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lung cancer & meninges metastases

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https://www.readbyqxmd.com/read/27785052/a-patient-previously-treated-with-alk-inhibitors-for-central-nervous-system-lesions-from-alk-rearranged-lung-cancer-a-case-report
#1
Jumpei Kashima, Yusuke Okuma, Tsunekazu Hishima
BACKGROUND: Patients with anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC) are now preferentially treated with tyrosine kinase inhibitors (TKIs). However, patients treated with ALK inhibitors end up with acquired resistance. CASE PRESENTATION: We present a patient with recurrent ALK-rearranged NSCLC that developed multiple brain metastases and meningitis carcinomatosa after sequential treatment with several lines of cytotoxic chemotherapy, crizotinib, and alectinib...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27561804/-analysis-of-clinicopathological-feature-and-prognosis-for-%C3%A2-leptomeningeal-metastasis-in-non-small-cell-lung-cancer
#2
Min Zhu, Yanhong Ren, Yan Liu, Chengjun Ban, Hua Gu, Zheng Wang, Yuhui Zhang
BACKGROUND: Leptomeningeal metastases (LM) is one of the most serious complications of advanced non-small cell lung cancer (NSCLC) due to the lower quality of life and poor prognosis. The aim of this study is to analyze the clinicopathological features and prognosis of patients with LM from NSCLC (NSCLC-LM). METHODS: Clinical data of 3 patients with NSCLC-LM collected from January 2015 to June 2016 were analyzed with a brief review. RESULTS: All 3 patients had adenocarcinoma histology harboring epidermal growth factor receptor (EGFR) exon 21 point mutations (m)...
August 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27446350/leptomeningeal-carcinomatosis-as-the-primary-presentation-of-relapse-in-breast-cancer
#3
Keith Sacco, Aun Muhammad, Waqar Saleem, Heba Alshaker, Leonardo Monzon, Mohammad Rafiqul Islam, Dmitri Pchejetski
Leptomeningeal metastasis (LM) is an uncommon presentation of relapse in breast cancer, which is associated with poor clinical outcomes and poor prognosis. Notably, LM most commonly occurs in breast cancer. The aim of the present review was to investigate the occurrence of LM as the primary presentation of relapse following remission in breast cancer patients and to determine whether specific histological subtypes are predisposed to meningeal metastases. In addition, the present review evaluated whether patients presenting with LM as the primary site of relapse exhibit differences in survival when compared with patients exhibiting metastasis to other sites...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/27042125/efficacy-of-multimodal-treatment-for-leptomeningeal-metastases-in-a-lung-cancer-harboring-an-egfr-mutation
#4
Daisuke Morichika, Toshio Kubo, Hiroko Gotoda, Tomoki Tamura, Kadoaki Ohashi, Katsuyuki Hotta, Masahiro Tabata, Kazuhiko Kurozumi, Mitsune Tanimoto, Katsuyuki Kiura
For lung cancer patients with epidermal growth factor receptor (EGFR) mutations, the advent of EGFR tyrosine kinase inhibitors (TKIs) has prolonged survival rates. Even though disease sites have been well controlled by EGFR-TKIs, some patients develop carcinomatous meningitis, which reduces their quality of life drastically. Although multidisciplinary approaches have improved patient survival and quality of life, the outcomes are not yet satisfactory. We report the case of a 54-year-old Japanese woman diagnosed with leptomeningeal metastases (LM) from a lung adenocarcinoma harboring an EGFR exon 21 L858R point mutation...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/26886902/cancerous-leptomeningitis-and-familial-congenital-hypopituitarism
#5
S Vujovic, S Vujosevic, S Kavaric, J Sopta, M Ivovic, A Saveanu, T Brue, M Korbonits, V Popovic
People are at higher risk of cancer as they get older or have a strong family history of cancer. The potential influence of environmental and behavioral factors remains poorly understood. Earlier population and case control studies reported that upper quartile of circulating IGF-I is associated with a higher risk of developing cancer suggesting possible involvement of the growth hormone (GH)/IGF system in initiation or progression of cancer. Since GH therapy increases IGF-1 levels, there have been concerns that GH therapy in hypopituitarism might increase the risk of cancer...
May 2016: Endocrine
https://www.readbyqxmd.com/read/26867467/-carcinomatous-meningitis-the-radiation-therapist-s-point-of-view
#6
REVIEW
S Espenel, A Vallard, J Langrand-Escure, M Ben Mrad, B Méry, R Rivoirard, G Moriceau, J-B Guy, J-C Trone, C Moncharmont, G Wang, P Diao, É Bernichon, É Chanal, P Fournel, N Magné
Carcinomatous meningitis complicates 5 to 10% of cancers, essentially with breast cancers, lung cancers and melanomas. The incidence probably increased because of therapeutic advances in oncology. Treatment is based on external beam radiotherapy, systemic treatment, intrathecal chemotherapy and supportive care. The aim of this work was to review data on external radiation therapy and carcinomatous meningitis. There are few evidences on the subject, but it is a major topic of interest. A whole brain radiation therapy is indicated in case of brain metastases or clinical encephalitis...
February 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/26805112/-a-case-of-brain-metastasis-from-rectal-cancer-with-synchronous-liver-and-lung-metastases-after-multimodality-treatment-a-case-report
#7
Masaru Udagawa, Ben Tominaga, Daisuke Kobayashi, Yuuya Ishikawa, Shuuichi Watanabe, Rama Adikrisna, Hiroyuki Okamoto, Eiichi Yabata
We report a case of brain metastasis from rectal cancer a long time after the initial resection. A 62-year-old woman, diagnosed with lower rectal cancer with multiple synchronous liver and lung metastases, underwent abdominoperineal resection after preoperative radiochemotherapy (40 Gy at the pelvis, using the de Gramont regimen FL therapy: 1 kur). The histological diagnosis was a moderately differentiated adenocarcinoma. Various regimens of chemotherapy for unresectable and metastatic colorectal cancer were administered, and a partial response was obtained; thereby, the metastatic lesions became resectable...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26724810/total-regression-of-brain-metastases-in-non-small-cell-lung-cancer-patients-harboring-egfr-mutations-treated-with-gefitinib-without-radiotherapy-two-case-reports
#8
Masashi Chonan, Norio Narita, Teiji Tominaga
BACKGROUND: Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor. Clinical trials have reported its effectiveness in the treatment of brain metastases from non-small cell lung cancer by overcoming the blood-brain barrier. Gefitinib is generally regarded as a relatively safe agent, and several reports have described its efficacy in patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer and a poor performance status. CASE PRESENTATION: We herein described two patients with brain metastasis from non-small cell lung cancer who achieved the total regression of metastasis with the administration of gefitinib...
January 2, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/26582158/long-term-survival-following-multidisciplinary-treatment-of-metastatic-sarcomatoid-renal-cell-carcinoma-a-case-report
#9
Hiroshi Yaegashi, Kouji Izumi, Hiroyuki Konaka, Atsushi Mizokami, Mikio Namiki
INTRODUCTION: We report the case of a 62-year-old woman diagnosed with sarcomatoid renal cell carcinoma. CASE PRESENTATION: A 62-year-old Asian woman presented with macroscopic hematuria. A histological and immunohistochemical study of a tumor biopsy specimen led to a suspected diagnosis of sarcomatoid renal cell carcinoma. She underwent surgical tumor resection that included her left kidney. A histological and immunohistochemical study of the resected tumor confirmed the diagnosis of sarcomatoid renal cell carcinoma...
2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/26545474/high-rate-of-bilaterality-in-internal-auditory-canal-metastases
#10
REVIEW
Michael T Chang, Elias M Michaelides
PURPOSE: Presentation of three cases of metastatic carcinoma to the internal auditory canal bilaterally, as well as a systematic review of the literature regarding the characteristics of these lesions. MATERIALS AND METHODS: Using a MEDLINE Ovid search (1946-2015), we identified and reviewed 102 cases of metastatic carcinoma to the internal auditory canal. Metrics recorded include: patient age, sex, tumor type, laterality, past oncologic history, co-occurring metastatic sites, clinical findings, radiographic findings, therapy received, and outcome...
November 2015: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/26445938/thyroid-metastasis-from-small-cell-lung-carcinoma-a-case-report-and-review-of-the-literature
#11
REVIEW
Ahmet Selçuk Can, Gülistan Köksal
INTRODUCTION: Small cell lung carcinoma frequently metastasizes to lymph nodes, liver, adrenal glands, bone, brain and pleura. Metastasis of small cell lung cancer to the thyroid gland is extremely rare. CASE PRESENTATION: A 55-year-old Turkish man presented with a mediastinal mass intermingled with mediastinal lymphadenopathy, measuring 11cm in total, and encasing superior vena cava and deviating his trachea, esophagus and vascular structures. He had superior vena cava syndrome...
2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/25434935/a-new-grading-system-focusing-on-neurological-outcomes-for-brain-metastases-treated-with-stereotactic-radiosurgery-the-modified-basic-score-for-brain-metastases
#12
Toru Serizawa, Yoshinori Higuchi, Osamu Nagano, Shinji Matsuda, Junichi Ono, Naokatsu Saeki, Tatsuo Hirai, Akifumi Miyakawa, Yuta Shibamoto
OBJECT: The Basic Score for Brain Metastases (BSBM) proposed by Lorenzoni and colleagues is one of the best grading systems for predicting survival periods after stereotactic radiosurgery (SRS) for brain metastases. However, it includes no brain factors and cannot predict neurological outcomes, such as preservation of neurological function and prevention of neurological death. Herein, the authors propose a modified BSBM, adding 4 brain factors to the original BSBM, enabling prediction of neurological outcomes, as well as of overall survival, in patients undergoing SRS...
December 2014: Journal of Neurosurgery
https://www.readbyqxmd.com/read/25334721/rare-case-of-leptomeningeal-carcinomatosis-without-evidence-of-brain-metastasis-presenting-as-first-sign-of-recurrent-nsclc
#13
Dhruv Lowe, Shreya Sinha, Arunpreet Kahlon
Cancer Student/Resident Case Report Posters IIISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Leptomeningeal carcinomatosis is a rare but grave consequence of advanced cancers with median overall survival of 2-3 months. Patients can present with a broad range of symptoms, hence, diagnosis requires a high index of suspicion.CASE PRESENTATION: We present a case of a 71 year old female with h/o ovarian cancer s/p TAH-BSO, pulmonary adenocarcinoma s/p left lung lobectomy who presented to the hospital with a one month history of intermittent lightheadedness and headaches...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25114510/clinical-utility-of-erlotinib-for-the-treatment-of-non-small-cell-lung-cancer-in-japanese-patients-current-evidence
#14
REVIEW
Yosuke Togashi, Hidetoshi Hayashi, Kazuhiko Nakagawa, Kazuto Nishio
Gefitinib, an epidermal growth factor tyrosine kinase inhibitor (EGFR-TKI), has been approved in Japan for the treatment of patients with advanced non-small-cell lung cancer (NSCLC) based on Phase II clinical trials since 2002. Erlotinib, another EGFR-TKI, was also approved a few years thereafter. In 2004, activating mutations in the EGFR gene were discovered to be a predictive biomarker for EGFR-TKI treatment, and gefitinib, which is not effective for patients with EGFR wild-type NSCLC, has since been used only in patients with EGFR-mutated NSCLC...
2014: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/24893802/leptomeningeal-metastasis-from-hepatocellular-carcinoma-with-other-unusual-metastases-a-case-report
#15
Zhenyu Pan, Guozi Yang, Tingting Yuan, Xiaochuan Pang, Yongxiang Wang, Limei Qu, Lihua Dong
BACKGROUND: Leptomeningeal metastasis, which results from metastasis of tumors to the arachnoid and pia mater, can lead to the dissemination of tumor cells throughout the subarachnoid space via the cerebral spinal fluid, and frequently with a poor prognosis. The primary tumor in adults is most often breast cancer, lung cancer, or melanoma. Although leptomeningeal metastasis due to cholangiocarcinoma has been reported, to the best of our knowledge there is no cytologically confirmed report of leptomeningeal metastasis from hepatocellular carcinoma...
2014: BMC Cancer
https://www.readbyqxmd.com/read/24831354/tumor-to-tumor-metastasis-of-the-central-nervous-system
#16
REVIEW
Hakan Erdogan, Mehmet Volkan Aydin, Erol Tasdemiroglu
Tumor-to-tumor metastasis is a well recognized phenomenon. Although any tumor may be potential recipient of metastasis, renal cell carcinoma and meningioma are the most common malignant and benign recipients, respectively, whereas the lung and breast are the most common metastatic donors respectively, in both settings. Patients with hereditary cancer syndromes may be at higher risk for the development of tumor-to-tumor metastases. The most common pattern of tumor-to-tumor metastasis for intracranial neoplasms is the type in which an aggressive high-grade malignancy serves as the source of tumor and a more indolent neoplasm serves as the recipient tumor...
2014: Turkish Neurosurgery
https://www.readbyqxmd.com/read/24751738/meningeal-carcinomatosis-of-the-internal-auditory-meatus-clinical-and-imagery-aided-differentiation
#17
Erwan de Mones del Pujol, Judith Kouassi, Jean-Philippe Maire, Valérie Franco-Vidal, Vincent Darrouzet
OBJECTIVES: To describe difficulties in diagnosing meningeal carcinomatosis of the internal auditory meatus (IAM-MC). STUDY DESIGN: Retrospective case review. SETTING: Tertiary skull base surgery referral center. PATIENTS: A series of six cases of patients diagnosed with IAM-CM over 14 years. RESULTS: The primary cancer was known before diagnosis in three cases (adenocarcinoma of lung, breast, and melanoma)...
June 2014: Otology & Neurotology
https://www.readbyqxmd.com/read/24635931/the-prognostic-significance-of-surgically-treated-hydrocephalus-in-leptomeningeal-metastases
#18
Tae-Young Jung, Woong-Ki Chung, In-Jae Oh
OBJECTIVE: The median survival of leptomeningeal metastases is short despite therapy and is sometime associated with hydrocephalus. We investigated the prognostic significance of surgically treated hydrocephalus in leptomeningeal metastases. MATERIALS AND METHODS: Between December 2005 and November 2012, 1343 patients had brain metastases from systemic solid tumors. Of these, 71 patients (5.3%) experienced leptomeningeal metastases from 45 lung cancers, 14 breast cancers, 4 gastric cancers and 8 other cancers...
April 2014: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/23924558/collecting-duct-renal-cell-carcinoma-with-the-syndrome-of-inappropriate-antidiuresis-an-autopsy-case-report
#19
Emi Yasuda, Hiroko Kuwabara, Yuro Shibayama
A 57-year-old Japanese man visited our hospital with a moist cough. Chest radiographic imaging showed a left hilar shadow. Adenocarcinoma cells were found on cytologic screening of fresh sputum. Although multiple metastases including brain were detected, no tumor was observed in the kidneys. The patient underwent whole-brain irradiation and chemotherapy for advanced-stage lung cancer. One month before his death, carcinomatous meningitis was detected. Hyponatremia, hypo-osmolality, and hypertonic urine suggested the syndrome of inappropriate antidiuresis...
January 2013: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/23717798/carcinomatous-meningitis-leptomeningeal-metastases-in-solid-tumors
#20
Emilie Le Rhun, Sophie Taillibert, Marc C Chamberlain
Leptomeningeal metastasis (LM) results from metastatic spread of cancer to the leptomeninges, giving rise to central nervous system dysfunction. Breast cancer, lung cancer, and melanoma are the most frequent causes of LM among solid tumors in adults. An early diagnosis of LM, before fixed neurologic deficits are manifest, permits earlier and potentially more effective treatment, thus leading to a better quality of life in patients so affected. Apart from a clinical suspicion of LM, diagnosis is dependent upon demonstration of cancer in cerebrospinal fluid (CSF) or radiographic manifestations as revealed by neuraxis imaging...
2013: Surgical Neurology International
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