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https://www.readbyqxmd.com/read/29160334/prevalence-of-speech-and-language-disorders-in-children-in-the-western-region-of-s%C3%A3-o-paulo
#1
Isadora Altero Longo, Gabriella Gonçalves Tupinelli, Caroline Hermógenes, Laís Vignati Ferreira, Daniela Regina Molini-Avejonas
PURPOSE: To establish the speech-language disorders in children living in the western region of São Paulo; to assess associations between diagnosis hypotheses (DH) and the age, gender and origin of referral; and to investigate the degree of agreement between the complaint and the DH at the moment of speech-language screening. METHODS: Observational epidemiological study conducted at a laboratory of Primary Health Care. A survey of 525 medical records of children between 2002 and 2011 was conducted...
November 9, 2017: CoDAS
https://www.readbyqxmd.com/read/29160302/role-of-cyp24a1-vdr-and-gc-gene-polymorphisms-on-deferasirox-pharmacokinetics-and-clinical-outcomes
#2
S Allegra, J Cusato, S De Francia, A Arduino, F Longo, E Pirro, D Massano, A De Nicolò, A Piga, A D'Avolio
β-Thalassemia patients develop deficiency in vitamin D absorption and liver hydroxylation, resulting in extremely low calcitriol levels. We explored the role of single-nucleotide polymorphisms (SNPs) involved in vitamin D metabolism, transport and activity on deferasirox pharmacokinetics and outcomes (effectiveness trough levels (Ctrough) and the area under the curve (AUC) cutoffs of 20 μg ml(-1) and 360 μg ml(-1) h(-1), respectively; nonresponse AUC limit of 250 μg ml(-1) h(-1)). Ninety-nine β-thalassemic patients were enrolled...
November 21, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29154848/role-of-clinical-and-surgical-factors-for-the-prediction-of-immediate-early-and-late-functional-result-and-its-relatonship-with-cardivascular-outcome-after-partial-nephrectomy-results-from-the-prospective-multicenter-record-1-project
#3
Alessandro Antonelli, Andrea Mari, Nicola Longo, Giacomo Novara, Francesco Porpiglia, Riccardo Schiavina, Vincenzo Ficarra, Marco Carini, Andrea Minervini
PURPOSE: To determine the predictors of short and long-term renal function impairment after partial nephrectomy. MATERIALS AND METHODS: The clinical data of 769 consecutive patients submitted to partial nephrectomy were prospectively recorded in 19 urological Italian centers from 2009 to 2012 (RECORd1 Project). Of these, the clinical data of 708 patients alive, free from disease recurrence, and with a minimum 2-year functional follow-up were extracted. RESULTS: Patients underwent open (47...
November 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29150137/knowledge-translation-in-pediatric-rehabilitation-expanding-access-to-scientific-knowledge
#4
Egmar Longo, Élida Rayanne Viana Pinheiro Galvão, Haryelle Náryma Confessor Ferreira, Ana Raquel Rodrigues Lindquist, Keiko Shikako-Thomas
No abstract text is available yet for this article.
November 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/29146721/development-of-a-function-blocking-antibody-against-fibulin-3-as-targeted-reagent-for-glioblastoma
#5
Mohan Sobhana Nandhu, Prajna Behera, Vivek Bhaskaran, Sharon L Longo, Lina M Barrera-Arenas, Sadhak Sengupta, Diego J Rodriguez-Gil, E Antonio Chiocca, Mariano S Viapiano
PURPOSE: We sought a novel approach against glioblastomas (GBM) focused on targeting signaling molecules localized in the tumor extracellular matrix (ECM). We investigated fibulin-3, a glycoprotein that forms the ECM scaffold of GBMs and promotes tumor progression by driving Notch and NF-kB signaling. EXPERIMENTAL DESIGN: We used deletion constructs to identify a key signaling motif of fibulin-3. A monoclonal antibody (mAb428.2) was generated against this epitope and extensively validated for specific detection of human fibulin-3...
November 16, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29145836/clinical-utility-of-computed-tomography-hounsfield-characterization-for-percutaneous-nephrolithotomy-a-cross-sectional-study
#6
Andrea Gallioli, Elisa De Lorenzis, Luca Boeri, Maurizio Delor, Stefano Paolo Zanetti, Fabrizio Longo, Alberto Trinchieri, Emanuele Montanari
BACKGROUND: Computed Tomography (CT) is considered the gold-standard for the pre-operative evaluation of urolithiasis. However, no Hounsfield (HU) variable capable of differentiating stone types has been clearly identified. The aim of this study is to assess the predictive value of HU parameters on CT for determining stone composition and outcomes in percutaneous nephrolithotomy (PCNL). METHODS: Seventy seven consecutive cases of PCNL between 2011 and 2016 were divided into 4 groups: 40 (52%) calcium, 26 (34%) uric acid, 5 (6%) struvite and 6 (8%) cystine stones...
November 16, 2017: BMC Urology
https://www.readbyqxmd.com/read/29145020/evaluation-of-7-be-and-133-xe-atmospheric-radioactivity-time-series-measured-at-four-ctbto-radionuclide-stations
#7
Stefano Bianchi, Alessandro Longo, Wolfango Plastino, Pavel P Povinec
Time series analysis of (7)Be and (133)Xe atmospheric data and meteorological parameters measured at four CTBTO/IMS radionuclide stations have shown great variability in terms of noise structures, harmonic content, cross-correlation patterns and local Hurst exponent behaviour. This study focused on highlighting and characterising both differences and similarities expected for these radionuclides due to their different physical and chemical characteristics along with their different source terms. Detrended crosscorrelation analysis of different meteorological parameters influencing the residuals time series has shown that for Canadian and American stations the parameters mostly affecting radionuclide concentrations in the air seem to be wind direction and atmospheric pressure...
November 2, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29139309/polyphenolic-characterisation-of-plant-mixture-lisosan%C3%A2-reduction-and-its-hypocholesterolaemic-effect-in-high-fat-diet-fed-mice
#8
Rossella Russo, Laura Pucci, Lucia Giorgetti, Július Árvay, Francesco Vizzarri, Vincenzo Longo, Luisa Pozzo
Lisosan® Reduction is a plant mixture produced from powder of fermented Triticum aestivum (Lisosan® G), Desmodium adscendens, Malus domestica, Picrorhiza kurroa and Hordeum vulgare. The aim of this study was to characterise the phenolic profile of Lisosan® Reduction and to evaluate the effects of aqueous extract on mice fed a high fat diet (HFD). Syringic acid, trans sinapic acid and neochlorogenic acid were identified by HPLC-DAD to be the dominant polyphenols of Lisosan® Reduction, followed by vitexin, trans p-coumeric acid and trans ferulic acid...
November 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29133968/effects-of-laser-therapy-and-grimaldi-s-muscle-shortening-manoeuvre-on-motor-control-of-subjects-with-incomplete-spinal-cord-injuries
#9
Diego Longo, Leonardo Longo, Paolo Lippi, Giulio Cherubini, Vanessa Mangé
Background and Objectives: From year 2003 we treated positively 251 patients with Traumatic Spinal Cord Injuries (TSCI), using Non-Surgical Laser Therapy (NSLT). In order to increase muscle strength, we have also started using a physical therapy practice called Grimaldi's Muscle Shortening Manoeuvre (GMSM)The goal of our study is to obtain objective data suggesting the real effectiveness of the association of these two treatments. Study Design and Methods: In 2015, 10 patients with incomplete TSCI were enrolled...
September 30, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29132749/use-of-immunomodulatory-drugs-at-a-uveitis-clinic
#10
Claudia Millán-Longo, Diana Peiteado, Armelle Schlincker, Ventura Hidalgo, Amara Pieren, Alejandro Balsa, Eugenio de Miguel
OBJECTIVE: The treatment of noninfectious uveitis includes steroids and immunomodulatory drugs, the use of which has increased in the last few years, and the options have been enriched with the development of new treatments. However, clear therapeutic guidelines and protocols have not been developed. The purpose is to analyze the response to the drugs used and the characteristics of the patients treated at a multidisciplinary uveitis clinic. MATERIAL AND METHODS: Observational and retrospective study of the patients attended to from January 2012 to December 2015...
November 10, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29131420/chromatographic-analysis-of-voc-patterns-in-exhaled-breath-from-smokers-and-nonsmokers
#11
Simonetta Capone, Maria Tufariello, Angiola Forleo, Valentina Longo, Lucia Giampietruzzi, Antonio Vincenzo Radogna, Flavio Casino, Pietro Siciliano
Cigarette smoking harms nearly every organ of the body and causes many diseases. The analysis of exhaled breath for exogenous and endogenous Volatile Organic Compounds (VOCs) can provide fundamental information on active smoking and insight into the health damage that smoke is creating. Various exhaled Volatile Organic Compounds (VOCs) have been reported as typical of smoking habit and recent tobacco consumption, but to date, no eligible biomarkers have been identified. Aiming to identify such potential biomarkers, in this pilot study we analysed the chemical patterns of exhaled breath from 26 volunteers divided in groups of nonsmokers and subgroups of smokers sampled at different periods of withdrawal from smoking...
November 13, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29126993/trophic-effect-of-pacap-on-human-corneal-endothelium
#12
Grazia Maugeri, Antonio Longo, Agata Grazia D'Amico, Daniela Maria Rasà, Michele Reibaldi, Andrea Russo, Vincenza Bonfiglio, Teresio Avitabile, Velia D'Agata
Cornea's posterior surface includes endothelium maintaining stromal hydration and clarity. Due to their limited proliferative capability, the loss of endothelial cells can outcome in permanent opacity. In the last years, different studies have demonstrated the protective effect of pituitary adenylate cyclase-activating polypeptide (PACAP) in different ocular diseases. However, its role on human corneal endothelial cells (HCECs) has not been investigated, yet. Here, we have developed a culture protocol to differentiate HCECs from donor's cornea...
November 8, 2017: Peptides
https://www.readbyqxmd.com/read/29125708/integration-of-dermoscopy-and-reflectance-confocal-microscopy-for-distinguishing-melanomas-from-nevi-of-the-breast-area
#13
V D Mandel, C Bombonato, R Pampena, A Kyrgidis, S Borsari, E Benati, M Mirra, S Piana, G Pellacani, C Longo
BACKGROUND: Nevi of special sites encompass a class of benign lesions characterized by the presence of atypical clinical and histopathologic features that can be difficult to distinguish from melanoma. Dermoscopy and reflectance confocal microscopy may improve the clinical assessment of melanocytic lesions in order to avoid unnecessary excisions. OBJECTIVES: The aim of this study was to assess the value of specific dermoscopic and confocal criteria in distinguishing melanomas from nevi of the breast area...
November 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29120085/novel-au-and-ag-carbene-complexes-exert-anti-tumor-effects-triggering-the-ros-dependent-intrinsic-apoptotic-pathway
#14
Domenico Iacopetta, Annaluisa Mariconda, Carmela Saturnino, Anna Caruso, Giuseppe Palma, Jessica Ceramella, Noemi Muià, Mariarita Perri, Maria Stefania Sinicropi, Maria Cristina Caroleo, Pasquale Longo
Cisplatin and other platinum-based drugs are well-known valid anticancer drugs. However, during the chemotherapy, the presence of numerous side effects and the onset of frequent phenomena of resistance pushes forward many research groups to devise new metal-based compounds holding improved anticancer properties and lower undesired effects. Amongst the variety of synthesized compounds, significant anti-proliferative effects were obtained employing organometallic compounds, particularly those based on silver or gold...
November 9, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29115737/reinterpreting-dermoscopic-pigment-network-with-reflectance-confocal-microscopy-for-identification-of-melanoma-specific-features
#15
B De Pace, F Farnetani, A Losi, S Ciardo, N De Carvalho, Anna M Cesinaro, L Reggiani Bonetti, J Chester, S Kaleci, E Del Duca, Steven P Nisticò, C Longo, G Pellacani
BACKGROUND: Pigment network is an important dermoscopic features for melanocytic lesions but alterations in grid line thickness are also observed in melanomas. OBJECTIVE: To investigate features of thick, thin and mixed pigment networks at dermoscopy and their respective features at Reflectance Confocal Microscopy (RCM) for differential diagnosis, correlated with histology METHODS: All melanocytic lesions with histological diagnosis, evaluated between January 2010 - May 2014, were enrolled and classified according to dermoscopy evaluation of the pigment network; thin, thick and mixed...
November 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29114037/reducing-eif4e-eif4g-interactions-restores-the-balance-between-protein-synthesis-and-actin-dynamics-in-fragile-x-syndrome-model-mice
#16
Emanuela Santini, Thu N Huynh, Francesco Longo, So Yeon Koo, Edward Mojica, Laura D'Andrea, Claudia Bagni, Eric Klann
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and autism spectrum disorder. FXS is caused by silencing of the FMR1 gene, which encodes fragile X mental retardation protein (FMRP), an mRNA-binding protein that represses the translation of its target mRNAs. One mechanism by which FMRP represses translation is through its association with cytoplasmic FMRP-interacting protein 1 (CYFIP1), which subsequently sequesters and inhibits eukaryotic initiation factor 4E (eIF4E). CYFIP1 shuttles between the FMRP-eIF4E complex and the Rac1-Wave regulatory complex, thereby connecting translational regulation to actin dynamics and dendritic spine morphology, which are dysregulated in FXS model mice that lack FMRP...
November 7, 2017: Science Signaling
https://www.readbyqxmd.com/read/29111877/dna-methylation-alterations-induced-by-transient-exposure-of-mcf-7-cells-to-maghemite-nanoparticles
#17
Raphael S Bonadio, Ana Carolina Arcanjo, Emilia Cd Lima, Alline T Vasconcelos, Renata C Silva, Frederico H Horst, Ricardo B Azevedo, Marcio José Poças-Fonseca, João Paulo F Longo
AIM: To evaluate the DNA methylation profile of MCF-7 cells during and after the treatment with maghemite nanoparticles (MNP-CIT). MATERIALS & METHODS: Noncytotoxic MNP-CIT concentrations and cell morphology were evaluated by standard methods. DNA methylation was assessed by whole genome bisulfite sequencing. DNA methyltransferase (DNMT) genes expression was analyzed by qRT-PCR. RESULTS: A total of 30 and 60 µgFeml(-1) MNP-CIT accumulated in cytoplasm but did not present cytotoxic effects...
November 7, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29109693/the-effectiveness-of-eye-movement-desensitization-and-reprocessing-integrative-group-protocol-with-adolescent-survivors-of-the-central-italy-earthquake
#18
Giada Maslovaric, Maria Zaccagnino, Clarice Mezzaluna, Sava Perilli, Denis Trivellato, Vittorio Longo, Cristina Civilotti
Earthquakes, which can cause widespread territorial and socio-economic destruction, are life-threatening, unexpected, unpredictable, and uncontrollable events caused by the shaking of the surface of the earth. The psychological consequences, such as PTSD, anxiety, depression, and suicidal ideation, are well-known to clinicians and researchers. This study was conducted with the aim of evaluating the use of the Eye Movement Desensitization and Reprocessing (EMDR) Integrative Group Treatment Protocol on a sample of adolescents, after the earthquake in Central Italy on 24 August 2016...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29108022/risk-factors-for-hiv-infection-among-female-sex-workers-in-bangui-central-african-republic
#19
Jean De Dieu Longo, Marcel Mbeko Simaleko, Henri Saint-Calvaire Diemer, Gérard Grésenguet, Gilles Brücker, Laurent Belec
OBJECTIVE: The aims of the study were i) to categorize female sex workers (FSW) according to socio-anthropologic criteria in Bangui; ii) to examine the association between a selection of demographic and risk variables with the different categories of female sex work as outcome, and iii) to investigate factors associated with HIV status. METHODS: A cross-sectional questionnaire survey was conducted to describe the spectrum of commercial sex work in Bangui among 345 sexually active women...
2017: PloS One
https://www.readbyqxmd.com/read/29106966/single-step-preparation-of-selected-biological-fluids-for-the-high-performance-liquid-chromatographic-analysis-of-fat-soluble-vitamins-and-antioxidants
#20
Giacomo Lazzarino, Salvatore Longo, Angela Maria Amorini, Valentina Di Pietro, Serafina D'Urso, Giuseppe Lazzarino, Antonio Belli, Barbara Tavazzi
Fat-soluble vitamins and antioxidants are of relevance in health and disease. Current methods to extract these compounds from biological fluids mainly need use of multi-steps and multi organic solvents. They are time-consuming and difficult to apply to treat simultaneously large sample number. We here describe a single-step, one solvent extraction of fat-soluble vitamins and antioxidants from biological fluids, and the chromatographic separation of all-trans-retinoic acid, 25-hydroxycholecalciferol, all-trans-retinol, astaxanthin, lutein, zeaxanthin, trans-β-apo-8'-carotenal, γ-tocopherol, β-cryptoxanthin, α-tocopherol, phylloquinone, lycopene, α-carotene, β-carotene and coenzyme Q10...
December 8, 2017: Journal of Chromatography. A
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