Chen Qian, Qing Wang, Yusen Qiao, Ze Xu, Linlin Zhang, Haixiang Xiao, Zhixiang Lin, Mingzhou Wu, Wenyu Xia, Huilin Yang, Jiaxiang Bai, Dechun Geng
BACKGROUND: Arachidonic acid (AA), one of the most ubiquitous polyunsaturated fatty acids (PUFAs), provides fluidity to mammalian cell membranes. It is derived from linoleic acid (LA) and can be transformed into various bioactive metabolites, including prostaglandins (PGs), thromboxanes (TXs), lipoxins (LXs), hydroxy-eicosatetraenoic acids (HETEs), leukotrienes (LTs), and epoxyeicosatrienoic acids (EETs), by different pathways. All these processes are involved in AA metabolism. Currently, in the context of an increasingly visible aging world population, several scholars have revealed the essential role of AA metabolism in osteoporosis, chronic obstructive pulmonary disease, and many other aging diseases...
May 4, 2024: Journal of Advanced Research