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Umberto Albert, David De Cori, Giovanni Blengino, Filippo Bogetto, Giuseppe Maina
INTRODUCTION AND AIM: Lithium is recommended by all treatment guidelines for bipolar disorder (BD) as a first-line maintenance treatment. However, the potential side effects and risks associated with long-term lithium use may at times make the implementation of these recommendations in daily practice challenging. The aim of the study is to review available literature on potential long-term side effects of lithium. MATERIALS AND METHODS: A PubMed/Medline search was performed on papers dealing with long-term treatment with lithium and side effects...
January 2014: Rivista di Psichiatria
Anna Wyszogrodzka-Kucharska, Jolanta Rabe-Jabłońska
The etiopathogenesis, risk factors and indications for prevention and treatment of osteoporosis in patients with schizophrenia are presented. Accelerated decrease in bone mineral density (BMD) is mostly attributed to antypsychotics (drug-induced hyperprolactinemia and decrease in levels of estrogen and testosterone), insufficient calcium intake, low physical activity and limited exposure to sunshine, alcohol and tobacco intake, polidypsia. Clinical symptoms of osteoporosis (eg. vertebral fractures) develop very slowly and in patients with schizophrenia are very rarely diagnosed...
2006: Przegla̧d Lekarski
G Bednarek-Tupikowska, T Tołłoczko, W Tupikowski, M Bogdańska, J Karwacki, M Medraś, A Milewicz
A case of 35-year-old woman with parathyroid cancer is presented. Five years ago she underwent surgery for follicular thyroid cancer. Parathyroid cancer was evidenced by palpable, solid, irregularly shaped cervical tumor 5 cm in diameter. The patient had severe hyperparathyroidism confirmed by biochemical findings of hypercalcemia reaching 16 mg%, hypophosphatemia and hyperphosphatasemia. Serum parathormone level was 23-fold higher than the norm. These findings were accompanied by polyuria, polidypsia, symptoms of bone damage and renal calcification...
May 2001: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
T Baptista, A Lacruz, A Acosta, C Colasante, M de Quijada, S de Mendoza, J M Mendoza, L Hernández
Few pharmacological tools are currently available to counteract the excessive body weight gain often observed during prolonged administration of antipsychotic drugs. Most antipsychotic drugs block dopamine receptors, and both the brain dopaminergic and opioid systems appear to be involved in initiation and maintenance of feeding behavior, respectively. We evaluated whether the opioid antagonist naltrexone (NAL, 0.5-16 mg/kg/ip for 21 days) (a) affects body weight and food intake in gonadally-intact and drug-free female rats, (b) prevents obesity, hyperphagia, hyperprolactinemia and vaginal cycle disruption induced by long-term administration of the antipsychotic drug sulpiride (SUL, 20 mg/kg/ip for 21 days), or (c) reverses the acute hyperphagia induced by SUL (15 microg bilaterally), when directly applied in the perifornical lateral hypothalamus (PFLH)...
February 2000: Appetite
J F Chevalier, N Gluck, E Marcel, M O Habert
The SPECT (Single Photon Emission Computed Tomography), a new advance in medical imagery, allows the measure of cerebral blood flow and could be of interest in studying mental disorders. We report here a case of pseudo-dementia for which a SPECT has been performed before and after treatment. Mrs V., a 49 years old female, has been suffering from a dementia-like syndrome for several months. She is divorced, has two children, lives with a boy-friend, and has been working in a factory for 25 years. The first psychiatric disorders began three years ago with a gradual apragmatism and muteness...
November 1992: L'Encéphale
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