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https://www.readbyqxmd.com/read/29684363/immunolabeling-of-cleared-human-pancreata-provides-insights-into-three-dimensional-pancreatic-anatomy-and-pathology
#1
Michaël Noë, Neda Rezaee, Kaushal Asrani, Michael Skaro, Vincent P Groot, Pei-Hsun Wu, Matthew T Olson, Seung-Mo Hong, Sung Joo Kim, Matthew J Weiss, Christopher L Wolfgang, Martin A Makary, Jin He, John L Cameron, Denis Wirtz, Nicholas J Roberts, G Johan A Offerhaus, Lodewijk A A Brosens, Laura D Wood, Ralph H Hruban
Visualizing pathologies in three dimensions (3D) can provide unique insights into the biology of human diseases. A rapid and easy-to-implement dibenzyl ether-based technique was used to clear thick sections of surgically resected human pancreatic parenchyma. Protocols were applicable to both fresh and formalin-fixed paraffin-embedded tissue. The penetration of antibodies into dense pancreatic parenchyma was optimized using both gradually increasing antibody concentrations and centrifugal flow. Immunolabeling with antibodies against CK19 was visualized using both light sheet and confocal laser scanning microscopy...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29684340/myeloid-sarcoma-with-megakaryoblastic-differentiation-presenting-as-a-breast-mass
#2
Ifeyinwa E Obiorah, Metin Ozdemirli
Myeloid sarcoma is an extramedullary tumor that consists of myeloblasts or immature myeloid cells. The neoplasm can occur in any part of the body, including the bone, periosteum, lymph nodes, skin, and soft tissue and they may occur de novo or in association with acute myeloid leukemia, myeloproliferative neoplasms and myelodysplastic syndromes. Most cases display a myelomonocytic or pure monoblastic morphology. Tumors with megakaryoblastic differentiation are extremely uncommon and may occur in association with transformation of a myeloproliferative disorder...
April 17, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29683536/a-retrospective-three-year-study-of-salivary-gland-fine-needle-aspiration-cytology-with-categorisation-using-the-milan-reporting-system
#3
S A Thiryayi, Y X Low, D Shelton, N Narine, D Slater, D N Rana
OBJECTIVE: To assess our practice using the recently developed standardised classification system designated The Milan System for Reporting Salivary Cytopathology (MSRSGC) and to ascertain the rates of malignancy for each category by means of a retrospective study. METHODS: All salivary gland FNA cytology samples received between 1 January 2013 and 31 December 2015 were retrospectively assigned a diagnostic category code from the MSRSGC. Cytology results were correlated with subsequent histology (where available), clinical and radiological follow up...
April 23, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29682524/pancd44-immunohistochemical-evaluation-in-prostatectomies-from-patients-with-adenocarcinoma
#4
Carlos Gustavo Hirth, Adriele Machado Dos Santos, João Batista Gadelha de Cerqueira, Francisco Vagnaldo Fechine Jamacaru, Maria do Perpétuo Socorro Saldanha da Cunha, Conceição Aparecida Dornelas
Introduction: CD44 has been proposed as a prognostic marker and a stem cell marker but studies in patients with prostate cancer have yielded inconsistent results. Patients and Methods: Patients submitted to radical prostatectomy between 2008 and 2013 at a university hospital were followed with biannual serum PSA tests to determine the biochemical recurrence (BR). Archived paraffin blocks with neoplastic and nonneoplastic tissue were evaluated immunohistochemically for a panCD44 and MYC...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682196/testosterone-metabolites-inhibit-proliferation-of-castration-and-therapy-resistant-prostate-cancer
#5
Felix Bremmer, Hubertus Jarry, Valerie Unterkircher, Silke Kaulfuss, Peter Burfeind, Heinz-Joachim Radzun, Philipp Ströbel, Paul Thelen
Novel treatments for castration-resistant prostate cancer (CRPC) such as abiraterone acetate (AA) or enzalutamide effectively target the androgen pathway to arrest aberrant signalling and cell proliferation. Testosterone is able to inhibit tumour cell growth in CRPC. Estrogen receptor-beta (ERβ) binds the testosterone-metabolites 3β-androstanediol and 3α-androstanediol in parallel to the canonical estradiol. In the prostate it is widely accepted that ERβ regulates estrogen signalling, mediating anti-proliferative effects...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29681940/variation-of-energy-in-photobiomodulation-for-the-control-of-radiotherapy-induced-oral-mucositis-a-clinical-study-in-head-and-neck-cancer-patients
#6
Cizelene do Carmo Faleiros Veloso Guedes, Silas Antonio Juvencio de Freitas Filho, Paulo Rogério de Faria, Adriano Mota Loyola, Robinson Sabino-Silva, Sérgio Vitorino Cardoso
Oral mucositis (OM) is a frequent and severe adverse effect of therapy against head and neck cancer. Photobiomodulation with the low-power laser is known to be effective against OM, but the diversity of protocols and the possibility of stimulating residual tumor cells are still obstacles. The present study aimed to compare two doses of laser energy delivered to the oral mucosa of patients under oncologic treatment for head and neck cancer, looking for differences in the control of mucositis, as well as in the frequency of tumoral recurrences...
2018: International Journal of Dentistry
https://www.readbyqxmd.com/read/29681810/incidental-squamous-cell-carcinoma-in-an-epidermal-inclusion-cyst-a-case-report-and-review-of-the-literature
#7
Ethan Frank, David Macias, Brian Hondorp, Justin Kerstetter, Jared C Inman
Epidermal inclusion cysts are common lesions that rarely develop into squamous cell carcinoma (SCC). Neoplastic change in these cysts can be associated with prominent symptoms such as pain, rapid growth, or ulceration. This study describes the case of a 64-year-old woman with a 4-year history of a largely asymptomatic neck mass, which after routine excision was found to be an epidermal inclusion cyst harboring well-differentiated SCC. The diagnosis was made incidentally after routine cyst bisection and hematoxylin and eosin staining...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29681644/paraneoplastic-lambert-eaton-syndrome-in-a-patient-with-disseminated-metastatic-cancer
#8
Gregorio Arellano-Aguilar, Erik Santiago Núñez-Mojica, José Luis Gutiérrez-Velazco, Luis Gerardo Domínguez-Carrillo
Background: Neurological paraneoplastic syndromes are rare, occur in 0.01% of all cancer patients; like part of them, the Lambert-Eaton syndrome is an autoimmune presynaptic disorder of neuromuscular transmission characterized by muscle weakness and neurovegetative dysfunction, and often associated with small cell lung cancer. Case report: A 72 years old female with a family history of lung cancer and leukemia, with 7 months of dry cough and 3 months with waist and pelvic muscle weakness, oropharyngeal dysphagia, dry mouth, chronic constipation and weight loss of 10 kg...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29680981/future-of-diagnosing-neoplasia-in-barrett-s-esophagus-volumetric-laser-endomicroscopy
#9
REVIEW
Muhammad Aziz, Rawish Fatima
Esophageal adenocarcinoma (EAC) is one of the deadliest carcinoma faced by gastroenterologists. Any insult to esophagus that causes replacement of normal squamous epithelium with columnar intestinal epithelium is labelled as the initiating event of the metaplasia-neoplasia sequence. Barrett's esophagus is the precursor to EAC. Currently, endoscopically obtained biopsies are used to detect neoplastic changes in patients with Barrett's esophagus (BE); however, it is not cost effective and hence a better screening modality is needed...
April 21, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29679610/mutated-mitf-e87r-in-melanoma-enhances-tumor-progression-via-s100a4
#10
Alice Nordlinger, Shani Dror, Abdel Elkahloun, Justine Del Rio, Elisa Stubbs, Tami Golan, Hagar Malcov, Todd D Pricket, Julia C Cronin, Shivang Parikh, Sapir Labes, Laetitia Thomas, Gal Yankovitz, Yuval Tabach, Carmit Levy, Yardena Samuels, Mehdi Khaled
Melanoma, a melanocyte origin neoplasm, is the most lethal type of skin cancer and incidence is increasing. Several familial and somatic mutations have been identified in the gene encoding the melanocyte lineage master regulator, microphthalmia-associated transcription factor (MITF); however, the neoplastic mechanisms of these mutant MITF variants are mostly unknown. Here, by performing unbiased analysis of the transcriptomes in cells expressing mutant MITF, we identified calcium-binding protein S100A4, as a downstream target of MITF-E87R...
April 18, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29679253/fever-of-unknown-origin-fuo-cmv-infectious-mononucleosis-or-lymphoma
#11
Burke A Cunha, Karishma Chawla
Fever of unknown origin (FUO) refers to fevers of > 101 °F that persist for > 3 weeks and remain undiagnosed after a focused inpatient or outpatient workup. FUO may be due to infectious, malignant/neoplastic, rheumatic/inflammatory, or miscellaneous disorders. The FUO category determines the focus of the diagnostic workup. In the case presented of an FUO in a young woman, there were clinical findings of both CMV infectious mononucleosis or a lymphoma, e.g., highly elevated ESR, elevated ferritin levels, and elevated ACE level, β-2 microglobulins...
April 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29678984/validating-malignant-melanoma-icd-9-cm-codes-in-umbria-asl-napoli-3-sud-and-friuli-venezia-giulia-administrative-healthcare-databases-a-diagnostic-accuracy-study
#12
Massimiliano Orso, Diego Serraino, Iosief Abraha, Mario Fusco, Gianni Giovannini, Paola Casucci, Francesco Cozzolino, Annalisa Granata, Michele Gobbato, Fabrizio Stracci, Valerio Ciullo, Maria Francesca Vitale, Paolo Eusebi, Walter Orlandi, Alessandro Montedori, Ettore Bidoli
OBJECTIVES: To assess the accuracy of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes in identifying subjects with melanoma. DESIGN: A diagnostic accuracy study comparing melanoma ICD-9-CM codes (index test) with medical chart (reference standard). Case ascertainment was based on neoplastic lesion of the skin and a histological diagnosis from a primary or metastatic site positive for melanoma. SETTING: Administrative databases from Umbria Region, Azienda Sanitaria Locale (ASL) Napoli 3 Sud (NA) and Friuli Venezia Giulia (FVG) Region...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678767/targeted-inhibition-of-tumor-survival-metastasis-and-angiogenesis-by-acacia-ferruginea-mediated-regulation-of-vegf-inflammatory-mediators-cytokine-profile-and-inhibition-of-transcription-factor-activation
#13
Kunnathur Murugesan Sakthivel, Chandrasekaran Guruvayoorappan
Acacia ferruginea extract (AFE) was studied for anti-metastasis/-angiogenesis activity against B16F-10 melanoma cells in C57BL/6 mice. In vitro cytotoxicity of AFE was first screened using MTT assay and it was shown to inhibit B16F-10 cells with IC50 value of 52.94 μg/ml. Anti-metastatic activity of AFE in vivo revealed administration of AFE (10 mg/kg.b.wt) in three different regimens has shown reduced metastatic colony formation in lungs and prolonged survival in metastatic tumor-bearing hosts. Biochemical analysis shown that treatment with AFE significantly reduced the lung collagen hydroxyproline, hexosamine, uronic acid, sialic acid and gamma-glutamyl transpeptidase content...
April 17, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29678710/pediatric-type-follicular-lymphoma-in-the-dura-a-case-report-and-literature-review
#14
Junya Yamaguchi, Seiichi Kato, Eri Iwata, Kosuke Aoki, Ryusuke Kabeya, Atsushi Natsume, Toshihiko Wakabayashi
BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a relatively common tumor of the central nervous system. Although PCNSLs generally arise from the parenchyma, lymphomas arising primarily from the dura are termed dural lymphomas (DL). Mucosa-associated lymphoid tissue is the most unique histological feature of DL. Due to its rarity, clinical characteristics and treatments for DL have not been fully elucidated to date. CASE DESCRIPTION: A 31-year-old man with no past medical history presented with numbness in his left upper limb...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29677902/re-microrna-mir-371a-3p-a-novel-serum-biomarker-of-testicular-germ-cell-tumors-evidence-for-specificity-from-measurements-in-testicular-vein-blood-and-in-neoplastic-hydrocele-fluid
#15
https://www.readbyqxmd.com/read/29677189/progress-in-the-pharmacological-treatment-of-human-cystic-and-alveolar-echinococcosis-compounds-and-therapeutic-targets
#16
Mar Siles-Lucas, Adriano Casulli, Roberto Cirilli, David Carmena
Human cystic and alveolar echinococcosis are helmintic zoonotic diseases caused by infections with the larval stages of the cestode parasites Echinococcus granulosus and E. multilocularis, respectively. Both diseases are progressive and chronic, and often fatal if left unattended for E. multilocularis. As a treatment approach, chemotherapy against these orphan and neglected diseases has been available for more than 40 years. However, drug options were limited to the benzimidazoles albendazole and mebendazole, the only chemical compounds currently licensed for treatment in humans...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29676344/histopathological-pattern-of-thyroid-diseases-in-zaria-a-10-year-review
#17
Nasiru Raheem, Saad A Ahmed, Modupeola Oa Samaila
Context: Majority of the previous studies on thyroid diseases in Northern Nigeria focussed mainly on neoplastic lesions. The non-neoplastic lesions are more common and constitute more public health burdens. Aim: To determine the histopathological pattern of thyroid diseases in our region and compare our findings with similar studies in Nigeria and elsewhere. Settings and Design: This is a retrospective study carried out at the Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, from January 2005 to December 2014 using specified criteria...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29675718/ultrasound-guided-brain-surgery-echographic-visibility-of-different-pathologies-and-surgical-applications-in-neurosurgical-routine
#18
Domenico Policicchio, Artan Doda, Enrico Sgaramella, Stefano Ticca, Filippo Veneziani Santonio, Riccardo Boccaletti
BACKGROUND: The use of intraoperative ultrasound (iUS) has increased in the last 15 years becoming a standard tool in many neurosurgical centers. Our aim was to assess the utility of routine use of iUS during various types of intracranial surgery. We reviewed our series to assess ultrasound visibility of different pathologies and iUS applications during the course of surgery. MATERIALS AND METHODS: This is a retrospective review of 162 patients who underwent intracranial surgery with assistance of the iUS guidance system (SonoWand)...
April 19, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29675626/imaging-of-the-sublingual-and-submandibular-spaces
#19
REVIEW
Swapnil Patel, Alok A Bhatt
Divided by the mylohyoid muscle, the sublingual and submandibular spaces represent a relatively small part of the oral cavity, but account for a disproportionate amount of pathological processes. These entities are traditionally separated into congenital, infectious/inflammatory, vascular and neoplastic aetiologies. This article reviews the relevant anatomy, clinical highlights and distinguishing imaging features necessary for accurate characterisation. TEACHING POINTS: • The mylohyoid sling is a key anatomical landmark useful in surgical planning...
April 19, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29674709/known-and-novel-roles-of-the-met-oncogene-in-cancer-a-coherent-approach-to-targeted-therapy
#20
REVIEW
Paolo M Comoglio, Livio Trusolino, Carla Boccaccio
The MET oncogene encodes an unconventional receptor tyrosine kinase with pleiotropic functions: it initiates and sustains neoplastic transformation when genetically altered ('oncogene addiction') and fosters cancer cell survival and tumour dissemination when transcriptionally activated in the context of an adaptive response to adverse microenvironmental conditions ('oncogene expedience'). Moreover, MET is an intrinsic modulator of the self-renewal and clonogenic ability of cancer stem cells ('oncogene inherence')...
April 19, 2018: Nature Reviews. Cancer
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