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https://www.readbyqxmd.com/read/29342421/the-relation-between-plasma-%C3%AE-synuclein-level-and-clinical-symptoms-or-signs-of-parkinson-s-disease
#1
Michalina Malec-Litwinowicz, Andrzej Plewka, Danuta Plewka, Edyta Bogunia, Michał Morek, Andrzej Szczudlik, Michał Szubiga, Monika Rudzińska-Bar
INTRODUCTION: Parkinson disease (PD) is the common neurodegenerative disease. α-Synuclein (ASN), main aggregating protein in neural cells of CNS in PD, was found in peripheral fluids. Testing ASN in plasma is potential test for diagnose PD, but previous studies are controversial. The aim of this study was to investigate if plasma ASN level may be a valuable biomarker, is the level of plasma ASN concentration different in various motor subtypes of diseases, is there a relation between the level of plasma ASN and the severity of motor symptoms...
November 21, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29340957/spontaneous-isomerization-of-peptide-cation-radicals-following-electron-transfer-dissociation-revealed-by-uv-vis-photodissociation-action-spectroscopy
#2
Naruaki Imaoka, Camille Houferak, Megan P Murphy, Huong T H Nguyen, Andy Dang, František Tureček
Peptide cation radicals of the z-type were produced by electron transfer dissociation (ETD) of peptide dications and studied by UV-Vis photodissociation (UVPD) action spectroscopy. Cation radicals containing the Asp (D), Asn (N), Glu (E), and Gln (Q) residues were found to spontaneously isomerize by hydrogen atom migrations upon ETD. Canonical N-terminal [z4 + H]+● fragment ion-radicals of the R-C●H-CONH- type, initially formed by N-Cα bond cleavage, were found to be minor components of the stable ion fraction...
January 16, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29339356/kidney-biomarkers-and-decline-in-egfr-in-patients-with-type-2-diabetes
#3
Katherine G Garlo, William B White, George L Bakris, Faiez Zannad, Craig A Wilson, Stuart Kupfer, Muthiah Vaduganathan, David A Morrow, Christopher P Cannon, David M Charytan
BACKGROUND AND OBJECTIVES: Biomarkers may improve identification of individuals at risk of eGFR decline who may benefit from intervention or dialysis planning. However, available biomarkers remain incompletely validated for risk stratification and prediction modeling. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We examined serum cystatin C, urinary kidney injury molecule-1 (uKIM-1), and urinary neutrophil gelatinase-associated lipocalin (UNGAL) in 5367 individuals with type 2 diabetes mellitus and recent acute coronary syndromes enrolled in the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care (EXAMINE) trial...
January 16, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29337068/the-impact-of-compression-force-and-pressure-at-prevalent-screening-on-subsequent-re-attendance-in-a-national-screening-program
#4
Nataliia Moshina, Sofie Sebuødegård, Åsne S Holen, Gunvor G Waade, Kaitlyn Tsuruda, Solveig Hofvind
Adherence to screening may indirectly help assess whether a prior screening examination deters women from returning for a subsequent examination. We investigated whether compression force and pressure in mammography were associated with re-attendance among prevalently screened women in the organized breast cancer screening program in BLINDED. Data on compression force (kg) and pressure (kPa) from women's first screening examination in the program (prevalent screening) and subsequent re-attendance were available for 31,225 women aged 50-68, screened during 2007-2013...
January 11, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29336997/modulation-of-nonessential-amino-acid-biosynthetic-pathways-in-virulent-hessian-fly-larvae-mayetiola-destructor-feeding-on-susceptible-host-wheat-triticum-aestivum
#5
Subhashree Subramanyam, Jacob T Shreve, Jill A Nemacheck, Alisha J Johnson, Brandi Schemerhorn, Richard H Shukle, Christie E Williams
Compatible interactions between wheat (Triticum aestivum), and its dipteran pest Hessian fly (Hf, Mayetiola destructor) result in successful establishment of larval feeding sites rendering the host plant susceptible. Virulent larvae employ an effector-based feeding strategy to reprogram the host physiology resulting in formation of a protein- and sugar-rich nutritive tissue beneficial to developing larvae. Previous studies documented increased levels of nonessential amino acids (NAA; that need not be received through insect diet) in the susceptible wheat in response to larval feeding, suggesting importance of plant-derived NAA in larval nutrition...
January 11, 2018: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29323348/mouse-antibody-of-igm-class-is-prone-to-non-enzymatic-cleavage-between-ch1-and-ch2-domains
#6
Tomasz Klaus, Krystyna Stalińska, Dominik Czaplicki, Paweł Mak, Bozena Skupien-Rabian, Sylwia Kedracka-Krok, Karolina Wiatrowska, Monika Bzowska, Monika Machula, Joanna Bereta
IgM is a multivalent antibody which evolved as a first line defense of adaptive immunity. It consists of heavy and light chains assembled into a complex oligomer. In mouse serum there are two forms of IgM, a full-length and a truncated one. The latter contains μ' chain, which lacks a variable region. Although μ' chain was discovered many years ago, its origin has not yet been elucidated. Our results indicate that μ' chain is generated from a full-length heavy chain by non-enzymatic cleavage of the protein backbone...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323236/molecular-determinants-of-ca2-sensitivity-at-the-intersubunit-interface-of-the-bk-channel-gating-ring
#7
Qin Li, Yingxin Li, Hua Wei, Hao-Min Pan, Alexandre G Vouga, Brad S Rothberg, Yunkun Wu, Jiusheng Yan
The large-conductance calcium-activated K+ (BK) channel contains two intracellular tandem Ca2+-sensing RCK domains (RCK1 and RCK2), which tetramerize into a Ca2+ gating ring that regulates channel opening by conformational expansion in response to Ca2+ binding. Interestingly, the gating ring's intersubunit assembly interface harbors the RCK2 Ca2+-binding site, known as the Ca2+ bowl. The gating ring's assembly interface is made in part by intersubunit coordination of a Ca2+ ion between the Ca2+ bowl and an RCK1 Asn residue, N449, and by apparent intersubunit electrostatic interactions between E955 in RCK2 and R786 and R790 in the RCK2 of the adjacent subunit...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316436/oncogenic-kras-regulates-amino-acid-homeostasis-and-asparagine-biosynthesis-via-atf4-and-alters-sensitivity-to-l-asparaginase
#8
Dana M Gwinn, Alex G Lee, Marcela Briones-Martin-Del-Campo, Crystal S Conn, David R Simpson, Anna I Scott, Anthony Le, Tina M Cowan, Davide Ruggero, E Alejandro Sweet-Cordero
KRAS is a regulator of the nutrient stress response in non-small-cell lung cancer (NSCLC). Induction of the ATF4 pathway during nutrient depletion requires AKT and NRF2 downstream of KRAS. The tumor suppressor KEAP1 strongly influences the outcome of activation of this pathway during nutrient stress; loss of KEAP1 in KRAS mutant cells leads to apoptosis. Through ATF4 regulation, KRAS alters amino acid uptake and asparagine biosynthesis. The ATF4 target asparagine synthetase (ASNS) contributes to apoptotic suppression, protein biosynthesis, and mTORC1 activation...
January 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29306003/genetic-analysis-of-l1r-myristoylated-protein-of-capripoxviruses-reveals-structural-homogeneity-among-poxviruses
#9
Monu Karki, Amit Kumar, Gnanavel Venkatesan, Sargam Arya, A B Pandey
Sheeppox virus (SPPV) and goatpox virus (GTPV) are members of the genus Capripoxvirus (CaPV) of the family Poxviridae. CaPVs are responsible for important contagious diseases of small ruminants that are enzootic to the Indian sub-continent, Central and Northern Africa and the Middle East. In the present study, the sequence and phylogenetic analysis of the L1R gene of sixteen CaPV isolates (seven SPPV and nine GTPV) from India were performed along with 3D homology modeling of the L1R protein. L1R is a myristoylated protein responsible for virion assembly and being present on intracellular mature virion (IMV) surface, it is also a potent target for eliciting neutralizing antibodies...
January 3, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29299118/identification-of-a-cytogenetic-and-molecular-subgroup-of-acute-myeloid-leukemias-showing-sensitivity-to-l-asparaginase
#10
Salvatore Nicola Bertuccio, Salvatore Serravalle, Annalisa Astolfi, Annalisa Lonetti, Valentina Indio, Anna Leszl, Andrea Pession, Fraia Melchionda
L-Asparaginase (L-Asp) is an enzyme that catalyzes the hydrolysis of L-asparagine to L-aspartic acid, and its depletion induces leukemic cell death. L-Asp is an important component of treatment regimens for Acute Lymphoblastic Leukemia (ALL). Sensitivity to L-Asp is due to the absence of L-Asparagine synthetase (ASNS), the enzyme that catalyzes the biosynthesis of L-asparagine. ASNS gene is located on 7q21.3, and its increased expression in ALLs correlates with L-Asp resistance. Chromosome 7 monosomy (-7) is a recurrent aberration in myeloid disorders, particularly in adverse-risk Acute Myeloid Leukemias (AMLs) and therapy-related myeloid neoplasms (t-MN), that leads to a significant downregulation of the deleted genes, including ASNS...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29298898/a-triad-of-residues-is-functionally-transferrable-between-5-ht3-serotonin-receptors-and-nicotinic-acetylcholine-receptors
#11
Richard Mosesso, Dennis A Dougherty
Cys-loop receptors are pentameric ligand-gated ion channels that facilitate communication within the nervous system. Upon neurotransmitter binding, these receptors undergo an allosteric activation mechanism connecting the binding event to the membrane-spanning channel pore, which expands to conduct ions. Some of the earliest steps in this activation mechanism are carried out by residues proximal to the binding site, the relative positioning of which may reflect functional differences among members of the Cys-loop family of receptors...
January 3, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29298761/nondepressive-psychosocial-factors-and-ckd-outcomes-in-black-americans
#12
Joseph Lunyera, Clemontina A Davenport, Nrupen A Bhavsar, Mario Sims, Julia Scialla, Jane Pendergast, Rasheeda Hall, Crystal C Tyson, Jennifer St Clair Russell, Wei Wang, Adolfo Correa, L Ebony Boulware, Clarissa J Diamantidis
BACKGROUND AND OBJECTIVES: Established risk factors for CKD do not fully account for risk of CKD in black Americans. We studied the association of nondepressive psychosocial factors with risk of CKD in the Jackson Heart Study. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used principal component analysis to identify underlying constructs from 12 psychosocial baseline variables (perceived daily, lifetime, and burden of lifetime discrimination; stress; anger in; anger out; hostility; pessimism; John Henryism; spirituality; perceived social status; and social support)...
January 3, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29287710/rifampin-resistance-in-staphylococcus-epidermidis-molecular-characterization-and-fitness-cost-of-rpob-mutations
#13
Yu Mi Wi, Kerryl E Greenwood-Quaintance, Cassandra L Brinkman, Jean Y H Lee, Benjamin P Howden, Robin Patel
Molecular mechanisms and characteristics of rifampin resistance in Staphylococcus epidermidis are poorly characterized, even though S. epidermidis is one of the most common nosocomial pathogens associated with indwelling medical device-related infections. The aim of this study was to investigate the evolution of rifampin resistance and to characterize the associated molecular mechanisms in S. epidermidis. Rifampin-resistant mutants from two rifampin-susceptible S. epidermidis strains, RP62A and IDRL-8883, were selected through in vitro and in vivo exposure to rifampin...
December 26, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29285838/vasomotor-urogenital-psychological-and-somatic-symptoms-in-association-with-cyp1b1-polymorphisms-in-slovak-women-of-different-menopausal-status
#14
Veronika Candráková Čerňanová, Zuzana Danková, Lenka Vorobeľová, Marta Cvíčelová, Daniela Siváková
OBJECTIVES: The aim of this study was to examine if the Arg48Gly, Ala119Ser, Leu432Val, and Asn453Ser polymorphisms in the CYP1B1 estrogen-metabolizing gene are associated with menopausal symptom experience in healthy Slovak women aged 40-60 years. We also investigated the possible association of other factors with menopausal symptoms, including health status, physical activity, reproductive history, psychological status, and smoking. METHODS: The total sample consisted of 367 women (mean age 49...
December 29, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29284145/ifnb-of-black-carp-functions-importantly-in-host-innate-immune-response-as-an-antiviral-cytokine
#15
Hui Wu, Liqun Liu, Sizhong Wu, Chanyuan Wang, Chaoliang Feng, Jun Xiao, Hao Feng
Type I interferons (IFN-Is) play an important role in the antiviral immune response in teleost fishes. In this study, one type I interferon (bcIFNb) from black carp (Mylopharyngodon piceus) has been cloned and characterized. The full-length cDNA of bcIFNb gene consists of 806 nucleotides and the predicted bcIFNb protein contains 188 amino acids. Basing on the cysteine number and evolutionary position, bcIFNb was classified into group II type I IFN. q-PCR analysis demonstrated that bcIFNb mRNA level varied in vivo and ex vivo in response to different stimuli...
December 25, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29282980/the-135-day-interventions-of-yam-dioscorin-and-the-dipeptide-asn-trp-nw-reduce-weight-gains-and-improve-impaired-glucose-tolerances-in-high-fat-diet-induced-c57bl-6-mice
#16
Guang-Cheng Wu, Shyr-Yi Lin, Hong-Jen Liang, Wen-Chi Hou
The C57BL/6J mice were fed a 135-day normal diet or a high-fat diet (HFD) without, or concurrent with, a single yam dioscorin (80 mg/kg) or dipeptide NW (40 mg/kg) intervention every day. The final body weights (g) of mice were 26.1 ± 1.4, 34.97 ± 2.1, 31.75 ± 2.6, and 31.66 ± 3.1, respectively, for normal diet-fed, HFD-fed, dioscorin-intervened, and NW-intervened group. The mice in both intervened groups showed similar less weight gains and had significant differences (P < 0.05) compared to those in the HFD group under the same cumulative HFD intakes...
December 28, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29280541/ventricular-arrhythmias-immediately-following-transcatheter-pulmonary-valve-implantation-a-cause-for-concern
#17
M Abigail Simmons, Robert W Elder, Veronika Shabanova, William Hellenbrand, Jeremy Asnes
BACKGROUND: Transcatheter pulmonary valve implantation (TPVI) has revolutionized the care of patients with congenital disorders of the right ventricular outflow tract (RVOT) and is increasingly being used in patients with native outflow tracts. This is the first study to specifically report the occurrence of ventricular arrhythmias in the immediate post-TPVI period. METHODS AND RESULTS: Medical records of all adult and pediatric patients who underwent TPVI at our institution between May 1, 2011 and March 1, 2016, were reviewed for the presence of clinically significant ventricular arrhythmias occurring within 30 days of TPVI...
December 27, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29279279/characterization-of-a-novel-variant-in-siblings-with-asparagine-synthetase-deficiency
#18
Stephanie J Sacharow, Elizabeth E Dudenhausen, Carrie L Lomelino, Lance Rodan, Christelle Moufawad El Achkar, Heather E Olson, Casie A Genetti, Pankaj B Agrawal, Robert McKenna, Michael S Kilberg
Asparagine Synthetase Deficiency (ASD) is a recently described inborn error of metabolism caused by bi-allelic pathogenic variants in the asparagine synthetase (ASNS) gene. ASD typically presents congenitally with microcephaly and severe, often medically refractory, epilepsy. Development is generally severely affected at birth. Tone is abnormal with axial hypotonia and progressive appendicular spasticity. Hyperekplexia has been reported. Neuroimaging typically demonstrates gyral simplification, abnormal myelination, and progressive cerebral atrophy...
December 20, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29274340/four-unreported-types-of-glycans-containing-mannose-6-phosphate-are-heterogeneously-attached-at-three-sites-including-newly-found-asn-233-to-recombinant-human-acid-alpha-glucosidase-that-is-the-only-approved-treatment-for-pompe-disease
#19
Heajin Park, Jihye Kim, Young Kwang Lee, Wooseok Kim, Seung Kwan You, Jonghye Do, Yeonjoo Jang, Doo-Byung Oh, Jae Il Kim, Ha Hyung Kim
Myozyme is a recombinant human acid alpha-glucosidase (rhGAA) that is currently the only drug approved for treating Pompe disease, and its low efficacy means that a high dose is required. Mannose-6-phosphate (M6P) glycosylation on rhGAA is a key factor influencing lysosomal enzyme targeting and the efficacy of enzyme replacement therapy (ERT); however, its complex structure and relatively small quantity still remain to be characterized. This study investigated M6P glycosylation on rhGAA using liquid chromatography (LC)-electrospray ionization (ESI)-high-energy collisional dissociation (HCD) tandem mass spectrometry (MS/MS)...
December 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29262493/-genetic-characterization-of-rubella-virus-isolated-in-guizhou-province-from-2012-to-2015
#20
X M Tang, Z Zhu, G Ren, X F Ye, L Zhang
Objective: To analyze the genetic characteristics of rubella virus isolated from 2012 to 2015 in Guizhou province. Methods: A total of 390 cases of suspected measles were collected from Guizhou measles network laboratory from 2012 to 2015 and 25 cases of rubella cases were diagnosed. Rubella virus isolation was performed using Vero/SLAM cells. The presence of rubella viral RNA was detected using Real-time RT-PCR after RNA extraction from infected tissue culture cells. Fragments of 480 bp and 633 bp nucleotides of E1 genes of the isolates were amplified by RT-PCR and the PCR products were sequenced and spliced...
December 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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