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https://www.readbyqxmd.com/read/28930547/use-of-non-ionizing-electromagnetic-fields-for-the-treatment-of-cancer
#1
Hugo Jimenez, Carl Blackman, Glenn Lesser, Waldemar Debinski, Michael Chan, Sambad Sharma, Kounosuke Watabe, Hui-Wen Lo, Alexandra Thomas, Dwayne Godwin, William Blackstock, Albert Mudry, James Posey, Rodney O'Connor, Ivan Brezovich, Keith Bonin, Daniel Kim-Shapiro, Alexandre Barbault, Boris Pasche
Cancer treatment and treatment options are quite limited in circumstances such as when the tumor is inoperable, in brain cancers when the drugs cannot penetrate the blood-brain-barrier, or when there is no tumor-specific target for generation of effective therapeutic antibodies. Despite the fact that electromagnetic fields (EMF) in medicine have been used for therapeutic or diagnostic purposes, the use of non-ionizing EMF for cancer treatment is a new emerging concept. Here we summarize the history of EMF from the 1890's to the novel and new innovative methods that target and treat cancer by non-ionizing radiation...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930078/how-should-i-treat-recurrent-severe-paravalvular-leakage-after-successful-interventional-closure-of-a-symptomatic-paravalvular-leak-with-four-plug-devices-following-complicated-bioprosthetic-aortic-valve-replacement-the-importance-of-closely-monitoring-patients
#2
https://www.readbyqxmd.com/read/28930054/impact-of-substance-messages-in-music-videos-on-youth-beware-the-influence-of-connectedness-and-its-potential-prevention-shielding-effect
#3
Cristel Antonia Russell, Véronique Régnier-Denois, Boris Chapoton, Denise Buhrau
OBJECTIVE: Two studies were conducted to investigate the role of connectedness with music videos in affecting youths' beliefs about substances (alcohol and tobacco) embedded therein and the potential for a prevention message to limit the impact of these images. METHOD: The first study used cross-sectional data from a national sample of 1,023 adolescents (54.3% male) to evaluate the relationship between youths' consumption of music videos and their beliefs about the consequences of consuming alcohol and tobacco...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28929159/electric-field-controllable-magnetic-coupling-of-localized-spins-mediated-by-itinerant-electrons-a-toy-model
#4
Andrew Palii, Sergey Aldoshin, Boris Tsukerblat, Juan Modesto Clemente-Juan, Alejandro Gaita-Ariño, Eugenio Coronado
In this paper, we propose a toy model to describe the magnetic coupling between the localized spins mediated by the itinerant electron in partially delocalized mixed-valence (MV) systems. This minimal model takes into account the key interactions that are common for all such systems, namely, electron transfer in the valence-delocalized moiety and magnetic exchange between the localized spins and the delocalized electrons. The proposed descriptive model is exactly solvable which allows us to qualitatively and quantitatively discuss the main features of the whole class of partially delocalized MV systems...
September 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28926856/positive-effects-of-promoting-physical-activity-and-balanced-diets-in-a-primary-school-setting-with-a-high-proportion-of-migrant-school-children
#5
Katharina S Weber, Olaf Spörkel, Melina Mertens, Alem Freese, Klaus Strassburger, Boris Kemper, Clemens Bachmann, Knut Diehlmann, Theodor Stemper, Anette E Buyken, Kerstin Ketelhut, Karsten Müssig
Background Children with migration background are at particular risk for overweight. We assessed the effects of a primary school-based initiative targeted at enhancing physical activity and dietary education among children with a high proportion of migration background. Methods Four 3(rd) and 4(th) grade classes (n=70 children, 77% with migration background) participated in a 10-months intervention comprising 2 additional exercise lessons weekly and 10 nutrition lessons per school year. 6 school classes (n=125 children, 65% with migration background) served as control...
September 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28926274/nh2-directed-c-h-alkenylation-of-2-vinylanilines-with-vinylbenziodoxolones
#6
Andreas Boelke, Lucien D Caspers, Boris J Nachtsheim
The first directing-group-mediated C-H alkenylation with alkenyl-λ(3)-iodanes as electrophilic alkene-transfer reagents has been developed. The application of free aromatic amines as challenging but synthetically valuable directing groups in combination with an Ir(III) catalyst enabled the synthesis of highly desirable 1,3-dienes in excellent yields of up to 98% with high to perfect (Z,E) stereoselectivity. A broad substrate scope and further synthetic modifications are demonstrated.
September 19, 2017: Organic Letters
https://www.readbyqxmd.com/read/28925256/catalytic-activity-of-peptide-nanoparticle-conjugates-regulated-by-a-conformational-change
#7
Dorian Jamal Mikolajczak, Jason Lee Heier, Boris Schade, Beate Koksch
Herein, we present the design and synthesis of a catalytically active peptide-nanoparticle conjugate whose activity is regulated by a defined conformational change in the self-assembled peptide monolayer. A catalytically active peptide, designed after the heterodimeric α-helical coiled-coil principle was immobilized onto gold nanoparticles and kinetic studies were performed according to the Michaelis-Menten model. The formed peptide monolayer at the gold nanoparticle surface accelerated p nitrophenylacetate (pNPA) hydrolysis by one order of magnitude compared to the soluble peptide while exhibiting no defined secondary structure as determined by infrared (IR) and circular dichroism (CD) spectroscopy...
September 19, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28924877/diagnostic-approach-to-neurotransmitter-monoamine-disorders-experience-from-clinical-biochemical-and-genetic-profiles
#8
Alice Kuster, Jean-Baptiste Arnoux, Magalie Barth, Delphine Lamireau, Nada Houcinat, Cyril Goizet, Bérénice Doray, Stéphanie Gobin, Manuel Schiff, Aline Cano, Daniel Amsallem, Christine Barnerias, Boris Chaumette, Marion Plaze, Abdelhamid Slama, Christine Ioos, Isabelle Desguerre, Anne-Sophie Lebre, Pascale de Lonlay, Laurence Christa
BACKGROUND AND AIM: To improve the diagnostic work-up of patients with diverse neurological diseases, we have elaborated specific clinical and CSF neurotransmitter patterns. METHODS: Neurotransmitter determinations in CSF from 1200 patients revealed abnormal values in 228 (19%) cases. In 54/228 (24%) patients, a final diagnosis was identified. RESULTS: We have reported primary (30/54, 56%) and secondary (24/54, 44%) monoamine neurotransmitter disorders...
September 18, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28924504/the-evolutionary-history-of-plant-t2-s-type-ribonucleases
#9
Karolis Ramanauskas, Boris Igić
A growing number of T2/S-RNases are being discovered in plant genomes. Members of this protein family have a variety of known functions, but the vast majority are still uncharacterized. We present data and analyses of phylogenetic relationships among T2/S-RNases, and pay special attention to the group that contains the female component of the most widespread system of self-incompatibility in flowering plants. The returned emphasis on the initially identified component of this mechanism yields important conjectures about its evolutionary context...
2017: PeerJ
https://www.readbyqxmd.com/read/28924422/femtosecond-laser-assisted-cataract-surgery-in-vitrectomized-eye-with-posterior-chamber-phakic-intraocular-lens
#10
Natalia Anisimova, Boris Malyugin, Lisa B Arbisser, Nikolay Sobolev
We describe a case of femtosecond laser-assisted cataract surgery (FLACS) in an eye with multiple comorbidities, including retinal detachment surgery, high myopia, posterior chamber phakic intraocular lens (PC pIOL) and residual, emulsified, silicone oil located in the anterior chamber. FLACS was affected by the optical blockage, but the incomplete capsular tear was recoverable. The case suggests that silicone oil bubbles concentrated at the dome of the posterior corneal surface, along with the PC pIOL optic edges and scars after corneal astigmatic relaxing incisions can lead to incomplete anterior capsulotomy...
2017: Digital Journal of Ophthalmology: DJO
https://www.readbyqxmd.com/read/28921882/recommendations-for-obesity-prevention-among-adolescents-from-disadvantaged-backgrounds-a-concept-mapping-study-among-scientific-and-professional-experts
#11
D A Kornet-van der Aa, C H van Randeraad-van der Zee, J Mayer, J M Borys, M J M Chinapaw
The present study aimed to enrich the scientific evidence on obesity prevention programmes for adolescents from socio-economically disadvantaged backgrounds with practice-based experiences from both scientific and professional experts in the field of youth obesity prevention. We used the participatory method of concept mapping. Two concept mapping sessions were conducted: one with programme coordinators of national/regional obesity prevention programmes across Europe (n = 8) and one with scientists participating in European obesity prevention projects (n = 5)...
September 18, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/28921850/prospective-comparison-of-transperineal-mri-ultrasound-fusion-biopsy-and-transrectal-systematic-biopsy-in-biopsy-na%C3%A3-ve-patients
#12
Angelika Borkowetz, Boris Hadaschik, Ivan Platzek, Marieta Toma, Georgi Torsev, Theresa Renner, Roman Herout, Martin Baunacke, Michael Laniado, Gustavo Baretton, Jan Philipp Radtke, Claudia Kesch, Markus Hohenfellner, Michael Froehner, Heinz-Peter Schlemmer, Manfred Wirth, Stefan Zastrow
OBJECTIVES: To evaluate the value of multiparametric magnetic resonance imaging (mpMRI) for the detection of significant prostate cancer (PCa) and to compare transperineal MRI/ultrasound-fusion biopsy (fusPbx) to conventional transrectal systematic biopsy (sysPbx) in biopsy-naïve patients. PATIENTS AND METHODS: This multicentre, prospective trial investigated biopsy-naïve patients with suspicion of PCa undergoing transperineal fusPbx in combination with transrectal sysPbx (comPbx)...
September 16, 2017: BJU International
https://www.readbyqxmd.com/read/28919818/standard-of-care-and-direct-medical-costs-of-the-treatment-of-chronic-lymphocytic-leukemia-among-the-adult-population-in-ukraine-russia-and-kazakhstan-data-from-the-leukospect-study
#13
Averyan Vasylyev, Valentina Molostvova, Boris A Rebrov, Janina Makarova, Andrey Zaritskey, Vadim Ptushkin, Raigul Ramazanova, Yuriy Popovych, Orest Tsyapka, Evgeny Pashanov
PURPOSE: The LEUKOSPECT study aimed to describe health service utilization and to estimate the direct medical costs (DMCs) of chronic lymphocytic leukemia (CLL) in 2013 in the adult population of three post-Soviet countries - Russia, Ukraine, and Kazakhstan. As oncologic medical care is provided by federal state-owned, specialized medical institutions, the cost estimation in this study primarily informs from a state budget perspective. Patients' contributions to medical costs were not included in the cost evaluation...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28919513/accompanying-indigenous-maya-patients-with-complex-medical-needs-a-patient-navigation-system-in-rural-guatemala
#14
Anita Chary, David Flood, Kirsten Austad, Marcela Colom, Jessica Hawkins, Katia Cnop, Boris Martinez, Waleska Lopez, Peter Rohloff
No abstract text is available yet for this article.
September 14, 2017: Healthcare
https://www.readbyqxmd.com/read/28919260/blockage-of-the-epithelial-to-mesenchymal-transition-is-required-for-embryonic-stem-cell-derivation
#15
Mehdi Totonchi, Seyedeh-Nafiseh Hassani, Ali Sharifi-Zarchi, Natalia Tapia, Kenjiro Adachi, Julia Arand, Boris Greber, Davood Sabour, Marcos J Araúzo-Bravo, Jörn Walter, Mohammad Pakzad, Hamid Gourabi, Hans R Schöler, Hossein Baharvand
Pluripotent cells emanate from the inner cell mass (ICM) of the blastocyst and when cultivated under optimal conditions immortalize as embryonic stem cells (ESCs). The fundamental mechanism underlying ESC derivation has, however, remained elusive. Recently, we have devised a highly efficient approach for establishing ESCs, through inhibition of the MEK and TGF-β pathways. This regimen provides a platform for dissecting the molecular mechanism of ESC derivation. Via temporal gene expression analysis, we reveal key genes involved in the ICM to ESC transition...
September 6, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28919106/selecting-relevant-features-from-the-electronic-health-record-for-clinical-code-prediction
#16
Elyne Scheurwegs, Boris Cule, Kim Luyckx, Léon Luyten, Walter Daelemans
A multitude of information sources is present in the electronic health record (EHR), each of which can contain clues to automatically assign diagnosis and procedure codes. These sources however show information overlap and quality differences, which complicates the retrieval of these clues. Through feature selection, a denser representation with a consistent quality and less information overlap can be obtained. We introduce and compare coverage-based feature selection methods, based on confidence and information gain...
September 14, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28918108/heart-failure-with-recovered-ejection-fraction-in-african-americans-results-from-the-african-american-heart-failure-trial
#17
Kay-Won Chang, Neil Beri, Nghia H Nguyen, Boris Arbit, Sutton Fox, Sean Mojaver, Paul Clopton, S William Tam, Anne L Taylor, Jay N Cohn, Alan S Maisel, Inder S Anand
BACKGROUND: Recent studies have described the entity of heart failure with recovered ejection fraction (HFrecEF), but population specific studies remain lacking. The aim of this study was to characterize patients enrolled in the African-American Heart Failure Trial (A-HeFT) who had significant improvement in their ejection fraction (EF) during the first 6 months of follow-up. METHODS AND RESULTS: Subjects (n = 59) with HFrecEF (improvement in EF from < 35% to > 40% in 6 months) were compared to 259 with heart failure and persistently reduced EF (HFrEF), defined as EF ≤ 40% at 6 month follow-up...
September 13, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28917855/chiroplasmonic-magnetic-gold-nanocomposites-produced-by-one-step-aqueous-method-using-%C3%AE%C2%BA-carrageenan
#18
Marina V Lesnichaya, Boris G Sukhov, Galina P Aleksandrova, Ekaterina R Gasilova, Tamara I Vakul'skaya, Spartak S Khutsishvili, Anatoliy N Sapozhnikov, Igor V Klimenkov, Boris A Trofimov
Novel water-soluble chiroplasmonic nanobiocomposites with directly varied gold content were synthesized by a one-step redox method in water using a biocompatible polysaccharide κ-carrageenan (industrial product from algae) as both reducing and stabilizing matrix. The influence of the reactants ratio, temperature, and pH on the reaction was studied and the optimal reaction parameters were found. The structure and the properties of composite nanomaterials were examined in solid state and aqueous solutions by using complementary physical-chemical methods X-ray diffraction analysis, transmission electron microscopy, spectroscopy of electron paramagnetic resonance, atomic absorption and optical spectroscopy, polarimetry including optical rotatory dispersion with registration of interphase-crossbred Cotton effect of a chiral polysaccharide matrix on plasmonic chromophore of gold nanoparticles, dynamic and static light scattering...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917642/efficient-gene-editing-via-non-viral-delivery-of-crispr-cas9-system-using-polymeric-and-hybrid-microcarriers
#19
Alexander S Timin, Albert R Muslimov, Kirill V Lepik, Olga S Epifanovskaya, Alena I Shakirova, Ulrike Mock, Kristoffer Riecken, Maria V Okilova, Vladislav S Sergeev, Boris V Afanasyev, Boris Fehse, Gleb B Sukhorukov
CRISPR-Cas9 is a revolutionary genome-editing technology that has enormous potential for the treatment of genetic diseases. However, the lack of efficient and safe, non-viral delivery systems has hindered its clinical application. Here, we report on the application of polymeric and hybrid microcarriers, made of degradable polymers such as polypeptides and polysaccharides and modified by silica shell, for delivery of all CRISPR-Cas9 components. We found that these microcarriers mediate more efficient transfection than a commercially available liposome-based transfection reagent (>70% vs...
September 13, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28917129/residential-road-traffic-noise-and-general-mental-health-in-youth-the-role-of-noise-annoyance-neighborhood-restorative-quality-physical-activity-and-social-cohesion-as-potential-mediators
#20
Angel Dzhambov, Boris Tilov, Iana Markevych, Donka Dimitrova
Given the ubiquitous nature of both noise pollution and mental disorders, their alleged association has not escaped the spotlight of public health research. The effect of traffic noise on mental health is probably mediated by other factors, which have not been elucidated sufficiently. Herein, we aimed to disentangle the pathways linking road traffic noise to general mental health in Bulgarian youth, with a focus on several candidate mediators - noise annoyance, perceived restorative quality of the living environment, physical activity, and neighborhood social cohesion...
September 13, 2017: Environment International
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