Read by QxMD icon Read

Adult Acute Lymphatic Leukemia

Ferdows Atiq, Annoek E C Broers, Louise M Andrews, Jeanette K Doorduijn, Birgit C P Koch, Teun Van Gelder, Jorie Versmissen
PURPOSE: Cyclosporine A (CsA) and imatinib are both CYP3A4 and P-glycoprotein substrates. Concomitant use after hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (ALL) may therefore result in a pharmacokinetic interaction. Although case reports and a recent small study in children indeed suggested there is a relevant pharmacokinetic interaction, a larger study in adults is lacking. In this study, we assessed the presence and extent of this interaction in patients with CML or Ph+ ALL undergoing HSCT...
June 2016: European Journal of Clinical Pharmacology
J Gjedsted, R Dall
This case report describes hypoglycemia during methadone escalation in an 8-year-old girl with acute lymphatic leukemia. After a significant increase in the methadone dosage, the blood glucose decreased from 12 mmol/l to 1 mmol/l. Nutrition and other medications were meticulously checked and no other apparent explanation was found. There are few reports from the adult palliative setting which describe this serious side effect. This is to our knowledge, the first described pediatric case.
November 2015: Acta Anaesthesiologica Scandinavica
Pk Gadhia, Gd Shastri, Eg Shastri
Patients suffering from adult acute lymphoblastic leukemia (ALL) are very ill and present most commonly with shortness of breath during physical activity, a pale complexion from anemia, a very low platelet count, the appearance of pinhead-sized red spots under the skin called petechiae, or prolonged bleeding from minor cuts and discomfort in the bones and joints. Fever in the absence of an obvious cause is common. Leukemic lymphoblasts may accumulate in the lymphatic system, and lymph nodes can be enlarged...
June 2014: Balkan Journal of Medical Genetics: BJMG
Werner Rabitsch, Alexandra Böhm, Marija Bojic, Peter Schellongowski, Stefan Wöhrer, Thamer Sliwa, Felix Keil, Nina Worel, Hildegard Greinix, Alexander Hauswirth, Peter Kalhs, Ulrich Jaeger, Peter Valent, Wolfgang R Sperr
BACKGROUND: Allogeneic haematopoietic stem cell transplantation (HSCT) is the only curative rescue therapy for patients (pts) with chemotherapy-refractory acute leukaemia. Disease control prior to HSCT is essential for long-term disease-free survival after HSCT. PATIENTS AND METHODS: We have retrospectively analysed the outcome of 20 pts aged 21-64 years with refractory leukaemia (acute myeloid leukaemia, n = 16; acute lymphatic leukaemia, n = 4) who received debulking therapy with clofarabine (10 mg/m², days 1-4) and cyclophosphamide (200 mg/m², days 1-4; ClofCy) prior to HSCT...
August 2014: European Journal of Clinical Investigation
Ji Hyun Kim, Anthony Stein, Nicole Tsai, Timothy E Schultheiss, Joycelynne Palmer, An Liu, Joseph Rosenthal, Stephen J Forman, Jeffrey Y C Wong
PURPOSE: Approximately 5% to 20% of patients who undergo total body irradiation (TBI) in preparation for hematopoietic cell transplantation (HCT) can develop extramedullary (EM) relapse. Whereas total marrow and lymphoid irradiation (TMLI) provides a more conformally targeted radiation therapy for patients, organ sparing has the potential to place the patient at a higher risk for EM relapse than TBI. This study evaluated EM relapse in patients treated with TMLI at our institution. METHODS AND MATERIALS: Patients eligible for analysis had been enrolled in 1 of 3 prospective TMLI trials between 2006 and 2012...
May 1, 2014: International Journal of Radiation Oncology, Biology, Physics
Mehmet Uzunel, Darius Sairafi, Mats Remberger, Jonas Mattsson, Michael Uhlin
In this retrospective study, 209 patients with malignant disease were analyzed for levels of T-cell receptor excision circles (TRECs) for the first 24 months after allogeneic stem cell transplantation. CD3(+) cells were separated by direct antibody-coupled magnetic beads, followed by DNA extraction according to a standard protocol. The δRec-ψJα signal joint TREC was measured with real-time quantitative PCR. Patients were grouped based on malignant disease: chronic myeloid leukemia, chronic lymphatic leukemia, acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and myelodysplastic syndrome (MDS)...
July 15, 2014: Stem Cells and Development
(no author information available yet)
AIM: To study the clinical manifestations of cryptococcosis, its diagnostic features, and treatment results in patients with hemoblastoses. SUBJECTS AND METHODS: The study included adult patients with cryptococcosis treated at the Hematology Research Center (HRC) in 2005 to 2011. The diagnosis of cryptococcosis was established on the basis of isolation of Cryptococcus neoformans from a blood culture or determination of positive cryptococcal antigen in the cerebrospinal fluid (CSF) of patients with infection symptoms...
2013: Terapevticheskiĭ Arkhiv
Filiz Ozbas-Gerceker, Nazli Bozman, Selcuk Kok, Mustafa Pehlivan, Mehmet Yilmaz, Sacide Pehlivan, Sibel Oguzkan-Balci
Hematological malignancies (HM) are a group of neoplasms derived from the cells of the bone marrow and lymphatic system. Genetic factors leading to susceptibility to HM have been investigated for years but little is known yet. Low molecular weight polypeptide (LMP) 2 and LMP7 genes are important subunits of the immunoproteasome and play significant role in antigen presentation. The polymorphisms of LMP genes have been reported to be risk factors for various types of diseases. The aim of this study was to investigate the association of LMP2 and LMP7 polymorphisms with the occurrence of particular types of HM...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
Ji Yoon Lee, Sohye Park, Donghyun Curt Kim, Jae-Ho Yoon, Seung Hwan Shin, Woo-Sung Min, Hee-Je Kim
PURPOSE: Although the importance of vascular endothelial growth factor receptor (VEGFR)-3 has been demonstrated in acute myeloid leukemia (AML), the role of VEGFR-3 in functioning natural killer (NK) cells remains largely unexplored. NK cells can destroy cancer cells by releasing the cytokine interferon (IFN)-γ, but NK cells in AML patients (AML NK cells) have low cytolytic activity. In the present study, we investigated whether lymphatic markers including VEGFR-3 are expressed on low-functioning AML NK cells and VEGFR-3 antagonist can restore expression of IFN-γ in NK cells...
May 2013: Journal of Clinical Immunology
Yutaka Miyawaki, Issei Imoto, Yutaka Tokairin, Kenro Kawada, Yasuaki Nakajima, Tetsuro Nishikage, Kagami Nagai, Michiko Kajiwara, Johji Inazawa, Tatsuyuki Kawano
Younger patients (aged <30 years) presenting with esophageal cancer are rare. Bone marrow transplantation offers a curative therapy in patients with malignant and nonmalignant lymphohematopoietic diseases and other disorders. However, one important late complication in transplantation survivors is the development of secondary malignancies including solid tumors. Although some solid cancers have been demonstrated to occur after bone marrow transplantation, only a few cases of esophageal squamous cell carcinoma have thus far been reported...
January 2013: Japanese Journal of Clinical Oncology
Thomas Weber, Sunday Ocheni, Mascha Binder, Sebastian Theurich, Christof Scheid, Christoph Schmid, Lutz Peter Müller, Maximilian Christopeit, Ulrike Bacher
No abstract text is available yet for this article.
2013: Acta Haematologica
Maria Marklund, Klaus Rostgaard, Lisa Hjalgrim, Kjeld Schmiegelow, Henrik Hjalgrim
Spurred by previous observations we assessed the relationship between offspring birth weight and parental leukaemia risk in a register-based investigation including 2.4 million parents of 2 million Danish children. Regardless of analytical approach, offspring birth weight was not associated with parental risk of leukaemia overall or of leukaemia subtypes except for a twofold increased acute lymphatic leukaemia risk in fathers of high birth weight offspring and an increasing paternal risk of chronic myeloid leukaemia with increasing offspring birth weight...
February 2013: Leukemia Research
Ellen Ruud, Adriani Kanellopoulos, Bernward Zeller, Eva Widing, Geir Erland Tjønnfjord, Sophie Dorothea Fosså
BACKGROUND: Over 80% of children with acute lymphatic leukaemia (ALL) survive, but many develop long-term effects after the therapy. The aim of the study was to reveal how much Norwegian adults treated for acute lymphatic leukaemia before the age of 16 know about the risk of long-term effects. MATERIAL AND METHOD: The participants (n = 139) were recruited from a cross-sectional study (ALLBARN) of adults treated for acute lymphatic leukaemia before the age of 16 in the period 1970-2002...
October 2, 2012: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Yutaka Okuno, Hiro Tatetsu, Kisato Nosaka, Hiroaki Mitsuya
Aggressive natural killer cell leukemia (ANKL) is a rare malignant disease of NK cells that has a median survival of less than 2 months and a strong association with the Epstein-Barr virus. Herein, we report three Japanese cases of the disease. A 21-year male patient, a 31-year female patient, and a 76-year female patient presented with high fever, lymphadenopathy, hepatosplenomegaly, and severe liver damage. All three cases had granular lymphocytes in both peripheral blood and bone marrow. The phenotype of these cells was CD2(+)CD3(-)CD56(+)HLA-DR(+)...
2012: Journal of Clinical and Experimental Hematopathology: JCEH
Noreen Sabir, Zafar Iqbal, Aamer Aleem, Tashfeen Awan, Tahir Naeem, Sultan Asad, Ammara H Tahir, Muhammad Absar, Rana M W Hasanato, Sulman Basit, Muhammad Azhar Chishti, Muhammad Faiyaz Ul-Haque, Ahmad Muktar Khalid, Muhammad Farooq Sabar, Mahmood Rasool, Sajjad Karim, Mahwish Khan, Baila Samreen, Afia M Akram, Muhammad Hassan Siddiqi, Saba Shahzadi, Sana Shahbaz, Agha Shabbir Ali, Amer Mahmood, Muhammad Akram, Tariq Saeed, Arsalan Saleem, Danish Mohsin, Ijaz Hussain Shah, Muhammad Khalid, Muhammad Asif, Mudassar Iqbal, Tanveer Akhtar
BACKGROUND AND OBJECTIVES: Chromosomal abnormalities play an important role in genesis of acute lymphoblastic leukemia (ALL) and have prognostic implications. Five major risk stratifying fusion genes in ALL are BCR-ABL, MLL-AF4, ETV6-RUNX11, E2A-PBX1 and SIL-TAL1. This work aimed to detect common chromosomal translocations and associated fusion oncogenes in adult ALL patients and study their relationship with clinical features and treatment outcome. METHODS: We studied fusion oncogenes in 104 adult ALL patients using RT-PCR and interphase-FISH at diagnosis and their association with clinical characteristics and treatment outcome...
2012: Asian Pacific Journal of Cancer Prevention: APJCP
Uwe Tröger, Andreas Drust, Jens Martens-Lobenhoffer, Ivan Tanev, Rüdiger C Braun-Dullaeus, Stefanie M Bode-Böger
One of the first-line drugs for empirical antibiotic therapy in patients with hospital-acquired infections is meropenem. An often neglected problem in sepsis is that patients with a normal serum creatinine concentration (SCr) might display augmented renal clearance (ARC). Here we describe two cases of sepsis with subtherapeutic exposures with standard meropenem dosing in whom therapy could be optimised by therapeutic drug monitoring (TDM). A 37-year-old man with acute lymphatic leukaemia and sepsis had a normal SCr at the beginning of his Intensive Care Unit (ICU) stay but showed decreased SCr of between 30 μmol/L and 40 μmol/L during his stay...
October 2012: International Journal of Antimicrobial Agents
Gabriele Nagel, Tanja Stocks, Daniela Späth, Anette Hjartåker, Björn Lindkvist, Göran Hallmans, Håkan Jonsson, Tone Bjørge, Jonas Manjer, Christel Häggström, Anders Engeland, Hanno Ulmer, Randi Selmer, Hans Concin, Pär Stattin, Richard F Schlenk
We investigated associations between metabolic factors and blood cancer subtypes. Data on body mass index (BMI), blood pressure, blood glucose, total cholesterol, and triglycerides from seven prospective cohorts were pooled (n = 578,700; mean age = 44 years). Relative risks of blood cancers were calculated from Cox regression models. During mean follow-up of 12 years, 2,751 incident and 1,070 fatal cases of blood cancers occurred. Overall, higher BMI was associated with an increased blood cancer risk. In gender-specific subgroup analyses, BMI was positively associated with blood cancer risk (p = 0...
October 2012: Annals of Hematology
Alexey Surov, Andreas Wienke, Jasmin Abbas
BACKGROUND: Breast leukemia is extremely rare. The published data on this manifestation include predominantly case reports and do not provide any statistical information. PURPOSE: To identify clinical signs and radiological features of breast leukemia. MATERIAL AND METHODS: PubMed and Medline databases between 1980 and 2010 were screened using 'breast leukemia' and 'leukemia of the breast' as keywords. Secondary references were also reviewed...
April 1, 2012: Acta Radiologica
Birgit Federmann, Martin Bornhauser, Christoph Meisner, Lambros Kordelas, Dietrich W Beelen, Gernot Stuhler, Matthias Stelljes, Rainer Schwerdtfeger, Maximilian Christopeit, Gerhard Behre, Christoph Faul, Wichard Vogel, Michael Schumm, Rupert Handgretinger, Lothar Kanz, Wolfgang A Bethge
BACKGROUND: We report a prospective multicenter phase II study of haploidentical hematopoietic stem cell transplantation using CD3/CD19-depleted grafts after reduced intensity conditioning with fludarabine, thiotepa, melphalan and OKT-3. DESIGN AND METHODS: Sixty-one adults with a median age of 46 years (range 19-65 years) have been enrolled. Diagnoses were acute myeloid leukemia (n=38), acute lymphoblastic leukemia (n=8), non-Hodgkin's lymphoma (n=6), myeloma (n=4), chronic myeloid leukemia (n=3), chronic lymphatic leukemia (n=1) and myelodysplastic syndrome (n=1)...
October 2012: Haematologica
Robert Frank Cornell, Jeanne Palmer
No abstract text is available yet for this article.
April 2012: Disease-a-month: DM
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"