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https://www.readbyqxmd.com/read/27927077/detection-and-characterization-of-the-metabolites-of-rutaecarpine-in-rats-based-on-ultra-high-performance-liquid-chromatography-with-linear-ion-trap-orbitrap-mass-spectrometer
#1
Wei Cai, Ying Guan, Yang Zhou, Yuwei Wang, Huaiping Ji, Zhihua Liu
CONTEXT: Rutaecarpine is an active indoloquinazoline alkaloid ingredient originating from Evodia rutaecarpa (Wu-zhu-yu in Chinese), which possesses a variety of effects. However, its metabolism has not been investigated thoroughly yet. OBJECTIVE: This study develops a highly sensitive and effective method for detection and characterization of the metabolites of rutaecarpine in Sprague-Dawley (SD) rats. MATERIALS AND METHODS: In this study, an efficient method was developed using ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer (UHPLC-LTQ-Orbitrap MS) to detect the metabolism profile of rutaecarpine in rat plasma...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27890875/induction-of-apoptosis-by-ethanol-extract-of-evodia-rutaecarpa-in-hela-human-cervical-cancer-cells-via-activation-of-amp-activated-protein-kinase
#2
Seon Young Park, Cheol Park, Shin-Hyung Park, Su-Hyun Hong, Gi-Young Kim, Sang Hoon Hong, Yung-Hyun Choi
The fruit of Evodia rutaecarpa (Juss.) Benth has been used widely in traditional medicine therapy. Although it has been shown to possess many pharmacological activities, the molecular mechanisms of its anti-cancer activity have not been clearly elucidated. In the present study, we investigated the pro-apoptotic effects of an ethanol extract isolated from immature fruits of E. rutaecarpa (EEER) in HeLa human cervical cancer cells. EEER treatment decreased the cell viability of HeLa cells in a concentration-dependent manner, which was related to apoptotic cell death resulting from apoptotic body formation, DNA fragmentation, and an increased population of annexin V(+)-positive cells...
November 27, 2016: Bioscience Trends
https://www.readbyqxmd.com/read/27873184/-%C3%A2-evodiakine-a-pair-of-rearranged-rutaecarpine-type-alkaloids-from-evodia-rutaecarpa
#3
Yan-Hong Li, Yu Zhang, Li-Yan Peng, Xiao-Nian Li, Qin-Shi Zhao, Rong-Tao Li, Xing-De Wu
(±)-Evodiakine (1a and 1b), a pair of rearranged rutaecarpine-type alkaloids with an unprecedented 6/5/5/7/6 ring system, were isolated from the nearly ripe fruits of Evodia rutaecarpa. Separation of the enantiomers have been achieved by chiral HPLC column. The structures of (±)-evodiakine were unambiguously elucidated by 1D and 2D NMR spectra, mass spectrometry, and single-crystal X-ray diffraction. Their absolute configurations were determined by comparison of experimental and calculated electronic circular dichroism spectra...
December 2016: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/27848250/pharmacological-effects-of-active-components-of-chinese-herbal-medicine-in-the-treatment-of-alzheimer-s-disease-a-review
#4
Zhi-Yong Wang, Jian-Gang Liu, Hao Li, Hui-Ming Yang
Alzheimer's disease (AD), the most common neurodegenerative disorder associated with dementia, not only severely decreases the quality of life for its victims, but also brings a heavy economic burden to the family and society. Unfortunately, few chemical drugs designed for clinical applications have reached the expected preventive or therapeutic effect so far, and combined with their significant side-effects, there is therefore an urgent need for new strategies to be developed for AD treatment. Traditional Chinese Medicine has accumulated many experiences in the treatment of dementia during thousands of years of practice; modern pharmacological studies have confirmed the therapeutic effects of many active components derived from Chinese herbal medicines (CHM)...
November 16, 2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27771931/evodiamine-and-its-role-in-chronic-diseases
#5
Qunyou Tan, Jingqing Zhang
Evodiamine (EVO) is a major alkaloid compound extracted from the dry unripened fruit Evodiae fructus (Evodia rutaecarpa Benth., Rutaceae). EVO has a variety of pharmacological activities, such as anti-obesity, anti-allergenic, analgesic, anti-tumor, anti-ulcerogenic, and neuroprotective activities. EVO has varying efficacies in animal models and humans. Here, the physicochemical properties of EVO are presented, and the EVO's functions and mechanisms of action in various chronic diseases are reviewed. EVO is worth exploring in more depth in the future for its potential use in various chronic diseases...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27769945/akt-activation-by-evodiae-fructus-extract-protects-ovary-against-4-vinylcyclohexene-diepoxide-induced-ovotoxicity
#6
Eun-Young Nam, Sun Ah Kim, Heejung Kim, Su-Hyun Kim, Jae-Hyun Han, Ju-Hee Lee, Dong-Il Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Evodiae Fructus (EF) is the dried, unripe fruit of Evodia rutaecarpa Benth., and one of the main components of traditional herbal prescriptions issued for the treatment of sterility caused by irregular menstruation in Korea. However, scientific evidence regarding the efficacy and action mechanism of EF is lacking. AIM OF THE STUDY: In this study, the authors established an in vitro screening tool to identify promising new drug candidates in herbal medicines for the prevention and treatment of premature ovarian failure...
October 18, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27748810/evodiamine-inhibits-pdgf%C3%A2-bb%C3%A2-induced-proliferation-of-rat-vascular-smooth-muscle-cells-through-the-suppression-of-cell-cycle-progression-and-oxidative-stress
#7
Xie Ge, Si-Yu Chen, Mei Liu, Ting-Ming Liang, Chang Liu
Vascular smooth muscle cell (VSMC) proliferation is a key event in the development of in‑stent restenosis. Evodiamine is an indole alkaloid extracted from the Chinese medicine, evodia, and has been shown to inhibit tumor cell proliferation and protect the cardiovascular system. However, whether evodiamine affects VSMC proliferation remains to be elucidated. Therefore, the present study examined the effects and the mechanisms of action of evodiamine on the proliferation of rat VSMCs. The cells were treated with evodiamine alone or in combination with platelet‑derived growth factor‑BB (PDGF‑BB) stimulation...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27577574/dehydroevodiamine-hcl-protects-against-memory-impairment-and-cerebral-amyloid-%C3%AE-production-in-tg2576-mice-by-acting-as-a-%C3%AE-secretase-inhibitor
#8
Ki Young Shin, Su-Jin Noh, Cheol Hyoung Park, Yun Ha Jeong, Keun A Chang, Jakyung Yoo, Hee Jin Kim, Sungji Ha, Hye-Sun Kim, Hyun-Ju Park, Jun-Ho Lee, Cheil Moon, Yoo-Hun Suh
We previously demonstrated that dehydroevodiamine•HCl (DHED), which was purified from Evodia rutaecarpa Bentham (Rutaceae), has beneficial effects on memory impairment and neuronal damage in three disease models. To investigate the preventive action of DHED in Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by memory decline, amyloid-β (Aβ) protein-containing neuritic plaques and neurofibrillary tangles, in this study, we proposed that DHED may be therapeutically effective against the memory impairment and disease-related neurochemical changes that occur in Tg2576 (Tg) mice...
August 15, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27485202/effect-of-evodiamine-on-the-proliferation-and-apoptosis-of-a549-human-lung-cancer-cells
#9
Li Lin, Li Ren, Liujing Wen, Yu Wang, Jin Qi
Evodia rutaecarpa is a plant, which has antitumor activity. Evodiamine is an alkaloid with antitumor activity present in E. rutaecarpa and has potential to be developed into a therapeutic antitumor agent. The present study investigated the effect of evodiamine on the proliferation of A549 human lung cancer cells and the mechanism underlying these effects. The results indicated that evodiamine significantly inhibited proliferation, induced apoptosis and the expression of reactive oxygen species, arrested the cell cycle, regulated the expression of Survivin, Bcl-2 and Cyclin B1, regulated the activity of caspase-3/8 and glutathione in tumor cells, and decreased the activity of AKT/nuclear factor‑κB (NF‑κB) and Sonic hedgehog/GLI family zinc finger 1 (SHH/GLI1) signaling pathways in A549 cells...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27446630/analysis-of-e-rutaecarpa-alkaloids-constituents-in-vitro-and-in-vivo-by-uplc-q-tof-ms-combined-with-diagnostic-fragment
#10
Shenshen Yang, Meng Tian, Lei Yuan, Haoyue Deng, Lei Wang, Aizhu Li, Zhiguo Hou, Yubo Li, Yanjun Zhang
Evodia rutaecarpa (Juss.) Benth. (Rutaceae) dried ripe fruit is used for dispelling colds, soothing liver, and analgesia. Pharmacological research has proved that alkaloids are the main active ingredients of E. rutaecarpa. This study aimed to rapidly classify and identify the alkaloids constituents of E. rutaecarpa by using UPLC-Q-TOF-MS coupled with diagnostic fragments. Furthermore, the effects of the material base of E. rutaecarpa bioactive ingredients in vivo were examined such that the transitional components in the blood of rats intragastrically given E...
2016: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/27422570/identification-and-structural-characterization-of-acylgluconic-acids-flavonol-glycosides-limonoids-and-alkaloids-from-the-fruits-of-evodia-rutaecarpa-by-high-performance-liquid-chromatography-coupled-to-electrospray-ionization-and-quadrupole-time-of-flight
#11
Yun Ling, Pei Hu, Lifang Zhang, Hongguang Jin, Jian Chen, Zhi Tao, Ling Huang, Ruoyu Ren
The dried fruit of Evodia rutaecarpa (Juss.) Benth. (ER) is a well-known traditional Chinese medicine and has been used in treatment of headache, abdominal pain, migraine, chill limbs, diarrhea, nausea, hyperbaropathy, dysmenorrheal and postpartum hemorrhage. In this work, a comprehensive characterization of chemical constituents in ER extract is carried out by high performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry. The increased power of higher mass resolution and exact mass measurements for precursor and fragment ions lead to detection of 3 acylgluconic acids, 3 flavonol glycosides, 6 limonoids and 24 alkaloids in ER, of which 6 quinolone alkaloids has not been reported previously to our best knowledge...
July 15, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27239783/screening-and-identification-of-hepatotoxic-component-in-evodia-rutaecarpa-based-on-spectrum-effect-relationship-and-uplc-q-tofms
#12
Wenlan Li, Xiangming Sun, Bingmei Liu, Lihui Zhang, Ziquan Fan, Yubin Ji
Evodia rutaecarpa (E. rutaecarpa) has been used to treat aches, vomiting and dysentery in traditional Chinese medicine. However, as a mildly toxic herb its toxic components have not been elucidated. An attempt was made to illuminate the hepatotoxic constituents of E. rutaecarpa. The 50% ethanol extracts of E. rutaecarpa from 19 different sources were used to establish UPLC fingerprints and administered to mice at a dose of 35 g/kg (crude medicine weight/mouse weight) once daily for 14 days. Serum levels of alanine transaminase, aspartate aminotransferase and liver coefficient were used as indices of liver injury...
December 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27165707/1-methyl-2-undecyl-4-1h-quinolone-a-derivative-of-quinolone-alkaloid-evocarpine-attenuates-high-phosphate-induced-calcification-of-human-aortic-valve-interstitial-cells-by-inhibiting-phosphate-cotransporter-pit-1
#13
Kazuhiko Seya, Ken-Ichi Furukawa, Mari Chiyoya, Zaiqiang Yu, Haruhisa Kikuchi, Kazuyuki Daitoku, Shigeru Motomura, Manabu Murakami, Yoshiteru Oshima, Ikuo Fukuda
An abnormally high serum phosphate level induces calcific aortic stenosis (CAS), which is characterized by ectopic valve calcification and stenosis of the orifice area. Inhibition of ectopic calcification is a critical function of any internal medical therapy for CAS disease. The aim of the present study was to investigate the inhibitory effects of several derivatives of evocarpine, methanolic extracts from the fruits of Evodia rutaecarpa Bentham (Japanese name: Go-Shu-Yu) on the high phosphate-induced calcification of human aortic valve interstitial cells (HAVICs) obtained from patients with CAS...
May 2016: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/27159637/partial-activation-and-inhibition-of-trpv1-channels-by-evodiamine-and-rutaecarpine-two-major-components-of-the-fruits-of-evodia-rutaecarpa
#14
Shenglan Wang, Satoshi Yamamoto, Yoko Kogure, Wensheng Zhang, Koichi Noguchi, Yi Dai
Evodiamine (1) and rutaecarpine (2) are the two major components of Evodia rutaecarpa, which has long been used in traditional medicine for the treatment of many diseases. Using transient receptor potential vanilloid 1 (TRPV1)-expressing HEK293 cells and patch-clamp recording, the inhibitory actions of 1 and 2 against TRPV1 channels were investigated. The effects of these compounds against capsaicin- or proton-activated TRPV1 activities were evaluated. The results showed that, although 1 and 2 can activate TRPV1, the maximum response was 3...
May 27, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/26975111/-study-on-efficacy-and-accompanying-toxic-and-side-effects-of-volatile-oil-of-evodia-fructus-based-on-stomach-cold-syndrome-model
#15
Xiao-yu Li, Rong Sun
OBJECTIVE: To preliminarily study the effective dosage range and mechanism of the abirritation of volatile oil of Evodia Fructus on the stomach cold syndrome model in mice, and discuss the correlation between its accompanying toxicity and oxidative damage mechanism, in order to provide the experimental basis for explaining the efficacy-syndrome-toxicity correlation. METHOD: The stomach cold-syndrome model in mice was induced by the classic hot plate test by orally administrating with different doses of volatile oil of Evodia Fructus, in order to observe its abirritation and companying toxic and side effects and detect serum ALT, AST, PGE2, NO, NOS, MDA, SOD, GSH, GSH-Px, BUN, CR and hepatic ALT, AST...
October 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/26972495/rutaecarpine-ameliorates-hyperlipidemia-and-hyperglycemia-in-fat-fed-streptozotocin-treated-rats-via-regulating-the-irs-1-pi3k-akt-and-ampk-acc2-signaling-pathways
#16
Xu-qiang Nie, Huai-hong Chen, Jian-yong Zhang, Yu-jing Zhang, Jian-wen Yang, Hui-jun Pan, Wen-xia Song, Ferid Murad, Yu-qi He, Ka Bian
AIM: We have shown that rutaecarpine extracted from the dried fruit of Chinese herb Evodia rutaecarpa (Juss) Benth (Wu Zhu Yu) promotes glucose consumption and anti-inflammatory cytokine expression in insulin-resistant primary skeletal muscle cells. In this study we investigated whether rutaecarpine ameliorated the obesity profiles, lipid abnormality, glucose metabolism and insulin resistance in rat model of hyperlipidemia and hyperglycemia. METHODS: Rats fed on a high-fat diet for 8 weeks, followed by injection of streptozotocin (30 mg/kg, ip) to induce hyperlipidemia and hyperglycemia...
April 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/26923350/new-alkaloids-from-the-leaves-of-evodia-rutaecarpa
#17
Xiao Xia, Jian-Guang Luo, Rui-Huan Liu, Ming-Hua Yang, Ling-Yi Kong
One new indole alkaloid (1) and one new indole alkaloidal glycoside (2), together with nine known alkaloids (3-11), were isolated from the leaves of Evodia rutaecarpa. Their structures were determined on the basis of spectroscopic and chemical methods. Compound 4 exhibited potent activity against Pseudomonas aeruginosa with an MIC value of 7.13 μg/ml.
October 2016: Natural Product Research
https://www.readbyqxmd.com/read/26902409/evodiamine-from-evodia-rutaecarpa-induces-apoptosis-via-activation-of-jnk-and-perk-in-human-ovarian-cancer-cells
#18
Tze-Chien Chen, Chih-Chiang Chien, Ming-Shun Wu, Yen-Chou Chen
BACKGROUND: Evodiamine (EVO; 8,13,13b,14-tetrahydro-14-methylindolo[2'3'-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one derived from the traditional herbal medicine Evodia rutaecarpa was reported to possess anticancer activity; however, the anticancer mechanism of EVO against the viability of human ovarian cancer cells is still unclear. PURPOSE: A number of studies showed that chemotherapeutic benefits may result from targeting the endoplasmic reticular (ER) stress signaling pathway...
January 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26859198/rutaecarpine-reverses-the-altered-connexin-expression-pattern-induced-by-oxidized-low-density-lipoprotein-in-monocytes
#19
Yong Liu, Yan-Qi Fu, Wei-Jie Peng, Yan-Rong Yu, Yu-Si Wu, Hang Yan, Qi-Ren Huang, Ming He, Dan Luo
Adhesion of monocytes to the vascular endothelium is crucial in atherosclerosis development. Connexins (Cxs) which form hemichannels or gap junctions, modulate monocyte-endothelium interaction. We previously found that rutaecarpine, an active ingredient of the Chinese herbal medicine Evodia, reversed the altered Cx expression induced by oxidized low-density lipoprotein (ox-LDL) in human umbilical vein endothelial cells, and consequently decreases the adhesive properties of endothelial cells to monocytes. This study further investigated the effect of rutaecarpine on Cx expression in monocytes exposed to ox-LDL...
June 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/26747020/uhplc-q-tofms-based-metabolomics-for-the-characterization-of-cold-and-hot-properties-of-chinese-materia-medica
#20
Yang Wang, Shujun Zhou, Meng Wang, Shuying Liu, Yuanjia Hu, Chengwei He, Peng Li, Jian-Bo Wan
ETHNOPHARMACOLOGICAL RELEVANCE: The cold/hot property of Chinese materia medica (CMM) and the application of its corresponding knowledge in the diagnosis, differentiation and treatment of diseases have been considered to be the extremely important part of traditional Chinese medicine (TCM). As highly abstracted TCM theory, the cold/hot property of CMMs is still not fully understood and remains to be elucidated by systems biology approach. The cold and hot properties of CMM are mainly defined by the response of the body to a given CMM...
February 17, 2016: Journal of Ethnopharmacology
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