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https://www.readbyqxmd.com/read/29933047/pharmacologic-inhibition-of-akt-leads-to-cell-death-in-relapsed-multiple-myeloma
#1
In-Sung Song, Yu Jeong Jeong, Seung Hun Jeong, Hyoung Kyu Kim, Nam-Chul Ha, MyungGeun Shin, Kyung Soo Ko, Byoung Doo Rhee, Sungbo Shim, Sung-Wuk Jang, Jin Han
Multiple myeloma (MM) is a neoplastic plasma cell disorder with high disease recurrence rates. Novel therapeutic approaches capable of improving outcomes in patients with MM are urgently required. The AKT signalling plays a critical regulatory role in MM pathophysiology, including survival, proliferation, metabolism, and has emerged as a key therapeutic target. Here, we identified a novel AKT inhibitor, HS1793, and defined its mechanism of action and clinical significance in MM. HS1793 disrupted the interaction between AKT and heat shock protein 90, resulting in protein phosphatase 2A-modulated phosphorylated-AKT (p-AKT) reduction...
June 19, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29932083/antibiotic-prophylaxis-in-children-undergoing-abdominal-surgery-for-neoplastic-diseases
#2
Luca Pio, Stefano Avanzini, Irene Paraboschi, Michela Wong, Aldo Naselli, Alberto Garaventa, Massimo Conte, Ubaldo Rosati, Giuseppe Losurdo, Giuseppe Fratino, Giuseppe Martucciello, Girolamo Mattioli, Elio Castagnola
Little is known about the effectiveness of antibiotic prophylaxis for prevention of surgical site infections (SSIs) in paediatric abdominopelvic surgical oncology. A retrospective analysis was performed upon the incidence of SSIs in children receiving a 24-hour antibiotic prophylaxis with cefazolin for abdominopelvic oncological surgery. In all, 145 patients (57% females) with a median age of 4 years underwent surgical procedures for abdominopelvic tumours. No SSIs were detected, despite the various risk factors known to be associated with their occurrence (such as pre- and post- surgical chemotherapy, long hospitalization, intensive care unit admission and drain placement)...
June 1, 2018: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29931826/the-two-faced-nature-of-bk-polyomavirus-lytic-infection-or-non-lytic-large-t-positive-carcinoma
#3
Volker Nickeleit, Harsharan K Singh, Daniel J Kenan, Piotr A Mieczkowski
In immunocompromised patients, reactivation of latent BK-polyomavirus (BKPyV) can cause disease with lytic infections of kidneys and the lower urinary tract. Emerging evidence also links BKPyV to oncogenesis and high grade intra-renal and transitional cell carcinomas. These neoplasms strongly express polyomavirus large-T antigen as a defining feature, i.e. they are "large-T positive carcinomas". Such neoplasms arise in immunocompromised patients, typically in renal allograft recipients and preferentially in tissues harboring latent BKPyV...
June 21, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29931379/-evidence-of-the-mini-one-anastomosis-gastric-bypass-for-being-a-standard-procedure-in-obesity-and-metabolic-surgery
#4
REVIEW
S Chiappetta, R Weiner
BACKGROUND: The Mini gastric bypass/One anastomosis gastric bypass (MGB/OAGB) was the third most commonly performed procedure in Germany, with 13.9% of all obesity and metabolic procedures in 2017 (StuDoQ|MBE). OBJECTIVE: This article reviews the currently published evidence for MGB/OAGB and the historical evidence on one anastomosis reconstruction. MATERIAL AND METHODS: A systematic literature search was performed in MEDLINE via PubMed and in Clinicaltrials...
June 21, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29930454/von-hipple-lindau-unusual-case-presentation-with-peripheral-and-juxtapapillary-retinal-hemangioma
#5
Kanika Jain, Manav Deep Singh
Von Hipple-Lindua (VHL) syndrome is an autosomal dominant neoplastic disorder in which multiple benign or malignant tumours and cysts develop in central nervous system and visceral organs. Retinal capillary hemangioma is the most frequent and often the earliest manifestation of VHL syndrome. We report a case with multisystemic involvement diagnosed as a case of multiple endocrine neoplasia (MEN) syndrome but the presence of multiple, unilateral peripheral and juxtapapillary retinal capillary hemangioma was able to clinche the definative diagnosis of VHL and thus helped in appropriate management of the patient...
May 2018: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29930212/-a-case-of-malignant-transformation-of-epidermoid-cyst-with-cerebrospinal-fluid-dissemination
#6
Yuuki Suematsu, Go Takeishi, Kiyotaka Yokogami, Hisao Uehara, Toshihiro Gi, Atsushi Yamashita, Yuichiro Sato, Hideo Takeshima
An epidermoid cyst is a benign tumor, accounting for 0.2-1.8% of all brain tumors. Histologically, an epidermoid cyst has a wall consisting of squamous epithelium with keratinization and without skin components. An epidermoid cyst tends to develop in the cerebellopontine angle(CPA), middle cranial fossa, pituitary fossa, spinal cord, and other locations. We describe a rare case of malignant transformation of an epidermoid cyst with cerebrospinal fluid(CSF)dissemination. A 54-year-old man was referred to our hospital with chief complaints of dysesthesia of the right leg, persisting for 6 months, and dizziness and dysarthria for 2 months...
June 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29930207/-diagnostic-algorithm-for-the-differential-diagnosis-of-intramedullary-non-neoplastic-lesions
#7
Toshihiro Takami, Kentaro Naito, Toru Yamagata, Hironori Arima, Kenji Ohata
No abstract text is available yet for this article.
June 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29930164/long-term-control-of-laryngeal-plasma-cell-mucositis-with-systemic-immunosuppression
#8
James Triplett, Geoffrey Hee, Andrew McLean-Tooke, Michaela Lucas
Plasma cell mucositis (PCM) is a rare non-neoplastic plasma cell proliferative disorder of the mucous membranes, which typically presents as soft tissue lesions involving oral, upper airway or genital mucosa. Laryngeal involvement resulting in stridor has been reported in four other cases previously, with three requiring tracheostomy. We present a case of supraglottic stenosis in a 53-year-old woman presenting with dysphonia and stridor, requiring surgical resection on three occasions accompanied by tracheostomy on two occasions; biopsy was consistent with PCM...
June 20, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29929595/female-genital-itch
#9
REVIEW
Jessica A Savas, Rita O Pichardo
Vulvar pruritus is a common complaint among young girls and women presenting to primary care physicians, gynecologists, and dermatologists. Female genital itch is especially disruptive because of its interference with sexual function and intimacy. Causes of vulvar itch are vast and may be inflammatory, environmental, neoplastic, or infectious, often with several causes coexisting simultaneously. Diagnosis may be difficult because of the unique anatomy and inherent properties of genital and perianal skin. Treatment is aimed at eliminating outside irritants, restoring epidermal barrier function, and suppressing inflammation...
July 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29928911/cadm1-is-a-diagnostic-marker-in-early-stage-mycosis-fungoides-multicenter-study-of-58-cases
#10
Akihiko Yuki, Satoru Shinkuma, Ryota Hayashi, Hiroki Fujikawa, Taisuke Kato, Erina Homma, Yohei Hamade, Osamu Onodera, Masao Matsuoka, Hiroshi Shimizu, Hiroaki Iwata, Riichiro Abe
BACKGROUND: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL). Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 (CADM1), initially identified as a tumor suppressor gene in human non-small-cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma (ATLL). OBJECTIVE: We investigated CADM1 expression in MF neoplastic cells, especially during early stages, and evaluated its usefulness as a diagnostic marker for MF...
June 18, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29928429/impaired-efferocytosis-by-monocytes-in-multiple-myeloma
#11
Ying Yu Liang, Ilse Schwarzinger, Ingrid Simonitsch-Klupp, Hermine Agis, Rudolf Oehler
Efficient clearance of apoptotic cells by efferocytosis is important for tissue homeostasis. Impaired efferocytosis leads to the accumulation of cell debris, which is regarded as a trigger in chronic inflammation and autoimmune diseases. Patients with hematological neoplastic disorders such as multiple myeloma (MM) exhibit high blood levels of apoptotic microparticles. The present study investigated whether these high levels of apoptotic microparticles are associated with insufficient dead cell clearance. Blood samples were collected from patients with MM immediately prior to and 3, 7 and 10 days after the initial cycle of bortezomib-based therapy...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928108/nora-s-lesion-of-2nd-metacarpal-treated-by-wide-excision-autologous-fibular-grafting-and-metacarpophalangeal-joint-replacement-a-rare-case-report
#12
Kavin Khatri, Vivek Tiwari, Shah Alam Khan, Devajit Nath, Asit Ranjan Mridha, Amrut Raje
Bizarre paroxysmal osteochondromatous proliferation (BPOP) is a rare benign neoplastic lesion predominantly affecting small bones of the hand and known for its recurrence after local excision. We describe a rare case of BPOP involving second metacarpal of the dominant hand which was treated using a novel technique. Wide excision and reconstruction with non-vascularised fibular autograft was performed along with metacarpophalangeal joint replacement. At a follow up of two years, there was no evidence of recurrence and patient had good functional outcome...
June 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29927321/hepatic-zip8-deficiency-is-associated-with-disrupted-selenium-homeostasis-liver-pathology-and-tumor-formation
#13
Liu Liu, Xiangrong Geng, Yihong Cai, Bryan L Copple, Masafumi Yoshinaga, Jian Shen, Daniel W Nebert, Hua Wang, Zijuan Liu
ZIP8 (encoded by Slc39a8) is a multi-functional membrane transporter that influxes essential metal cations Zn2+ , Mn2+ , Fe2+ and non-metal inorganic selenite (HSeO3 - ). Physiological roles of ZIP8 in different cell-types and tissues remain to be elucidated. We aimed to investigate ZIP8 functions in liver. Two mouse models were used in this study: one, 13- to 21-month-old Slc39a8(+/neo) hypomorphs having diminished ZIP8 levels; the other, a liver-specific ZIP8 acute knockdown mouse (Ad-shZip8). Histology, immunohistochemistry, and Western-blotting were used to investigate ZIP8-deficiency effects on hepatic injury, inflammatory changes, and oxidative stress...
June 21, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29926990/a-simply-modified-lymphocyte-for-systematic-cancer-therapy
#14
Di-Wei Zheng, Jin-Xuan Fan, Xin-Hua Liu, Xue Dong, Pei Pan, Lu Xu, Xian-Zheng Zhang
Cytotherapy has received considerable attention in the field of cancer therapy, and various chemical or genetic methods have been applied to remold natural cells for improved therapeutic outcome of cytotherapy. A simple method to modify lymphocytes for cancer treatment by using a clinically used molecule, δ-aminolevulinic acid (δ-ALA), is reported here. After incubation with this molecule, tumor-targeted lymphocytes spontaneously synthesize anti-neoplastic drug protoporphyrin X (PpIX), and specifically accumulate in cancer tissue...
June 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29926943/periodontal-manifestations-of-systemic-diseases-and-developmental-and-acquired-conditions-consensus-report-of-workgroup-3-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#15
Søren Jepsen, Jack G Caton, Jasim M Albandar, Nabil F Bissada, Philippe Bouchard, Pierpaolo Cortellini, Korkud Demirel, Massimo de Sanctis, Carlo Ercoli, Jingyuan Fan, Nicolaas C Geurs, Francis J Hughes, Lijian Jin, Alpdogan Kantarci, Evanthia Lalla, Phoebus N Madianos, Debora Matthews, Michael K McGuire, Michael P Mills, Philip M Preshaw, Mark A Reynolds, Anton Sculean, Cristiano Susin, Nicola X West, Kazuhisa Yamazaki
BACKGROUND: A variety of systemic diseases and conditions can affect the course of periodontitis or have a negative impact on the periodontal attachment apparatus. Gingival recessions are highly prevalent and often associated with hypersensitivity, the development of caries and non-carious cervical lesions on the exposed root surface and impaired esthetics. Occlusal forces can result in injury of teeth and periodontal attachment apparatus. Several developmental or acquired conditions associated with teeth or prostheses may predispose to diseases of the periodontium...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926815/neurological-complications-of-hematopoietic-cell-transplantation-in-children-and-adults
#16
REVIEW
Adriana Octaviana Dulamea, Ioana Gabriela Lupescu
Hematopoietic cell transplantation (HCT) is widely performed for neoplastic and non-neoplastic diseases. HCT involves intravenous infusion of hematopoietic progenitor cells from human leukocyte antigen (HLA)-matched donor (allogeneic) or from the patient (autologous). Before HCT, the patient is prepared with high dose chemotherapy and/or radiotherapy to destroy residual malignant cells and to reduce immunologic resistance. After HCT, chemotherapy is used to prevent graft rejection and graft versus host disease (GvHD)...
June 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29926500/periodontal-manifestations-of-systemic-diseases-and-developmental-and-acquired-conditions-consensus-report-of-workgroup-3-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#17
Søren Jepsen, Jack G Caton, Jasim M Albandar, Nabil F Bissada, Philippe Bouchard, Pierpaolo Cortellini, Korkud Demirel, Massimo de Sanctis, Carlo Ercoli, Jingyuan Fan, Nicolaas C Geurs, Francis J Hughes, Lijian Jin, Alpdogan Kantarci, Evanthia Lalla, Phoebus N Madianos, Debora Matthews, Michael K McGuire, Michael P Mills, Philip M Preshaw, Mark A Reynolds, Anton Sculean, Cristiano Susin, Nicola X West, Kazuhisa Yamazaki
BACKGROUND: A variety of systemic diseases and conditions can affect the course of periodontitis or have a negative impact on the periodontal attachment apparatus. Gingival recessions are highly prevalent and often associated with hypersensitivity, the development of caries and non-carious cervical lesions on the exposed root surface and impaired esthetics. Occlusal forces can result in injury of teeth and periodontal attachment apparatus. Several developmental or acquired conditions associated with teeth or prostheses may predispose to diseases of the periodontium...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29926151/-treatment-of-chylothorax
#18
M Schirren, S Sponholz, J Schirren
Chylothorax is an infrequent but important form of pleural effusion. The most common causes are of postoperative and neoplastic origin. No prospective or randomized trials have been performed to evaluate the available treatment options for chylothorax. The basic principles of conservative treatment include drainage of the effusion and dietary measures. Chylothorax is typically treated conservatively. In the case of failure of conservative treatment, interventional radiological or surgical procedures are applied...
June 20, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29924283/-tuberculosis-that-mimics-cancer-cases-referred-to-the-national-institute-of-neoplastic-diseases-lima-peru
#19
Juliana R Villena-Suarez, William Vicente, Luis Taxa, Luis Cuéllar, Maria T Nuñez-Butrón, Valeria Villegas, Miluska Castillo, Carlos A Castañeda
Tuberculosis (TB) is a major public health problem that, due to the clinical variability of its presentation, can be confused with cancer. The aim of this study was to identify the clinical-radiological characteristics and to describe the methodology that allowed to achieve a TB diagnosis in patients referred to the National Institute of Neoplastic Diseases (INEN) with a presumed diagnosis of cancer between 2014 and 2016. The study included 170 patients (52.4% men) with an average age of 41.1 years; 18% presented a history of contact with TB, and 5...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29924276/-optimal-cytoreduction-in-advanced-ovarian-cancer-treated-with-dose-dense-paclitaxel-and-carboplatin-followed-by-interval-surgery-at-the-peruvian-national-institute-of-neoplastic-diseases
#20
Cindy Alcarraz, Johana Muñiz, Luis Mas, Mivael Olivera, Zaida Morante, Manuel Alvarez, Raul Mantilla, Jhajaira Araujo, Joseph Pinto
To determine the rate of optimal cytoreduction in patients with advanced ovarian cancer who received neoadjuvant chemotherapy with dose-dense carboplatin and paclitaxel followed by interval debulking surgery (IDS). A retrospective study of a series of cases of Peruvian women treated with neoadjuvant chemotherapy with carboplatin (6 AUC mg/mL/min) and paclitaxel (80 mg/m2 weekly) followed by IDS, at the National Institute of Neoplastic Diseases during the 2010-2014 period. The 41 patients who made it to the interval surgery had a median age of 59 years (range: 47-73 years)...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
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