Christina T Fiske, Amondrea Blackman, Fernanda Maruri, Peter F Rebeiro, Moises Huaman, Jamie Kator, Holly M Scott Algood, Timothy R Sterling
BACKGROUND: Independent of HIV infection, extrapulmonary TB (EPTB) risk is increased in women, persons of black race or foreign birth, and by genetic variants in vitamin D receptor (VDR), interleukin-1 beta (IL-1β), and toll-like receptor (TLR)-2; functional correlates are unclear. We evaluated macrophage expression of VDR, TLR2, cathelicidin, and TNF-α, and production of IL-1β in HIV-seronegative persons with previous EPTB, previous pulmonary TB, latent M. tuberculosis infection, and uninfected TB contacts...
April 30, 2019: BMC Infectious Diseases