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the effect of sleep deprivation

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https://www.readbyqxmd.com/read/28543440/chronic-sleep-restriction-disrupts-interendothelial-junctions-in-the-hippocampus-and-increases-blood-brain-barrier-permeability
#1
G Hurtado-Alvarado, J Velázquez-Moctezuma, B Gómez-González
Chronic sleep loss in the rat increases blood-brain barrier permeability to Evans blue and FITC-dextrans in almost the whole brain and sleep recovery during short periods restores normal blood-brain barrier permeability. Sleep loss increases vesicle density in hippocampal endothelial cells and decreases tight junction protein expression. However, at the ultrastructural level the effect of chronic sleep loss on interendothelial junctions is unknown. In this study we characterised the ultrastructure of interendothelial junctions in the hippocampus, the expression of tight junction proteins, and quantified blood-brain barrier permeability to fluorescein-sodium after chronic sleep restriction...
May 23, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28541527/sleep-dependent-modulation-of-metabolic-rate-in-drosophila
#2
Bethany A Stahl, Melissa E Slocumb, Hersh Chaitin, Justin R Diangelo, Alex C Keene
Dysregulation of sleep is associated with metabolic diseases, and metabolic rate is acutely regulated by sleep-wake behavior. In humans and rodent models, sleep loss is associated with obesity, reduced metabolic rate, and negative energy balance, yet little is known about the neural mechanisms governing interactions between sleep and metabolism. We have developed a system to simultaneously measure sleep and metabolic rate in individual Drosophila, allowing for interrogation of neural systems governing interactions between sleep and metabolic rate...
May 25, 2017: Sleep
https://www.readbyqxmd.com/read/28539994/the-prevalence-of-restless-legs-syndrome-in-patients-undergoing-hemodialysis-a-systematic-review-and-meta-analysis-study
#3
REVIEW
Reza Ghanei Gheshlagh, Mohammad Farajzadeh, Mozhdeh Zarei, Vajiheh Baghi, Sahar Dalvand, Kourosh Sayehmiri
INTRODUCTION: Restless legs syndrome is a sensory-motor disorder that causes sleep disorder. The syndrome in patients undergoing hemodialysis associates with depression, sleep deprivation, performance disorder, day fatigue, excessive daytime sleepiness, stress, anxiety, and higher risk of cardiovascular diseases. The objective of this systematic meta-analysis study was to estimate prevalence of restless legs syndrome in patients undergoing hemodialysis. METHODS: Twenty-six relevant articles published between 2000 and 2015 indexed in Iranian (MagIran and IranMedex) and international databases (SID, Google Scholar, ScienceDirect, PubMed, Pre Quest, and Scopus) were selected...
March 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/28526620/evidence-for-cortical-structural-plasticity-in-humans-after-a-day-of-waking-and-sleep-deprivation
#4
Torbjørn Elvsåshagen, Nathalia Zak, Linn B Norbom, Per Ø Pedersen, Sophia H Quraishi, Atle Bjørnerud, Dag Alnæs, Nhat Trung Doan, Ulrik F Malt, Inge R Groote, Lars T Westlye
Sleep is an evolutionarily conserved process required for human health and functioning. Insufficient sleep causes impairments across cognitive domains, and sleep deprivation can have rapid antidepressive effects in mood disorders. However, the neurobiological effects of waking and sleep are not well understood. Recently, animal studies indicated that waking and sleep are associated with substantial cortical structural plasticity. Here, we hypothesized that structural plasticity can be observed after a day of waking and sleep deprivation in the human cerebral cortex...
May 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28526252/determinants-of-sleep-behavior-in-adolescents-a-pilot-study
#5
Reut Gruber, Gail Somerville, Soukaina Paquin, Johanne Boursier
PURPOSE: To identify determinants of sleep behavior in adolescents of middle to high socioeconomic status. METHODS: Eighteen students (9 boys, 9 girls) with a mean age of 14.9±1.5years were interviewed using a standardized script inspired by the theory of planned behavior. Interviews were audio-recorded and anonymously transcribed verbatim. In addition, participants completed a survey assessing demographic and health characteristics and their sleep duration was measured using actigraphy...
June 2017: Sleep Health
https://www.readbyqxmd.com/read/28516391/denial-of-a-sleep-deprivation-message-situational-and-dispositional-influences-on-message-rejection
#6
Suzanne C Thompson, Haley W Marber, Laeesha N Cornejo, Bryn M Launer, Kimberly Ona Ayala
Two studies investigated situational and dispositional influences on rejection of a sleep deprivation warning message for young adults. The hassle of protection (Study 1) and the self-relevance of the problem (Study 2) were manipulated; the disposition to use denial (threat orientation) for warning messages was measured. In both studies, it was found that both dispositional denial and the situational manipulation (more protection-hassle or self-relevance) showed at least one denial effect by reducing perceived susceptibility, perceived severity, or credibility...
May 17, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28515433/the-sleep-deprived-human-brain
#7
REVIEW
Adam J Krause, Eti Ben Simon, Bryce A Mander, Stephanie M Greer, Jared M Saletin, Andrea N Goldstein-Piekarski, Matthew P Walker
How does a lack of sleep affect our brains? In contrast to the benefits of sleep, frameworks exploring the impact of sleep loss are relatively lacking. Importantly, the effects of sleep deprivation (SD) do not simply reflect the absence of sleep and the benefits attributed to it; rather, they reflect the consequences of several additional factors, including extended wakefulness. With a focus on neuroimaging studies, we review the consequences of SD on attention and working memory, positive and negative emotion, and hippocampal learning...
May 18, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28512397/leukocyte-expression-of-type-1-and-type-2-purinergic-receptors-and-pro-inflammatory-cytokines-during-total-sleep-deprivation-and-or-sleep-extension-in-healthy-subjects
#8
Mounir Chennaoui, Pierrick J Arnal, Catherine Drogou, Damien Leger, Fabien Sauvet, Danielle Gomez-Merino
The purinergic type P1 (adenosine A1 and A2A) receptors and the type P2 (X7) receptor have been suggested to mediate physiological effects of adenosine and adenosine triphosphate on sleep. We aimed to determine gene expression of A1R (receptor), A2AR, and P2RX7 in leukocytes of healthy subjects during total sleep deprivation followed by sleep recovery. Expression of the pro-inflammatory cytokines IL-1β and TNF-α were also determined as they have been characterized as sleep regulatory substances, via P2RX7 activation...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28511822/posttraumatic-stress-disorder-ptsd-and-the-dermatology-patient
#9
Madhulika A Gupta, Patricia Jarosz, Aditya K Gupta
Dermatologic symptoms can be associated with posttraumatic stress disorder (PTSD) in several situations: (1) as features of some core PTSD symptoms, such as intrusion symptoms manifesting as cutaneous sensory flashbacks, as autonomic arousal manifesting as night sweats and idiopathic urticaria, and as dissociation manifesting as numbness and dermatitis artefacta; (2) the cutaneous psychosomatic effects of emotional and physical neglect and sexual abuse (eg, infantile eczema, cutaneous self-injury, and body-focused repetitive behaviors such as trichotillomania and skin picking disorder) and eating disorders, which can have dermatologic effects; (3) the direct effect of physical or sexual abuse or catastrophic life events (eg, earthquakes) on the skin; and (4) as a result of significant alterations in hypothalamic-pituitary-adrenal and sympatho-adrenal medullary axes, which can affect neuroendocrine and immune functions, and can lead to exacerbations of stress-reactive inflammatory dermatoses such as psoriasis, chronic urticaria, and atopic dermatitis...
May 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28511588/an-evening-milk-drink-can-affect-word-recall-in-indonesian-children-with-decreased-sleep-efficiency-a-randomized-controlled-trial
#10
Rini Sekartini, Dian Novita Chandra, Tiana Arsianti, Saptawati Bardosono, Tjhin Wiguna, Anne Schaafsma
STUDY OBJECTIVES: Sleep is important for memory consolidation in children. This study intended to find out whether an evening milk-based drink could influence sleep efficiency and memory recall in a group of Indonesian children (5-6 years old) with sleep deprivation. METHODS: Children were randomly allocated to one of three interventions: Reference product, satiety-stimulating product, and a relaxing product. The intervention lasted for 6 weeks and children consumed two servings per day of each 200 ml, the serving in the morning being the same for all children...
May 16, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28506620/bombesin-administration-impairs-memory-and-does-not-reverse-memory-deficit-caused-by-sleep-deprivation
#11
L B T Ferreira, S L B Oliveira, J Raya, L A Esumi, D C Hipolide
Sleep deprivation impairs performance in emotional memory tasks, however this effect on memory is not completely understood. Possible mechanisms may involve an alteration in neurotransmission systems, as shown by the fact that many drugs that modulate neural pathways can prevent memory impairment by sleep loss. Gastrin releasing peptide (GRP) is a neuropeptide that emerged as a regulatory molecule of emotional memory through the modulation of other neurotransmission systems. Thus, the present study addressed the effect of intraperitoneal (IP) administration of bombesin (BB) (2...
May 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28493899/distinct-behavioral-and-brain-changes-after-different-durations-of-the-modified-multiple-platform-method-on-rats-an-animal-model-of-central-fatigue
#12
Chenxia Han, Feng Li, Jie Ma, Yan Liu, Weihong Li, Yingqiu Mao, Yuehan Song, Siyuan Guo, Jing Liu
The modified multiple platform method (MMPM) is a classical sleep deprivation model. It has been widely used in behavioral and brain research, due to its effects on physical and mental functions. However, different MMPM protocols can promote distinct effects in rats. Although the MMPM has been proved to induce central fatigue, the effects of different durations of subjection to the MMPM remain undetermined. This study aims to investigate the changes in behavior, N-Methyl-d-Aspartate receptor 1 (NR1) and 2A (NR2A), as well as the ultrastructural alteration in the hippocampus after different MMPM modelling, to compare the central fatigue effect induced by dynamic MMPM...
2017: PloS One
https://www.readbyqxmd.com/read/28485189/the-effects-of-sleep-deprivation-on-soccer-skills
#13
Ståle Pallesen, Hilde Stokvold Gundersen, Morten Kristoffersen, Bjørn Bjorvatn, Eirunn Thun, Anette Harris
Many athletes sleep poorly due to stress, travel, and competition anxiety. In the present study, we investigated the effects of sleep deprivation on soccer skills (juggling, dribbling, ball control, continuous kicking, 20 and 40 m sprint, and 30 m sprint with changes of direction). In all, 19 male junior soccer players (14-19 years old) were recruited and participated in a cross-balanced experimental study comprising two conditions; habitual sleep and 24 hours sleep deprivation. In both conditions, testing took place between 8 a...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28484881/quality-of-sleep-in-patients-receiving-androgen-deprivation-therapy-for-prostate-cancer
#14
Asli Koskderelioglu, Muhtesem Gedizlioglu, Yasin Ceylan, Bulent Gunlusoy, Nilden Kahyaoglu
Androgen deprivation is a therapeutic option for patients with prostate cancer (PC). However, it has negative effects on sleep quality and psychological condition. Here, we evaluated the appearance of sleep disturbances in patients on androgen deprivation therapy (ADT). We administered Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), Epworth Sleepiness Scale (ESS), and Fatigue Severity Scale (FSS) to consecutive prostate cancer patients who had undergone radical prostatectomy and are presently either under adjuvant ADT or followed in an unmedicated program (non-ADT)...
May 8, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28482312/poor-habitual-sleep-efficiency-is-associated-with-increased-cardiovascular-and-cortisol-stress-reactivity-in-men
#15
Stijn A A Massar, Jean C J Liu, Nabilah B Mohammad, Michael W L Chee
Inadequate sleep and psychological stress can both elevate physiological stress markers, such as cortisol. Prior studies that have applied induced psychosocial stress after a night of experimental sleep deprivation have found these effects to be compounded. We examined whether the relationship between stress reactivity and poor sleep also extends to habitual sleep patterns. Fifty-nine adult male participants were recruited. Habitual sleep patterns were monitored with actigraphy for a week. Participants subsequently underwent the Trier Social Stress Test...
April 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28481358/decreased-alertness-due-to-sleep-loss-increases-pain-sensitivity-in-mice
#16
Chloe Alexandre, Alban Latremoliere, Ashley Ferreira, Giulia Miracca, Mihoko Yamamoto, Thomas E Scammell, Clifford J Woolf
Extended daytime and nighttime activities are major contributors to the growing sleep deficiency epidemic, as is the high prevalence of sleep disorders like insomnia. The consequences of chronic insufficient sleep for health remain uncertain. Sleep quality and duration predict presence of pain the next day in healthy subjects, suggesting that sleep disturbances alone may worsen pain, and experimental sleep deprivation in humans supports this claim. We demonstrate that sleep loss, but not sleep fragmentation, in healthy mice increases sensitivity to noxious stimuli (referred to as 'pain') without general sensory hyper-responsiveness...
May 8, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28479951/acute-effects-of-24-h-sleep-deprivation-on-salivary-cortisol-and-testosterone-concentrations-and-testosterone-to-cortisol-ratio-following-supplementation-with-caffeine-or-placebo
#17
Ciaran Mc Donald, Joss Moore, Alan McIntyre, Kevin Carmody, Bernard Donne
Caffeine has become a popular ergogenic aid amongst athletes and usage to improve athletic performance has been well documented. The effect of caffeine on anabolic and catabolic hormones in a sleep-deprived s tate has had little investigation to date. The purpose of the current study was to investigate the potential of caffeine to offset the effects, if any, of short-term sleep deprivation and exercise on an athlete's testosterone and cortisol concentrations via salivary technique. Eleven competitive male athletes volunteered to be part of this prospective double-blinded study...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28479928/cardioprotective-effects-of-huoxueanshen-recipe-against-myocardial-injuries-induced-by-sleep-deprivation-in-rats
#18
Rong Yuan, Li-Li Guo, Heng-Wen Chen, Jun-Ping Li, Zhong Chen, Ben-Jun Wei, Jie Wang
Background. Traditional Chinese Medicine is extensively used in China and HuoxueAnshen Recipe (HAR) was formulated according to its method in treating CHD accompanied with insomnia in clinic. However, there are few studies related to the effect of HAR on myocardial injury and sleep disorders. Purpose. To investigate the effects of HAR on sleep deprivation- (SD-) induced myocardial I/R injury. Methods. Male Wistar rats receiving a daily gavage of HAR or vehicle were exposed to SD intervention while control rats had normal sleep...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28466271/exercise-as-a-positive-modulator-of-brain-function
#19
REVIEW
Karim A Alkadhi
Various forms of exercise have been shown to prevent, restore, or ameliorate a variety of brain disorders including dementias, Parkinson's disease, chronic stress, thyroid disorders, and sleep deprivation, some of which are discussed here. In this review, the effects on brain function of various forms of exercise and exercise mimetics in humans and animal experiments are compared and discussed. Possible mechanisms of the beneficial effects of exercise including the role of neurotrophic factors and others are also discussed...
May 2, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28463859/adiponectin-lipids-and-atherosclerosis
#20
Niki Katsiki, Christos Mantzoros, Dimitri P Mikhailidis
PURPOSE OF REVIEW: Adiponectin is an adipokine with anti-inflammatory, antioxidant, antiatherogenic, pro-angiogenic, vasoprotective and insulin-sensitizing properties. Several factors may influence adiponectin levels, such as genetic polymorphisms, obesity / body fat distribution, diet and exercise as well as cardiovascular risk factors such as sleep deprivation and smoking as well as medications. Adiponectin has been proposed as a potential prognostic biomarker and a therapeutic target in patients with cardiometabolic diseases...
April 29, 2017: Current Opinion in Lipidology
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