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https://www.readbyqxmd.com/read/29792321/explanation-of-dramatic-ph-dependence-of-hydrogen-binding-on-noble-metal-electrode-greatly-weakened-water-adsorption-at-high-ph
#1
Tao Cheng, Lu Wang, Boris V Merinov, William A Goddard
Hydrogen oxidation reaction (HOR) and hydrogen evolution reac-tion (HER) are both two orders slower in alkaline electrolyte than in acidic electrolyte, but no explanation has been provided. The first step towards understanding this dramatic pH-dependent HOR/HER performance is to explain the pH-dependent hydrogen binding to the electrode, a perplexing behavior observed experimentally. In this work, we carried out Quantum Mechanics Molecular Dynam-ics (QMMD) with explicit considerations of solvent and applied voltage (U) to in situ simulate water/Pt (100) interface in the condi-tion of under-potential adsorption of hydrogen (HUPD)...
May 24, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29791905/disparities-in-chronic-kidney-disease-prevalence-among-males-and-females-in-195-countries-analysis-of-the-global-burden-of-disease-2016-study
#2
Boris Bikbov, Norberto Perico, Giuseppe Remuzzi
BACKGROUND: Chronic kidney disease (CKD) imposes a substantial burden on health care systems. There are some especially vulnerable groups with a high CKD burden, one of which is women. We performed an analysis of gender disparities in the prevalence of all CKD stages and renal replacement therapy (defined as impaired kidney function [IKF]) in 195 countries. METHODS: We used estimates produced by the Global Burden of Disease (GBD) Study 2016 revision using a Bayesian-regression analytic tool, DisMoD-MR 2...
May 23, 2018: Nephron
https://www.readbyqxmd.com/read/29790255/risk-of-major-congenital-malformations-following-first-trimester-exposure-to-vaginal-azoles-used-for-treating-vulvovaginal-candidiasis-a-population-based-retrospective-cohort-study
#3
Reut Rotem, Boris Fishman, Sharon Daniel, Gideon Koren, Eitan Lunenfeld, Amalia Levy
OBJECTIVE: To evaluate the risk for major malformations following first trimester exposure to vaginal azoles. DESIGN: A population based retrospective cohort study of women exposed to vaginal azoles from the first day of the last menstrual period Until the 90th gestational day. SETTING: A combination of four computerized databases: medications, birth, infant hospitalizations and pregnancy terminations. POPULATION: All women who gave birth or undergone a pregnancy termination at Soroka Medical Center, Beer-Sheva, Israel, between 1999 to 2009...
May 22, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29789904/revision-knee-arthroplasty-with-rotating-hinge-systems-in-patients-with-gross-ligament-instability
#4
Sebastian P Boelch, Joerg Arnholdt, Boris M Holzapfel, Axel Jakuscheit, Maximilian Rudert, Maik Hoberg
PURPOSE: The clinical and radiographic outcomes after revision total knee arthroplasty (TKA) for instability with two rotating hinge knee prostheses were compared. METHODS: Fifty-one patients revised for TKA instability were prospectively randomized to either the Link Endo-Model (N = 26) or the EnduRo (N = 25). Clinical and radiographic outcome scores were compared pre-operatively and at 12 months' follow-up. Failure mechanisms were recorded. RESULTS: Age, BMI, operation, and tourniquet-time did not differ significantly between groups...
May 22, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29789532/ferroptosis-inducing-agents-compromise-in-vitro-human-islet-viability-and-function
#5
Antonio Bruni, Andrew R Pepper, Rena L Pawlick, Boris Gala-Lopez, Anissa F Gamble, Tatsuya Kin, Karen Seeberger, Gregory S Korbutt, Stefan R Bornstein, Andreas Linkermann, A M James Shapiro
Human islet transplantation has been hampered by donor cell death associated with the islet preparation procedure before transplantation. Regulated necrosis pathways are biochemically and morphologically distinct from apoptosis. Recently, ferroptosis was identified as a non-apoptotic form of iron-dependent regulated necrosis implicated in various pathological conditions. Mediators of islet oxidative stress, including glutathione peroxidase-4 (GPX4), have been identified as inhibitors of ferroptosis, and mechanisms that affect GPX4 function can impact islet function and viability...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29788768/short-term-impact-of-tdcs-over-the-right-inferior-frontal-cortex-on-impulsive-responses-in-a-go-no-go-task
#6
Salvatore Campanella, Elisa Schroder, Marie-Anne Vanderhasselt, Chris Baeken, Charles Kornreich, Paul Verbanck, Boris Burle
Inhibitory control, a process deeply studied in laboratory settings, refers to the ability to inhibit an action once it has been initiated. A common way to process data in such tasks is to take the mean response time (RT) and error rate per participant. However, such an analysis ignores the strong dependency between spontaneous RT variations and error rate. Conditional accuracy function (CAF) is of particular interest, as by plotting the probability of a response to be correct as a function of its latency, it provides a means for studying the strength of impulsive responses associated with a higher frequency of fast response errors...
May 1, 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29788308/pheprob-probabilistic-phenotyping-using-diagnosis-codes-to-improve-power-for-genetic-association-studies
#7
Jennifer A Sinnott, Fiona Cai, Sheng Yu, Boris P Hejblum, Chuan Hong, Isaac S Kohane, Katherine P Liao
Objective: Standard approaches for large scale phenotypic screens using electronic health record (EHR) data apply thresholds, such as ≥2 diagnosis codes, to define subjects as having a phenotype. However, the variation in the accuracy of diagnosis codes can impair the power of such screens. Our objective was to develop and evaluate an approach which converts diagnosis codes into a probability of a phenotype (PheProb). We hypothesized that this alternate approach for defining phenotypes would improve power for genetic association studies...
May 17, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29785775/somatic-hematopoietic-tp53-mosaicism-in-women-with-breast-cancer-exposed-to-ionizing-radiation
#8
Sergey Melnov, Patricia Murphy, Thomas Foley, Eldar Nadyrov, Vyacheslav Kipen, Boris Leushev, Francesmary Modugno
No abstract text is available yet for this article.
May 21, 2018: Breast Journal
https://www.readbyqxmd.com/read/29785418/regioselective-ortho-functionalization-of-bromofluorenecarbaldehydes-using-tmpmgcl%C3%A2-licl
#9
Dominik Göbel, Nils Clamor, Boris J Nachtsheim
A highly regioselective functionalization of 7-bromofluorene-2-carbaldehydes, potent organic chromophores, in position C3 using a mild ortho-metallation strategy (DoM) with TMPMgCl·LiCl has been developed. This approach allows the preparation of highly functionalized fluorene derivatives by conversion of the in situ generated metalated species with various electrophiles giving a fast access to novel organic phosphorescent dyes.
May 22, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29783720/p53-autophagy-metastasis-link
#10
REVIEW
Tatiana V Denisenko, Anastasia D Pivnyuk, Boris Zhivotovsky
The tumor suppressor p53 as the "guardian of the genome" plays an essential role in numerous signaling pathways that control the cell cycle, cell death and in maintaining the integrity of the human genome. p53, depending on the intracellular localization, contributes to the regulation of various cell death pathways, including apoptosis, autophagy and necroptosis. Accumulated evidence suggests that this function of p53 is closely involved in the process of cancer development. Here, present knowledge concerning a p53-autophagy-metastasis link, as well as therapeutic approaches that influence this link, are discussed...
May 18, 2018: Cancers
https://www.readbyqxmd.com/read/29783247/predictors-of-thrombogenesis-by-the-state-of-pro-and-anticoagulant-components-of-hemostasis-in-the-patients-with-stage-vd-chronic-kidney-disease
#11
Olexiy B Storozhuk, Iryna B Seleznyova, Larisa O Storozhuk, Boris G Storozhuk, Tetyana V Dovgalyuk
OBJECTIVE: Introduction: One of the major complications of stage V chronic kidney disease (CKD), treated by program hemodialysis, are hemostatic system disturbances resulting in thrombosis development. To detect early predictors of potential thrombosis in study category of patients is rather difficult because of inflammatory process, accumulation of antibodies, continuous damage of blood elements. The aim: To estimate potential applicability of activators and inhibitors of thrombogenesis as thrombophilia markers in the patients with stage V CKD, treated by program hemodialysis...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782700/nonionic-dendritic-and-carbohydrate-based-amphiphiles-self-assembly-and-transport-behavior
#12
Suchita Prasad, Katharina Achazi, Boris Schade, Rainer Haag, Sunil K Sharma
Herein, a new series of non-ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C-10 and C-18 hydrophobic alkyl chains, respectively, exhibit low critical aggregation concentration (CAC) in the order of 10-5 m and hydrodynamic diameters in the 8-10 nm range and supplemented by cryogenic transmission electron microscopy...
May 21, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29781815/lymph-node-fibrosis-a-structural-barrier-to-unleashing-effective-vaccine-immunity
#13
Boris Julg, Galit Alter
There is marked variability in vaccine efficacy among global populations. In particular, individuals in low- to middle-income countries have been shown to be less responsive to vaccines than those from developed nations. Several factors, including endemic infections, nutrition, genetics, and gut microbiome composition, have been proposed to underlie discrepancies in vaccine response. In this issue of the JCI, Kityo et al. evaluated response to yellow fever virus vaccine, inflammation, and lymphatic tissue architecture and fibrosis in three cohorts: two from the U...
May 21, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29781402/life-expectancy-and-comorbidities-in-patients-with-hereditary-hemorrhagic-telangiectasia
#14
Freya Droege, Kruthika Thangavelu, Boris A Stuck, Andreas Stang, Stephan Lang, Urban Geisthoff
There are only a few published studies that demonstrate associations between life expectancy, severe comorbidities, and their complications in patients with hereditary hemorrhagic telangiectasia (HHT). Relatives of 73 deceased patients with suspected HHT completed a questionnaire about causes of death, and symptoms and comorbidities that the patients had developed. We compared the data for 55 cases where HHT had been clinically confirmed with the general population. Patients suffering from HHT lost, on average, 19 years (SD 11 years) of potential life compared to the general population...
May 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29780542/unusual-mechanisms-in-claisen-rearrangements-an-ionic-fragmentation-leading-to-a-meta-selective-rearrangement
#15
Boris Maryasin, Dainis Kaldre, Renan Galaverna, Immo Klose, Stefan Ruider, Martina Drescher, Hanspeter Kählig, Leticia González, Marcos N Eberlin, Igor D Jurberg, Nuno Maulide
A mechanistic investigation of the acid-catalysed redox-neutral oxoarylation reaction of ynamides using electrospray ionisation mass-spectrometry (ESI-MS) and quantum chemical calculations (DFT and MP2) is presented. This study reveals the diversity of pathways and products available from an otherwise deceptively simple-looking, classical transformation: fragmentation, an unusual meta -arylation and competing α-carbonyl cation pathways are some of the alternatives unveiled by ESI-MS and mechanistic experiments...
May 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780379/point-mutation-of-a-non-elastase-binding-site-in-human-%C3%AE-1-antitrypsin-alters-its-anti-inflammatory-properties
#16
Yotam Lior, Mariana Zaretsky, David E Ochayon, Diana Lotysh, Boris M Baranovski, Ronen Schuster, Ofer Guttman, Amir Aharoni, Eli C Lewis
Introduction: Human α1-antitrypsin (hAAT) is a 394-amino acid long anti-inflammatory, neutrophil elastase inhibitor, which binds elastase via a sequence-specific molecular protrusion (reactive center loop, RCL; positions 357-366). hAAT formulations that lack protease inhibition were shown to maintain their anti-inflammatory activities, suggesting that some attributes of the molecule may reside in extra-RCL segments. Here, we compare the protease-inhibitory and anti-inflammatory profiles of an extra-RCL mutation (cys232pro) and two intra-RCL mutations (pro357cys, pro357ala), to naïve [wild-type (WT)] recombinant hAAT, in vitro , and in vivo ...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29779445/early-or-late-cranioplasty-following-decompressive-craniotomy-for-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#17
Feng Zheng, Hao Xu, Niklas von Spreckelsen, Pantelis Stavrinou, Marco Timmer, Roland Goldbrunner, Fang Cao, Qishan Ran, Gang Li, Ruiming Fan, Qiang Zhang, Wei Chen, Shengtao Yao, Boris Krischek
Objective To evaluate the effectiveness of early (<3 months) cranioplasty (CP) and late CP (>3 months) on post-operative complications in patients receiving decompressive craniotomy (DC) for traumatic brain injury (TBI). Methods The Cochrane Library, PubMed and EMBASE databases were systematically searched for studies published prior to May 21, 2017. A meta-analysis examined post-operative overall complication rates, infection rates, subdural fluid collection and operating times according to early and late CP...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29779192/impact-of-weak-water-deficit-on-growth-photosynthetic-primary-processes-and-storage-processes-in-pine-and-spruce-seedlings
#18
Ilya E Zlobin, Yury V Ivanov, Alexander V Kartashov, Boris A Sarvin, Andrey N Stavrianidi, Vladimir D Kreslavski, Vladimir V Kuznetsov
We investigated the influence of 40 days of drought on growth, storage processes and primary photosynthetic processes in 3-month-old Scots pine and Norway spruce seedlings growing in perlite culture. Water stress significantly affected seedling water status, whereas absolute dry biomass growth was not substantially influenced. Water stress induced an increase in non-structural carbohydrate content (sugars, sugar alcohols, starch) in the aboveground part of pine seedlings in contrast to spruce seedlings. Due to the relatively low content of sugars and sugar alcohols in seedling organs, their expected contribution to osmotic potential changes was quite low...
May 19, 2018: Photosynthesis Research
https://www.readbyqxmd.com/read/29778968/environmental-risk-factors-associated-with-low-birth-weight-the-case-study-of-the-haifa-bay-area-in-israel
#19
Alina Svechkina, Jonathan Dubnov, Boris A Portnov
BACKGROUND: Low birth weight (LBW) is known to be associated with infant mortality and postnatal health complications. Previous studies revealed strong relationships between LBW rate and several socio-demographic factors, including ethnicity, maternal age, and family income. However, studies of association between LBW rate and environmental risk factors remain infrequent. STUDY METHODS: We retrieved a geo-referenced data set, containing 7216 individual records of children born in 2015 in the Haifa Bay Area in Israel...
May 17, 2018: Environmental Research
https://www.readbyqxmd.com/read/29778304/postural-orthostatic-tachycardia-syndrome-in-children-and-adolescents
#20
REVIEW
Jeffrey R Boris
Postural orthostatic tachycardia syndrome (POTS) affects up to 3,000,000 people in the United States, with at least one-third of them developing POTS before the age of 18. POTS as a disorder is similar in adult and pediatric populations, but there are factors specific to pediatric patients that affect how it presents and how it is experienced that make pediatric POTS different. This review discusses the both the similarities in this population to their adult counterparts and the unique challenges faced by pediatric POTS patients, including management of schooling and education as well as the complex interactions between these pediatric patients and their parents...
May 12, 2018: Autonomic Neuroscience: Basic & Clinical
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