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the effect of sleep deprivation

Harini C Krishnan, Catherine E Gandour, Joshua L Ramos, Mariah C Wrinkle, Joseph J Sanchez-Pacheco, Lisa C Lyons
STUDY OBJECTIVE: Insufficient sleep in individuals appears increasingly common due to the demands of modern work schedules and technology use. Consequently, there is a growing need to understand the interactions between sleep deprivation and memory. The current study determined the effects of acute sleep deprivation on short- and long-term associative memory using the marine mollusk Aplysia californica, a relatively simple model system well known for studies of learning and memory. DESIGN: Aplysia were sleep deprived for 9 h using context changes and tactile stimulation prior to or after training using the operant learning paradigm, learning that food is inedible (LFI)...
October 10, 2016: Sleep
Dr T J Lasisi, S T Shittu, C C Meludu, A A Salami
OBJECTIVE: Aim of this study was to investigate the effects of sleep deprivation on salivary factors in rats. DESIGN: Animals were randomly assigned into three groups of 6 animals each as control, total sleep deprivation (TSD) and partial sleep deprivation (PSD) groups. The multiple platform method was used to induce partial and total sleep deprivation for 7days. On the 8th day, stimulated saliva samples were collected for the analysis of salivary lag time, flow rate, salivary amylase activity, immunoglobulin A secretion rate and corticosterone levels using ELISA and standard kinetic enzyme assay...
September 26, 2016: Archives of Oral Biology
Lengqiu Guo, Zhuangli Guo, Xiaoqing Luo, Rui Liang, Shui Yang, Haigang Ren, Guanghui Wang, Xuechu Zhen
Sleep, particularly rapid eye movement (REM) sleep, is implicated in the consolidation of emotional memories. In the present study, we investigated the protective effects of a phosphodiesterase 10A (PDE10A) inhibitor MP-10 on deficits in long-term fear memory induced by REM sleep deprivation (REM-SD). REM-SD caused deficits in long-term fear memory, however, MP-10 administration ameliorated the deleterious effects of REM-SD on long term fear memory. Brain-derived neurotropic factor (BDNF) and phosphorylated cAMP response element-binding protein (pCREB) were altered in specific brain regions associated with learning and memory in REM-SD rats...
October 12, 2016: Neuroscience Letters
Valeriy A Poroyko, Alba Carreras, Abdelnaby Khalyfa, Ahamed A Khalyfa, Vanessa Leone, Eduard Peris, Isaac Almendros, Alex Gileles-Hillel, Zhuanhong Qiao, Nathaniel Hubert, Ramon Farré, Eugene B Chang, David Gozal
Chronic sleep fragmentation (SF) commonly occurs in human populations, and although it does not involve circadian shifts or sleep deprivation, it markedly alters feeding behaviors ultimately promoting obesity and insulin resistance. These symptoms are known to be related to the host gut microbiota. Mice were exposed to SF for 4 weeks and then allowed to recover for 2 weeks. Taxonomic profiles of fecal microbiota were obtained prospectively, and conventionalization experiments were performed in germ-free mice...
October 14, 2016: Scientific Reports
Xiaowen Xu, Liang Wang, Yan Zhang, Tianjiao Su, Liying Chen, Yan Zhang, Weifeng Ma, Yuanyuan Xie, Tiantian Wang, Fan Yang, Li He, Wenjiao Wang, Xuemei Fu, Hongxia Hao, Yuanzheng Ma
Epidemiological studies have shown that chronic sleep disturbances resulted in metabolic disorders. The purpose of this study was to assess the relationship between chronic sleep deprivation (CSD) and the glucose homeostasis in rats. Twenty-four rats were randomly divided into CSD group and control (CON) group. The CSD rats were intervened by a modified multiple platform method (MMPM) to establish an animal model of chronic sleep disturbances. After 3-month intervention, all rats were subjected to an intraperitoneal glucose tolerance test (IPGTT) and an insulin tolerance test (ITT), and the body weight, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, lipid profile group, and homeostasis model assessment-IR (HOMA-IR) were measured...
2016: Sleep and Biological Rhythms
Idan Elbaz, David Zada, Adi Tovin, Tslil Braun, Tali Lerer-Goldshtein, Gordon Wang, Philippe Mourrain, Lior Appelbaum
Sleep is tightly regulated by the circadian clock and homeostatic mechanisms. Although the sleep/wake cycle is known to be associated with structural and physiological synaptic changes that benefit the brain, the function of sleep is still debated. The hypothalamic hypocretin/orexin (Hcrt) neurons regulate various functions including feeding, reward, sleep, and wake. Continuous imaging of single neuronal circuits in live animals is vital to understanding the role of sleep in regulating synaptic dynamics, and the transparency of the zebrafish model enables time-lapse imaging of single synapses during both day and night...
October 12, 2016: Molecular Neurobiology
Xinqi Zhou, Taoyu Wu, Jing Yu, Xu Lei
Accumulating evidence supports that sleep deprivation (SD) and aging have similar effects: decreased cognition performance and impaired brain function. Some investigators even proposed the SD as a model of aging. However, few direct comparisons were ever explored between the effects of SD and aging by network module analysis with the resting-state fMRI. In this study, both within- and between-module connectivities were calculated in the whole brain to describe a complete picture of brain networks' functional connectivity among three groups (young normal sleep, young SD and old group)...
October 12, 2016: Brain Connectivity
Fabianne Furtado, Bruno da Silva B Gonçalves, Isabela Lopes Laguardia Abranches, Ana Flávia Abrantes, Arturo Forner-Cordero
The lack of sleep, both in quality and quantity, is an increasing problem in modern society, often related to workload and stress. A number of studies have addressed the effects of acute (total) sleep deprivation on postural control. However, up to date, the effects of chronic sleep deficits, either in quantity or quality, have not been analyzed. Thirty healthy adults participated in the study that consisted of registering activity with a wrist actigraph for more than a week before performing a series of postural control tests...
2016: PloS One
S Cohen, G Ifergane, E Vainer, M A Matar, Z Kaplan, J Zohar, A A Mathé, H Cohen
Pharmacotherapeutic intervention during traumatic memory consolidation has been suggested to alleviate or even prevent the development of posttraumatic stress disorder (PTSD). We recently reported that, in a controlled, prospective animal model, depriving rats of sleep following stress exposure prevents the development of a PTSD-like phenotype. Here, we report that administering the wake-promoting drug modafinil to rats in the aftermath of a stressogenic experience has a similar prophylactic effect, as it significantly reduces the prevalence of PTSD-like phenotype...
October 11, 2016: Translational Psychiatry
Lisa Caulley, Alexandra E Quimby, Nick Barrowman, Katherine Moreau, Jean-Philippe Vaccani
OBJECTIVE: To inform institutional policies regarding call encounters through an evaluation of the effect of home-call on academic experience and fatigue among surgical residents. This study conducted an assessment of the nature of resident call encounters premidnight and postmidnight and a comparative analysis of sleep deprivation and efficiency in residents during home-call and off call. DESIGN, SETTING, AND PARTICIPANTS: All Otolaryngology-Head and Neck Surgery residents (n = 9) at single Canadian institution were asked to establish the time and nature of call encounters during home-call...
October 4, 2016: Journal of Surgical Education
Salome Kurth, Douglas C Dean, Peter Achermann, Jonathan O'Muircheartaigh, Reto Huber, Sean C L Deoni, Monique K LeBourgeois
Brain networks respond to sleep deprivation or restriction with increased sleep depth, which is quantified as slow-wave activity (SWA) in the sleep electroencephalogram (EEG). When adults are sleep deprived, this homeostatic response is most pronounced over prefrontal brain regions. However, it is unknown how children's developing brain networks respond to acute sleep restriction, and whether this response is linked to myelination, an ongoing process in childhood that is critical for brain development and cortical integration...
2016: Frontiers in Human Neuroscience
Behrouz Rasaei, Ruzita Abd Talib, Mohd Ismail Noor, Majid Karandish, Norimah A Karim
BACKGROUND AND OBJECTIVES: Sleep deprivation and coffee caffeine consumption have been shown to affect glucose homeostasis separately, but the combined effects of these two variables are unknown. METHODS AND STUDY DESIGN: Forty-two healthy Iranian men, aged 20-40 years old, were assigned to three groups in a randomised crossover trial involving three treatments with two-week washout periods. Subjects were moderate coffee consumers (<=3 cups/day), and had a Pittsburgh Sleep Quality Index <=5...
December 2016: Asia Pacific Journal of Clinical Nutrition
Keri S Taylor, Hisayoshi Murai, Philip J Millar, Nobuhiko Haruki, Derek S Kimmerly, Beverley L Morris, George Tomlinson, T Douglas Bradley, John S Floras
Obstructive apnea during sleep elevates the set point for efferent sympathetic outflow during wakefulness. Such resetting is attributed to hypoxia-induced upregulation of peripheral chemoreceptor and brain stem sympathetic function. Whether recurrent arousal from sleep also influences daytime muscle sympathetic nerve activity is unknown. We therefore tested, in a cohort of 48 primarily nonsleepy, middle-aged, male (30) and female (18) volunteers (age: 59±1 years, mean±SE), the hypothesis that the frequency of arousals from sleep (arousal index) would relate to daytime muscle sympathetic burst incidence, independently of the frequency of apnea or its severity...
October 3, 2016: Hypertension
J Perrier, S Jongen, E Vuurman, M L Bocca, J G Ramaekers, A Vermeeren
The present study mainly aimed to assess whether and how sleepiness due to sleep deprivation interacts with Time on Task (ToT) effects both on electroencephalography (EEG) measures and driving performance in real driving conditions. Healthy participants performed a one hour on-the-road monotonous highway driving task while EEG was recorded continuously after one night of normal sleep and after one night of total sleep deprivation. The main outcome parameter in the highway driving test was the Standard Deviation of Lateral Position (SDLP)...
September 30, 2016: Biological Psychology
Lynn M Trotti
The transition from sleep to wake is marked by sleep inertia, a distinct state that is measurably different from wakefulness and manifests as performance impairments and sleepiness. Although the precise substrate of sleep inertia is unknown, electroencephalographic, evoked potential, and neuroimaging studies suggest the persistence of some features of sleep beyond the point of awakening. Forced desynchrony studies have demonstrated that sleep inertia impacts cognition differently than do homeostatic and circadian drives and that sleep inertia is most intense during awakenings from the biological night...
September 4, 2016: Sleep Medicine Reviews
Jonathan Cedernaes, Flaminia Fanelli, Alessia Fazzini, Uberto Pagotto, Jan-Erik Broman, Heike Vogel, Suzanne L Dickson, Helgi B Schiöth, Christian Benedict
Following binding to cannabinoid receptors, endocannabinoids regulate a variety of central nervous system processes including appetite and mood. Recent evidence suggests that the systemic release of these lipid metabolites can be altered by acute exercise and that their levels also vary across the 24-h sleep-wake cycle. The present study utilized a within-subject design (involving 16 normal-weight men) to determine whether daytime circulating endocannabinoid concentrations differ following three nights of partial sleep deprivation (4...
September 22, 2016: Psychoneuroendocrinology
Hadine Joffe, Sybil L Crawford, Marlene P Freeman, David P White, Matt T Bianchi, Semmie Kim, Nicole Economou, Julie Camuso, Janet E Hall, Lee S Cohen
CONTEXT: Women are at increased risk for mood disturbance during the menopause transition. Hot flashes (HFs), sleep disruption, and fluctuating estradiol levels correlate with menopause-associated depression but co-occur, making cause and effect relationships difficult to disentangle. OBJECTIVE: Using a GnRH agonist (GnRHa) experimental model, we investigated whether depressive symptoms are associated with HFs and/or are explained by concomitant sleep fragmentation in the absence of estradiol fluctuation...
October 2016: Journal of Clinical Endocrinology and Metabolism
Gordon B Feld, Patrick P Weis, Jan Born
Sleep supports memory consolidation. However, the conceptually important influence of the amount of items encoded in a memory test on this effect has not been investigated. In two experiments, participants (n = 101) learned lists of word-pairs varying in length (40, 160, 320 word-pairs) in the evening before a night of sleep (sleep group) or of sleep deprivation (wake group). After 36 h (including a night allowing recovery sleep) retrieval was tested. Compared with wakefulness, post-learning sleep enhanced retention for the 160 word-pair condition (p < 0...
2016: Frontiers in Psychology
Tae Kyun Kim, Young Sook Park, Haing-Woon Baik, Jin Hyun Jun, Eun Kyung Kim, Jae Woong Sull, Ho Joong Sung, Jin Woo Choi, Sook Hee Chung, Myung Chan Gye, Ju Yeon Lim, Jun Bong Kim, Seong Hwan Kim
AIM: To determine adiponectin expression in colonic tissue of murine colitis and systemic cytokine expression after melatonin treatments and sleep deprivation. METHODS: The following five groups of C57BL/6 mice were used in this study: (1) group I, control; (2) group II, 2% DSS induced colitis for 7 d; (3) group III, 2% DSS induced colitis and melatonin treatment; (4) group IV, 2% DSS induced colitis with sleep deprivation (SD) using specially designed and modified multiple platform water baths; and (5) group V, 2% DSS induced colitis with SD and melatonin treatment...
September 7, 2016: World Journal of Gastroenterology: WJG
Zhi-Qian Zhang, Degejin, Di Geng, Qi Zhang, Yan Tian, Yuan Xi, Wen-Qi Wang, Hua-Qi Tang, Bing Xu, Hong-Ying Lin, Yi-Kun Sun
The present study aimed to establish a pharmacodynamic method using the pySolo software to explore the influence of freeze-dried powders of Shuangxia Decoction (SXD) on the sleep of normal Drosophila melanogaster and the Drosophila melanogaster whose sleep was divested by light. The dose-effect and the time-effect relationships of SXD on sleep were examined. The effect-onset concentration of SXD was 0.25%, the plateau appeared at the concentration of 2.5% and the total sleep time showed a downtrend when the concentration was greater than 2...
September 2016: Chinese Journal of Natural Medicines
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