Yue-Ming Zhang, Ru-Meng Wei, Jing-Ya Zhang, Shuang Liu, Kai-Xuan Zhang, Xiao-Yi Kong, Yi-Jun Ge, Xue-Yan Li, Gui-Hai Chen
Accumulating evidence confirms that sleep insufficiency is a high risk factor for cognitive impairment, which involves inflammation and synaptic dysfunction. Resveratrol, an agonist of the Sirt1, has demonstrated anti-inflammation and neuroprotective effects in models of Alzheimer's disease, Parkinson's disease, and schizophrenia. However, the beneficial effects of resveratrol on sleep deprivation-induced cognitive deficits and its underlying molecular mechanisms are unclear. In the present study, thirty-two male C57BL/6 J mice were randomly divided into a Control+DMSO group, Control+Resveratrol group, SD+DMSO group, and SD+Resveratrol group...
April 2024: Journal of Biochemical and Molecular Toxicology