi, Omar Andrés Galdame, Fernando Bessone, Hugo Alberto Fainboim, Silvia Frías, Mariano Cartier, Adrián Carlos Gadano
We report the first real-world prospective multicenter cohort study that evaluated the effectiveness and safety of original or generic sofosbuvir-based regimens in patients with chronic hepatitis C in Latin America. The main endpoints were assessment of sustained virological response and serious adverse events rates. A total of 321 patients with chronic hepatitis C treated with the following regimens were included: sofosbuvir plus daclatasvir for 12 (n = 34) or 24 (n = 135) weeks, sofosbuvir plus daclatasvir plus ribavirin for 12 (n = 84) or 24 (n = 56) weeks, or sofosbuvir plus ribavirin for 12 (n = 8) or 24 (n = 2) weeks...
January 19, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29350350/biochemical-changes-and-clinical-outcomes-in-34-patients-with-classic-galactosemia
#6
Tatiana Yuzyuk, Krista Viau, Ashley Andrews, Marzia Pasquali, Nicola Longo
Impaired activity of galactose-1-phosphate uridyltransferase (GALT) causes galactosemia, an autosomal recessive disorder of galactose metabolism. Early initiation of a galactose-restricted diet can prevent or resolve neonatal complications. Despite therapy, patients often experience long-term complications including speech impairment, learning disabilities, and premature ovarian insufficiency in females. This study evaluates clinical outcomes in 34 galactosemia patients with markedly reduced GALT activity and compares outcomes between patients with different levels of mean galactose-1-phosphate in red blood cells (GAL1P) using logistic regression: group 1 (n = 13) GAL1P ≤1...
January 19, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29341263/dermoscopy-versus-reflectance-confocal-microscopy-for-the-diagnosis-of-lentigo-maligna
#7
E Cinotti, B Labeille, S Debarbieux, C Carrera, F Lacarrubba, A M Witkowski, E Moscarella, E Arzberger, H Kittler, P Bahadoran, S Gonzalez, P Guitera, M Agozzino, F Farnetani, R Hofmann-Wellenhof, M Ardigò, P Rubegni, L Tognetti, J Łudzik, I Zalaudek, G Argenziano, C Longo, S Ribero, J Malvehy, G Pellacani, F Cambazard, J L Perrot
BACKGROUND: Several dermoscopic and in vivo reflectance confocal microscopy (RCM) diagnostic criteria of lentigo maligna (LM)/lentigo maligna melanoma (LMM) have been identified. However, no study compared the diagnostic accuracy of these techniques. OBJECTIVE: We evaluated the diagnostic accuracy of dermoscopy and RCM for LM/LMM using a holistic assessment of the images. METHODS: 223 facial lesions were evaluated by 21 experts. Diagnostic accuracy of the clinical, dermoscopic and RCM examination were compared...
January 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29336131/vestibular-schwannoma-and-ipsilateral-endolymphatic-hydrops-an-unusual-association
#8
Massimo Ralli, Antonio Greco, Giancarlo Altissimi, Rosaria Turchetta, Lucia Longo, Vittorio D'Aguanno, Mario Tombolini, Giancarlo Cianfrone, Marco de Vincentiis
Vestibular schwannoma and endolymphatic hydrops are two conditions that may present with similar audio-vestibular symptoms. The association of the two in the same patient represents an unusual finding that may lead clinicians to errors and delays in diagnosis and clinical management of affected subjects. We discuss the case of a patient with an intrameatal vestibular schwannoma reporting symptoms suggestive for ipsilateral endolymphatic hydrops. The patient presented with fluctuating hearing loss, tinnitus, and acute rotatory vertigo episodes, and underwent a full audiological evaluation and imaging of the brain with contrast-enhanced Magnetic Resonance Imaging...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29336129/somatic-tinnitus
#9
REVIEW
Massimo Ralli, Antonio Greco, Fabrizio Cialente, Arianna Di Stadio, Lucia Longo, Andrea Ciofalo, Rosaria Turchetta, Giancarlo Cianfrone, Marco de Vincentiis
Modulation of tinnitus characteristics such as pitch and loudness has been extensively described following movements of the head, neck and limbs, vertical or horizontal eye gaze, pressure on myofascial trigger points, cutaneous stimulation of the hands, electrical stimulation of the median nerve, and transcranial direct current stimulation. Modulation of tinnitus follows complex interactions between auditory and somatosensory afferents and can be favored by underlying somatic disorders. When tinnitus appears to be preceded or strictly linked to a somatic disorder, and therefore related to problems of the musculoskeletal system rather than of the ear, it is defined somatic tinnitus...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29331263/glial-scars-are-permeable-to-the-neurotoxic-environment-of-chronic-stroke-infarcts
#10
Jacob C Zbesko, Thuy-Vi V Nguyen, Tao Yang, Jennifer Beischel Frye, Omar Hussain, Megan Hayes, Amanda Chung, W Anthony Day, Kristina Stepanovic, Maj Krumberger, Justine Mona, Frank M Longo, Kristian P Doyle
Following stroke, the damaged tissue undergoes liquefactive necrosis, a stage of infarct resolution that lasts for months, although the exact length of time is currently unknown. One method of repair involves reactive astrocytes and microglia forming a glial scar to compartmentalize the area of liquefactive necrosis from the rest of the brain. The formation of the glial scar is a critical component of the healing response to stroke, as well as other central nervous system (CNS) injuries. The goal of this study was to evaluate the toxicity of the extracellular fluid present in areas of liquefactive necrosis and determine how effectively it is segregated from the remainder of the brain...
January 10, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29330778/isotopic-exchange-hplc-hrms-ms-applied-to-cyclic-proanthocyanidins-in-wine-and-cranberries
#11
Edoardo Longo, Fabrizio Rossetti, Matteo Scampicchio, Emanuele Boselli
Cyclic B-type proanthocyanidins in red wines and grapes have been discovered recently. However, proanthocyanidins of a different chemical structure (non-cyclic A-type proanthocyanidins) already known to be present in cranberries and wine possess an identical theoretical mass. As a matter of fact, the retention times and the MS/MS fragmentations found for the proposed novel cyclic B-type tetrameric proanthocyanidin in red wine and the known tetrameric proanthocyanidin in a cranberry extract are herein shown to be identical...
January 12, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29326167/the-protein-kinase-ck2-substrate-jabba-modulates-lipid-metabolism-during-drosophila-oogenesis
#12
Emily A McMillan, Sheila M Longo, Michael D Smith, Sarah Broskin, Baicheng Lin, Nisha K Singh, Todd I Strochlic
Lipid metabolism plays a critical role in female reproduction. During oogenesis, maturing oocytes accumulate high levels of neutral lipids that are essential for both energy production and for the synthesis of other lipid molecules. Metabolic pathways within the ovary are partially regulated by protein kinases that link metabolic status to oocyte development. While the functions of several kinases in this process are well established, the roles that many other kinases play in coordinating metabolic state with female germ cell development are unknown...
January 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29318875/a-polycapillary-optics-based-confocal-micro-xrf-and-xas-setup-at-esrf-crg-beamline-dubble-bm26a
#13
Stephen Bauters, Pieter Tack, Jennifer Helen Rudloff-Grund, Dipanjan Banerjee, Alessandro Longo, Bart Vekemans, Wim Bras, Frank E Brenker, Roelof van Silfhout, Laszlo Vincze
A novel plug-and-play setup based on polycapillary X-ray optics enables 3D confocal XRF and XAS down to 8×8×11 µm3 (17 keV) at the ESRF CRG beamline DUBBLE, BM26A. A complete description and analytical characterization is presented, together with 2 recently performed experimental cases. In Deep Earth diamond SL-FFM 16, an Olivine rich inclusion was mapped with full 3D XRF elemental imaging. The preliminary tests on an Iron Gall ink containing historical document, a letter from the court of King Philip II of Spain, reveals both the delicate nature of Iron Gall ink and the lack of Fe-Ni chemical bonding...
January 10, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29310267/gold-leaf-from-gilding-to-the-fabrication-of-disposable-wearable-and-low-cost-electrodes
#14
Mauro Sérgio Ferreira Santos, Wilson Akira Ameku, Ivano Gebhardt Rolf Gutz, Thiago Regis Longo Cesar Paixão
Gold is among the most used materials in electrocatalysis. Despite this, this noble metal is still too expensive to be used in the fabrication of low cost and disposable devices. In the present work, gold-leaf sheets, usually employed in decorative crafts and wedding candies, is introduced as an inexpensive source of gold. Planar-disc and nanoband gold electrodes were simply and easily manufactured by combining gold leaf and polyimide tape. The planar disc electrode exhibited electrochemical behavior similar to that of a commercial gold electrode in 0...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29307077/analysis-of-ct-features-and-quantitative-texture-analysis-in-patients-with-thymic-tumors-correlation-with-grading-and-staging
#15
Angelo Iannarelli, Beatrice Sacconi, Francesca Tomei, Marco Anile, Flavia Longo, Mario Bezzi, Alessandro Napoli, Luca Saba, Michele Anzidei, Giulia D'Ovidio, Roberto Scipione, Carlo Catalano
OBJECTIVES: To evaluate potential relationship between qualitative CT features, quantitative texture analysis (QTA), histology, WHO staging, Masaoka classification and myasthenic syndrome in patients with thymic tumors. MATERIALS AND METHODS: Sixteen patients affected by histologically proven thymic tumors were retrospectively included in the study population. Clinical information, with special regard to myasthenic syndrome and serological positivity of anti-AchR antibodies, were recorded...
January 6, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29306246/hyperbolic-relation-between-beta-cell-function-and-insulin-sensitivity-for-type-2-diabetes-mellitus-malaria-influenza-helicobacter-pylori-chlamydia-pneumoniae-and-hepatitis-c-virus-infection-induced-inflammation-oxidative-stress-and-temporary-insulin-resistance
#16
Jean Bosco Kasiam Lasi On'kin, Benjamin Longo-Mbenza, Venant Tchokonte-Nana, Augustin Nge Okwe, Nelly Kangola Kabangu
Background/aim: We calculated the homeostatic model assessment (HOMA) for estimating insulin sensitivity and beta-cell function in normal, healthy nondiabetics with infections (malaria, influenza, HIV, Helicobacter pylori, Chlamydia pneumoniae, and hepatitis C virus), type 2 diabetic black patients, and healthy controls from Kinshasa, DR Congo. Materials and methods: A case-control study was carried out between 2006 and 2007 for black Central African participants managed for HOMA.Results: In total, 219 patients and 110 healthy controls were matched for sex and age...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29301908/deletion-of-a-long-range-dlx5-enhancer-disrupts-inner-ear-development-in-mice
#17
Kenneth R Johnson, Leona H Gagnon, Cong Tian, Chantal M Longo-Guess, Benjamin E Low, Michael V Wiles, Amy E Kiernan
Distal enhancers are thought to play important roles in the spatiotemporal regulation of gene expression during embryonic development, but few predicted enhancer elements have been shown to affect transcription of their endogenous genes or to alter phenotypes when disrupted. Here, we demonstrate that a 123.6 kb deletion within the mouse Slc25a13 gene is associated with reduced transcription of Dlx5, a gene located 660 kb away. Mice homozygous for the Slc25a13 deletion mutation (named hyperspin, hspn) have malformed inner ears and are deaf with balance defects, whereas previously reported Slc25a13 knockout mice showed no phenotypic abnormalities...
January 3, 2018: Genetics
https://www.readbyqxmd.com/read/29300224/achilles-tendinopathy
#18
Umile Giuseppe Longo, Mario Ronga, Nicola Maffulli
Achilles tendinopathy is a common cause of disability. Despite the economic and social relevance of the problem, the causes and mechanisms of Achilles tendinopathy remain unclear. Tendon vascularity, gastrocnemius-soleus dysfunction, age, sex, body weight and height, pes cavus, and lateral ankle instability are considered common intrinsic factors. The essence of Achilles tendinopathy is a failed healing response, with haphazard proliferation of tenocytes, some evidence of degeneration in tendon cells and disruption of collagen fibers, and subsequent increase in noncollagenous matrix...
March 2018: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/29297523/znwo4-nanocrystals-synthesis-morphology-photoluminescence-and-photocatalytic-properties
#19
P F S Pereira, A F Gouveia, M Assis, R C de Oliveira, I M Pinatti, M Penha, R F Gonçalves, L Gracia, J Andrés, E Longo
The present joint experimental and theoretical work provides in-depth understanding on the morphology and structural, electronic, and optical properties of ZnWO4 nanocrystals. Monoclinic ZnWO4 nanocrystals were prepared at three different temperatures (140, 150, and 160 °C) by a microwave hydrothermal method. Then, the samples were investigated by X-ray diffraction with Rietveld refinement analysis, field-emission scanning electron microscopy, transmission electronic microscopy, micro-Raman and Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, and photoluminescence measurements...
January 3, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29296035/grid-block-design-based-on-monte-carlo-simulated-dosimetry-the-linear-quadratic-and-hug-kellerer-radiobiological-models
#20
Somayeh Gholami, Hassan Ali Nedaie, Francesco Longo, Mohammad Reza Ay, Sharifeh A Dini, Ali S Meigooni
Purpose: The clinical efficacy of Grid therapy has been examined by several investigators. In this project, the hole diameter and hole spacing in Grid blocks were examined to determine the optimum parameters that give a therapeutic advantage. Methods: The evaluations were performed using Monte Carlo (MC) simulation and commonly used radiobiological models. The Geant4 MC code was used to simulate the dose distributions for 25 different Grid blocks with different hole diameters and center-to-center spacing...
October 2017: Journal of Medical Physics
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