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https://www.readbyqxmd.com/read/29334181/donor-variability-in-growth-kinetics-of-healthy-hmscs-using-manual-processing-considerations-for-manufacture-of-cell-therapies
#1
Giulia Detela, Owen W Bain, Hae-Won Kim, David J Williams, Chris Mason, Anthony Mathur, Ivan B Wall
Human mesenchymal stromal cells (hMSCs) are excellent candidates for cell therapy but their expansion to desired clinical quantities can be compromised by ex vivo processing, due to differences between donor material and process variation. The aim of this article was to characterize growth kinetics of healthy baseline "reference" hMSCs using typical manual processing. Bone-marrow derived hMSCs from ten donors were isolated based on plastic adherence, expanded and analyzed for their growth kinetics until passage 4...
January 15, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29332374/transcatheter-aortic-valve-replacement-in-bicuspid-aortic-valve-stenosis-where-do-we-stand
#2
Sung-Han Yoon, Rahul Sharma, Tarun Chakravarty, Masaki Miyasaka, Tomoki Ochiai, Takahiro Nomura, Norman Gellada, Shadi Nemanpour, Mamoo Nakamura, Wen Chen, Raj Makkar
Bicuspid aortic valve is the most common congenital cardiac defect in adults, and symptom typically develops in adulthood. In the majority of cases, bicuspid aortic valve disease progress with ages and surgical aortic valve replacement is performed with excellent operative outcomes. However, with the relatively slow progression of disease, surgical aortic valve replacement is required in elderly patients but the surgical risk often deemed extremely high due to old age and multiple comorbidities. Transcatheter aortic valve replacement (TAVR) has evolved from a novel technology to an established therapy for intermediate- and high-risk patients with symptomatic severe aortic valve stenosis (AS)...
January 11, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29332104/assessment-of-the-fit-of-removable-partial-denture-fabricated-by-computer-aided-designing-computer-aided-manufacturing-technology
#3
Khalid A O Arafa
To assess the level of evidence that supports the quality of fit for removable partial denture (RPD) fabricated by computer-aided designing/computer aided manufacturing (CAD/CAM) and rapid prototyping (RP) technology. Methods: An electronic search was performed in Google Scholar, PubMed, and Cochrane library search engines, using Boolean operators. All articles published in English and published in the period from 1950 until April 2017 were eligible to be included in this review. The total number of articles contained the search terms in any part of the article (including titles, abstracts, or article texts) were screened, which resulted in 214 articles...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29330963/metal-organic-framework-based-in-syringe-solid-phase-extraction-for-the-on-site-sampling-of-polycyclic-aromatic-hydrocarbons-from-environmental-water-samples
#4
Xiaoqiong Zhang, Peiyi Wang, Qiang Han, Hengzhen Li, Tong Wang, Mingyu Ding
In-syringe solid-phase extraction is a promising sample pretreatment method for the on-site sampling of water samples because of its outstanding advantages of portability, simple operation, short extraction time and low cost. In this work, a novel in-syringe solid-phase extraction device using metal-organic frameworks as the adsorbent was fabricated for the on-site sampling of polycyclic aromatic hydrocarbons from environmental waters. Trace polycyclic aromatic hydrocarbons were effectively extracted through the self-made device followed by gas chromatography with mass spectrometry analysis...
January 13, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29329706/unattended-reaction-monitoring-using-an-automated-microfluidic-sampler-and-on-line-liquid-chromatography
#5
Darshan C Patel, Yaqi Fara Lyu, Jorge Gandarilla, Steve Doherty
In-process sampling and analysis is an important aspect of monitoring kinetic profiles and impurity formation or rejection, both in development and during commercial manufacturing. In pharmaceutical process development, the technology of choice for a substantial portion of this analysis is high-performance liquid chromatography (HPLC). Traditionally, the sample extraction and preparation for reaction characterization have been performed manually. This can be time consuming, laborious, and impractical for long processes...
April 3, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29329141/precision-of-optic-nerve-head-and-retinal-nerve-fiber-layer-parameter-measurements-by-spectral-domain-optical-coherence-tomography
#6
Laura M Schrems-Hoesl, Wolfgang A Schrems, Robert Laemmer, Friedrich E Kruse, Christian Y Mardin
PURPOSE: The aim of this study was to assess the repeatability and reproducibility (R&R) of Bruch's Membrane Opening - based on Minimum Rim Width (BMO-MRW), Minimum Rim Area (BMO-MRA) and peripapillary retinal nerve fiber layer thickness (RNFLT) with the Spectralis OCT (Heidelberg Engineering) for normal and glaucoma subjects. Precise measurement of these parameters can support detection of structural glaucomatous damage and progression. METHODS: This cross-sectional study included 16 healthy controls and 16 patients with glaucoma...
January 11, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29329115/developing-a-mitral-valve-center-of-excellence
#7
Ahmed El-Eshmawi, Javier G Castillo, Gilbert H L Tang, David H Adams
PURPOSE OF REVIEW: Despite the proven superiority of mitral repair over replacement for degenerative mitral disease, mitral valve replacement remains common. Guidelines now recommend referral of patients, particularly those whom are asymptomatic, to valve centers of excellence, although criteria that define such centers remain to be established. The purpose of this review is to define the structure of a mitral center of excellence and to review current clinical outcomes which are possible in such a center...
January 10, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29328318/efficient-continuous-wave-and-passively-q-switched-pulse-laser-operations-in-a-diffusion-bonded-sapphire-er-yb-yal3-bo3-4-sapphire-composite-crystal-around-1-55-%C3%AE-m
#8
Yujin Chen, Yanfu Lin, Jianhua Huang, Xinghong Gong, Zundu Luo, Yidong Huang
A composite crystal consisting of a 1.5-mm-thick Er:Yb:YAl3(BO3)4 crystal between two 1.2-mm-thick sapphire crystals was fabricated by the thermal diffusion bonding technique. Compared with a lone Er:Yb:YAl3(BO3)4 crystal measured under the identical experimental conditions, higher laser performances were demonstrated in the sapphire/Er:Yb:YAl3(BO3)4/sapphire composite crystal due to the reduction of the thermal effects. End-pumped by a 976 nm laser diode in a hemispherical cavity, a 1.55 μm continuous-wave laser with a maximum output power of 1...
January 8, 2018: Optics Express
https://www.readbyqxmd.com/read/29328000/conscious-sedation-with-dexmedetomidine-compared-with-asleep-awake-asleep-craniotomies-in-glioma-surgery-an-analysis-of-180-patients
#9
Eric Suero Molina, Stephanie Schipmann, Isabelle Mueller, Johannes Wölfer, Christian Ewelt, Matthias Maas, Benjamin Brokinkel, Walter Stummer
OBJECTIVE Awake craniotomies have become a feasible tool over time to treat brain tumors located in eloquent regions. Different techniques have been applied in neurooncology centers. Both "asleep-awake-asleep" (asleep) and "conscious sedation" were used subsequently at the authors' neurosurgical department. Since 2013, the authors have only performed conscious sedation surgeries, predominantly using the α2-receptor agonist dexmedetomidine as the anesthetic drug. The aim of this study was to compare both mentioned techniques and evaluate the clinical use of dexmedetomidine in the setting of awake craniotomies for glioma surgery...
January 12, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29327558/-modified-osteotomy-of-olecranon-for-the-management-of-inter-condylar-fracture-of-the-humerus
#10
Zheng-Feng Mei, Wen-Tao Lei, Dong-Hui Huang, Qi-Hui Zhao, Hang-Bo Qu, Lian-Zhi Ni
OBJECTIVE: To explore the surgical method and clinical outcome of modified osteotomy of olecranon for the treatment of inter-condylar fracture of humerus. METHODS: From May 2007 to December 2012, 32 patients of intercondylar fracture of humerus were treated surgically through the approach of modified osteotomy of olecranon. The patients were 21 males and 11 females with a mean age of 46.3 years (ranged 18 to 65 years). Nineteen fractures occurred on the right extremity and 13 on the left extremity...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29327557/-surgical-treatment-for-14-patients-with-old-fractures-of-humeral-lateral-condyle-in-children
#11
Kai Liu, Ru-Guo Shang, Yan Xiao, Jan-Wei Hu, Yong-Xin Yu
OBJECTIVE: To study clinical effects of operation for the treatment of old fractures of the humerus lateral condyle in children. METHODS: From January 2012 to January 2014 in our department, 14 children of old humeral lateral condyle fractures were treated with operation. Ten cases were male, 4 cases were female; age from 2 to 12 years old, average 5.8 years old. The initial diagnosis was type IIfracture according to the Milch ciassification, the loss of treatment in 11 cases, conservative treatment in 3 cases of nonunion after fracture displacement...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29327556/-surgical-treatment-for-the-fractures-and-dislocations-of-the-elbow-in-old-patients
#12
Hua Xu, Li-Feng Shen, Hua-Jun Yu, Xiao-Wen Zhang, Qiao-Feng Guo
OBJECTIVE: To introduce and report the preliminary results of 7 old patients with fractures and dislocations of the elbow. METHODS: From July 2011 to August 2015, 7 old patients suffered from fractures and dislocations of the elbow(5 of which were terrible triad). One patient had type Iradial head fracture, 3 type IIand 1 type III according to the Mason classification, and 1 type I, 5 type IIand 1 type III according to the Regan-Morrey classification. All the 7 patients received operation and then were treated with external fixation...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29327541/-mini-locking-plates-for-the-treatment-of-regan-morrey-type-iii-fracture-of-ulnar-coronoid-process-through-anterior-approach-of-elbow-joint
#13
Xiao Lian, Yun-Ji Zeng
OBJECTIVE: To explore clinical effects of mini-locking plates for the treatment of Regan-Morrey type III fractures of ulnar coronoid process through an anterior approach of elbow joint. METHODS: A retrospective analysis on 12 patients with Regan-Morrey type III fractures of the ulnar coronoid process was performed from January 2011 to June 2014, who were treated with unini-locking plates through the anterior approach of elbow joint. There were 7 males and 5 females, ranging in age from 23 to 65 years old, averaged 43 years old...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29326767/internal-fixation-of-only-the-distal-end-in-a-bipolar-segmental-clavicle-fracture-a-case-report
#14
T Ogawa, T Sasaki, M K Masayuki-Kawashima, A Okawa, M K Mahito-Kawashima
Bipolar segmental clavicle fractures are simultaneous clavicle fractures of both proximal and distal ends. Few case reports describing these fractures have been published, and the management of these injuries have remained controversial. Non-operative treatment is likely to result in poor shoulder function due to the instability of the fracture in patients with high physical demands. In contrast, surgical treatment with fixation of both proximal and distal ends of the clavicle possibly may cause life-threatening complications...
November 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29326760/both-bone-forearm-fractures-in-children-with-minimum-four-years-of-growth-remaining-can-cast-achieve-a-good-outcome-at-skeletal-maturity
#15
D Hadizie, I Munajat
Introduction: Both-bone forearm fractures in children can be treated non-operatively with a cast. Most previous studies have shown favourable outcome; however, information on the functional outcome after skeletal maturity is still scanty. Therefore, this study was conducted to determine the functional outcome after skeletal maturity in fractures with at least four years of growth remaining. Materials and Methods: This retrospective study was conducted from March 2012 until March 2013. Age at the time of fracture was taken as until 10 years for females and until 12 years old for males with at least four years of growth remaining...
November 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29325984/minimally-invasive-repair-of-pectus-carinatum
#16
Mustafa Yuksel, Tunc Lacin, Nezih Onur Ermerak, Esra Yamansavci Sirzai, Bihter Sayan
BACKGROUND: The second most common deformity of the anterior chest wall, pectus carinatum, is a diverse deformity that has been largely managed using open techniques. This study reviews clinical experience with a newly designed bar for minimally invasive repair of pectus carinatum. METHODS: We reviewed the records of all patients recorded in our Chest Wall Deformities Clinical Database. Between January 2006 and November 2016, minimally invasive repair of pectus carinatum was performed in 172 patients...
January 9, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29325954/anterior-skull-base-tumor-resection-by-transciliary-supraorbital-keyhole-craniotomy-a-single-institutional-experience
#17
Ya-Jui Lin, Ko-Ting Chen, Cheng-Chi Lee, Cheng-Hong Toh, Tai-Wei Erich Wu, Yin-Cheng Huang, Peng-Wei Hsu, Yu-Jen Lu, Chi-Cheng Chuang, Pin-Yuan Chen, Kuo-Chen Wei
BACKGROUND: The prognosis and recurrence rate following resection of an anterior skull base lesion via transciliary supraorbital keyhole craniotomy depends on residual tumor volume. The extent to which pathology and size of tumor influence the resection rate using this approach is unknown. METHODS: Sixty-two patients underwent a total of 64 operations using the supraorbital keyhole approach in this retrospective study. Meningioma was the most common tumor, followed by pituitary adenoma and craniopharyngioma...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325801/editorial-the-role-of-medical-physics-in-lung-sbrt
#18
EDITORIAL
Pietro Mancosu, Andrew Nisbet, Núria Jornet
Stereotactic body radiation therapy (SBRT) has become a standard treatment for non-operable patients with early stage non-small cell lung cancer (NSCLC). In this context, medical physics community has largely helped in the starting and the growth of this technique. In fact, SBRT requires the convergence of many different features for delivering large doses in few fractions to small moving target in an heterogeneous medium. The special issue of last month, was focused on the different physics challenges in lung SBRT...
January 9, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29325725/who-goes-to-inpatient-rehabilitation-or-skilled-nursing-facilities-unexpectedly-following-total-knee-arthroplasty
#19
Alexander J Rondon, Timothy L Tan, Max R Greenky, Karan Goswami, Noam Shohat, Jessica L Phillips, James J Purtill
BACKGROUND: Inpatient rehabilitation facilities (IRFs) and skilled nursing facilities (SNFs) represent a significant portion of post-operative expenses of bundled payments for total knee arthroplasty (TKA). Although many surgeons no longer routinely send patients to IRFs or SNFs, some patients are unable to be discharged directly home. This study identified patient factors for discharge to post-acute care facilities with an institutional protocol of discharging TKA patients home. METHODS: A retrospective review of patients undergoing primary unilateral TKA at a single institution from 2012 to 2017 was performed...
December 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29325585/clinical-research-ethics-review-process-in-lebanon-efficiency-and-functions-of-research-ethics-committees-results-from-a-descriptive-questionnaire-based-study
#20
David Atallah, Malak Moubarak, Nadine El Kassis, Sara Abboud
BACKGROUND: Clinical trials conducted in Lebanon are increasing. However, little is known about the performance of research ethics committees (RECs) in charge of reviewing the research protocols. This study aimed to assess the level of adherence to the ethics surrounding the conduct of clinical trials and perceptions of team members regarding roles of the RECs during the conduct of clinical trials in Lebanon. The research question was: Are RECs adherent to the ethics surrounding the conduct of clinical trials (chapters II and IV in 'Standards and Operational Guidance for Ethics Review of Health-related Research with Human Participants' in Lebanon?' METHODS: This was a quantitative and descriptive questionnaire-based study conducted among RECs of university hospitals in Lebanon...
January 11, 2018: Trials
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