Prateek Kumar, Annie M Goettemoeller, Claudia Espinosa-Garcia, Brendan R Tobin, Ali Tfaily, Ruth S Nelson, Aditya Natu, Eric B Dammer, Juliet V Santiago, Sneha Malepati, Lihong Cheng, Hailian Xiao, Duc D Duong, Nicholas T Seyfried, Levi B Wood, Matthew J M Rowan, Srikant Rangaraju
Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer's Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally-relevant insights. We used cell-type-specific in-vivo biotinylation of proteins (CIBOP) coupled with mass spectrometry to obtain native-state PV-IN proteomes. PV-IN proteomic signatures include high metabolic and translational activity, with over-representation of AD-risk and cognitive resilience-related proteins...
April 1, 2024: Nature Communications