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https://www.readbyqxmd.com/read/29243779/effects-of-ngx6-expression-on-proliferation-and-invasion-of-nasopharyngeal-carcinoma-cells-and-survival-of-patients
#1
Y-T Wang, X-Y Sun, H Wang, T-T Huang, Y Wang, M-X Yang
OBJECTIVE: To detect the expressions of nasopharyngeal carcinoma-associated gene 6 (NGX6) in nasopharyngeal carcinoma cells and tissues, and to investigate the effects of NGX6 on the proliferation and invasion of nasopharyngeal carcinoma cells and the survival of patients. PATIENTS AND METHODS: The human nasopharyngeal carcinoma cells (HONE1) and immortalized human nasopharyngeal epithelial cells (NP69) were selected and cultured. The mRNA and protein expression levels of NGX6 were detected via quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243545/the-role-of-macrophages-in-the-differentiation-process-of-ureteral-polyps
#2
Yue-Hui Wang, Tian-Qi Zhang, Ji-Ning Fu, Ying Liu, Hai-Yan Jia
Objective To evaluate the role of macrophage infiltration in the differentiation process of ureteral polyps and cancers. Methods This retrospective immunohistochemical study analysed archival samples of pathologically-confirmed specimens of low- and high-grade ureteral cancer, ureteral papilloma and ureteral polyps. The samples were immunohistochemically stained for cluster of differentiation (CD)4, CD8, CD16, CD25, CD56 and CD68 using immunofluorescence in order to identify different T-lymphocyte populations and macrophages...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29243124/gut-microbiome-a-new-player-in-gastrointestinal-disease
#3
Gregor Gorkiewicz, Alexander Moschen
The gastrointestinal (GI) tract harbors a diverse and host-specific gut microbial community. Whereas host-microbe interactions are based on homeostasis and mutualism, the microbiome also contributes to disease development. In this review, we summarize recent findings connecting the GI microbiome with GI disease. Starting with a description of biochemical factors shaping microbial compositions in each gut segment along the longitudinal axis, improved histological techniques enabling high resolution visualization of the spatial microbiome structure are highlighted...
December 14, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29242509/shp2-associates-with-nuclear-localization-of-stat3-significance-in-progression-and-prognosis-of-colorectal-cancer
#4
Yan Huang, Jie Wang, Fuao Cao, Hailong Jiang, An Li, Jianzhong Li, Lei Qiu, Hao Shen, Wenjun Chang, Chuanxiang Zhou, Yamin Pan, Yiming Lu
Tyrosine phosphatase SHP2, encoded by PTPN11, has been implicated in many physiologic and pathologic processes in neoplastic progression. However, controversies are emerging from many studies, indicating SHP2 has a dual role in different types of tumors. We aimed to explore the role of SHP2 in progression and prognosis of colorectal cancer (CRC). SHP2 inhibited CRC cell proliferation and migration, and the phosphorylation of STAT3 was negatively regulated by SHP2 in CRC. SHP2 and nuclear STAT3 were examined in 270 CRC tissues...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242209/circulating-hypergranular-neoplastic-cells-not-always-leukemic-promyelocytes
#5
Concepción Prats-Martín, Rosario M Morales-Camacho
No abstract text is available yet for this article.
December 14, 2017: Blood
https://www.readbyqxmd.com/read/29241974/endometriosis-associated-ovarian-neoplasia
#6
REVIEW
Xavier Matias-Guiu, Colin J R Stewart
This article reviews the most relevant pathological and molecular features of ovarian tumours that are associated with endometriosis. Endometriosis is a common condition, affecting 5-15% of all women, and it has been estimated that 0.5-1% of cases are complicated by neoplasia. The most common malignant tumours in this setting are endometrioid adenocarcinoma and clear cell adenocarcinoma, each accounting for approximately 10% of ovarian carcinomas in Western countries. A minority of cases are associated with Lynch syndrome...
December 11, 2017: Pathology
https://www.readbyqxmd.com/read/29241970/identification-of-a-folate-receptor-targeted-near-infrared-molecular-contrast-agent-to-localize-pulmonary-adenocarcinomas
#7
Jarrod D Predina, Andrew D Newton, Courtney Connolly, Ashley Dunbar, Michael Baldassari, Charuhas Deshpande, Edward Cantu, Jason Stadanlick, Sumith A Kularatne, Philip S Low, Sunil Singhal
Non-small cell lung cancer (NSCLC) is the number one cancer killer in the United States. Despite attempted curative surgical resection, nearly 40% of patients succumb to recurrent disease. High recurrence rates may be partially explained by data suggesting that 20% of NSCLC patients harbor synchronous disease that is missed during resection. In this report, we describe the use of a novel folate receptor-targeted near-infrared contrast agent (OTL38) to improve the intraoperative localization of NSCLC during pulmonary resection...
October 26, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29241742/diagnostic-utility-of-histone-h3-3g34-w-g34r-and-g34-v-mutant-specific-antibodies-for-giant-cell-tumors-of-bone
#8
Hidetaka Yamamoto, Takeshi Iwasaki, Yuichi Yamada, Yoshihiro Matsumoto, Hiroshi Otsuka, Masato Yoshimoto, Kenichi Kohashi, Kenichi Taguchi, Ryohei Yokoyama, Yasuharu Nakashima, Yoshinao Oda
Giant cell tumors of bone (GCTBs) are characterized by mononuclear stromal cells and osteoclast-like giant cells; up to 95% have H3F3A gene mutation. The RANKL inhibitor denosumab, when used for the treatment of GCTB, leads to histological changes such as new bone formation and giant cell depletion. Here we assessed the diagnostic utility of immunohistochemical staining with the antibodies against histone H3.3G34 W, G34R and G34 V mutant proteins for GCTB and other histologically similar bone and joint lesions...
December 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/29241375/peritoneal-dissemination-of-ovarian-cancer-role-of-muc16-mesothelin-interaction-and-implications-for-treatment
#9
Ricardo Coelho, Lara Marcos-Silva, Sara Ricardo, Filipa Ponte, Antonia Costa, Jose Manuel Lopes, Leonor David
Peritoneal dissemination is a particular form of malignant progression in ovarian cancer, preceding hematogenic or lymphatic dissemination. Thus, prevention of peritoneal implantation of cancer cells is envisioned to inhibit neoplastic dissemination and therefore prolong disease remission and patient's survival. Areas covered: An extended review on the role of MUC16 (CA125) and mesothelin (MSLN), expressed in a high percentage of ovarian carcinomas, indicate that this duet is relevant for the contact between cancer cells and mesothelial cells in homotypic (cancer cell-cancer cell) and heterotypic (cancer cell-mesothelial cell) interactions...
December 14, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29241169/imaging-of-intracranial-gliomas
#10
Yuko Ono, Mikhail F Chernov, Yoshihiro Muragaki, Takashi Maruyama, Kayoko Abe, Hiroshi Iseki
Combined use of contemporary radiological modalities, particularly integration of structural, metabolic, and functional imaging, provides optimal multifaceted information for detailed characterization of intracranial gliomas. It allows differentiation of the tumor from non-neoplastic pathology, its non-invasive histopathological typing and grading, prediction of patient prognosis and clinical course of the disease, detailed planning of surgical resection or biopsy, critical postoperative assessment of the residual lesion, effective surveillance during follow-up with evaluation of effectiveness of the adjuvant therapy and timely identification of recurrence, and even insights into molecular signatures of the neoplasms...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29240722/g-protein-coupled-receptors-at-the-crossroad-between-physiologic-and-pathologic-angiogenesis-old-paradigms-and-emerging-concepts
#11
REVIEW
Ernestina M De Francesco, Federica Sotgia, Robert B Clarke, Michael P Lisanti, Marcello Maggiolini
G protein-coupled receptors (GPCRs) have been implicated in transmitting signals across the extra- and intra-cellular compartments, thus allowing environmental stimuli to elicit critical biological responses. As GPCRs can be activated by an extensive range of factors including hormones, neurotransmitters, phospholipids and other stimuli, their involvement in a plethora of physiological functions is not surprising. Aberrant GPCR signaling has been regarded as a major contributor to diverse pathologic conditions, such as inflammatory, cardiovascular and neoplastic diseases...
December 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29240254/nf-%C3%AE%C2%BAb-regulated-mir-155-via-repression-of-qki-contributes-to-the-acquisition-of-csc-like-phenotype-during-the-neoplastic-transformation-of-hepatic-cells-induced-by-arsenite
#12
Chao Chen, Fei Luo, Qianlei Yang, Dapeng Wang, Ping Yang, Junchao Xue, Xiangyu Dai, Xinlu Liu, Hui Xu, Jiachun Lu, Aihua Zhang, Qizhan Liu
Chronic exposure to arsenite can cause various human tumors. For the initiation and recurrence of human liver cancer, the acquisition of CSC-like properties is essential. In various cancers, microRNAs (miRNAs) act as regulators in induction of CSC-like properties. Liver cancers over-express miR-155, but the mechanism relating miR-155 and arsenite-induced liver cancer is unknown. Here, we show that long-term exposure of L-02 cells to arsenite increases miR-155 levels by activation of NF-κB and leads to the acquisition of CSC-like properties...
December 14, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29239192/-combined-regimens-in-immunotherapy
#13
B Melichar, M Spisarová
The advent of immunotherapy has changed our concept of how to manage metastatic disease. With the exception of relatively rare tumors, the treatment of metastatic cancer is still considered as palliative, and in systemic treatment immunotherapy is often selected, considering better tolerance. Immunotherapy opens the perspective of a long-term, possibly durable, response, and, in contrast to other approaches to targeted therapy, is active across a spectrum of tumors. Combined regimens that increase the efficacy, given the context, are thus of importance...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29239100/insulin-like-growth-factor-2-expression-in-prostate-cancer-is-regulated-by-specific-promoter-methylation
#14
Stefan Küffer, Tobias Gutting, Djeda Belharazem, Christian Sauer, M S Michel, Alexander Marx, Lutz Trojan, Philipp Ströbel
Deregulation of the Insulin-like Growth Factor (IGF) axis and dysbalance of components of the IGF system as potential therapeutic targets have been described in different tumor types. IGF2 is a major embryonic growth factor and an important activator of IGF signaling. It is regulated by imprinting in a development- and tissue-dependent manner and has been implicated in a broad range of malignancies including prostate cancer (PCa). Loss of imprinting (LOI) usually results in bi-allelic gene expression and increased levels of IGF2...
December 14, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/29238637/spinal-instability-neoplastic-score-sins-reliability-among-spine-fellows-and-resident-physicians-in-orthopedic-surgery-and-neurosurgery
#15
Shandy Fox, Michael Spiess, Luke Hnenny, Daryl R Fourney
Study Design: Reliability analysis. Objectives: The Spinal Instability Neoplastic Score (SINS) was developed for assessing patients with spinal neoplasia. It identifies patients who may benefit from surgical consultation or intervention. It also acts as a prognostic tool for surgical decision making. Reliability of SINS has been established for spine surgeons, radiologists, and radiation oncologists, but not yet among spine surgery trainees. The purpose of our study is to determine the reliability of SINS among spine residents and fellows, and its role as an educational tool...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29238579/acute-abdomen-with-a-misleading-clinical-entity
#16
Jitendra Singh Nigam, Pushpanjali Ojha, Chitrawati Bal Gargade, Archana Hemant Deshpande
Massive ovarian edema is a rare, non-neoplastic solid tumor-like lesion. It results from compromised venous and lymphatic drainage due to partial or intermittent torsion of ovarian pedicle. Pain, distension or abdominal mass, menstrual irregularities, infertility and hormone-related symptoms can be the clinical presentation. We report a case of massive ovarian edema in a 28-year-old female who presented with acute pain abdomen. She was diagnosed clinico-radiologically with solid ovarian tumor and massive ovarian edema on histology...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29237911/functional-analysis-of-ret-with-multiple-endocrine-neoplasia-type-2
#17
Meihua Zhang, Yao Liu, Jie Fu, Ying Hu, Zheng Sun
BACKGROUND: Multiple endocrine neoplastic type 2 (MEN2) is an endocrine carcinoma syndrome which is caused by a germline activation mutation that occurs during transfection (RET) proto-oncogene transmission. MEN2A patients are affected by RET (C634Y, C634R) mutation; MEN2B patients are affected by RET (M918T) mutation. AIMS: We aim to identify RET mutations' (C634R and M918T) expression, location, and signaling activation during the disease's progression, which providing a theoretical basis for the study on etiology of multiple endocrine neoplasia...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29237805/preclinical-evaluation-of-scc244-glumetinib-a-novel-potent-and-highly-selective-inhibitor-of-c-met-in-met-dependent-cancer-models
#18
Jing Ai, Yi Chen, Xia Peng, Yinchun Ji, Yong Xi, Yanyan Shen, Xinying Yang, Yi Su, Yi-Ming Sun, Yinglei Gao, Yuchi Ma, Bing Xiong, Jingkang Shen, Jian Ding, Meiyu Geng
Because the receptor tyrosine kinase c-Met plays a critical role in tumor growth, metastasis, tumor angiogenesis and drug resistance, the c-Met axis represents an attractive therapeutic target. Herein, we report the first preclinical characterization of SCC244, a novel, potent and highly selective inhibitor of c-Met kinase. SCC244 showed subnanomolar potency against c-Met kinase activity and high selectivity versus 312 other tested protein kinases, making it one of the most selective c-Met inhibitors described to date...
December 13, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29237458/cellular-effects-of-a-turmeric-root-and-rosemary-leaf-extract-on-canine-neoplastic-cell-lines
#19
Corri B Levine, Julie Bayle, Vincent Biourge, Joseph J Wakshlag
BACKGROUND: The use of nutraceuticals is gaining in popularity in human and canine oncology with a relatively limited understanding of the effects in the vastly different tumor types seen in canine oncology. We have previously shown that turmeric root (TE) and rosemary leaf (RE) extracts can work synergistically to reduce neoplastic cell growth, but the mechanisms are poorly understood and require further elucidation. RESULTS: Three different canine cell lines (C2 mastocytoma, and CMT-12 mammary carcinoma, D17 osteosarcoma) were treated with 6...
December 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29237392/chronic-exposure-of-cigarette-smoke-and-chewing-tobacco-alters-expression-of-micrornas-in-esophageal-epithelial-cells
#20
Aafaque Ahmad Khan, Jayshree Advani, Krishna Patel, Vishalakshi Nanjappa, Hitendra S Solanki, Premendu Prakash Mathur, Bipin Nair, T S Keshava Prasad, Aditi Chatterjee, Harsha Gowda
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers with high mortality rate. Cigarette smoke and chewing tobacco are well known risk factors associated with ESCC. However, molecular mechanisms associated with development of ESCC among smokers and chewers are poorly understood. MicroRNAs play an important role in regulating physiological and disease processes including esophageal cancer. OBJECTIVE AND METHODS: In this study, we developed an in vitro model by treating non-neoplastic Het-1A esophageal cell line with cigarette smoke and chewing tobacco...
December 13, 2017: MicroRNA
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