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https://www.readbyqxmd.com/read/28550043/al-amyloidosis-patients-with-low-amyloidogenic-free-light-chain-levels-at-first-diagnosis-have-an-excellent-prognosis
#1
Tobias Dittrich, Tilmann Bochtler, Christoph Kimmich, Natalia Becker, Anna Jauch, Hartmut Goldschmidt, Anthony D Ho, Ute Hegenbart, Stefan O Schönland
The difference between involved minus uninvolved serum free light chains (dFLC) has been established as invaluable hematologic parameter in systemic light chain amyloidosis (AL). However, patients with initial dFLC below 50mg/L are currently deemed not evaluable for response to therapy. Therefore, we aimed to characterize this subgroup and to define novel hematologic response parameters. We retrospectively analyzed 783 AL patients newly diagnosed at our center between 2002 and 2016. Patients with dFLC<50 showed a smaller bone marrow plasmacytosis (7% vs...
May 26, 2017: Blood
https://www.readbyqxmd.com/read/28544916/electro-oxidative-determination-of-aromatic-amine-o-phenylenediamine-using-organic-inorganic-hybrid-composite
#2
Ragu Sasikumar, Palraj Ranganathan, Shen-Ming Chen, Syang-Peng Rwei, Muthukrishnan
A highly sensitive o-phenylenediamine (OPD) sensor based on a Fe3O4 doped with functionalized multi-walled carbon nanotubes (Fe3O4@f-MWCNTs) composite fabricated glassy carbon electrode (GCE) was developed. The modified Fe3O4@f-MWCNTs/GCE showed an enhanced current (Ipa) response toward OPD relative to that of a Fe3O4/GCE, f-MWCNTs/GCE, and a bare GCE. Under optimum conditions, the Fe3O4@f-MWCNTs/GCE showed a wide linear range remove at OPD concentrations of 0.6-80µM. The limit of detection and sensitivity of the f-MWCNTs/GCE, Fe3O4/GCE sensor were found to be 50µM, and 2...
May 17, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28544741/diagnostic-accuracy-of-a-hybrid-approach-of-instantaneous-wave-free-ratio-and-fractional-flow-reserve-using-high-dose-intracoronary-adenosine-to-characterize-intermediate-coronary-lesions-results-of-the-pals-practical-assessment-of-lesion-severity-prospective
#3
Fernando Rivero, Javier Cuesta, Teresa Bastante, Amparo Benedicto, Marcos García-Guimaraes, Manuel Fuentes-Ferrer, Teresa Alvarado, Fernando Alfonso
OBJECTIVES: We sought to investigate the diagnostic accuracy of instantaneous wave-free ratio (iFR) and high-dose intracoronary adenosine fractional flow reserve (IC-FFR) compared with classical intravenous adenosine fractional flow reserve (IV-FFR) to assess coronary stenosis severity. The usefulness of two hybrid strategies combining iFR and high-dose IC-FFR was also evaluated. BACKGROUND: Physiological assessment of intermediate coronary stenoses to guide revascularization is currently recommended...
May 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28544219/mechanism-based-enantiodivergence-in-manganese-reduction-catalysis-a-chiral-pincer-complex-for-the-highly-enantioselective-hydroboration-of-ketones
#4
Lutz Gade, Hubert Wadepohl, Vladislav Vasilenko, Clemens K Blasius
A manganese alkyl complex containing a chiral "boxmi" pincer ligand is a precatalyst for a catalyst of unprecedented activity and selectivity in the enantioselective hydroboration of ketones producing preparatively useful chiral alcohols in excellent yields and up to >99 %ee. It is applicable for both aryl alkyl and dialkyl ketone reduction under mild conditions (TOF >450 h-1 at -40°C) and an earth abundant base metal catalyst which operates at very low catalyst loadings (as low as 0.1 mol%) and with a high level of functional group tolerance...
May 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28543979/a-modular-flow-design-for-the-meta-selective-c-h-arylation-of-anilines
#5
Hannes P L Gemoets, Gabriele Laudadio, Kirsten Verstraete, Volker Hessel, Timothy Noël
Described herein is an effective and practical modular flow design for the meta-selective C-H arylation of anilines. The design consists of four continuous-flow modules (i.e., diaryliodonium salt synthesis, meta-selective C-H arylation, inline copper extraction, and aniline deprotection) which can be operated either individually or consecutively to provide direct access to meta-arylated anilines. With a total residence time of 1 hour, the desired product could be obtained in high yield and excellent purity without the need for column chromatography, and the residual copper content meets the standards for parenterally administered pharmaceutical substances...
May 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28542103/predictive-accuracy-of-surgimaptm-surgical-planning-for-sagittal-imbalance-a-cohort-study
#6
Francesco Langella, Jorge Hugo Villafañe, Marco Damilano, Riccardo Cecchinato, Matteo Pejrona, Maryem Ismael, Pedro Berjano
STUDY DESIGN: A cohort study. OBJECTIVE: To evaluate the predictive value of surgical planning using Surgimap™ regarding postoperative sagittal alignment. SUMMARY OF BACKGROUND DATA: Surgical planning in sagittal imbalance is recognized as a key step of treatment to ensure results. METHODS: The study involved 40 non-consecutive patients who underwent surgery for sagittal misalignment. Postoperative alignment measured by sagittal vertical axis (SVA) and pelvic tilt (PT) was considered the gold standard...
May 25, 2017: Spine
https://www.readbyqxmd.com/read/28540840/living-donor-kidney-transplant-in-a-patient-with-type-b-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome-reconstructed-vagina-and-abnormal-pelvic-vessels-a-case-report
#7
Mariarosaria Campise, Mariano Ferraresso, Evaldo Favi, Claudio Beretta, Caterina Colico, Piergiorgio Messa
Mayer-Rokitansky-Küster-Hauser syndrome is a rare disorder consisting of vaginal aplasia and other müllerian duct abnormalities. Urinary tract malfor-mations possibly leading to renal failure are also common. For these patients, kidney transplant remains the best option. However, aberrant anatomy and scarring from previous operations may actually preclude successful implantation of the graft. In this setting, careful pretransplant evaluation with high-resolution imaging studies and multidisciplinary planning are mandatory...
May 22, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28540731/strain-mediated-coexistence-of-volatile-and-non-volatile-converse-magnetoelectric-effects-in-fe-pb-mg1-3nb2-3-0-7ti0-3o3-heterostructure
#8
Sen Zhang, Qianping Chen, Yan Liu, Aitian Chen, Lifeng Yang, Peisen Li, Zhou Shi Ming, Yi Yu, Wen Sun, Xiaozhong Zhang, Yuelei Zhao, Young Sun, Yonggang Zhao
Strain-mediated ferromagnetic/ferroelectric heterostructures have played an important role among the multiferroic materials to investigate the electric-field control of magnetism in the past decade, owing to their excellent performances such as room temperature operation and large magnetoelectric coupling effect. Due to the different ferroelectric-switching-originated strain behaviors and varied interfacial coupling effect, both loop-like (non-volatile) and butterfly-like (volatile) converse magnetoelectric effects have been reported...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28540460/ultrasensitive-and-high-throughput-analysis-of-chlorophyll-a-in-marine-phytoplankton-extracts-using-a-fluorescence-microplate-reader
#9
Manolis Mandalakis, Austėja Stravinskaitė, Anna Lagaria, Stella Psarra, Paraskevi Polymenakou
Chlorophyll a (Chl a) is the predominant pigment in every single photosynthesizing organism including phytoplankton and one of the most commonly measured water quality parameters. Various methods are available for Chl a analysis, but the majority of them are of limited throughput and require considerable effort and time from the operator. The present study describes a high-throughput, microplate-based fluorometric assay for rapid quantification of Chl a in phytoplankton extracts. Microplate sealing combined with ice cooling was proved an effective means for diminishing solvent evaporation during sample loading and minimized the analytical errors involved in Chl a measurements with a fluorescence microplate reader...
May 25, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28540253/craniocervical-junction-abnormalities-with-atlantoaxial-subluxation-caused-by-ventral-subluxation-of-c2-in-a-dog
#10
Harumichi Itoh, Kazuhito Itamoto, Shotaro Eto, Tomoya Haraguchi, Shimpei Nishikawa, Kenji Tani, Yoshiki Itoh, Masato Hiyama, Toshie Iseri, Munekazu Nakaichi, Yasuho Taura
Craniocervical junction abnormalities with atlantoaxial subluxation caused by ventral subluxation of C2 were diagnosed in a 6-month-old female Pomeranian with tetraplegia as a clinical sign. Lateral survey radiography of the neck with flexion revealed atlantoaxial subluxation with ventral subluxation of C2. Computed tomography revealed absence of dens and atlanto-occipital overlapping. Magnetic resonance imaging showed compression of the spinal cord and indentation of caudal cerebellum. The diagnosis was Chiari-like malformation, atlantoaxial subluxation with ventral displacement of C2, atlanto-occipital overlapping, and syringomyelia...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28537353/low-ankle-sprains-a-current-review-of-diagnosis-and-treatment
#11
Anthony J Scillia, Todd P Pierce, Kimona Issa, Craig Wright, John J Callaghan, Anthony Festa, Vincent K McInerney
LLow ankle sprains are common injuries in young athletes. Hence, it is imperative that low ankle sprains are diagnosed and treated quickly and effectively. We reviewed the: (1) anatomy; (2) imaging; (3) physical exam findings; and (4) treatment modalities regarding these injuries. Plain radiographs are standard of care and routine MRI is not recommended for suspected sprains. However, physical exam findings often may guide management decisions. The majority of patients diagnosed with low ankle sprains are treated with a one- to two-week immobilization period with physical therapy focused on peroneal proprioception and strength...
May 24, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28537212/accuracy-and-coverage-of-diagnosis-and-procedural-coding-of-severely-injured-patients-in-the-finnish-hospital-discharge-register-comparison-to-patient-files-and-the-helsinki-trauma-registry
#12
M Heinänen, T Brinck, L Handolin, V M Mattila, T Söderlund
BACKGROUND AND AIMS: The Finnish Hospital Discharge Register data are frequently used for research purposes. The Finnish Hospital Discharge Register has shown excellent validity in single injuries or disease groups, but no studies have assessed patients with multiple trauma diagnoses. We aimed to evaluate the accuracy and coverage of the Finnish Hospital Discharge Register but at the same time validate the data of the trauma registry of the Helsinki University Hospital's Trauma Unit. MATERIALS AND METHODS: We assessed the accuracy and coverage of the Finnish Hospital Discharge Register data by comparing them to the original patient files and trauma registry files from the trauma registry of the Helsinki University Hospital's Trauma Unit...
March 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28536978/a-6-dof-parallel-bone-grinding-robot-for-cervical-disc-replacement-surgery
#13
Heqiang Tian, Chenchen Wang, Xiaoqing Dang, Lining Sun
Artificial cervical disc replacement surgery has become an effective and main treatment method for cervical disease, which has become a more common and serious problem for people with sedentary work. To improve cervical disc replacement surgery significantly, a 6-DOF parallel bone-grinding robot is developed for cervical bone-grinding by image navigation and surgical plan. The bone-grinding robot including mechanical design and low level control is designed. The bone-grinding robot navigation is realized by optical positioning with spatial registration coordinate system defined...
May 24, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28536040/the-flir-one-thermal-imager-for-the-assessment-of-burn-wounds-reliability-and-validity-study
#14
M E H Jaspers, M E Carrière, A Meij-de Vries, J H G M Klaessens, P P M van Zuijlen
BACKGROUND: Objective measurement tools may be of great value to provide early and reliable burn wound assessment. Thermal imaging is an easy, accessible and objective technique, which measures skin temperature as an indicator of tissue perfusion. These thermal images might be helpful in the assessment of burn wounds. However, before implementation of a novel measurement tool into clinical practice is considered, it is appropriate to test its clinimetric properties (i.e. reliability and validity)...
May 20, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28535847/perceptions-of-pain-injury-and-transition-retirement-the-experiences-of-professional-dancers
#15
Carly Harrison, Mandy Ruddock-Hudson
Dancers are often referred to as "athletes of the arts," and like other athletes they undergo years of hard physical training in pursuit of excellence. Previous research has indicated that dancers develop high pain thresholds and push past their pain barriers. This has potential implications for their health and wellbeing in both their professional careers and life after dance. Therefore, the purpose of this pilot study was to explore the perceptions and experiences of injury, pain, and retirement among professional dancers...
June 15, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/28535766/a-novel-anatomic-severity-grading-score-for-acute-type-b-aortic-dissections-and-correlation-to-aortic-reinterventions-after-thoracic-endovascular-aortic-repair
#16
Shirui Chen, Sebastian Larion, Sadaf S Ahanchi, Chad P Ammar, Colin T Brandt, Jean M Panneton
BACKGROUND: We introduce a novel preoperative anatomic severity grading system for acute type B aortic dissections and validate the system in a cohort of patients who underwent thoracic endovascular aortic repair. METHODS: We identified a cohort of patients who received thoracic endovascular aortic repair (TEVAR) for acute type B aortic dissection from 2008 to 2014. We developed an anatomic severity grading score (ASG) to measure attributes of aortic anatomy that we hypothesized may affect difficulty or durability of repair...
May 23, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28535562/isocentric-navigation-of-percutaneous-endoscopic-transforaminal-discectomy-at-the-l5-s1-level-in-difficult-puncture-cases-a-technical-note
#17
Guoxin Fan, Teng Wang, Shuo Hu, Xiaofei Guan, Xin Gu, Shisheng He
BACKGROUND: Accurate puncture during percutaneous transforaminal endoscopic discectomy at the L5/S1 level in cases with high iliac crest and narrow foramen were difficult, even though the difficulties of foraminoplasty could be overcome by advanced instruments like reamers. OBJECTIVES: The report aimed to describe an isocentric navigation technique with a definite pathway in difficult puncture cases at the L5/S1 level. STUDY DESIGN: Technical note...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28535559/initial-clinical-outcomes-of-percutaneous-full-endoscopic-lumbar-discectomy-using-an-interlaminar-approach-at-the-l4-l5
#18
Jun-Ichiro Nakamura, Kiyoshi Yoshihara
BACKGROUND: Percutaneous full-endoscopic discectomy (PED) is being increasingly used because of its potential to minimalize soft-tissue damage and decrease hospital stay. PED using the interlaminar approach (PED-IL) at L4-L5 is performed by only a few surgeons. To the best of our knowledge, the safety and efficacy of PED-IL at L4-L5, without experience in PED via a transforaminal approach (PED-TF) has not been previously reported. OBJECTIVE: This study aimed to evaluate initial clinical outcomes and complications of PED-IL at L4-L5 without experience in PED-TF...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28534899/fabrication-of-pt-cu3-po4-2-ultrathin-nanosheet-heterostructure-for-photoelectrochemical-microrna-sensing-using-novel-g-wire-enhanced-strategy
#19
Cui Ye, Min Qiang Wang, Ling Jie Li, Hong Qun Luo, Nian Bing Li
Herein, we focus on preparing a highly efficient photocatalytic material to construct a signal-on photoelectrochemical (PEC) sensing platform in view of the rigorous demand of accurate miRNA quantification. The well-dispersed Pt nanoclusters-coated copper phosphate ultrathin nanosheets (PtNCs/Cu3(PO4)2NSs) were first successfully synthesized as a photoelectrode material. Because of the ultrathin two-dimensional lamellar structure of Cu3(PO4)2NSs with a 1.3 nm thickness, as well as the homogeneous size and abundant PtNCs loaded on Cu3(PO4)2NSs, the resultant PtNCs/Cu3(PO4)2NSs were employed as a photoelectrode material for the first time and revealed outstanding photocatalytic activity in PEC sensing as a substrate...
May 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28534393/simple-approach-to-high-performance-stretchable-heaters-based-on-kirigami-patterning-of-conductive-paper-for-wearable-thermotherapy-applications
#20
Nam-Su Jang, Kang-Hyun Kim, Sung-Hun Ha, Soo-Ho Jung, Hye Moon Lee, Jong-Man Kim
Recent efforts to develop stretchable resistive heaters open up the possibility for their use in wearable thermotherapy applications. Such heaters should have high electrothermal performance and stability to be used practically, and the fabrication must be simple, economic, reproducible, and scalable. Here we present a simple yet highly efficient way of producing high-performance stretchable heaters, which is based on a facile kirigami pattering (the art of cutting and folding paper) of a highly conductive paper for practical wearable thermotherapy...
May 23, 2017: ACS Applied Materials & Interfaces
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