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https://www.readbyqxmd.com/read/28523429/kir-lilrb-and-their-ligands-genes-as-potential-biomarkers-in-recurrent-implantation-failure
#1
REVIEW
Izabela Nowak, Karolina Wilczyńska, Jacek R Wilczyński, Andrzej Malinowski, Paweł Radwan, Michał Radwan, Piotr Kuśnierczyk
Reproductive failure in humans is a very important social and economic problem, because nowadays women decide to conceive later in life and delay motherhood. Unfortunately, with increasing age they have less chance for natural fertilization and maintenance of pregnancy. Many of them need assisted reproductive technology. Approximately 10% of women after in vitro fertilization-embryo transfers experience recurrent implantation failure (RIF). Multiple factors may contribute to RIF, including oocyte and sperm quality, parental chromosomal anomalies, genetic or metabolic abnormalities of the embryo, poor uterine receptivity, immunological disturbances in the implantation site, and some gynecologic pathologies such as endometriosis, uterine fibroids, hydrosalpinx and endometrial polyps...
May 18, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28521061/extracellular-camp-activates-molecular-signalling-pathways-associated-with-sperm-capacitation-in-bovines
#2
Carlos Agustín I Alonso, Claudia E Osycka-Salut, Luciana Castellano, Andreína Cesari, Nicolás Di Siervi, Adrián Mutto, Anders Johannisson, Jane M Morrell, Carlos Davio, Silvina Perez-Martinez
STUDY QUESTION: Is extracellular cAMP involved in the regulation of signalling pathways in bovine sperm capacitation? SUMMARY ANSWER: Extracellular cAMP-induced sperm capacitation through the activation of different signalling pathways that involve phospholipase C (PLC), PKC/ERK1-2 signalling and an increase in sperm Ca2+ levels, as well as soluble AC and cAMP/protein kinase A (PKA) signalling. WHAT IS KNOWN ALREADY: In order to fertilize the oocyte, ejaculated spermatozoa must undergo a series of changes in the female reproductive tract, known as capacitation...
May 18, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28520729/top-quality-blastocyst-formation-rates-in-relation-to-progesterone-levels-on-the-day-of-oocyte-maturation-in-gnrh-antagonist-ivf-icsi-cycles
#3
V S Vanni, E Somigliana, M Reschini, L Pagliardini, E Marotta, S Faulisi, A Paffoni, P Vigano', W Vegetti, M Candiani, E Papaleo
Cycles with progesterone elevation during controlled ovarian stimulation (COS) for IVF/ICSI are commonly managed with a "freeze-all" strategy, due to a well-recognized detrimental effect of high progesterone levels on endometrial receptivity. However, also a detrimental effect of elevated progesterone on day-3 embryo quality has recently been found with regards to top quality embryo formation rate. Because blastocyst culture and cryopreservation are largely adopted, we deemed relevant to determine whether this detrimental effect is also seen on blastocyst quality on day 5-6...
2017: PloS One
https://www.readbyqxmd.com/read/28513460/the-role-of-oxidative-stress-in-female-infertility-and-in-vitro-fertilization
#4
Joanna Wojsiat, Jerzy Korczyński, Marta Borowiecka, Halina Małgorzata Żbikowska
Infertility problem involves many couples of reproductive age. It has been estimated that in Poland 0.7-1.0 million pairs require treatment, while for more than half of them assisted reproduction is the only recommended and effective method. Infertility affects 13 to 15% of the world's population. A major concern is the age-related decline in female fertility even more that often a decision about pregnancy is taken at later age. Recent studies show that increased production of reactive oxygen species is an important factor in etiopathogenesis of pregnancy and affects female reproduction...
May 9, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28512855/insulin-like-growth-factor-i-enhances-the-developmental-competence-of-yak-embryos-by-modulating-aquaporin-3
#5
P Chen, Y Pan, Y Cui, Z Wen, P Liu, H He, Q Li, X Peng, T Zhao, S Yu
The objective of our present study was to determine the effects of insulin-like growth factor I (IGF-I) on the development of yak (Bos grunniens) embryos after cumulus-oocyte complex (COC) vitrification and warming followed by in vitro fertilization (IVF). In Experiment 1, the yak COCs underwent vitrification and then IVF. Embryos were incubated in synthetic oviductal fluid (SOF) supplemented with four concentrations (0, 50, 100 and 200 ng/ml) of IGF-I, while the yak COCs without vitrification or IGF-I supplementation acted as the control group; the BAX, BCL-2, AQP3mRNA and aquaporin 3 (AQP3) protein expression levels in the five groups of blastocysts were evaluated using quantitative real-time PCR and immunofluorescence analyses...
May 16, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28507606/transcription-and-chromatin-determinants-of-de-novo-dna-methylation-timing-in-oocytes
#6
Lenka Gahurova, Shin-Ichi Tomizawa, Sébastien A Smallwood, Kathleen R Stewart-Morgan, Heba Saadeh, Jeesun Kim, Simon R Andrews, Taiping Chen, Gavin Kelsey
BACKGROUND: Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established largely as a consequence of transcription events. Molecular and functional studies have shown that imprinted genes become methylated at different times during oocyte growth; however, little is known about the kinetics of methylation gain genome wide and the reasons for asynchrony in methylation at imprinted loci...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28504655/transcription-factors-sohlh1-and-sohlh2-coordinate-oocyte-differentiation-without-affecting-meiosis-i
#7
Yong-Hyun Shin, Yu Ren, Hitomi Suzuki, Kayla J Golnoski, Hyo Won Ahn, Vasil Mico, Aleksandar Rajkovic
Following migration of primordial germ cells to the genital ridge, oogonia undergo several rounds of mitotic division and enter meiosis at approximately E13.5. Most oocytes arrest in the dictyate (diplotene) stage of meiosis circa E18.5. The genes necessary to drive oocyte differentiation in parallel with meiosis are unknown. Here, we have investigated whether expression of spermatogenesis and oogenesis bHLH transcription factor 1 (Sohlh1) and Sohlh2 coordinates oocyte differentiation within the embryonic ovary...
May 15, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28504648/the-so-h-l-h-o-drivers-of-oocyte-growth-and-survival-but-not-meiosis-i
#8
T Rajendra Kumar
The spermatogenesis/oogenesis helix-loop-helix (SOHLH) proteins SOHLH1 and SOHLH2 play important roles in male and female reproduction. Although previous studies indicate that these transcriptional regulators are expressed in and have in vivo roles in postnatal ovaries, their expression and function in the embryonic ovary remain largely unknown. Because oocyte differentiation is tightly coupled with the onset of meiosis, it is of significant interest to determine how early oocyte transcription factors regulate these two processes...
May 15, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28502832/sexually-dimorphic-expression-in-developing-and-adult-gonads-shows-an-important-role-of-gonadal-soma-derived-factor-during-sex-differentiation-in-olive-flounder-paralichthys-olivaceus
#9
Yuezhong Liu, Wei Zhang, Xinxin Du, Jun Zhao, Xiaobing Liu, Xiaojing Li, Quanqi Zhang, Xubo Wang
Gonadal soma-derived factor (gsdf) is a new member of transforming growth factor beta (TGF-β) superfamily. As a teleost- and gonad-specific growth factor, gsdf has been indicated to play an important role in early germ cell development. However, little is known about its significance in germ cell development of olive flounder (Paralichthys olivaceus). In the present study, a 1338 bp gsdf gene was isolated from P. olivaceus for the first time. Bioinformatic analysis revealed that the genomic structure and synteny relationship of gsdf in teleosts were conserved...
May 11, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28487477/a-magnesium-transporter-osmgt1-plays-a-critical-role-in-salt-tolerance-in-rice
#10
Zhi Chang Chen, Naoki Yamaji, Tomoaki Horie, Jing Che, Gynheung An, Jian Feng Ma, Jian Li
Salt stress is one of the major factors limiting rice production globally. Although several transporters involved in thesalt-tolerance have been identified in rice, the mechanisms regulating their transport activity are still poorly understood. Here, we show evidence that a rice Mg transporter OsMGT1 is required for the salt-tolerance probably by regulating transport activity of OsHKT1;5, a key transporter for the removal of Na+ from the xylem sap at the root mature zone. Knockout of OsMGT1 did not affect total Na uptake, but increased Na concentration in the shoots and xylem sap, resulting in a significant increase in salt sensitivity at low external Mg2+ concentration (20-200 μM)...
May 9, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28486664/microrna-21-plays-a-pivotal-role-in-the-oocyte-secreted-factor-induced-suppression-of-cumulus-cell-apoptosis%C3%A2
#11
Xiao Han, Rui Xue, Hong-Jie Yuan, Tian-Yang Wang, Juan Lin, Jie Zhang, Bo Liang, Jing-He Tan
It is known that oocytes and cumulus cells (CCs) are more resistant to apoptosis than other compartments of the antral follicle. However, although oocyte-secreted factors (OSFs) have been found to be involved in suppressing bovine CC apoptosis, little is known about the intra-cellular mechanisms by which OSFs render CCs resistant to apoptosis. Here we show that coculture with mouse or pig cumulus-denuded oocytes, culture with recombinant mouse growth differentiation factor-9 (GDF-9) or culture in pig oocyte-conditioned medium (POCM) significantly inhibited CC apoptosis of mouse oocytectomized cumulus oophorus complexes (OOXs)...
May 8, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28486131/large-cytoplasm-is-linked-to-the-error-prone-nature-of-oocytes
#12
Hirohisa Kyogoku, Tomoya S Kitajima
Chromosome segregation during meiosis in oocytes is error prone. The uniquely large cytoplasmic size of oocytes, which provides support for embryogenesis after fertilization, might be a predisposing factor for meiotic errors. However, this hypothesis remains unproven. Here, we show that cytoplasmic size affects the functionality of the acentrosomal spindle. Artificially decreasing the cytoplasmic size in mouse oocytes allows the acentrosomal spindle poles to have a better-focused distribution of microtubule-organizing centers and to biorient chromosomes more efficiently, whereas enlargement of the cytoplasmic size has the opposite effects...
May 8, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28476182/assessing-reproductive-choices-of-women-and-the-likelihood-of-oocyte-cryopreservation-in-the-era-of-elective-oocyte-freezing
#13
Lauren W Milman, Suneeta Senapati, Mary D Sammel, Katherine D Cameron, Clarisa Gracia
OBJECTIVE: To assess reproductive choices of reproductive-age women in the United States and factors that influence consideration of elective egg freezing (EF). DESIGN: Cross-sectional internet-based survey. SETTING: Not applicable. PATIENTS: One thousand women aged 21-45 years. INTERVENTION(S): An anonymous 63-item self-administered questionnaire was distributed to a representative cross-section of women aged 21-45 years, stratified by age <35 years...
May 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28473896/changes-in-the-expression-of-oct4-in-mouse-ovary-during-estrous-cycle
#14
Narges Bagheripour, Saeed Zavareh, Mohammad Taghi Ghorbanian, Seyed Hassan Paylakhi, Seyed Reza Mohebbi
The transcriptional factor OCT4 regulates pluripotency of stem cells and has an important role during oocyte growth. Whereas, its role has remained ambiguous in ovarian tissue during reproductive cycle. Therefore, this study was aimed to investigate the expression patterns of OCT4 in mouse ovaries during the normal estrous cycle. Adult National Medical Research Institute mice were classified as proestrous, estrous, metestrous and diestrous on the basis of vaginal smear cytology. Their ovaries were removed and the protein and gene expression levels of OCT4 were assessed using immunohistochemical staining and real-time quantitative reverse-transcription PCR, respectively...
2017: Veterinary Research Forum
https://www.readbyqxmd.com/read/28473127/long-term-breast-cancer-risk-following-ovarian-stimulation-in-young-egg-donors-a-call-for-follow-up-research-and-informed-consent
#15
Jennifer Schneider, Jennifer Lahl, Wendy Kramer
In the USA and other countries, oocyte donation is gaining increasing importance. Although sufficient data exist on procedure-associated short-term risks for oocyte donors, such as ovarian hyperstimulation syndrome, long-term follow-up studies of egg donors are lacking and their health risks are unknown. The lack of information may be misleadingly interpreted as lack of risk. Long-term hormone replacement therapy is recognized as a risk factor for breast cancer; the breast cancer risk of ovarian stimulation for egg donors is unknown but is a possibility...
May 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28472405/the-ovarian-response-in-fragile-x-patients-and-premutation-carriers-undergoing-ivf-pgd-reappraisal
#16
Sarit Avraham, Benny Almog, Adi Reches, Liat Zakar, Mira Malcov, Amit Sokolov, Sharon Alpern, Foad Azem
STUDY QUESTION: What is the association between the ovarian response and the number of CGG repeats among full mutation and premutation carriers of fragile X (FMR1), undergoing controlled ovarian hyperstimulation (COH) for PGD? SUMMARY ANSWER: Ovarian response was normal in full mutation patients but decreased in premutation carriers, although the number of repeats was not statistically significantly associated with the number of oocytes retrieved. WHAT IS KNOWN ALREADY: There is inconsistent data in the literature regarding ovarian response in FMR1 carriers...
May 3, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28469172/protective-effect-of-antioxidants-on-the-pre-maturation-aging-of-mouse-oocytes
#17
Li-Feng Liang, Shu-Tao Qi, Ye-Xing Xian, Lin Huang, Xiao-Fang Sun, Wei-Hua Wang
Pre-maturation aging of immature oocytes may adversely affect the fate of an oocyte. Oxidative stress is one of the most detrimental factors affecting oocyte developmental competence and maturation during aging. In this study, experiments were designed to examine whether supplementation of antioxidants in a culture medium could protect immature mouse oocytes from damages caused by oxidative stress. Mouse oocytes at germinal vesicle stage were prevented from meiosis resumption and cultured in a medium with or without antioxidants for 12-36 h to allow oocytes to undergo aging...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28466233/age-related-expression-of-tgf-beta-family-receptors-in-human-cumulus-oophorus-cells
#18
A Ribeiro, C Freitas, L Matos, A Gouveia, F Gomes, J L Silva Carvalho, H Almeida
PURPOSE: During ovarian follicle growth, local cellular interactions are essential for oocyte quality acquisition and successful fertilization. While cumulus cells (CCs) nurture oocytes, they also deliver oocyte-secreted factors (OSFs) that activate receptors on CCs. We hypothesized that disturbance of those interactions contributes to age-related lower reproductive success in women submitted to assisted reproductive technology treatments. METHODS: Women aged 27-48, without recognized personal reproductive disorder, were enrolled in the study and divided in <35- and ≥35-year-old groups...
May 2, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28458300/rna-associated-protein-lsm-family-member-14-controls-oocyte-meiotic-maturation-through-regulating-mrna-pools
#19
Teng Zhang, Yuanyuan Li, Hui Li, Xue-Shan Ma, Ying-Chun Ouyang, Yi Hou, Heide Schatten, Qing-Yuan Sun
LSM family member 14 (LSM14) belongs to the RNA-associated protein (RAP) family that is widely expressed in different species, and whose functions include associating and storing mRNAs. In the present study, we found that LSM14b was essential for oocyte meiotic maturation. Lack of LSM14b caused oocyte meiotic arrest at metaphase, and misalignment of chromosomes, as well as abnormal spindle assembly checkpoint (SAC) and maturation promoting factor (MPF) activation. Cyclin B1 and Cdc20 mRNAs, whose contents changed with LSM14b expression, were likely direct targets of LSM14b...
April 30, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28456966/use-of-chemicals-to-inhibit-dna-replication-transcription-and-protein-synthesis-to-study-zygotic-genome-activation
#20
Kyungjun Uh, Kiho Lee
Maternal-to-zygotic transition is an event that developmental control of early embryos is switched from oocyte-derived factors to the zygotic genome. Ability to inhibit DNA replication, transcription, and translation is an important tool in studying events, such as zygotic genome activation, during embyogenesis. Here, we describe approaches to block DNA replication, transcription, and translation using chemical inhibitors. Then we also demonstrate how the transcript level of a maternally inherited gene, ten-eleven translocation methylcytosine dioxygenase 3, responses to the chemical treatments...
2017: Methods in Molecular Biology
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