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https://www.readbyqxmd.com/read/27915105/the-effects-of-sleep-restriction-and-sleep-deprivation-in-producing-false-memories
#1
Alex Chatburn, Mark J Kohler, Jessica D Payne, Sean P A Drummond
False memory has been claimed to be the result of an associative process of generalisation, as well as to be representative of memory errors. These can occur at any stage of memory encoding, consolidation, or retrieval, albeit through varied mechanisms. The aim of this paper is to experimentally determine: i) if cognitive dysfunction brought about by sleep loss at the time of stimulus encoding can influence false memory production; and ii) whether this relationship holds across sensory modalities. Subjects undertook both the Deese-Roedigger-McDermott (DRM) false memory task and a visual task designed to produce false memories...
November 30, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27910751/recent-advances-in-pharmacotherapeutic-paradigm-of-mild-to-recalcitrant-atopic-dermatitis
#2
Zahid Hussain, Shariza Sahudin, Hnin Ei Thu, Ahmad Nazrun Shuid, Syed Nasir Abbas Bukhari, Endang Kumolosasi
Atopic dermatitis (AD) is a common, chronic skin inflammatory disorder characterized by perivascular infiltration of immunoglobulin E (IgE), T lymphocytes, and mast cells. The key factors responsible for the pathophysiology of this disease are immunological disorders and defects in epidermal barrier properties. Pruritus, intense itching, psychological stress, deprived physical and mental performance, and sleep disturbance are the hallmark features of this dermatological disorder. Preventive interventions such as educational programs, avoidance of allergens, and exclusive care toward the skin could play a partial role in suppressing the symptoms...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27900800/effects-of-partial-sleep-deprivation-on-reaction-time-in-anesthesiologists
#3
Haleh Saadat, Bruno Bissonnette, Dmitry Tumin, Vidya Raman, Julie Rice, N'Diris Barry, Joseph Tobias
BACKGROUND: Fatigue in anesthesiologists may have implications that extend beyond individual well-being. AIM: The aim of the present study was to evaluate the impact of sleep deprivation on the reaction time in anesthesiologists either after an overnight call or regular working hours. Moderation of this effect by coping strategies was observed. METHODS: Psychomotor vigilance test was used to assess reaction time in 23 anesthesiologists at two time-points: (i) on a regular non-call day and (ii) after a 17-h in-house call...
November 30, 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27900260/gut-microbiota-and-glucometabolic-alterations-in-response-to-recurrent-partial-sleep-deprivation-in-normal-weight-young-individuals
#4
Christian Benedict, Heike Vogel, Wenke Jonas, Anni Woting, Michael Blaut, Annette Schürmann, Jonathan Cedernaes
OBJECTIVE: Changes to the microbial community in the human gut have been proposed to promote metabolic disturbances that also occur after short periods of sleep loss (including insulin resistance). However, whether sleep loss affects the gut microbiota remains unknown. METHODS: In a randomized within-subject crossover study utilizing a standardized in-lab protocol (with fixed meal times and exercise schedules), we studied nine normal-weight men at two occasions: after two nights of partial sleep deprivation (PSD; sleep opportunity 02:45-07:00 h), and after two nights of normal sleep (NS; sleep opportunity 22:30-07:00 h)...
December 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27896948/acute-partial-sleep-deprivation-due-to-environmental-noise-increases-weight-gain-by-reducing-energy-expenditure-in-rodents
#5
Jennifer B Parrish, Jennifer A Teske
OBJECTIVE: Chronic partial sleep deprivation (SD) by environmental noise exposure increases weight gain and feeding in rodents, which contrasts weight loss after acute SD by physical methods. This study tested whether acute environmental noise exposure reduced sleep and its effect on weight gain, food intake, physical activity, and energy expenditure (EE). It was hypothesized that acute exposure would (1) increase weight gain and feeding and (2) reduce sleep, physical activity, and EE (total and individual components); and (3) behavioral changes would persist throughout recovery from SD...
November 29, 2016: Obesity
https://www.readbyqxmd.com/read/27890550/paradoxical-sleep-deprivation-in-rats-causes-a-selective-reduction-in-the-expression-of-type-2-metabotropic-glutamate-receptors-in-the-hippocampus
#6
Isabella Panaccione, Luisa Iacovelli, Luigi di Nuzzo, Francesca Nardecchia, Gianluca Mauro, Delfina Janiri, Antonio De Blasi, Gabriele Sani, Ferdinando Nicoletti, Rosamaria Orlando
Paradoxical sleep deprivation in rats is considered as an experimental animal model of mania endowed with face, construct, and pharmacological validity. We induced paradoxical sleep deprivation by placing rats onto a small platform surrounded by water. This procedure caused the animal to fall in the water at the onset of REM phase of sleep. Control rats were either placed onto a larger platform (which allowed them to sleep) or maintained in their home cage. Sleep deprived rats showed a substantial reduction in type-2 metabotropic glutamate (mGlu2) receptors mRNA and protein levels in the hippocampus, but not in the prefrontal cortex or corpus striatum, as compared to both groups of control rats...
November 23, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27880816/paradoxical-sleep-deprivation-causes-cardiac-dysfunction-and-the-impairment-is-attenuated-by-resistance-training
#7
Sara Quaglia de Campos Giampá, Marcos Mônico-Neto, Marco Tulio de Mello, Helton de Sá Souza, Sergio Tufik, Kil Sun Lee, Marcia Kiyomi Koike, Alexandra Alberta Dos Santos, Ednei Luiz Antonio, Andrey Jorge Serra, Paulo José Ferreira Tucci, Hanna Karen Moreira Antunes
BACKGROUND: Paradoxical sleep deprivation activates the sympathetic nervous system and the hypothalamus-pituitary-adrenal axis, subsequently interfering with the cardiovascular system. The beneficial effects of resistance training are related to hemodynamic, metabolic and hormonal homeostasis. We hypothesized that resistance training can prevent the cardiac remodeling and dysfunction caused by paradoxical sleep deprivation. METHODS: Male Wistar rats were distributed into four groups: control (C), resistance training (RT), paradoxical sleep deprivation for 96 hours (PSD96) and both resistance training and sleep deprivation (RT/PSD96)...
2016: PloS One
https://www.readbyqxmd.com/read/27869249/a-case-crossover-study-of-sleep-fatigue-and-other-transient-exposures-at-workplace-and-the-risk-of-non-fatal-occupational-injuries-among-the-employees-of-an-italian-academic-hospital
#8
Francesca Valent, Marika Mariuz, Giulia Liva, Fabrizio Bellomo, Daniela De Corti, Stefania Degan, Alberto Ferrazzano, Silvio Brusaferro
OBJECTIVES: Transient exposure with acute effect has been shown to affect the risk of occupational injuries in various industrial settings and at the healthcare workplace. The objective of this study has been to identify transient exposures related to occupational injury risk in an Italian teaching hospital. MATERIAL AND METHODS: A case-crossover study was conducted among the employees of the University Hospital of Udine who reported an occupational injury, commuting accident, or incident involving biological risk in a 15-month period in the years 2013 and 2014...
November 18, 2016: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/27867438/total-sleep-deprivation-and-pain-perception-during-cold-noxious-stimuli-in-humans
#9
Robert A Larson, Jason R Carter
BACKGROUND AND AIMS: A substantial portion of the population suffers from chronic pain leading to significant health care costs and lost productivity. Loss of sleep duration and quality are widely reported in patients suffering from a variety of acute or chronic pain conditions. Conversely, sleep loss has been known to elevate pain perception; thus a potential bi-directional relationship exists between sleep deprivation and pain. To date, the majority of studies examining the relationship between experimentally induced pain and sleep loss have focused on the measurement of pain threshold...
October 2016: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/27855759/sleep-consolidates-motor-learning-of-complex-movement-sequences-in-mice
#10
Hirotaka Nagai, Luisa de Vivo, Michele Bellesi, Maria Felice Ghilardi, Giulio Tononi, Chiara Cirelli
STUDY OBJECTIVES: Sleep-dependent consolidation of motor learning has been extensively studied in humans, but it remains unclear why some, but not all learned skills benefit from sleep. METHODS: Here we compared 2 different motor tasks, both requiring the mice to run on an accelerating device. In the rotarod task mice learn to maintain balance while running on a small rod, while in the complex wheel task mice run on an accelerating wheel with an irregular rung pattern...
November 14, 2016: Sleep
https://www.readbyqxmd.com/read/27848277/-sorry-were-you-sleeping-nurses-role-in-the-promotion-of-sleep-for-critically-ill-patients
#11
Felicity Dick-Smith
BACKGROUND: During critical illness sleep is important for immune function and restorative processes. Despite theoretical evidence and scientific understanding of the effects of sleep deprivation in the critically ill, research is yet to be entirely translated into institutional practices and department cultural norms. OBJECTIVES: This article was adapted from an undergraduate essay that considered the nurse's role in addressing fragmented sleep in critical care patients'...
November 29, 2016: Contemporary Nurse
https://www.readbyqxmd.com/read/27822504/sleep-and-serotonin-modulate-paracapsular-nitric-oxide-synthase-expressing-neurons-of-the-amygdala
#12
Marco Bocchio, Simon P Fisher, Gunes Unal, Tommas J Ellender, Vladyslav V Vyazovskiy, Marco Capogna
Unraveling the roles of distinct neuron types is a fundamental challenge to understanding brain function in health and disease. In the amygdala, a brain structure regulating emotional behavior, the diversity of GABAergic neurons has been only partially explored. We report a novel population of GABAergic amygdala neurons expressing high levels of neuronal nitric oxide synthase (nNOS). These cells are predominantly localized along basolateral amygdala (BLA) boundaries. Performing ex vivo patch-clamp recordings from nNOS(+) neurons in Nos1-Cre(ER);Ai9 mice, we observed that nNOS(+) neurons located along the external capsule display distinctive electrophysiological properties, axonal and dendritic arborization, and connectivity...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27819787/-insomnia-a-severe-health-care-problem
#13
Ana Gabriela Sánchez-Cárdenas, Christian Navarro-Gerrard, Haiko Nellen-Hummel, José Halabe-Cherem
The magnitude which sleep has on personal well-being is similar to the effects of diet and exercise. Sleep deprivation has severe negative effects on an individual's overall health, and this is usually overseen. From 30 to 40 % of the population has presented insomnia at a certain moment of life and from 9 to 15 % have evolved into a chronic and severe insomnia. Recent investigations have related sleep deprivation with obesity, metabolic disorders, heart disease, mental health problems and dementia. Recently, more investigations have focused on the multiple alterations suffered by the immune system in cases of sleep deprivation...
November 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27812555/sleep-physiology-in-toddlers-effects-of-missing-a-nap-on-subsequent-night-sleep
#14
Jonathan M Lassonde, Thomas Rusterholz, Salome Kurth, Allyson M Schumacher, Peter Achermann, Monique K LeBourgeois
The shift from a biphasic to a monophasic sleep schedule is a fundamental milestone in early childhood. This transition, however, may result in periods of acute sleep loss as children may nap on some but not all days. Although data indicating the behavioral consequences of nap deprivation in young children are accumulating, little is known about changes to sleep neurophysiology following daytime sleep loss. This study addresses this gap in knowledge by examining the effects of acute nap deprivation on subsequent nighttime sleep electroencephalographic (EEG) parameters in toddlers...
October 2016: Neurobiology of Sleep and Circadian Rhythms
https://www.readbyqxmd.com/read/27810176/effects-of-acute-sleep-deprivation-on-state-anxiety-levels-a-systematic-review-and-meta-analysis
#15
REVIEW
Gabriel Natan Pires, Andreia Gomes Bezerra, Sergio Tufik, Monica Levy Andersen
Increased anxiety levels have been widely recognized as one of the most important consequences of sleep deprivation. However, despite this general consensus, there are still aspects of this relationship, such as the extent of the anxiogenic potential and the specific effects of different types of sleep deprivation, which remain unclear. As no broad review has been undertaken to evaluate this relationship, we performed a systematic review and meta-analysis regarding the effects of sleep deprivation on state anxiety...
August 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27804960/the-effects-of-partial-sleep-deprivation-on-energy-balance-a-systematic-review-and-meta-analysis
#16
H K Al Khatib, S V Harding, J Darzi, G K Pot
BACKGROUND/OBJECTIVES: It is unknown whether short sleep duration causatively contributes to weight gain. Studies investigating effects of partial sleep deprivation (PSD) on energy balance components report conflicting findings. Our objective was to conduct a systematic review and meta-analysis of human intervention studies assessing the effects of PSD on energy intake (EI) and energy expenditure (EE). SUBJECTS/METHODS: EMBASE, Medline, Cochrane CENTRAL, Web of Science and Scopus were searched...
November 2, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27803179/physicians-attentional-performance-following-a-24-hour-observation-period-do-we-need-to-regulate-sleep-prior-to-work
#17
P Smyth, K Maximova, J D Jirsch
BACKGROUND: The tradition of physicians working while sleep deprived is increasingly criticised. Medical regulatory bodies have restricted resident physician duty-hours, not addressing the greater population of physicians. We aimed to assess factors such as sleep duration prior to a 24-hour observation period on physicians' attention. METHODS: We studied 70 physicians (mean age 38 years old (SD 10.8 years)): 36 residents and 34 faculty from call rosters at the University of Alberta...
November 1, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27801296/removal-of-unwanted-variation-reveals-novel-patterns-of-gene-expression-linked-to-sleep-homeostasis-in-murine-cortex
#18
Jason R Gerstner, John N Koberstein, Adam J Watson, Nikolai Zapero, Davide Risso, Terence P Speed, Marcos G Frank, Lucia Peixoto
BACKGROUND: Why we sleep is still one of the most perplexing mysteries in biology. Strong evidence indicates that sleep is necessary for normal brain function and that sleep need is a tightly regulated process. Surprisingly, molecular mechanisms that determine sleep need are incompletely described. Moreover, very little is known about transcriptional changes that specifically accompany the accumulation and discharge of sleep need. Several studies have characterized differential gene expression changes following sleep deprivation...
October 25, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27799236/effects-of-statin-on-arrhythmia-and-heart-rate-variability-in-healthy-persons-with-48-hour-sleep-deprivation
#19
Wei Ren Chen, Hong Bin Liu, Yuan Sha, Yang Shi, Hao Wang, Da Wei Yin, Yun Dai Chen, Xiang Min Shi
BACKGROUND: It has been reported that sleep deprivation is associated with cardiac autonomic disorder, inflammation, and oxidative stress. Statins have significant cardiovascular protective effects in patients with cardiovascular disease. This study aimed to investigate the protective effect of statins on arrhythmia and heart rate variability in young healthy persons after 48-hour sleep deprivation. METHODS AND RESULTS: This study enrolled 72 young healthy participants aged 26...
October 31, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27797541/slow-wave-and-rem-sleep-deprivation-effects-on-explicit-and-implicit-memory-during-sleep
#20
Sarah J Casey, Luke C Solomons, Joerg Steier, Neeraj Kabra, Anna Burnside, Martino F Pengo, John Moxham, Laura H Goldstein, Michael D Kopelman
OBJECTIVE: It has been debated whether different stages in the human sleep cycle preferentially mediate the consolidation of explicit and implicit memories, or whether all of the stages in succession are necessary for optimal consolidation. Here we investigated whether the selective deprivation of slow wave sleep (SWS) or rapid eye movement (REM) sleep over an entire night would have a specific effect on consolidation in explicit and implicit memory tasks. METHOD: Participants completed a set of explicit and implicit memory tasks at night, prior to sleep...
November 2016: Neuropsychology
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