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https://www.readbyqxmd.com/read/29777784/cd146-mediates-an-e-cadherin-to-n-cadherin-switch-during-tgf-%C3%AE-signaling-induced-epithelial-mesenchymal-transition
#1
Yanbin Ma, Haofeng Zhang, Chaoliang Xiong, Zheng Liu, Qingji Xu, Jing Feng, Jun Zhang, Zhaoqing Wang, Xiyun Yan
Cadherin switch is an initiating factor of epithelial-mesenchymal transition (EMT) and is intimately correlated with cancer metastatic potential; however, its underlying mechanisms remain unclear. Here, using a transforming growth factor-β (TGF-β)-induced EMT model, we provide explicit evidence that CD146, with elevated expression and activity in a variety of cancers, is a key factor involved in the cadherin switch. We show that CD146 can be induced by TGF-β signaling. Moreover, CD146 expression is positively correlated with the activation levels of STAT3/Twist and ERK pathways...
May 16, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29774060/metformin-prevents-nerve-growth-factor-dependent-proliferative-and-proangiogenic-effects-in-epithelial-ovarian-cancer-cells-and-endothelial-cells
#2
Maritza P Garrido, Carolina Vera, Margarita Vega, Andrew F G Quest, Carmen Romero
Background: Epithelial ovarian cancer (EOC) is characterized by exacerbated angiogenesis regulated by proangiogenic and growth factors. Nerve growth factor (NGF) is overexpressed in EOC where it promotes proliferation as well as survival and is considered a proangiogenic factor. Metformin, a drug commonly used in the treatment of diabetes, is attributed to antineoplastic effects, but the underlying mechanisms remain unknown. Given that current therapies yield modest results in EOC patients, the aim of this study was to determine the effects of metformin on NGF-enhanced proliferation of EOC cells and the angiogenic potential of endothelial cells...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29770618/peritoneal-cancer-index-as-a-predictor-of-survival-in-advanced-stage-serous-epithelial-ovarian-cancer-a-prospective-study
#3
Alaa A Elzarkaa, Waleed Shaalan, Doaa Elemam, Hassan Mansour, Mahmoud Melis, Eduard Malik, Amr A Soliman
OBJECTIVE: A numerical score, the peritoneal cancer index (PCI), was developed to reflect the extent of tumor growth in gastric and colorectal cancers and to tailor treatment. This study aimed to examine the value of the PCI score in advanced epithelial ovarian cancer (EOC) regarding completeness of surgical cytoreduction and survival. METHODS: This was a prospective observational cohort study. Patients with primary serous EOC at International Federation of Gynecology and Obstetrics (FIGO) stages IIIB or higher were included...
March 8, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29770329/aeg-1-contributes-to-metastasis-in-hypoxia-related-ovarian-cancer-by-modulating-the-hif-1alpha-nf-kappab-vegf-pathway
#4
Xiaoyu Yu, Yan Wang, Huilei Qiu, Hongtao Song, Di Feng, Yang Jiang, Shuzhe Deng, Hongxue Meng, Jingshu Geng
Objective: Ovarian carcinoma represents one of the deadliest malignancies among female cancer patients. Astrocyte-elevated gene-1 (AEG-1) participates in the ontogenesis of multiple human malignant diseases. Here we evaluated AEG-1, hypoxia-inducible factor- (HIF-) 1 α , nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κ B), and vascular endothelial growth factor (VEGF) amounts in hypoxia induced ovarian carcinoma cells. This study aimed to explore the mechanism by which AEG-1 regulates metastasis in hypoxia induced ovarian carcinoma...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29768958/bevacizumab-induced-atypical-hemolytic-uremic-syndrome-and-treatment-with-eculizumab
#5
Anusha Vakiti, Daulath Singh, Ravi Pilla, Muhamad A Moustafa, Kelly W Fitzpatrick
Bevacizumab (Avastin) is a recombinant humanized monoclonal antibody used for the management of various solid malignancies including colorectal, lung, brain, renal, and ovarian cancers as well as age-related macular degeneration of the eye. It is a vascular endothelial growth factor inhibitor which exhibits its action by blocking the growth of blood vessels in cancerous tissue. Common side effects include hypertension, fatigue, headaches, and increased risk of infections. Atypical hemolytic uremic syndrome is a serious side effect associated with bevacizumab due to its anti-angiogenic effect...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29752431/ddb2-represses-ovarian-cancer-cell-dedifferentiation-by-suppressing-aldh1a1
#6
Tiantian Cui, Amit Kumar Srivastava, Chunhua Han, Dayong Wu, Nissar Wani, Lu Liu, Zhiqin Gao, Meihua Qu, Ning Zou, Xiaoli Zhang, Ping Yi, Jianhua Yu, Erica H Bell, Shyh-Ming Yang, David J Maloney, Yanfang Zheng, Altaf A Wani, Qi-En Wang
Cancer stem cells (CSCs), representing the root of many solid tumors including ovarian cancer, have been implicated in disease recurrence, metastasis, and therapeutic resistance. Our previous study has demonstrated that the CSC subpopulation in ovarian cancer can be limited by DNA damage-binding protein 2 (DDB2). Here, we demonstrated that the ovarian CSC subpopulation can be maintained via cancer cell dedifferentiation, and DDB2 is able to suppress this non-CSC-to-CSC conversion by repression of ALDH1A1 transcription...
May 11, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29751991/influence-of-ca125-platelet-count-and-neutrophil-to-lymphocyte-ratio-on-the-immune-system-of-ovarian-cancer-patients
#7
Thaïs Baert, Joke Van Camp, Lisa Vanbrabant, Pieter Busschaert, Annouschka Laenen, Sileny Han, Els Van Nieuwenhuysen, Ignace Vergote, An Coosemans
OBJECTIVE: The effect of CA125, neutrophil to lymphocyte ratio (NLR) and thrombocytosis on survival has been studied in ovarian cancer. This study explores the link between these variables and serum markers of ovarian cancer patients, such as signaling proteins and cytokines. METHODS: Serum samples of 39 patients with high-grade serous ovarian cancer (HGSOC) were collected at diagnosis and were retrospectively analysed for clinical characteristics, clinical parameters (NLR, CA125, platelet count) and immune profile [IL-4 (interleukin), IL-10, IL-13, IL-17, transforming growth factor-β, Arginase-1, Interferon gamma), vascular endothelial growth factor (VEGF), galectin-1 and chemokine (C-C) motif ligand 2...
May 8, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29751820/physical-interaction-of-stat1-isoforms-with-tgf-%C3%AE-receptors-leads-to-functional-crosstalk-between-two-signaling-pathways-in-epithelial-ovarian-cancer
#8
Xiaoling Tian, Wencai Guan, Lingyun Zhang, Wenwen Sun, Daibing Zhou, Qunbo Lin, Weimin Ren, Lubna Nadeem, Guoxiong Xu
BACKGROUND: The signal transducer and activator of transcription (STAT) and transforming growth factor-β (TGF-β) signaling pathways play important roles in epithelial ovarian cancer (EOC). However, the mechanism of crosstalk between two pathways is not completely understood. METHODS: The expression of STAT1 protein was detected by tissue microarray and immunoblotting (IB). The interaction of STAT1 isoforms with TGF-β receptors was confirmed by immunoprecipitation and IB...
May 11, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29737581/blockade-of-onecut2-expression-in-ovarian-cancer-inhibited-tumor-cell-proliferation-migration-invasion-and-angiogenesis
#9
Tongyi Lu, Binhua Wu, Yunfei Yu, Wenhui Zhu, Simin Zhang, Yinmei Zhang, Jiaying Guo, Ning Deng
ONECUT2 (One Cut Homeobox 2, OC-2) is a newly discovered transcription factor and aberrant expression of OC-2 is closely related to cell proliferation, migration, invasion and angiogenesis. In this study, we found that the OC-2 expression was up-regulated in ovarian adenocarcinoma cells by western blot. The results of immunohistochemistry showed that the expression of OC-2 was also increased in malignant ovarian cancer tissue. In order to explore the role of OC-2 in the development of ovarian cancer, siRNA that specifically targets OC-2 were designed...
May 8, 2018: Cancer Science
https://www.readbyqxmd.com/read/29733540/fabp4-suppresses-proliferation-and-invasion-of-hepatocellular-carcinoma-cells-and-predicts-a-poor-prognosis-for-hepatocellular-carcinoma
#10
Cheng-Qian Zhong, Xiu-Ping Zhang, Ning Ma, Er-Bin Zhang, Jing-Jing Li, Ya-Bo Jiang, Yu-Zhen Gao, Yan-Mei Yuan, Shi-Qian Lan, Dong Xie, Shu-Qun Cheng
Adipocyte fatty acid-binding protein (FABP4) is abundant in macrophage and adipocyte. It is known to be involved in lipid metabolism. The role of FABP4 has been reported in various cancers, such as non-small cell lung cancer, breast cancer, ovarian cancer, and prostatic cancer. However, its role remains unclear in hepatocellular carcinoma (HCC). In our study, we investigated the expression of FABP4 at both mRNA and protein levels, and by examining 175 cases of patients with cancer of the liver tissue microarray, the significance between the expression of FABP4 and clinical characteristics had been discussed...
May 7, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29732458/hepatocellular-carcinoma-virilization-and-hilus-cell-hyperplasia-in-a-girl-with-turner-syndrome
#11
Jennifer R Law, Sang Lee, Eizaburo Sasatomi, Christine E Bookhout, Julie Blatt
Patients with Turner syndrome (TS) are known to be at risk for excess androgen production and virilization associated with gonadoblastoma and Y chromosome mosaicism, and excess androgens are a risk factor for the development of hepatocellular carcinoma. However, virilization and hepatocellular carcinoma have not been described in a patient with TS. A 10-year-old with nonmosaic 45,X TS presented with clitoromegaly, accelerated linear growth velocity, advanced bone age, and elevated testosterone levels as well as a second occurrence of hepatocellular carcinoma...
May 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29731973/co-expression-and-prognostic-significance-of-the-her-family-members-egfrviii-c-met-cd44-in-patients-with-ovarian-cancer
#12
Soozana Puvanenthiran, Sharadah Essapen, Ben Haagsma, Izhar Bagwan, Margaret Green, Said Abdullah Khelwatty, Alan Seddon, Helmout Modjtahedi
EGFR and HER-2 are important targets but none of the monoclonal antibodies or small molecule tyrosine kinase inhibitors specific for the HER members has been approved for the treatment of patients with ovarian cancers. In some studies, co-expression of other growth factor receptors has been associated with resistance to therapy with the HER inhibitors. The aim of the present study was to determine the relative expression, cellular location, and prognostic significance of HER-family members, the EGFR mutant (EGFRvIII) c-MET, IGF-1R and the cancer stem cell biomarker CD44 in 60 patients with FIGO stage III and IV ovarian cancer...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29725336/tribody-her2-2-xcd16-is-more-effective-than-trastuzumab-in-enhancing-%C3%AE-%C3%AE-t-cell-and-natural-killer-cell-cytotoxicity-against-her2-expressing-cancer-cells
#13
Hans H Oberg, Christian Kellner, Daniel Gonnermann, Susanne Sebens, Dirk Bauerschlag, Martin Gramatzki, Dieter Kabelitz, Matthias Peipp, Daniela Wesch
An enhanced expression of human epidermal growth factor receptor 2 (HER2, ErbB2) often occurs in an advanced stage of breast, ovarian, gastric or esophageal cancer, and pancreatic ductal adenocarcinoma (PDAC). Commonly, HER2 expression is associated with poor clinical outcome or chemoresistance in ovarian and breast cancer patients. Treatment with humanized anti-HER2 monoclonal antibodies, such as trastuzumab or pertuzumab, has improved the outcome of patients with HER2-positive metastatic gastric or breast cancer, but not all patients benefit...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29723542/effects-of-fibroblast-growth-factors-and-the-transcription-factor-early-growth-response-1-on-bovine-theca-cells
#14
Peng Han, Hilda Guerrero-Netro, Anthony Estienne, Christopher A Price
The theca cell layer of the ovarian follicle secretes growth factors that impact the function of granulosa cells. One such factor is fibroblast growth factor 18 (FGF18) that causes apoptosis of granulosa cells, however it is not known if FGF18 induces apoptosis also in theca cells. Addition of recombinant FGF18 to bovine theca cells in vitro inhibited steroidogenesis but, in contrast to previous data in granulosa cells, decreased the incidence of apoptosis. FGF18 activated typical FGF signaling pathways in theca cells, which was not previously observed in granulosa cells...
May 1, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29720538/sympathetic-innervation-regulates-macrophage-activity-in-rat-with-polycystic-ovary
#15
Florencia Figueroa, Gisela Mendoza, Dario Cardozo, Fabian Mohamed, Liliana Oliveros, Myriam Liliana Forneris
Polycystic ovary syndrome (PCOS) is a low grade inflammatory disease characterized by hyperandrogenism and ovarian hyperinnervation. The aim of this work is to investigate whether in vivo bilateral superior ovarian nerve (SON) section in adult rats with estradiol valerate induced polycystic ovarian syndrome (PCO rats) affects macrophage spleen cells (MФ) and modifies the steroidogenic ability of their secretions. Culture media of MФ from PCO rats and PCO rats with SON section (PCO-SON rats) were used to stimulate in vitro intact ovaries...
May 2, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29719665/effect-of-lysophosphatidic-acid-on-the-follicular-development-and-the-expression-of-lysophosphatidic-acid-receptor-genes-during-in-vitro-culture-of-mouse-ovary
#16
Neda Abedpour, Mojdeh Salehnia, Nassim Ghorbanmehr
Lysophosphatidic acid (LPA) known as a serum-derived growth factor, is involved in several cell physiological functions in the female reproductive system including: oocyte maturation, in vitro fertilization and embryo implantation by its transmembrane G protein-coupled receptors. The aim of the present study was to examine the effect of LPA on in vitro follicular development of mouse ovarian tissue. Neonatal mouse ovarian tissues were cultured in five different concentrations of LPA (0, 5, 10, 20 and 40 µM)...
2018: Veterinary Research Forum
https://www.readbyqxmd.com/read/29718710/identification-of-hepatic-fibroblast-growth-factor-21-as-a-mediator-in-17%C3%AE-estradiol-induced-white-adipose-tissue-browning
#17
Lun Hua, Yong Zhuo, Dandan Jiang, Jing Li, Xiaohua Huang, Yingguo Zhu, Zhen Li, Lijun Yan, Chao Jin, Xuemei Jiang, Lianqiang Che, Zhengfeng Fang, Yan Lin, Shengyu Xu, Jian Li, Bin Feng, De Wu
Both ovarian E2 and hepatic fibroblast growth factor 21 (FGF21) are critical for energy homeostasis and white adipose tissue browning. Estrogen receptor α (ERα) is abundantly expressed in liver. However, whether FGF21 has a role in E2-induced white adipose tissue browning remains uncertain. In this study, we showed that hepatic Fgf21 expression and secretion during estrus cycle changed with the tetradian oscillatory secretion of circulation E2 in adult, female mice, with their peak expressions and secretions at the proestrus...
May 2, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29714649/personalized-therapy-based-on-sequential-molecular-analysis-leads-to-30-months-of-survival-in-a-patient-with-diffuse-unresectable-gastric-linitis-plastica
#18
Linda Mahjoubi, Fabiola Cecchi, Christophe Massard, Fabio Calabro, Anas Gazzah, Rastislav Bahleda, Philippe Jamme, Maximiliano Gelli, Diane Goere, Ludovic Lacroix, Julien Adam, Lukas Heukamp, Patrizia Trenta, Todd Hembrough, Jean-Charles Soria, Cora Sternberg, Michel Ducreux
INTRODUCTION: Diffuse gastric cancer is associated with poor prognosis. We report a patient with metastatic gastric linitis plastica harboring human epidermal growth factor receptor 2 ( HER2) activating mutation and HER2 amplification. CASE DESCRIPTION: The patient received 5-fluorouracil/folinic acid and oxaliplatin combined with trastuzumab/pertuzumab, resulting in disease control for 8 months. Second-line therapy with nivolumab and trastuzumab/pertuzumab was well-tolerated, with macroscopic peritoneal response...
March 1, 2018: Tumori
https://www.readbyqxmd.com/read/29710481/caffeic-acid-phenethyl-ester-inhibits-the-progression-of-ovarian-cancer-by-regulating-nf-b-signaling
#19
Ge-Lin Liu, Nai-Zhi Han, Shi-Shun Liu
Ovarian cancer is one of the most common malignancies in women and characterized by a rapid progression to metastasis, which restricts effective treatment options. Caffeic acid phenethyl ester (CAPE), a natural honeybee product, exhibits a variety of biological activities, anti-tumor is included. Our study aims to explore whether CAPE could inhibit the progression of ovarian cancer and the underlying molecular mechanism. The establishment of ovarian cancer model was set up in mice through caudal vein injection of SKOV-3 cells...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29706932/potential-functions-of-igfbp-2-for-ovarian-folliculogenesis-and-steroidogenesis
#20
REVIEW
Marion Spitschak, Andreas Hoeflich
Ovarian follicles, as transient structural and functional complexes with the oocyte and the associated cells, determine the female reproductive cycle and thus fertility. Ovarian function is subject to the strict control of hormones and growth factors and thus regulated by auto-, para-, and endocrine mechanisms but influenced also by endogenous factors. During the waves of follicular growth and development, one follicle (monoovulatory) or a limited number of them (polyovulatory) are selected under hypothalamic-gonadal control for maturation until ovulation, resulting in the fertile oocyte...
2018: Frontiers in Endocrinology
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