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https://www.readbyqxmd.com/read/27918114/confined-metastable-2-line-ferrihydrite-for-affordable-point-of-use-arsenic-free-drinking-water
#1
Avula Anil Kumar, Anirban Som, Paolo Longo, Chennu Sudhakar, Radha Gobinda Bhuin, Soujit Sen Gupta, Anshup, Mohan Udhaya Sankar, Amrita Chaudhary, Ramesh Kumar, Thalappil Pradeep
Arsenic-free drinking water, independent of electrical power and piped water supply, is possible only through advanced and affordable materials with large uptake capacities. Confined metastable 2-line ferrihydrite, stable at ambient temperature, shows continuous arsenic uptake in the presence of other complex species in natural drinking water and an affordable water purification device has been made using the same.
December 5, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27917118/no-correlation-between-distorted-body-representations-underlying-tactile-distance-perception-and-position-sense
#2
Matthew R Longo, Rosa Morcom
Both tactile distance perception and position sense are believed to require that immediate afferent signals be referenced to a stored representation of body size and shape (the body model). For both of these abilities, recent studies have reported that the stored body representations involved are highly distorted, at least in the case of the hand, with the hand dorsum represented as wider and squatter than it actually is. Here, we investigated whether individual differences in the magnitude of these distortions are shared between tactile distance perception and position sense, as would be predicted by the hypothesis that a single distorted body model underlies both tasks...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27912088/enhancing-stem-cell-transplantation-with-nutri-technology
#3
Valter D Longo, Salvatore Cortellino
It is necessary to employ myeloablative irradiation or chemotherapy to deplete the HSC niche to optimize hematopoietic stem cell transplantation. In a recent issue of Science, Taya and colleagues provide evidence for an alternative to the toxic chemoirradiative procedure by showing that a valine-restricted diet is sufficient to empty the bone marrow niche.
December 1, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/27911323/short-term-response-is-not-predictive-of%C3%A2-long-term-response-to%C3%A2-acetylcholinesterase-inhibitors-in-old-age-subjects-with-alzheimer-s-disease-a%C3%A2-real-world-study
#4
Virginia Boccardi, Marta Baroni, Nicoletta Smirne, Alessandra Clodomiro, Sara Ercolani, Annalisa Longo, Carmelinda Ruggiero, Amalia C Bruni, Patrizia Mecocci
BACKGROUND: Most of clinical guidelines recommend discontinuing treatment with cholinesterase inhibitors (ChEIs) in patients with Alzheimer's disease (AD) who do not show an initial response to therapy as evaluated with the Mini-Mental State Examination (MMSE) scale. However, understanding the relationship between the initial response to ChEI treatment and the subsequent course of the disease is extremely important in clinical practice, but evidence is limited, particularly in the old-old population...
November 29, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911232/intracranial-venous-sinus-thrombosis-as-unusual-presentation-of-bing-neel-syndrome-case-illustration
#5
Rosa Morabito, Giovanni Grasso, Valeria Barresi, Paolo La Spina, Giada Garufi, Elisabetta Alafaci, Francesco M Salpietro, Marcello Longo, Francesca Granata, Concetta Alafaci
No abstract text is available yet for this article.
December 2, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27903674/atezolizumab-a-pd-l1-blocking-antibody-for-bladder-cancer
#6
Brant A Inman, Thomas A Longo, Sundhar Ramalingam, Michael R Harrison
Atezolizumab (Tecentriq™, MPDL3280A) is an FcγR-binding deficient, fully humanized, IgG1 monoclonal antibody designed to interfere with the binding of PD-L1 ligand to its two receptors, PD-1 and B7.1. By blocking the PD-L1/PD-1 immune checkpoint, atezolizumab reduces immunosuppressive signals found within the tumor microenvironement and consequently increases T cell mediated immunity against the tumor. Atezolizumab has been FDA-approved as second-line therapy for advanced bladder cancer. This accelerated approval was based on phase 2 trial data in patients with metastatic bladder cancer that showed unexpected and durable tumor responses...
November 30, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27895580/increased-levels-of-mirna-146a-in-serum-and-histologic-samples-of-patients-with-uveal-melanoma
#7
Andrea Russo, Rosario Caltabiano, Antonio Longo, Teresio Avitabile, Livio M Franco, Vincenza Bonfiglio, Lidia Puzzo, Michele Reibaldi
Purpose: To analyze MiRs expression in serum of UM patients, respect to healthy donors, and to compare this data with MiRs expressed in formalin-fixed, paraffin-embedded UM samples. Methods: Expression profile of 754 miRNAs was performed in serum of patients with uveal melanoma who underwent primary enucleation. The level of miRNAs increased in serum was individually analyzed on FFPE UM samples and compared to choroidal melanocytes from unaffected eyes. Results: Fourteen patients with uveal melanoma were included in the study...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27884153/performance-evaluation-of-the-touchscreen-based-muse%C3%A2-auto-cd4-cd4-single-platform-system-for-cd4-t-cell-numeration-in-absolute-number-and-in-percentage-using-blood-samples-from-children-and-adult-patients-living-in-the-central-african-republic
#8
Christian Diamant Mossoro-Kpinde, André Kouabosso, Ralph-Sydney Mboumba Bouassa, Jean De Dieu Longo, Edouard Kokanzo, Rosine Féissona, Gérard Grésenguet, Laurent Bélec
BACKGROUND: The new microcapillary and fluorescence-based EC IVD-qualified Muse™ Auto CD4/CD4% single-platform assay (EMD Millipore Corporation, Merck Life Sciences, KGaA, Darmstadt, Germany) for CD4 T cell numeration in absolute number and in percentage was evaluated using Central African patients' samples compared against the reference EC IVD-qualified BD FACSCount (Becton-Dickinson, USA) flow cytometer. METHODS: EDTA-blood samples from 124 adults, 10 adolescents, 13 children and 3 infants were tested in parallel at 2 reference laboratories in Bangui...
November 25, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27884140/phase-ii-clinical-study-of-valproic-acid-plus-cisplatin-and-cetuximab-in-recurrent-and-or-metastatic-squamous-cell-carcinoma-of-head-and-neck-v-chance-trial
#9
Francesco Caponigro, Elena Di Gennaro, Franco Ionna, Francesco Longo, Corrado Aversa, Ettore Pavone, Maria Grazia Maglione, Massimiliano Di Marzo, Paolo Muto, Ernesta Cavalcanti, Antonella Petrillo, Fabio Sandomenico, Piera Maiolino, Roberta D'Aniello, Gerardo Botti, Rossella De Cecio, Nunzia Simona Losito, Stefania Scala, Annamaria Trotta, Andrea Ilaria Zotti, Francesca Bruzzese, Antonio Daponte, Ester Calogero, Massimo Montano, Monica Pontone, Gianfranco De Feo, Francesco Perri, Alfredo Budillon
BACKGROUND: Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in this stage. Thus, the concomitant use of novel compounds represents a critical strategy to improve treatment results. Histone deacetylase inhibitors (HDACi) enhance the activity of several anticancer drugs including cisplatin and anti-Epidermal Growth Factor Receptor (anti-EGFR) compounds...
November 25, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27881236/deferasirox-pharmacokinetics-evaluation-in-a-woman-with-hereditary-haemochromatosis-and-heterozygous-%C3%AE-thalassaemia
#10
Sarah Allegra, Silvia De Francia, Filomena Longo, Davide Massano, Jessica Cusato, Arianna Arduino, Elisa Pirro, Antonio Piga, Antonio D'Avolio
We present the deferasirox pharmacokinetics evaluation of a female patient on iron chelation, for the interesting findings from her genetic background (hereditary haemochromatosis and heterozygous β-thalassaemia) and clinical history (ileostomy; iron overload from transfusions). Drug plasma concentrations were measured by an HPLC-UV validated method, before and after ileum resection. Area under deferasirox concentration curve over 24h (AUC) values were determined by the mixed log-linear rule, using Kinetica software...
November 20, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27877844/identifying-and-rationalizing-the-morphological-structural-and-optical-properties-of-formula-see-text-ag2moo4-microcrystals-and-the-formation-process-of-ag-nanoparticles-on-their-surfaces-combining-experimental-data-and-first-principles-calculations
#11
Maria T Fabbro, Carla Saliby, Larissa R Rios, Felipe A La Porta, Lourdes Gracia, Máximo S Li, Juan Andrés, Luís P S Santos, Elson Longo
We present a combined theoretical and experimental study on the morphological, structural, and optical properties of β-Ag2MoO4 microcrystals. β-Ag2MoO4 samples were prepared by a co-precipitation method. The nucleation and formation of Ag nanoparticles on β-Ag2MoO4 during electron beam irradiation were also analyzed as a function of electron beam dose. These events were directly monitored in real-time using in situ field emission scanning electron microscopy (FE-SEM). The thermodynamic equilibrium shape of the β-Ag2MoO4 crystals was built with low-index surfaces (001), (011), and (111) through a Wulff construction...
December 2015: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27876194/predictive-factors-of-overall-and-major-postoperative-complications-after-partial-nephrectomy-results-from-a-multicenter-prospective-study-the-record-1-project
#12
A Mari, A Antonelli, R Bertolo, G Bianchi, M Borghesi, V Ficarra, C Fiori, M Furlan, S Giancane, N Longo, V Mirone, G Morgia, F Porpiglia, B Rovereto, R Schiavina, S Serni, C Simeone, A Volpe, M Carini, A Minervini
INTRODUCTION AND OBJECTIVES: To analyze postoperative complications and to assess for significant predictive factors during partial nephrectomy (PN) using a large multicenter dataset. METHODS: Patients who underwent PN for clinical T1 renal tumors at 19 urological Italian centers (Registry of Conservative Renal Surgery [RECORd] project) were evaluated between 2009 and 2012. Anthropometric data, comorbidities and perioperative outcomes were analyzed. Complications were divided as intra- and postoperative, medical and surgical, as appropriate...
November 5, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27874288/n-heterocyclic-carbene-complexes-of-silver-and-gold-as-novel-tools-against-breast-cancer-progression
#13
Carmela Saturnino, Ines Barone, Domenico Iacopetta, Annaluisa Mariconda, Maria Stefania Sinicropi, Camillo Rosano, Antonella Campana, Stefania Catalano, Pasquale Longo, Sebastiano Andò
AIM: Metal carbenic complexes have received considerable attention in both the catalysis and biological fields for their potential applications in cancer and antimicrobial therapies. RESULTS: A small series of new silver and gold N-heterocyclic carbene complexes has been designed and synthesized. Among the tested complexes, one compound was particularly active in inhibiting anchorage-dependent and -independent breast cancer proliferation, and inducing cell apoptosis via a mitochondria-related process...
November 22, 2016: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/27872594/modafinil-induces-rapid-onset-behavioral-sensitization-and-cross-sensitization-with-cocaine-in-mice-implications-for-the-addictive-potential-of-modafinil
#14
Raphael Wuo-Silva, Daniela F Fukushiro, André W Hollais, Renan Santos-Baldaia, Elisa Mári-Kawamoto, Laís F Berro, Thaís S Yokoyama, Leonardo B Lopes-Silva, Carolina S Bizerra, Roberta Procópio-Souza, Debora Hashiguchi, Lilian A Figueiredo, Jose L Costa, Roberto Frussa-Filho, Beatriz M Longo
There is substantial controversy about the addictive potential of modafinil, a wake-promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and used indiscriminately by healthy individuals due to its positive effects on arousal and cognition. The rapid-onset type of behavioral sensitization (i.e., a type of sensitization that develops within a few hours from the drug priming administration) has been emerged as a valuable tool to study binge-like patterns of drug abuse and the neuroplastic changes that occur quickly after drug administration that ultimately lead to drug abuse...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27872127/targeting-cancer-metabolism-dietary-and-pharmacologic-interventions
#15
REVIEW
Claudio Vernieri, Stefano Casola, Marco Foiani, Filippo Pietrantonio, Filippo de Braud, Valter Longo
: Most tumors display oncogene-driven reprogramming of several metabolic pathways, which are crucial to sustain their growth and proliferation. In recent years, both dietary and pharmacologic approaches that target deregulated tumor metabolism are beginning to be considered for clinical applications. Dietary interventions exploit the ability of nutrient-restricted conditions to exert broad biological effects, protecting normal cells, organs, and systems, while sensitizing a wide variety of cancer cells to cytotoxic therapies...
December 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27867739/dermoscopic-hemorrhagic-dots-an-early-predictor-of-response-of-psoriasis-to-biologic-agents
#16
Aimilios Lallas, Giuseppe Argenziano, Iris Zalaudek, Zoe Apalla, Marco Ardigo, Patricia Chellini, Natalia Cordeiro, Mariana Guimaraes, Athanassios Kyrgidis, Elizabeth Lazaridou, Caterina Longo, Elvira Moscarella, Ilias Papadimitriou, Giovanni Pellacani, Elena Sotiriou, Efstratios Vakirlis, Dimitrios Ioannides
BACKGROUND: Biologic agents are routinely used in the treatment of severe psoriasis. The evaluation of treatment response is mainly based on the physician's global clinical assessment. OBJECTIVE: To investigate whether dermoscopy might enhance the assessment of response of psoriasis to treatment with biologic agents. METHODS: Patients with severe psoriasis scheduled to receive a biologic agent were enrolled in the study. A target lesion from each patient was clinically and dermoscopically documented at baseline and after one, two and six months...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27864140/the-role-of-mir-190a-in-methylglyoxal-induced-insulin-resistance-in-endothelial-cells
#17
Paola Mirra, Cecilia Nigro, Immacolata Prevenzano, Teresa Procopio, Alessia Leone, Gregory Alexander Raciti, Francesco Andreozzi, Michele Longo, Francesca Fiory, Francesco Beguinot, Claudia Miele
Methylglyoxal (MGO) is a reactive dicarbonyl produced as by-product of glycolysis, and its formation is heightened in hyperglycaemia. MGO plasma levels are two-fold to five-fold increased in diabetics and its accumulation promotes the progression of vascular complications. Impairment of endothelium-derived nitric oxide represents a common feature of endothelial dysfunction in diabetics. We previously demonstrated that MGO induces endothelial insulin resistance. Increasing evidence shows that high glucose and MGO modify vascular expression of several microRNAs (miRNAs), suggesting their potential role in the impairment of endothelial insulin sensitivity...
November 15, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27863720/can-residents-detect-errors-in-technique-while-observing-central-line-insertions
#18
Kevin Pei, Jonathan Merola, Kimberly A Davis, Walter E Longo
BACKGROUND: Procedural teaching and the ability to detect and correct errors are important components of surgical education. This study evaluates whether review of an instructional video will improve residents' ability to detect errors. We hypothesized that clinical experience and confidence do not correlate with ability to detect errors. METHODS: Participants were randomized to 2 groups: the study group viewed an instructional video demonstrating correct technique, whereas the control group did not view the instructional video...
October 19, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27861261/lung-recruitment-improves-right-ventricular-performance-after-cardiopulmonary-bypass-a-randomised-controlled-trial
#19
Silvina Longo, Juan Siri, Cecilia Acosta, Alberto Palencia, Arturo Echegaray, Iván Chiotti, Andrés Parisi, Lila Ricci, Marcela Natal, Fernando Suarez-Sipmann, Gerardo Tusman
BACKGROUND: Atelectasis after cardiopulmonary bypass (CPB) can affect right ventricular (RV) performance by increasing its outflow impedance. OBJECTIVE: The aim of this study was to determine whether a lung recruitment manoeuvre improves RV function by re-aerating the lung after CPB. DESIGN: Randomised controlled study. SETTING: Single-institution study, community hospital, Córdoba, Argentina. PATIENTS: Forty anaesthetised patients with New York Heart Association class I or II, preoperative left ventricular ejection fraction at least 50% and Euroscore 6 or less scheduled for cardiac surgery with CPB...
November 16, 2016: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/27859114/on-the-dual-nature-of-lichen-induced-rock-surface-weathering-in-contrasting-micro-environments
#20
Joana Marques, João Gonçalves, Cláudia Oliveira, Sergio E Favero-Longo, Graciela Paz-Bermúdez, Rubim Almeida, Beatriz Prieto
Contradictory evidence from biogeomorphological studies has increased the debate on the extent of lichen contribution to differential rock surface weathering in both natural and cultural settings. This study, undertaken in Côa Valley Archaeological Park, aimed at evaluating the effect of rock surface orientation on the weathering ability of dominant lichens. Hyphal penetration and oxalate formation at the lichen-rock interface were evaluated as proxies of physical and chemical weathering, respectively. A new protocol of pixel-based supervised image classification for the analysis of periodic acid-Schiff stained cross-sections of colonized schist revealed that hyphal spread of individual species was not influenced by surface orientation...
October 2016: Ecology
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