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https://www.readbyqxmd.com/read/28727628/replication-confirms-the-association-of-loci-in-foxe1-pde8b-capzb-and-pde10a-with-thyroid-traits-a-genetics-of-diabetes-audit-and-research-tayside-study
#1
Enrique Soto-Pedre, Moneeza K Siddiqui, Alex S Doney, Colin N A Palmer, Ewan R Pearson, Graham P Leese
OBJECTIVE: Replication of associations in genome-wide association studies is desirable to ensure that such signals are potentially clinically meaningful. This study aimed to replicate associations of selected single-nucleotide polymorphisms (SNPs) with hypothyroidism and serum thyroid-stimulating hormone (TSH) using electronic medical records (EMRs). PATIENTS AND METHODS: A cross-sectional study was carried out among patients of European Caucasian ethnicity from the Genetics of Diabetes Audit and Research Tayside recruited in Tayside (Scotland, UK)...
July 19, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28724498/patients-with-hiv-and-coronary-disease-are-we-meeting-national-guidelines
#2
Sam Emmanuel, James Nadel, Damien Fagan, Sirinya Teeraananchai, Matthew Law, Cameron J Holloway
Cardiovascular disease (CVD) has a higher incidence in patients with HIV infection. This study sought to determine whether HIV-infected patients with established CVD were being managed according to national guidelines. Data were collected from Australian general practitioners for 77 HIV-infected patients with a median age of 59 (range 54-64). There was good adherence to guidelines with regards to anti-platelet (84%; n=65; 95% confidence interval (CI) 74-92%) and statin therapy (97%; n=75; 95% CI 91-100%), despite a failure to meet cholesterol targets, with only 31% (n=24; 95% CI 21-42%) of the cohort meeting low-density lipoprotein target values...
July 20, 2017: Sexual Health
https://www.readbyqxmd.com/read/28723917/evidence-base-and-practice-variation-in-acute-care-processes-for-knee-and-hip-arthroplasty-surgeries
#3
Marcel Mayer, Justine Naylor, Ian Harris, Helen Badge, Sam Adie, Kathryn Mills, Joseph Descallar
BACKGROUND: Lack of evidence contributes to unnecessary variation in treatment costs and outcomes. This study aimed to identify from interventions historically used for total knee or hip arthroplasty (TKA, THA): i) if routine use is supported by high-level evidence; ii) whether surgeon use aligns with the evidence. METHODS: Part 1: Systematic search of electronic library databases for systematic reviews and practice guidelines concerning seven acute-care interventions...
2017: PloS One
https://www.readbyqxmd.com/read/28717977/-challenges-of-implementing-a-geriatric-trauma-network-a-regional-structure
#4
Carsten Schoeneberg, Bjoern Hussmann, Thomas Wesemann, Ludger Pientka, Marie-Christin Vollmar, Christine Bienek, Markus Steinmann, Benjamin Buecking, Sven Lendemans
BACKGROUND: At present, there is a high percentage and increasing tendency of patients presenting with orthogeriatric injuries. Moreover, significant comorbidities often exist, requiring increased interdisciplinary treatment. These developments have led the German Society of Trauma Surgery, in cooperation with the German Society of Geriatrics, to establish geriatric trauma centers. METHODS: As a conglomerate hospital at two locations, we are cooperating with two external geriatric clinics...
July 17, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28714828/reducing-wrong-intraocular-lens-implants-in-cataract-surgery
#5
Huey Peng Loh, Dirk Frans de Korne, Soon Phaik Chee, Ranjana Mathur
Purpose Wrong lens implants have been associated with the highest frequency of medical errors in cataract surgery. The purpose of this paper is to explore the use of the Systems Engineering Initiative for Patient Safety (SEIPS) framework to sustainably reduce wrong intraocular lens (IOL) implants in cataract surgery. Design/methodology/approach In this mixed-methods study, the SEIPS framework was used to analyse a series of (near) misses of IOL implants in a national tertiary specialty hospital in Singapore...
July 10, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28714742/application-of-the-european-quality-indicators-for-psychosocial-dementia-care-in-long-term-care-facilities-in-the-asia-pacific-region-a-pilot-study
#6
Yun-Hee Jeon, Wai Tong Chien, Ju-Young Ha, Rahimah Ibrahim, Belinda Kirley, Lay Ling Tan, Papan Thaipisuttikul, Emmelyne Vasse, Myrra Vernooij-Dassen, Huali Wang, Jong-Chul Youn, Henry Brodaty
OBJECTIVES: An Asia-Pacific regional collaboration group conducted its first multi-country research project to determine whether or not European quality indicators (QIs) for psychosocial care in dementia could be implemented as a valid tool in residential aged care across seven Asia-Pacific sites (Australia, Hong Kong Special Administrative Region, Mainland China, Malaysia, Singapore, South Korea, and Thailand). METHOD: Following the European QI protocol, auditing and data extraction of medical records of consenting residents with dementia were conducted by trained auditors with relevant health care backgrounds...
July 17, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28705208/testing-feedback-message-framing-and-comparators-to-address-prescribing-of-high-risk-medications-in-nursing-homes-protocol-for-a-pragmatic-factorial-cluster-randomized-trial
#7
Noah M Ivers, Laura Desveaux, Justin Presseau, Catherine Reis, Holly O Witteman, Monica K Taljaard, Nicola McCleary, Kednapa Thavorn, Jeremy M Grimshaw
BACKGROUND: Audit and feedback (AF) interventions that leverage routine administrative data offer a scalable and relatively low-cost method to improve processes of care. AF interventions are usually designed to highlight discrepancies between desired and actual performance and to encourage recipients to act to address such discrepancies. Comparing to a regional average is a common approach, but more recipients would have a discrepancy if compared to a higher-than-average level of performance...
July 14, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28704160/assessment-of-tribal-bison-worker-hazards-using-trusted-research-facilitators
#8
Ellen Duysen, Kelsey Irvine, Aaron Yoder, Christina Topliff, Clayton Kelling, Shireen Rajaram
OBJECTIVES: Agriculture is one of the most hazardous industries in the United States. Within agriculture, livestock handling is particularly dangerous. While injury and fatality rates for bison handlers have not been reported, workers in many of the newly established tribal bison herds have limited safety training and animal handling experience, making this a vulnerable workforce. Veterinarians and herd managers, working with tribal bison herds, recognized the need for improvement in the working environment and for worker safety training...
July 13, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28697295/using-electronic-medical-records-to-assess-the-rate-of-treatment-for-osteoporosis-in-australia
#9
Megan Elliott-Rudder, Catherine Harding, Joseph McGirr, Alexa Seal, Louis Pilotto
BACKGROUND: Despite available Medicare Benefits Schedule subsidies, it has been suggested that screening and treatment for osteoporosis are under-accessed in Australia, particularly in patients ≥70 years. This study describes the rate of osteoporosis treatment in those aged ≥70 years in regional New South Wales as identified in the electronic medical records (EMR) of 11 general practices. METHODS: EMR data were extracted using a Canning Tool adaptation. The prevalence of osteoporosis, fracture and bone-active medication prescriptions were described, and associations examined...
2017: Australian Family Physician
https://www.readbyqxmd.com/read/28692953/motivations-for-reducing-alcohol-consumption-an-international-survey-exploring-experiences-that-may-lead-to-a-change-in-drinking-habits
#10
Emma L Davies, Dominic Conroy, Adam R Winstock, Jason Ferris
AIMS: Brief interventions delivered by doctors and other healthcare practitioners might be meaningfully enhanced by understanding what individual experiences might lead patients to cut down. The aim of the current paper was to explore the experiences that might lead people to reduce their alcohol consumption and to compare these findings between respondents from 21 different countries. METHODS: Global Drug Survey is an online cross sectional, opportunistic anonymous survey...
June 30, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28692425/perceptions-of-medical-graduates-and-their-workplace-supervisors-towards-a-medical-school-clinical-audit-program
#11
Stephanie Davis, Ilse O'Ferrall, Samuel Hoare, Bulsara Caroline, Donna B Mak
Objectives: This study explores how medical graduates and their workplace supervisors perceive the value of a structured clinical audit program (CAP) undertaken during medical school. Methods: Medical students at the University of Notre Dame Fremantle complete a structured clinical audit program in their final year of medical school.  Semi-structured interviews were conducted with 12 Notre Dame graduates (who had all completed the CAP), and seven workplace supervisors (quality and safety staff and clinical supervisors)...
July 7, 2017: International Journal of Medical Education
https://www.readbyqxmd.com/read/28686150/use-of-fresh-frozen-plasma-in-2012-at-the-fondazione-ca-granda-hospital-of-milan-assessment-of-appropriateness-using-record-linkage-techniques-applied-to-data-routinely-recorded-in-various-hospital-information-systems
#12
Monica Lanzoni, Barbara Olivero, Andrea Artoni, Maurizio Marconi, Elisabetta Raspollini, Silvana Castaldi
BACKGROUND: The Quality Unit of a research and teaching hospital in Milan assessed the increased clinical use of fresh-frozen plasma in patients treated during 2012 in order to evaluate the appropriateness of this use. MATERIALS AND METHODS: For each patient in the study, a pathology profile was generated by means of record linkage techniques involving data collected through different information systems. Patients' information was combined using the patient identifier key generating pathology profiles exported to an Excel file...
June 19, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28684832/a-retrospective-audit-of-the-outcome-of-composites-used-to-restore-worn-teeth
#13
D Bartlett, S Varma
Objectives The aim of this audit was to monitor the outcome of composite restorations placed at an increased vertical dimension in patients with severe tooth wear.Methods This convenience sample of patients were treated by 11 specialist trainees in prosthodontics, and restored with direct composites. Exclusion criteria included bruxism, poor medical health and a preference for monitoring rather than intervention. The restorations were placed between 2012 and 2016 and were placed over more than one appointment and the outcome monitored for up to 14 months...
July 7, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28683580/use-of-a-mental-health-guideline-by-occupational-physicians-and-associations-with-return-to-work-in-workers-sick-listed-due-to-common-mental-disorders-a-retrospective-cohort-study
#14
Karlijn M van Beurden, Margot C W Joosen, Berend Terluin, Jaap van Weeghel, Jac J L van der Klink, Evelien P M Brouwers
PURPOSE: The aim of this study was to evaluate (1) whether adherence to the Dutch occupational mental health guideline by occupational physicians was associated with time to return to work in workers sick-listed due to common mental disorders; and (2) whether adherence to specific guideline items was associated with time to return to work. METHODS: Twelve performance indicators were developed to assess occupational physicians' guideline adherence. Medical records of 114 sick-listed workers were audited...
July 7, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28681827/exploring-the-prescribing-behaviours-and-the-mind-of-antibiotic-prescribers-is-critical-for-a-successful-antibiotic-stewardship-programme-results-of-a-survey-from-eastern-india
#15
Nikhila Ravi, Anirban Laha, Lalawmpuia Hmar, Suddhasatwya Chatterjee, Jyotsna Goswami, Gaurav Goel, Kingshuk Dhar, Tanushree Ghosh, Soumyadip Chatterjee, Soumitra Shankar Datta, Sanjay Bhattacharya
Quantitative and qualitative analysis were used to ascertain practices, perceptions and barriers about antibiotic stewardship program (ASP) in an oncology hospital in eastern India. In 2014 and 2017, 62% and 69.1% of the patients audited were found to be on anti infective medications respectively. Nearly 47% of patients in the study group (2014) who were on therapeutic antibiotics had an average cost of $46.48 per patient per day (inter-quartile range: $17.23-$94.76). Antibiotic related consultations from clinical microbiologists, was found to be in demand, and education of prescribers and policymakers was identified as critical to the success of ASP...
April 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28680175/outcome-after-discontinuation-of-proton-pump-inhibitors-at-a-residential-care-site-quality-improvement-project
#16
Candy Lee, Anita Lo, Kiran Ubhi, Michael Milewski
BACKGROUND: Increased prescribing of proton pump inhibitors (PPIs) in the past few decades can be attributed mainly to long-term use of this type of therapy. Recent evidence indicates signals of harm associated with long-term use of PPIs, such as increased risk of Clostridium difficile infection, recurrence of C. difficile infection, and fracture. A few studies have assessed the effectiveness of step-down management of patients receiving long-term PPI therapy in ambulatory care settings...
May 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28679465/evaluation-of-australia
#17
Stephen J Bright, Cylie M Williams
The aim of the present case study was to evaluate the service-wide implementation of Australia's first older adult-specific early intervention called Older Wiser Lifestyles (OWL). OWL was designed to reduce alcohol consumption and alcohol-related harm among people identified as being at risk. OWL used the Australian Alcohol-Related Problems Survey (A-ARPS) to classify people's drinking patterns as non-hazardous, hazardous or harmful. Participants of the present study were aged ≥60 years and consumed alcohol in the past month, although they did not require treatment for dependence...
July 6, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28674611/reducing-the-number-of-unnecessary-liver-function-tests-requested-on-the-paediatric-intensive-care-unit
#18
Lynn Sinitsky, Joe Brierley
Between January and October 2014, Great Ormond Street Hospital Paediatric Intensive Care Unit (PICU) was spending an average £23,392 on blood tests per month. Blood tests should be requested based on previous results and the patient's clinical condition, medication and nutritional status. However, more blood tests were being ordered than clinically indicated: an audit in October 2014 showed liver function tests (LFTs) were requested daily on most patients, even with previous normal results. A driver diagram identified three primary drivers for blood test requesting: decision-making, situational awareness and computer-based ordering...
2017: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/28673530/comparison-of-the-substance-use-brief-screen-subs-to-the-audit-c-and-assist-for-detecting-unhealthy-alcohol-and-drug-use-in-a-population-of-hospitalized-smokers
#19
Benjamin H Han, Scott E Sherman, Alissa R Link, Binhuan Wang, Jennifer McNeely
Hospitalized patients have high rates of unhealthy substance use, which has important impacts on health both during and after hospitalization, but is infrequently identified in the absence of screening. The Substance Use Brief Screen (SUBS) was developed as a brief, self-administered instrument to identify use of tobacco, alcohol, illicit drugs, and non-medical use of prescription drugs, and was previously validated in primary care patients. This study assessed the diagnostic accuracy of the SUBS in comparison to longer screening instruments to identify unhealthy and high-risk alcohol and drug use in hospitalized current smokers...
August 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28669681/factors-contributing-to-vancomycin-resistant-enterococcus-spp-horizontal-transmission-events-exploration-of-the-role-of-antibacterial-consumption
#20
Elise M Gilbert, Teresa R Zembower, Nathaniel J Rhodes, Chao Qi, Sandra Reiner, Michael Malczynski, Marc H Scheetz
BACKGROUND: The relationship between antibiotic consumption and resistance is relatively well defined at the population/ecologic level. Increases in antimicrobial consumption correlate with increased antibiotic resistance for clinical and surveillance isolates. However, the impact of antimicrobial consumption on nosocomial transmission of resistant bacteria is less well defined. This study explores the association between antimicrobial consumption, hand hygiene, and horizontal resistant organism transmission...
June 2, 2017: Diagnostic Microbiology and Infectious Disease
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