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https://www.readbyqxmd.com/read/28927150/upfront-high-dose-chemotherapy-combined-with-autologous-stem-cell-transplantation-potential-survival-benefit-for-patients-with-high-risk-diffuse-large-b-cell-lymphoma
#1
Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Tomoki Ito, Shosaku Nomura
In patients with diffuse large B-cell lymphoma (DLBCL) classified as high-intermediate risk or high risk using the International Prognosis Index, the efficacy of high-dose chemotherapy combined with upfront autologous stem cell transplantation (HDT/ASCT) remains controversial in the rituximab era. In the present study, 27 patients who had been treated with HDT/ASCT in an upfront setting were retrospectively analyzed, and compared with 77 patients with similar characteristics who had received conventional chemotherapy without HDT/ASCT (the non-upfront setting)...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927049/a-prognostic-model-for-lung-adenocarcinoma-patient-survival-with-a-focus-on-four-mirnas
#2
Xianqiu Li, Zhaoling An, Peihui Li, Haihua Liu
There is currently no effective biomarker for determining the survival of patients with lung adenocarcinoma. The purpose of the present study was to construct a prognostic survival model using microRNA (miRNA) expression data from patients with lung adenocarcinoma. miRNA data were obtained from The Cancer Genome Atlas, and patients with lung adenocarcinoma were divided into either the training or validation set based on the random allocation principle. The prognostic model focusing on miRNA was constructed, and patients were divided into high-risk or low-risk groups as per the scores, to assess their survival time...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926880/-emphasis-on-standardization-and-refinement-in-the-diagnosis-and-treatment-of-dry-eye
#3
Z G Liu
Dry eye is the second most common ocular disease. In China, the incidence rate of dry eye has reached 21% to 30%, and dry eye patients have accounted for more than 30% of the total ophthalmology outpatients. Dry eye has become a common health problem that affects the working efficiency and life quality of Chinese people. Over the past decade, due to the rapid development of diagnostic equipments and new treatments for dry eye, dry eye has become one of the areas with greatest concerns in ophthalmology, and many eye institutions have set up their dry eye clinics...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28926870/cardiovascular-responses-to-resistance-exercise-performed-with-large-and-small-muscle-mass
#4
Lenifran Matos-Santos, Paulo Farinatti, Juliana P Borges, Renato Massaferri, Walace Monteiro
Prior research about the effects of the amount of exercised muscle mass upon cardiovascular responses (CVR) has neglected a potential bias related to total exercise and concentric/eccentric duration. Autonomic responses and perceived exertion (RPE) were compared in resistance exercises performed with larger and smaller muscle mass and matched for total exercise and concentric/eccentric duration. Twelve men performed 4 sets of 12 repetitions of unilateral (UNI) and bilateral (BIL) knee extensions at 70% of 12RM...
September 19, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28926868/polycystic-ovary-syndrome-pcos-in-juvenile-and-adult-type-1-diabetes-in-a-german-austrian-cohort
#5
Christina Reinauer, Esther Bollow, Elke Fröhlich-Reiterer, Katharina Laubner, Dominik Bergis, Christof Schöfl, Hans-Peter Kempe, Michael Hummel, Pia Hennes, Katja Gollisch, Holger Haberland, Nicolin Datz, Thomas Meissner, Reinhard W Holl
Context While an association between PCOS and type 2 diabetes is well established, to date there have been few data on clinical care of type 1 diabetes (T1D) patients with PCOS. Objective The aim of our study was to characterize T1D patients with the comorbidity of PCOS within the DPV cohort with regard to diabetes phenotype, therapy and metabolic control. Design and Setting Clinical data from the prospective German/Austrian DPV cohort on patients with T1D and documented PCOS (n=76) were compared to female T1D controls (n=32,566) in reproductive age...
September 19, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28926828/are-all-amplitude-integrated-electroencephalogram-systems-equal
#6
Tobias Werther, Monika Olischar, Gunnar Naulaers, Philipp Deindl, Katrin Klebermass-Schrehof, Nathan Stevenson
BACKGROUND: Filter and peak detection algorithms implemented in amplitude-integrated electroencephalogram (aEEG) systems are not standardized. New aEEG systems are continuously enriching the market and clinicians are faced with different aEEG devices whose tracings may vary. OBJECTIVES: The aim of this work was to determine the role of different aEEG systems on quantitative measurements of the aEEG. METHODS: In this observational study, a single-channel aEEG recording (Olympic CFM 6000) with corresponding EEG signal was obtained from 32 infants at a gestational age of 36-44 weeks...
September 20, 2017: Neonatology
https://www.readbyqxmd.com/read/28926634/nasal-and-pharyngeal-carriage-of-methicillin-resistant-staphylococcus-sciuri-among-hospitalised-patients-and-healthcare-workers-in-a-serbian-university-hospital
#7
Ivana Cirkovic, Jasmina Trajkovic, Tomasz Hauschild, Paal Skytt Andersen, Adebayo Shittu, Anders Rhod Larsen
There has been a paucity of data on methicillin-resistant Staphylococcus sciuri (MRSS) epidemiology in European healthcare settings. The aim of the study was to determine the prevalence of nasal and pharyngeal carriage and diversity of MRSS among inpatients and healthcare workers (HCWs) in the largest healthcare centre in Serbia, and to assess performance of different methods for MRSS screening. Nasal and pharyngeal swabs were obtained from 195 patients and 105 HCWs in different departments. Each swab was inoculated directly onto MRSA-ID, oxacillin-resistance screening agar and mannitol salt agar (MSA) with 2 mg/L of oxacillin...
2017: PloS One
https://www.readbyqxmd.com/read/28926580/simple-yet-effective-historical-proximity-variables-improve-the-species-distribution-models-for-invasive-giant-hogweed-heracleum-mantegazzianum-s-l-in-poland
#8
Piotr Mędrzycki, Ingeborga Jarzyna, Artur Obidziński, Barbara Tokarska-Guzik, Zofia Sotek, Piotr Pabjanek, Adam Pytlarczyk, Izabela Sachajdakiewicz
Species distribution models are scarcely applicable to invasive species because of their breaking of the models' assumptions. So far, few mechanistic, semi-mechanistic or statistical solutions like dispersal constraints or propagule limitation have been applied. We evaluated a novel quasi-semi-mechanistic approach for regional scale models, using historical proximity variables (HPV) representing a state of the population in a given moment in the past. Our aim was to test the effects of addition of HPV sets of different minimal recentness, information capacity and the total number of variables on the quality of the species distribution model for Heracleum mantegazzianum on 116000 km2 in Poland...
2017: PloS One
https://www.readbyqxmd.com/read/28926565/a-snp-panel-and-online-tool-for-checking-genotype-concordance-through-comparing-qr-codes
#9
Yonghong Du, Joshua S Martin, John McGee, Yuchen Yang, Eric Yi Liu, Yingrui Sun, Matthias Geihs, Xuejun Kong, Eric Lingfeng Zhou, Yun Li, Jie Huang
In the current precision medicine era, more and more samples get genotyped and sequenced. Both researchers and commercial companies expend significant time and resources to reduce the error rate. However, it has been reported that there is a sample mix-up rate of between 0.1% and 1%, not to mention the possibly higher mix-up rate during the down-stream genetic reporting processes. Even on the low end of this estimate, this translates to a significant number of mislabeled samples, especially over the projected one billion people that will be sequenced within the next decade...
2017: PloS One
https://www.readbyqxmd.com/read/28926529/first-line-folfiri-and-bevacizumab-in-patients-with-advanced-colorectal-cancer-prospectively-stratified-according-to-serum-ldh-final-results-of-the-giscad-italian-group-for-the-study-of-digestive-tract-cancers-central-colorectalavastintrialldh-trial
#10
Riccardo Giampieri, Marco Puzzoni, Bruno Daniele, Daris Ferrari, Sara Lonardi, Alberto Zaniboni, Luigi Cavanna, Gerardo Rosati, Nicoletta Pella, Maria Giulia Zampino, Pietro Sozzi, Domenico Germano, Vittorina Zagonel, Carla Codecà, Michela Libertini, Roberto Labianca, Stefano Cascinu, Mario Scartozzi
BACKGROUND: Previous findings suggested that bevacizumab might be able to improve response rate (RR) in colorectal cancer patients with high lactic dehydrogenase (LDH) basal levels. METHODS: We conducted a phase II trial to prospectively ascertain whether bevacizumab in combination with FOLFIRI could have an improved clinical activity in patients with high LDH serum levels. Primary end point of the study was RR; secondary end points were median overall survival and median progression-free survival (mPFS)...
September 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28926501/moral-distress-and-associated-factors-among-baccalaureate-nursing-students-a-multisite-descriptive-study
#11
Lorretta Krautscheid, Deborah A DeMeester, Valorie Orton, Austin Smith, Conor Livingston, Susan M McLennon
AIM: The three study aims were to assess moral distress among senior baccalaureate nursing students, describe ethical dilemmas contributing to their moral distress in practice settings, and identify reasons for inaction when encountering dilemmas. BACKGROUND: Previous studies have linked postlicensure nurses' moral distress to compassion fatigue, frustration, and turnover. Little is known about this phenomenon in students. METHOD: This study employed a descriptive cross-sectional survey design to measure moral distress and reasons for not taking action across three academic sites (N = 267)...
September 19, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28926488/potential-acceptability-of-a-pediatric-ventilator-management-computer-protocol
#12
Katherine A Sward, Christopher J L Newth, Robinder G Khemani, Kent Page, Kathleen L Meert, Joseph A Carcillo, Thomas P Shanley, Frank W Moler, Murray M Pollack, Heidi J Dalton, David L Wessel, John T Berger, Robert A Berg, Rick E Harrison, Allan Doctor, J Michael Dean, Richard Holobkov, Tammara L Jenkins, Carol E Nicholson
OBJECTIVES: To examine issues regarding the granularity (size/scale) and potential acceptability of recommendations in a ventilator management protocol for children with pediatric acute respiratory distress syndrome. DESIGN: Survey/questionnaire. SETTING: The eight PICUs in the Collaborative Pediatric Critical Care Research Network. PARTICIPANTS: One hundred twenty-two physicians (attendings and fellows). INTERVENTIONS: None...
September 16, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28926474/parasympathetic-activation-enhanced-by-slow-respiration-modulates-early-auditory-sensory-gating
#13
Atsushi Aoyama, Yu Shimura, Takao Ohmuta, Yohei Nomoto, Masashi Kawasumi
Sensory gating is a preattentional mechanism to filter irrelevant information from the environment. It is typically reflected as a suppression of the event-related P50 component for successive sounds in the auditory modality. Although stress-induced sympathetic activation has been reported to disrupt P50 suppression, little is known about the modulatory effect of parasympathetic activation on early auditory sensory gating. We determined the parasympathetic effect on the magnetic P50 (P50m) suppression by controlling the respiratory rhythm and recording data simultaneously with magnetoencephalography and electrocardiography, using three successive click sounds as stimulus and ten normal individuals as study participants...
September 18, 2017: Neuroreport
https://www.readbyqxmd.com/read/28925890/the-use-of-hemodynamic-and-cerebral-monitoring-to-study-pharmacodynamics-in-neonates
#14
A Smits, L Thewissen, A Dereymaeker, E Dempsey, A Caicedo, Gunnar Naulaers
BACKGROUND: Drugs acting on the cardiovascular and central nervous system often display relatively fast clinical responses, which may differ in neonates compared to children and adults. Introduction of bedside monitoring tools might be of additional value in the pharmacodynamic (PD) assessment of such drugs in neonates. METHODS: We aim to provide an overview of the frequently used monitoring tools to assess drug effects on the hemodynamic status as well as the cerebral circulation, oxygenation and cerebral metabolism in neonates...
September 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28925798/laparoscopic-resections-of-colorectal-cancer-and-synchronous-liver-metastases-a-case-controlled-study
#15
Xiao Xu, Yulin Guo, Guijin Chen, Chen Li, Hongguang Wang, Guanglong Dong
PURPOSE: To investigate the efficacy and safety of laparoscopic simultaneous resections of colorectal cancer and synchronous colorectal liver metastases (SCRLM), relative to open surgery. METHODS: Between 1 January 2009 and 20 April 2014, 20 of 25 patients who underwent laparoscopic simultaneous colorectal cancer and SCRLM resections were matched with 20 of 29 patients who underwent an open approach, based on prognostic propensity scores. Perioperative results and survival outcomes were compared...
September 19, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28925330/preoperative-positron-emission-tomography-for-node-positive-head-and-neck-cutaneous-squamous-cell-carcinoma
#16
Nir Hirshoren, Elizabeth Olayos, Alan Herschtal, Aravind S Ravi Kumar, David E Gyorki
Objectives Surgery is the primary treatment modality for node-positive cutaneous squamous cell carcinoma of the head and neck with no distant disease (HNcSCC-M0). The role of preoperative positron emission tomography/computed tomography (PET/CT) scan for these patients is unclear. We compared preoperative PET/CT with final histopathology among patients undergoing lymphadenectomy and/or parotidectomy for HNcSCC-M0. Study Design Case series with chart review. Setting Single Australian center. Subjects and Methods Investigation included disease parameters and preoperative CT and PET/CT findings of 64 patients with node-positive HNcSCC without distant metastatic disease...
September 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28925010/temporal-trends-in-quality-of-primary-care-for-patients-with-type-2-diabetes-mellitus-a-population-based-retrospective-cohort-study-after-implementation-of-a-quality-improvement-initiative
#17
Carlos K H Wong, Colman S C Fung, Esther Y T Yu, Eric Y F Wan, Anca K C Chan, Cindy L K Lam
BACKGROUND: This study examined whether temporal trends exist in treatment of patients with type 2 diabetes (T2D) and quality of diabetes care after implementation of quality improvement initiative in primary care setting. METHODS: We conducted a population-based retrospective cohort study of 202,284 patients with T2D who were routinely managed in primary care clinics. We examined the change over time and the variability between clinics in quality-of-care from Hospital Authority administrative data over a five-year period (2009-2013), and used multilevel logistic regression to adjust for patient and clinic characteristics...
September 19, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28924969/norms-for-10-491-spanish-words-for-five-discrete-emotions-happiness-disgust-anger-fear-and-sadness
#18
Hans Stadthagen-González, Pilar Ferré, Miguel A Pérez-Sánchez, Constance Imbault, José Antonio Hinojosa
The discrete emotion theory proposes that affective experiences can be reduced to a limited set of universal "basic" emotions, most commonly identified as happiness, sadness, anger, fear, and disgust. Here we present norms for 10,491 Spanish words for those five discrete emotions collected from a total of 2,010 native speakers, making it the largest set of norms for discrete emotions in any language to date. When used in conjunction with the norms from Hinojosa, Martínez-García et al. (Behavior Research Methods, 48, 272-284, 2016) and Ferré, Guasch, Martínez-García, Fraga, & Hinojosa (Behavior Research Methods, 49, 1082-1094, 2017), researchers now have access to ratings of discrete emotions for 13,633 Spanish words...
September 18, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28924919/use-of-accessible-examination-tables-in-the-primary-care-setting-a-survey-of-physical-evaluations-and-patient-attitudes
#19
Megan A Morris, Allysha C Maragh-Bass, Joan M Griffin, Lila J Finney Rutten, Tara Lagu, Sean Phelan
BACKGROUND: Accessible diagnostic equipment, including height-adjustable examination tables, is necessary to accommodate patients with disabilities. Studies demonstrate that only a minority of clinics provide accessible equipment. For clinics with this equipment, no studies have examined the use of such equipment in routine clinical care. OBJECTIVE: In primary care clinics with and without height-adjustable examination tables, we compared the frequency and variation in physical evaluations on examination tables and patients' perceptions of quality care...
September 18, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28924815/automatic-determination-of-the-need-for-intravenous-contrast-in-musculoskeletal-mri-examinations-using-ibm-watson-s-natural-language-processing-algorithm
#20
Hari Trivedi, Joseph Mesterhazy, Benjamin Laguna, Thienkhai Vu, Jae Ho Sohn
Magnetic resonance imaging (MRI) protocoling can be time- and resource-intensive, and protocols can often be suboptimal dependent upon the expertise or preferences of the protocoling radiologist. Providing a best-practice recommendation for an MRI protocol has the potential to improve efficiency and decrease the likelihood of a suboptimal or erroneous study. The goal of this study was to develop and validate a machine learning-based natural language classifier that can automatically assign the use of intravenous contrast for musculoskeletal MRI protocols based upon the free-text clinical indication of the study, thereby improving efficiency of the protocoling radiologist and potentially decreasing errors...
September 18, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
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