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Ergonovine

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https://www.readbyqxmd.com/read/28808762/relationships-between-more-than-90-coronary-luminal-narrowing-induced-by-ergonovine-provocation-test-and-ecg-ischemic-change-as-well-as-chest-symptoms
#1
Shozo Sueda, Hiroaki Kohno
In the clinic, patients with ≥90% luminal narrowing during ergonovine (ER) testing had variable response. We investigated ischemic findings and chest symptoms in patients with ≥90% luminal narrowing when performing ER tests, retrospectively. We performed 1210 ER tests over 26 years (1991-2016). We analyzed chest symptoms and positive ischemic ECG changes during ER tests. More than 90% luminal narrowing was found in 352 patients (29.1%) including 211 patients in the right coronary artery (RCA) and 217 patients in the left coronary artery (LCA)...
August 14, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28766048/association-of-epicardial-adipose-tissue-with-coronary-spasm-and-coronary-atherosclerosis-in-patients-with-chest-pain-analysis-of-data-collated-by-the-korean-women-s-chest-pain-registry-korose
#2
Mi-Na Kim, Hack-Lyoung Kim, Seong-Mi Park, Mi Seung Shin, Cheol Woong Yu, Myung-A Kim, Kyung-Soon Hong, Wan-Joo Shim
Epicardial adipose tissue (EAT) represents a cardio-metabolic risk factor; it secretes several adipokines related to coronary atherosclerosis. However, the precise relationship between EAT and coronary vasospasm is unknown. This study aimed to investigate the relationship between EAT and coronary vasospasm using data from the KoRean wOmen'S chest pain rEgistry (koROSE). This study included 551 patients (female/male = 366/185; mean age = 60.2 ± 10.2 years) who presented with chest pain at an outpatient clinic, and who subsequently underwent echocardiography and coronary angiography...
August 1, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28659551/impact-of-stent-type-and-presence-of-vasospastic-angina-on-long-term-prognosis
#3
Reo Hata, Naoki Oka, Shunsuke Kubo, Akimune Kuwayama, Masanobu Ohya, Takenobu Shimada, Katsuya Miura, Hidewo Amano, Yusuke Hyodo, Suguru Otsuru, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazushige Kadota
BACKGROUND: Little is known about the impact of stent type on the prognosis of vasospastic angina (VSA) in patients who undergo stent implantation.Methods and Results:We evaluated consecutive patients undergoing coronary angiography with positive (n=650; VSA) and negative (n=2,872; non-VSA) ergonovine testing. Among them, 304 patients undergoing stent implantation for organic stenosis were classified for comparison into 3 respective VSA and non-VSA groups based on stent type (68 and 78 with bare-metal stent [BMS]; 21 and 49 with sirolimus-eluting stent [SES]; 26 and 62 with newer generation drug-eluting stent [N-DES])...
June 28, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28622945/safety-of-intracoronary-provocative-testing-for-the-diagnosis-of-coronary-artery-spasm
#4
Giuseppe Ciliberti, Sreenivasa Rao Kondapally Seshasai, Giuseppe Ambrosio, Juan Carlos Kaski
AIMS: Systematic review of literature to evaluate safety of intracoronary (i.c.) pharmacologic testing with acetylcholine (ACh), or ergonovine (ERGO), to induce coronary artery spasm. METHODS AND RESULTS: Review of all relevant publications using MEDLINE and EMBASE databases yielded 10 publications, totalling 9,444 patients. Prevalence of provoked spasm varied from 2.3% to 54.7% of patients tested in the selected studies. The wide variability in prevalence was due to heterogeneity of study populations and provocation protocols...
June 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28592384/gender-differences-in-long-term-clinical-outcomes-and-prognostic-factors-in-patients-with-vasospastic-angina
#5
Da Hyon Lee, Taek Kyu Park, Choong Sil Seong, Hye Bin Gwag, A Young Lim, Min Seok Oh, Sung Woo Cho, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Sang Hoon Lee, Hyeon-Cheol Gwon, Seung-Hyuk Choi
BACKGROUND: Men are more likely to suffer from vasospastic angina (VSA) than women; however, gender differences in the long-term prognosis of VSA patients have not been fully elucidated. We sought to investigate clinical outcomes and predictive factors of VSA patients according to gender. METHODS: A total of 986 patients (838 men and 148 women) with a positive result on intracoronary ergonovine provocation test between January 2003 and December 2014 were analyzed...
May 26, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28476516/effects-of-neuropeptide-y-on-coronary-artery-vasomotion-in-patients-with-microvascular-angina
#6
Giuseppe M C Rosano, Dimitris Tousoulis, Eugene McFadden, John Clarke, Graham J Davies, Juan Carlos Kaski
BACKGROUND: Patients with microvascular angina (exertional angina, positive exercise tests and normal coronary arteriograms) usually have a reduced coronary blood flow reserve. Neuropeptide Y (NPY) is a potent endogenous vasoconstrictor involved in modulation of coronary vasomotor tone and may play a role in microvascular angina. METHODS: We compared the effects of NPY (0.2-1.0pmol/kg, intracoronary) on the vasomotor response of proximal and distal segments of the coronary arteries in 7 patients with microvascular angina, 9 with chronic stable angina, and 9 control individuals...
March 16, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28438445/minimal-pneumothorax-with-dynamic-changes-in-st-segment-similar-to-myocardial-infarction
#7
Seok-Ran Yeom, Sung-Wook Park, Young-Dae Kim, Byung-Jae Ahn, Jin-Hee Ahn, Il-Jae Wang
Pneumothorax can cause a variety of electrocardiographic changes. ST segment elevation, which is mainly observed in myocardial infarction, can also be induced by pneumothorax. The mechanism is presumed to be a decrease in cardiac output, due to increased intra-thoracic pressure. We encountered a patient with ST segment elevation with minimal pneumothorax. Coronary angiography with ergonovine provocation test and echocardiogram had normal findings. The ST segment elevation was normalized by decreasing the amount of pneumothorax...
August 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28348898/conventional-coronary-angiography-induced-takotsubo-cardiomyopathy-complicated-with-cardiac-tamponade
#8
Min Gyu Kang, Kye-Hwan Kim, Jin-Sin Koh, Young-Hoon Jeong, Jin-Yong Hwang, Jeong Rang Park
Takotsubo cardiomyopathy (TCM) is a transient left ventricular dysfunction that typically occurs after emotional or physical stress. TCM has a benign prognosis and serious complications are uncommon. However, though very rarely reported, cardiac tamponade has occurred on some occasions. We hereby report the case of a 70-year-old woman who underwent coronary angiography with an ergonovine provocation test to evaluate recurrent chest pain and was readmitted 7 days later presenting with TCM, followed by left ventricular outflow tract obstruction and cardiac tamponade...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28331112/differential-incidence-and-morphology-of-spasm-according-to-coronary-arterial-location-by-intracoronary-ergonovine-spasm-provocation-testing
#9
Shozo Sueda, Hiroaki Kohno
BACKGROUND: We reported less provoked spasm in the left circumflex artery (LCX) by acetylcholine testing compared with the left anterior descending artery (LAD) and right coronary artery (RCA), so we investigated the clinical characteristics of provoked spasm in the LCX by ergonovine (ER) testing.Methods and Results:We retrospectively analyzed 1,185 consecutive cases of intracoronary ER testing during 25 years. Maximal ER dose was 64 μg into the left coronary artery (LCA) and 40 μg into the RCA...
March 23, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27939277/thrombus-and-plaque-erosion-characterized-by-optical-coherence-tomography-in-patients-with-vasospastic-angina
#10
Eun-Seok Shin, Ae-Young Her, Soe Hee Ann, Gillian Balbir Singh, Heeyoun Cho, Eui Cheol Jung, Eun Bo Shim, Bon-Kwon Koo, Takashi Akasaka
INTRODUCTION AND OBJECTIVES: Vasospastic angina (VSA) can result in endothelial damage and thrombus formation. The aim of this study was to evaluate the incidence of thrombus and plaque characteristics at coronary spasm segments compared with nonspasm segments by using optical coherence tomography (OCT) in patients with suspected VSA. METHODS: One hundred and eighty-three patients with suspected VSA were enrolled in this study. The ergonovine provocation test was performed in all patients for the diagnosis of VSA except in patients with spontaneous spasm...
December 7, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27856130/overview-of-the-pharmacological-spasm-provocation-test-comparisons-between-acetylcholine-and-ergonovine
#11
REVIEW
Shozo Sueda, Hiroaki Kohno, Takaaki Ochi, Tadao Uraoka, Kensuke Tsunemitsu
The spasm provocation tests of ergonovine and acetylcholine have been employed in the cardiac catheterization laboratory. Ergonovine acts through the serotogenic receptors, while acetylcholine acts through the muscarinic cholinergic receptors. Different mediators may have the potential to cause different coronary responses. However, there are few reports concerning the coronary response between ergonovine and acetylcholine in the same patients. Acetylcholine is supersensitive for females; spasm provoked by ergonovine is focal and proximal, whereas provoked spasm by acetylcholine is diffuse and distal...
January 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/27852592/clinical-outcomes-of-vasospastic-angina-patients-presenting-with-acute-coronary-syndrome
#12
Sung Woo Cho, Taek Kyu Park, Hye Bin Gwag, A Young Lim, Min Seok Oh, Da Hyon Lee, Choong Sil Seong, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Sang Hoon Lee, Hyeon-Cheol Gwon, Seung-Hyuk Choi
BACKGROUND: Coronary vasospasm is an important pathogenesis of acute coronary syndrome (ACS). However, the clinical features and prognosis of vasospastic angina (VA) patients presenting with ACS (VAACS) are still unclear. We aimed to evaluate the clinical characteristics and long-term outcomes of VAACS patients without significant coronary artery stenosis. METHODS AND RESULTS: A total of 986 VA patients confirmed by ergonovine provocation test were analyzed. VAACS was defined as VA patients visiting the emergency room with documented electrocardiographic changes, significant arrhythmias, or elevated cardiac biomarkers...
November 16, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27693027/diagnostic-performance-of-320-slice-computed-tomography-coronary-angiography-for-symptomatic-patients-in-clinical-practice
#13
Futoshi Yamanaka, Koki Shishido, Tomoki Ochiai, Noriaki Moriyama, Kazuki Tobita, Tomoyuki Tani, Kyosuke Furuhashi, Kazuya Sugitatsu, Daisuke Hachinohe, Tadashi Wada, Shingo Mizuno, Hidetaka Suenaga, Yutaka Tanaka, Masato Murakami, Junya Matsumi, Saeko Takahashi, Takeshi Akasaka, Shinji Tanaka, Shigeru Saito
OBJECTIVE: Multi-slice computed tomography (MSCT) coronary angiography has been reported as an effective alternative to invasive conventional coronary angiography (CCA) for the diagnosis of coronary artery disease (CAD). However, in previous reports, the diagnostic accuracy of MSCT has not been significant enough to be of benefit in symptomatic patients. The aim of this study was to identify the usefulness of 320-slice computed tomography coronary angiography (320-CTA) for symptomatic patients in terms of the diagnostic accuracy of 320-CTA and the prevalence of vasospastic angina pectoris (VSAP) within the study cohort...
September 29, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27573612/impact-of-statin-therapy-on-long-term-clinical-outcomes-of-vasospastic-angina-without-significant-stenosis-a-propensity-score-matched-analysis
#14
Min Seok Oh, Jeong Hoon Yang, Da Hyun Lee, Taek Kyu Park, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Sang Hoon Lee, Hyeon-Cheol Gwon, Seung-Hyuk Choi
BACKGROUND: Limited data are available on the efficacy of statin therapy for secondary prevention in patients with vasospastic angina (VSA). We investigated the association of statin therapy with long-term clinical outcomes in VSA patients without significant coronary artery disease. METHODS: From January 2003 to June 2014, we enrolled a total of 804 patients with VSA proven by an ergonovine provocation test without significant (≥70% diameter stenosis) coronary artery disease...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27434364/impact-of-epicardial-adipose-tissue-volume-quantified-by-non-contrast-electrocardiogram-gated-computed-tomography-on-ergonovine-induced-epicardial-coronary-artery-spasm
#15
Tsuyoshi Ito, Hiroshi Fujita, Taku Ichihashi, Nobuyuki Ohte
OBJECTIVE: Endothelial dysfunction of the coronary artery is thought to lead to the development of coronary spasms. Epicardial adipose tissue may be a marker of coronary atherosclerosis. This study investigated the diagnostic impact of epicardial fat volume (EFV), quantified with non-contrast electrocardiogram (ECG)-gated computed tomography (CT), on ergonovine-induced coronary spasms. METHODS: We included 97 patients with suspected coronary spastic angina who underwent ECG-gated CT and an ergonovine provocation test...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27400315/clinical-implications-of-low-dose-aspirin-on-vasospastic-angina-patients-without-significant-coronary-artery-stenosis-a-propensity-score-matched-analysis
#16
A Young Lim, Taek Kyu Park, Sung Woo Cho, Min Seok Oh, Da Hyon Lee, Choong Sil Seong, Hye Bin Gwag, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Sang Hoon Lee, Hyeon-Cheol Gwon, Joonghyun Ahn, K C Carriere, Seung-Hyuk Choi
BACKGROUND: High-dose aspirin has been reported to exacerbate coronary artery spasm in patients with vasospastic angina. We investigated clinical implications of low-dose aspirin on vasospastic angina patients without significant coronary artery stenosis. METHODS: We included patients without significant coronary artery stenosis on coronary angiography (CAG) and with positive results on intracoronary ergonovine provocation test between January 2003 and December 2014...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27380904/noninvasive-detection-of-coronary-vasospastic-angina-using-a-double-acquisition-coronary-ct-angiography-protocol-in-the-presence-and-absence-of-an-intravenous-nitrate-a-pilot-study
#17
Eun-Ju Kang, Moo Hyun Kim, Cai De Jin, Jeongmin Seo, Dong Won Kim, Seong Kuk Yoon, Tae-Ho Park, Ki-Nam Lee, Sang Il Choi, Yeonyee Elizabeth Yoon
OBJECTIVES: To evaluate the feasibility of a double-acquisition coronary CT angiography (CCTA) protocol in the presence and absence of an intravenous (IV) vasodilator infusion for detecting vasospastic angina. METHODS: Twenty patients with a high clinical probability of vasospastic angina were enrolled. All subjects underwent baseline CCTA without a vasodilator in the early morning followed by a catheterized coronary angiography with ergonovine provocation test...
March 2017: European Radiology
https://www.readbyqxmd.com/read/27366554/management-of-neuraxial-anaesthesia-for-emergent-caesarean-section-for-placenta-previa
#18
Berrin Günaydın, Mertihan Kurdoğlu, İsmail Güler, Mehrnoosh Bashiri, Fırat Büyüktaşkın, Mine Dağgez Keleşoğlu, Gözde İnan
Abnormal placental attachments, such as placenta accreta, increta or percrata, can result in increased morbidity and mortality because of the risk of severe postpartum haemorrhage. We aimed to present the management of spinal anaesthesia and surgical approach for emergent caesarean section because of vaginal bleeding in a multiparous pregnant woman with placenta previa at 36 weeks' gestation. Hyperbaric bupivacaine 12 mg, fentanyl 10 μg and morphine 150 μg were intrathecally administered for spinal anaesthesia...
February 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27301847/high-susceptibility-of-atherosclerotic-coronary-arteries-to-the-onset-of-vasospasm-and-angina-pectoris-like-symptoms-due-to-coronary-spasm-in-whhlmi-rabbits
#19
Tomonari Koike, Shiori Tamura, Ying Yu, Nobue Kuniyoshi, Masashi Shiomi
We examined the relationship between atherosclerosis and the provocation of coronary spasm as well as the influence of coronary spasm on the onset of acute ischemic myocardial disease. Coronary spasm was provoked in anesthetized normal Japanese white (JW) rabbits and myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits, an animal model for coronary atherosclerosis and myocardial infarction, by injecting ergonovine during the infusion of norepinephrine through a marginal ear vein. A decrease in contrast flow in the left circumflex artery was observed on coronary angiograms...
November 1, 2016: Experimental Animals
https://www.readbyqxmd.com/read/27234219/overview-of-complications-during-pharmacological-spasm-provocation-tests
#20
REVIEW
Shozo Sueda, Hiroaki Kohno
Pharmacological spasm provocation tests are invasive methods and we always have the potential to encounter complications when performing these tests. In 1980, Buxton et al. reported three deaths when they performed intravenous ergonovine testing. However, we now employ the intracoronary ergonovine test instead of the intravenous injection of ergonovine from a safety procedure point of view. Past serious major complications of intravenous ergonovine tests, intracoronary ergonovine tests, and intracoronary acetylcholine tests were 0...
July 2016: Journal of Cardiology
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