keyword
MENU ▼
Read by QxMD icon Read
search

neoplasticity

keyword
https://www.readbyqxmd.com/read/29453728/single-site-port-robotic-assisted-hysterectomy-an-update
#1
REVIEW
Christos Iavazzo, Evelyn Eleni Minis, Ioannis D Gkegkes
Single-incision approach in robotic gynecology is a relatively new concept. The role of single-port systems in robotic hysterectomy, their advantages and disadvantages, as well as the technical challenges, are still under investigation. A systematic review was performed by searching in PubMed and Scopus databases. In 810 out of 1225 patients, hysterectomy was performed for non-neoplastic disease. Single-Site ® was the most common port system. Duration of the procedure and relative blood loss ranged from 60 to 311 min and 7 to 750 ml, respectively...
February 16, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29453652/significance-of-the-nonneoplastic-renal-parenchymal-findings-in-robotic-partial-nephrectomy-series
#2
Ercan Malkoç, Matthew J Maurice, Oktay Akça, Önder Kara, Homayoun Zargar, Hiury Andrade, Daniel Ramirez, Peter Caputo, Robert Stein, Demirjian Sevag, Jihad H Kaouk
AIM: To describe the pathological characteristics of the peritumoral non-neoplastic renal parenchyma (NNRP) and to investigate their impact on long-term renal function after partial nephrectomy. MATERIALS AND METHODS: In our institutional robotic partial nephrectomy database, we identified 394 cases with pathological assessment of the NNRP and long-term postoperative renal functional follow-up. The NNRP was classified as normal (healthy renal parenchyma) or abnormal, based on the presence of arteriosclerosis, glomerulosclerosis, interstitial fibrosis, interstitial inflammation, and/or tubulopapillary hyperplasia...
February 16, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29453563/rabbit-sertoli-cells-immunohistochemical-profile-from-neonatal-to-adult-age
#3
Valeria Grieco, Barbara Banco
Immunohistochemistry (IHC) on formalin-fixed paraffin-embedded tissue specimens is a widely used laboratory technique that allows the demonstration and the direct microscopical observation of antigens within tissue sections by means of specific antibodies. IHC is one the best tools to define the immunophenotype of a cell during maturation or neoplastic transformation.To investigate the immunophenotype of postnatal rabbit Sertoli cell, from neonatal to adult age, in this chapter, the immunohistochemical protocol described is one of the most common: the avidin-biotin complex (ABC) method...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29453045/activation-of-ppar%C3%AE-mediates-icaritin-induced-cell-cycle-arrest-and-apoptosis-in-glioblastoma-multiforme
#4
Yongji Liu, Ling Shi, Yuan Liu, Peng Li, Guoping Jiang, Xiaoning Gao, Yongbin Zhang, Chuanwu Jiang, Weiping Zhu, Hongxing Han, Fang Ju
BACKGROUND: Glioblastoma multiforme (GBM) is the most prevalent primary malignancy of the brain. This study was designed to investigate whether icaritin exerts anti-neoplastic activity against GBM in vitro. MATERIALS AND METHODS: Cell Counting Kit-8 (CCK-8) assay was utilized to examine the viability of GBM cells. The apoptotic cell population was measured by flow cytometry analysis. Cell cycle distribution was detected by flow cytometry as well. Western blot analysis was performed to examine the level of biomarker proteins in GBM cells...
February 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29451848/mr-imaging-of-atraumatic-muscle-disorders
#5
Edward Smitaman, Dyan V Flores, Catalina Mejía Gómez, Mini N Pathria
Atraumatic disorders of skeletal muscles include congenital variants; inherited myopathies; acquired inflammatory, infectious, or ischemic disorders; neoplastic diseases; and conditions leading to muscle atrophy. These have overlapping appearances at magnetic resonance (MR) imaging and are challenging for the radiologist to differentiate. The authors organize muscle disorders into four MR imaging patterns: (a) abnormal anatomy with normal signal intensity, (b) edema/inflammation, (c) mass, and (d) atrophy, highlighting each of their key clinical and imaging findings...
February 16, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29451524/-diet-and-gut-microbiota-two-sides-of-the-same-coin
#6
Ramona Schiumerini, Francesca Pasqui, Davide Festi
Gut microbiota is a complex ecosystem, resident in the digestive tract, exerting multiple functions that can have a significant impact on the pathophysiology of the host organism. The composition and functions of this "superorganism" are influenced by many factors, and among them, the host's dietary habits seem to have a significant effect. Dietary changes in the evolution of human history and in the different stages of life of the human subjects are responsible for qualitative and functional modification of gut microbiota...
January 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29450854/imaging-of-the-scrotum-beyond-sonography
#7
REVIEW
Gian Carlo Parenti, Francesco Feletti, Aldo Carnevale, Licia Uccelli, Melchiore Giganti
The aim of this article is to describe the role of second-level imaging techniques after an initial ultrasonography evaluation in the assessment of scrotal diseases. While ultrasonography remains central as the primary imaging modality for the evaluation of pathologic conditions of the scrotum, the role of magnetic resonance imaging continues to evolve: it can actually be valuable as a problem-solving tool when sonographic findings are equivocal or inconclusive. Magnetic resonance imaging of the scrotum may provide accurate detection and characterization of scrotal diseases, well depicting the precise location of scrotal masses (intratesticular or extratesticular) and reliably characterizing benign conditions simulating neoplastic processes, thus preventing unnecessary radical surgery...
February 15, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29449531/car-t-cells-the-long-and-winding-road-to-solid-tumors
#8
REVIEW
Maria Michela D'Aloia, Ilaria Grazia Zizzari, Benedetto Sacchetti, Luca Pierelli, Maurizio Alimandi
Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the "next generation" of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surrounding the neoplastic foci. The intricate net of cross-interactions occurring between tumor components, stromal and immune cells leads to an ineffective anergic status favoring the evasion from the host's defenses. Our goal is hereby to trace the road imposed by solid tumors to CAR-T cells, highlighting pitfalls and strategies to be developed and refined to possibly overcome these hurdles...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29449433/highly-similar-genomic-landscapes-in-monoclonal-b-cell-lymphocytosis-and-ultra-stable-chronic-lymphocytic-leukemia-with-low-frequency-of-driver-mutations
#9
Andreas Agathangelidis, Viktor Ljungström, Lydia Scarfò, Claudia Fazi, Maria Gounari, Tatjana Pandzic, Lesley-Ann Sutton, Kostas Stamatopoulos, Giovanni Tonon, Richard Rosenquist, Paolo Ghia
Despite the recent discovery of recurrent driver mutations in chronic lymphocytic leukemia, the genetic factors involved in disease onset remain largely unknown. To address this issue, we performed whole-genome sequencing in 11 individuals with monoclonal B-cell lymphocytosis, both of the low-count and high-count subtypes, and 5 patients with ultra-stable chronic lymphocytic leukemia (>10 years without progression from initial diagnosis). All three entities were indistiguishable at the genomic level exhibiting low genomic complexity and similar types of somatic mutations...
February 15, 2018: Haematologica
https://www.readbyqxmd.com/read/29449275/circulating-tumor-dna-reveals-genetics-clonal-evolution-and-residual-disease-in-classical-hodgkin-lymphoma
#10
Valeria Spina, Alessio Bruscaggin, Annarosa Cuccaro, Maurizio Martini, Martina Di Trani, Gabriela Forestieri, Martina Manzoni, Adalgisa Condoluci, Alberto Arribas, Lodovico Terzi-Di-Bergamo, Silvia Laura Locatelli, Elisa Cupelli, Luca Ceriani, Alden A Moccia, Anastasios Stathis, Luca Nassi, Clara Deambrogi, Fary Diop, Francesca Guidetti, Alessandra Cocomazzi, Salvatore Annunziata, Vittoria Rufini, Alessandro Giordano, Antonino Neri, Renzo Boldorini, Bernhard Gerber, Francesco Bertoni, Michele Ghielmini, Georg Stüssi, Armando Santoro, Franco Cavalli, Emanuele Zucca, Luigi Maria Larocca, Gianluca Gaidano, Stefan Hohaus, Carmelo Carlo-Stella, Davide Rossi
The rarity of neoplastic cells in the biopsy imposes major technical hurdles that have so far limited genomic studies in classical Hodgkin lymphoma (cHL). By using a highly sensitive and robust deep-next-generation-sequencing approach for circulating tumor DNA (ctDNA), here we aimed at tracking the genetics of cHL in different clinical phases, and its modifications upon treatment. The analysis was based on specimens collected from 80 newly diagnosed and 32 refractory cHL patients, including longitudinal samples collected under ABVD chemotherapy and longitudinal samples from relapsing patients treated with chemotherapy and immunotherapy...
February 15, 2018: Blood
https://www.readbyqxmd.com/read/29449042/computed-tomography-imaging-of-non-neoplastic-and-neoplastic-benign-gastric-disease
#11
REVIEW
Maria Zulfiqar, Anup Shetty, Vilaas Shetty, Christine Menias
Gastric disease is a common finding in patients imaged in the emergency department, with radiologists encountering more and more benign gastric disease on CT. In this case based review, we discuss CT appearance of various benign gastric pathology including self-limiting conditions such as gastritis, different benign gastric neoplasms, as well as life threatening disorders such as perforation, obstruction, and hemorrhage.
January 11, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29449039/clinical-guidelines-for-endoscopic-mucosal-resection-of-non-pedunculated-colorectal-lesions
#12
Eduardo Albéniz, María Pellisé, Antonio Z Gimeno García, Alfredo José Lucendo, Pedro A Alonso Aguirre, Alberto Herreros de Tejada, Marco Antonio Álvarez, María Fraile, Maite Herráiz Bayod, Leopoldo López Rosés, David Martínez Ares, Akiko Ono, Adolfo Parra Blanco, Eduardo Redondo, Andrés Sánchez Yagüe, Santiago Soto, José Díaz Tasende, Marta Montes Díaz, Manuel Rodríguez Téllez, Orlando García, Alba Zuñiga Ripa, Marta Hernández Conde, Fernando Alberca de Las Parras, Carla Gargallo, Esteban Saperas, Miguel Muñoz Navas, Javier Gordillo, Felipe Ramos Zabala, José Manuel Echevarría, Marco Bustamante, Mariano González Haba, Ferrán González Huix, Begoña González Suárez, Juan José Vila Costas, Carlos Guarner Argente, Fernando Múgica, Julyssa Cobián, Joaquín Rodríguez Sánchez, Bartolomé López Viedma, Noel Pin, José Carlos Marín Gabriel, Óscar Nogales, Joaquín de la Peña, Francisco Javier Navajas León, Helena León Brito, David Remedios, José Miguel Esteban, David Barquero, Juan Gabriel Martínez Cara, Felipe Martínez Alcalá, Ignacio Fernández Urién, Eduardo Valdivielso
This document summarizes the contents of the Clinical Guidelines for the Endoscopic Mucosal Resection of Non-Pedunculated Colorectal Lesions that was developed by the working group of the Spanish Society of Digestive Endoscopy (GSEED of Endoscopic Resection). This document presents recommendations for the endoscopic management of superficial colorectal neoplastic lesions.
February 12, 2018: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29448904/proliferative-lesions-of-the-endometrium-of-50-four-toed-hedgehogs-atelerix-albiventris
#13
James K Chambers, Takanori Shiga, Haruka Takimoto, Atsushi Dohata, Yasutsugu Miwa, Hiroyuki Nakayama, Kazuyuki Uchida
Uteri from 50 four-toed hedgehogs ( Atelerix albiventris) with clinical signs of uterine disease were histopathologically examined. Sixteen animals (32%) were diagnosed with endometrial hyperplasia, 7 animals (14%) were diagnosed with endometrial polyp, and 27 animals (54%) were diagnosed with endometrial neoplasia. The mean ages of the animals with endometrial hyperplasia, polyp, and neoplasia were 28.7 months, 29.4 months, and 25.2 months, respectively. The neoplasms were classified into 7 endometrial mixed tumors, 12 endometrial stromal nodules, and 8 endometrial stromal sarcomas...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29447925/dj-1-is-a-useful-biomarker-for-invasive-extrahepatic-cholangiocarcinoma
#14
Yukiko Tabata, Yoshitsugu Nakanishi, Kanako C Hatanaka, Yutaka Hatanaka, Takahiro Tsuchikawa, Keisuke Okamura, Takehiro Noji, Toshiaki Shichinohe, Yoshihiro Matsuno, Satoshi Hirano
We have previously reported that DJ-1 protein is up-regulated in cholangiocarcinoma compared with non-neoplastic epithelium of the bile duct in a study using liquid chromatography mass spectrometry-based proteomics. The aim of this study was to clarify whether DJ-1 expression offers a biomarker for patients with invasive extrahepatic cholangiocarcinoma (EHCC) who undergo surgical resection with curative intent. Positive immunohistochemical (IHC) staining of DJ-1 was significantly more frequent in the cytoplasm of 96 invasive EHCCs (n=28, 29...
February 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29446940/ru-ii-compounds-next-generation-anticancer-metallotherapeutics
#15
Sreekanth Thota, Daniel A Rodrigues, Debbie C Crans, Eliezer J Barreiro
Metal based therapeutics are a precious class of drugs in oncology research that include examples of theranostic drugs, which are active both in diagnostic, specifically imaging, and therapeutics applications. Ruthenium compounds have shown selective bioactivity and the ability to overcome the resistance that platinum-based therapeutics face, making them effective oncotherapeutic competitors in rational drug invention approaches. The development of antineoplastic ruthenium therapeutics is of particular interest because ruthenium containing complexes NAMI-A, KP1019 and KP1339 entered clinical trials and DW1/2 is in preclinical levels...
February 15, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29446156/3d-nir-ii-molecular-imaging-distinguishes-targeted-organs-with-high-performance-nir-ii-bioconjugates
#16
Shoujun Zhu, Sonia Herraiz, Jingying Yue, Mingxi Zhang, Hao Wan, Qinglai Yang, Zhuoran Ma, Yan Wang, Jiahuan He, Alexander L Antaris, Yeteng Zhong, Shuo Diao, Yi Feng, Ying Zhou, Kuai Yu, Guosong Hong, Yongye Liang, Aaron J Hsueh, Hongjie Dai
Greatly reduced scattering in the second near-infrared (NIR-II) region (1000-1700 nm) opens up many new exciting avenues of bioimaging research, yet NIR-II fluorescence imaging is mostly implemented by using nontargeted fluorophores or wide-field imaging setups, limiting the signal-to-background ratio and imaging penetration depth due to poor specific binding and out-of-focus signals. A newly developed high-performance NIR-II bioconjugate enables targeted imaging of a specific organ in the living body with high quality...
February 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29444964/electrical-stimulation-of-the-dorsolateral-prefrontal-cortex-impairs-semantic-cognition
#17
Guillaume Herbet, Sylvie Moritz-Gasser, Hugues Duffau
OBJECTIVE: To identify the prefrontal cortical structures causally involved in verbal and nonverbal semantic cognition in both cerebral hemispheres. METHODS: We retrospectively screened the intraoperative brain mapping data of 584 patients who underwent neurosurgery for neoplastic tumor under local anesthesia with direct cortical electrostimulation. Patients were included if they were right-handed, recently diagnosed with a diffuse low-grade glioma, and had a positive language mapping for verbal (naming task) and nonverbal (visual semantic association task) semantic cognition in the prefrontal cortex (n = 49)...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444544/uridine-5-diphospho-glucuronosyltransferase-1a-expression-as-an-independent-prognosticator-in-urothelial-carcinoma-of-the-upper-urinary-tract
#18
Koji Izumi, Satoshi Inoue, Hiroki Ide, Kazutoshi Fujita, Taichi Mizushima, Guiyang Jiang, Seiji Yamaguchi, Hiroaki Fushimi, Norio Nonomura, Hiroshi Miyamoto
OBJECTIVE: To determine the expression status of uridine 5'diphospho-glucuronosyltransferase 1A, a major phase II drug metabolism enzyme, in upper urinary tract urothelial carcinoma, as well as to assess its prognostic significance. METHODS: We immunohistochemically stained for uridine 5'diphospho-glucuronosyltransferase 1A in tissue microarray consisting of 99 upper urinary tract urothelial carcinoma samples and paired non-neoplastic urothelial tissues. We also assessed the effect of uridine 5'diphospho-glucuronosyltransferase 1A knockdown on urothelial cancer cell growth...
February 14, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29443924/identification-of-key-pathways-and-genes-in-the-dynamic-progression-of-hcc-based-on-wgcna
#19
Li Yin, Zhihui Cai, Baoan Zhu, Cunshuan Xu
Hepatocellular carcinoma (HCC) is a devastating disease worldwide. Though many efforts have been made to elucidate the process of HCC, its molecular mechanisms of development remain elusive due to its complexity. To explore the stepwise carcinogenic process from pre-neoplastic lesions to the end stage of HCC, we employed weighted gene co-expression network analysis (WGCNA) which has been proved to be an effective method in many diseases to detect co-expressed modules and hub genes using eight pathological stages including normal, cirrhosis without HCC, cirrhosis, low-grade dysplastic, high-grade dysplastic, very early and early, advanced HCC and very advanced HCC...
February 14, 2018: Genes
https://www.readbyqxmd.com/read/29443391/human-papillomavirus-genome-integration-in-squamous-carcinogenesis-what-have-next-generation-sequencing-studies-taught-us
#20
REVIEW
Ian J Groves, Nicholas Coleman
Human papillomavirus (HPV) infection is associated with ~5% of all human cancers, including a range of squamous cell carcinomas (SCCs). Persistent infection by high-risk HPVs (HRHPVs) is associated with the integration of virus genomes (which are usually stably maintained as extrachromosomal episomes) into host chromosomes. Although HRHPV integration rates differ across human sites of infection, this process appears to be an integral event in HPV-associated neoplastic progression, leading to deregulation of virus oncogene expression, host gene expression modulation and further genomic instability...
February 14, 2018: Journal of Pathology
keyword
keyword
63684
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"