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JOURNAL ARTICLE
Zheng Zhang, Elizabeth Cisneros, Ha Yeon Lee, Jeanne P Vu, Qiyu Chen, Casey N Benadof, Jacob Whitehill, Ryin Rouzbehani, Dominique T Sy, Jeannie S Huang, Terrence J Sejnowski, Joseph Jankovic, Stewart Factor, Christopher G Goetz, Richard L Barbano, Joel S Perlmutter, Hyder A Jinnah, Brian D Berman, Sarah Pirio Richardson, Glenn T Stebbins, Cynthia L Comella, David A Peterson
OBJECTIVE: Deviated head posture is a defining characteristic of cervical dystonia (CD). Head posture severity is typically quantified with clinical rating scales such as the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). Because clinical rating scales are inherently subjective, they are susceptible to variability that reduces their sensitivity as outcome measures. The variability could be circumvented with methods to measure CD head posture objectively. However, previously used objective methods require specialized equipment and have been limited to studies with a small number of cases...
May 2022: Annals of Clinical and Translational Neurology
#22
JOURNAL ARTICLE
Jeanne P Vu, Elizabeth Cisneros, Ha Yeon Lee, Linh Le, Qiyu Chen, Xiaoyan A Guo, Ryin Rouzbehani, Joseph Jankovic, Stewart Factor, Christopher G Goetz, Richard L Barbano, Joel S Perlmutter, Hyder A Jinnah, Sarah Pirio Richardson, Glenn T Stebbins, Rodger Elble, Cynthia L Comella, David A Peterson
BACKGROUND: Head tremor (HT) is a common feature of cervical dystonia (CD), usually quantified by subjective observation. Technological developments offer alternatives for measuring HT severity that are objective and amenable to automation. OBJECTIVES: Our objectives were to develop CMOR (Computational Motor Objective Rater; a computer vision-based software system) to quantify oscillatory and directional aspects of HT from video recordings during a clinical examination and to test its convergent validity with clinical rating scales...
March 15, 2022: Journal of the Neurological Sciences
#23
JOURNAL ARTICLE
Clare Rock, Rebecca Perlmutter, David Blythe, Jacqueline Bork, Kimberly Claeys, Sara E Cosgrove, Kate Dzintars, Valeria Fabre, Anthony D Harris, Emily Heil, Yea-Jen Hsu, Sara Keller, Lisa L Maragakis, Aaron M Milstone, Daniel J Morgan, Prashila Dullabh, Petry S Ubri, Christina Rotondo, Richard Brooks, Surbhi Leekha
To evaluate changes in Clostridioides difficile incidence rates for Maryland hospitals that participated in the Statewide Prevention and Reduction of C. difficile (SPARC) collaborative. Pre-post, difference-in-difference analysis of non-randomised intervention using four quarters of preintervention and six quarters of postintervention National Healthcare Safety Network data for SPARC hospitals (April 2017 to March 2020) and 10 quarters for control hospitals (October 2017 to March 2020). Mixed-effects negative binomial models were used to assess changes over time...
February 2022: BMJ Quality & Safety
#24
JOURNAL ARTICLE
Meng Wang, Tolulope Sajobi, Francesca Morgante, Charles Adler, Pinky Agarwal, Tobias Bäumer, Alfredo Berardelli, Brian D Berman, Joel Blumin, Max Borsche, Allison Brashear, Andres Deik, Kevin Duque, Alberto J Espay, Gina Ferrazzano, Jeanne Feuerstein, Susan Fox, Samuel Frank, Mark Hallett, Joseph Jankovic, Mark S LeDoux, Julie Leegwater-Kim, Abhimanyu Mahajan, Irene A Malaty, William Ondo, Alexander Pantelyat, Sarah Pirio-Richardson, Emmanuel Roze, Rachel Saunders-Pullman, Oksana Suchowersky, Daniel Truong, Marie Vidailhet, Aparna Wagle Shukla, Joel S Perlmutter, Hyder A Jinnah, Davide Martino
BACKGROUND AND PURPOSE: Several clinical and demographic factors relate to anatomic spread of adult-onset isolated dystonia, but a predictive model is still lacking. The aims of this study were: (i) to develop and validate a predictive model of anatomic spread of adult-onset isolated dystonia; and (ii) to evaluate whether presence of tremor associated with dystonia influences model predictions of spread. METHODS: Adult-onset isolated dystonia participants with focal onset from the Dystonia Coalition Natural History Project database were included...
July 22, 2021: European Journal of Neurology
#25
COMMENT
David S Knopman, Joel S Perlmutter
No abstract text is available yet for this article.
September 14, 2021: Neurology
#26
JOURNAL ARTICLE
Elizabeth Cisneros, Jeanne P Vu, Ha Yeon Lee, Qiyu Chen, Casey N Benadof, Zheng Zhang, Emily A Pettitt, Subhagya K Joshi, Richard L Barbano, Joseph Jankovic, Hyder A Jinnah, Joel S Perlmutter, Brian D Berman, Abhimanyu Mahajan, Christopher G Goetz, Glenn T Stebbins, Cynthia L Comella, David A Peterson
Background: A defining characteristic of dystonia is its position-dependence. In cervical dystonia (CD), sensory tricks ameliorate head tremor (HT). But it remains unknown whether raising the arms alone has the same impact. Methods: We analyzed data collected from patients enrolled by the Dystonia Coalition. For 120 patients with HT, we assessed how raising their arms without touching their head changed their HT severity. Results: Forty-eight out of 120 patients exhibited changes in HT severity when raising their arms...
June 23, 2021: Tremor and Other Hyperkinetic Movements
#27
JOURNAL ARTICLE
Irene Rembado, Weiguo Song, David K Su, Ariel Levari, Larry E Shupe, Steve Perlmutter, Eberhard Fetz, Stavros Zanos
Vagus nerve stimulation (VNS) has been tested as therapy for several brain disorders and as a means to modulate cortical excitability and brain plasticity. Cortical effects of VNS, manifesting as vagal-evoked potentials (VEPs), are thought to arise from activation of ascending cholinergic and noradrenergic systems. However, it is unknown whether those effects are modulated by brain state at the time of stimulation. In 2 freely behaving macaque monkeys, we delivered short trains of 5 pulses to the left cervical vagus nerve at different frequencies (5-300 Hz) while recording local field potentials (LFPs) from sites in contralateral prefrontal, sensorimotor and parietal cortical areas...
June 21, 2021: Cerebral Cortex
#28
JOURNAL ARTICLE
Sara M Tolaney, Elizabeth Garrett-Mayer, Julia White, Victoria S Blinder, Jared C Foster, Laleh Amiri-Kordestani, E Shelley Hwang, Judith M Bliss, Eileen Rakovitch, Jane Perlmutter, Patricia A Spears, Elizabeth Frank, Nadine M Tung, Anthony D Elias, David Cameron, Neelima Denduluri, Ana F Best, Angelo DiLeo, Lawrence Baizer, Lynn Pearson Butler, Elena Schwartz, Eric P Winer, Larissa A Korde
PURPOSE: The Standardized Definitions for Efficacy End Points (STEEP) criteria, established in 2007, provide standardized definitions of adjuvant breast cancer clinical trial end points. Given the evolution of breast cancer clinical trials and improvements in outcomes, a panel of experts reviewed the STEEP criteria to determine whether modifications are needed. METHODS: We conducted systematic searches of ClinicalTrials.gov for adjuvant systemic and local-regional therapy trials for breast cancer to investigate if the primary end points reported met STEEP criteria...
August 20, 2021: Journal of Clinical Oncology
#29
REVIEW
Gamze Kilic-Berkmen, Laura J Wright, Joel S Perlmutter, Cynthia Comella, Mark Hallett, Jan Teller, Sarah Pirio Richardson, David A Peterson, Carlos Cruchaga, Codrin Lungu, H A Jinnah
Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal postures, repetitive movements, or both. Research in dystonia has been challenged by several factors. First, dystonia is uncommon. Dystonia is not a single disorder but a family of heterogenous disorders with varied clinical manifestations and different causes. The different subtypes may be seen by providers in different clinical specialties including neurology, ophthalmology, otolaryngology, and others...
2021: Frontiers in Neurology
#30
JOURNAL ARTICLE
Patricia M LoRusso, Aleksandar Sekulic, Jeffrey A Sosman, Winnie S Liang, John Carpten, David W Craig, David B Solit, Alan H Bryce, Jeffrey A Kiefer, Jessica Aldrich, Sara Nasser, Rebecca Halperin, Sara A Byron, Mary Jo Pilat, Scott A Boerner, Diane Durecki, William P D Hendricks, Daniel Enriquez, Tyler Izatt, Jonathan Keats, Christophe Legendre, Svetomir N Markovic, Amy Weise, Fatima Naveed, Jessica Schmidt, Gargi D Basu, Shobana Sekar, Jonathan Adkins, Erica Tassone, Karthigayini Sivaprakasam, Victoria Zismann, Valerie S Calvert, Emanuel F Petricoin, Leslie Anne Fecher, Christopher Lao, J Paul Eder, Nicholas J Vogelzang, Jane Perlmutter, Mark Gorman, Barbara Manica, Lisa Fox, Nicholas Schork, Daniel Zelterman, Michelle DeVeaux, Richard W Joseph, C Lance Cowey, Jeffrey M Trent
Although combination BRAF and MEK inhibitors are highly effective for the 40-50% of cutaneous metastatic melanomas harboring BRAFV600 mutations, targeted agents have been ineffective for BRAFV600wild-type (wt) metastatic melanomas. The SU2C Genomics-Enabled Medicine for Melanoma Trial utilized a Simon two-stage optimal design to assess whether comprehensive genomic profiling improves selection of molecular-based therapies for BRAFV600wt metastatic melanoma patients who had progressed on standard-of-care therapy, which may include immunotherapy...
2021: PloS One
#31
JOURNAL ARTICLE
Lila H Levinson, David J Caldwell, Jeneva A Cronin, Brady Houston, Steve I Perlmutter, Kurt E Weaver, Jeffrey A Herron, Jeffrey G Ojemann, Andrew L Ko
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a clinically effective tool for treating medically refractory Parkinson's disease (PD), but its neural mechanisms remain debated. Previous work has demonstrated that STN DBS results in evoked potentials (EPs) in the primary motor cortex (M1), suggesting that modulation of cortical physiology may be involved in its therapeutic effects. Due to technical challenges presented by high-amplitude DBS artifacts, these EPs are often measured in response to low-frequency stimulation, which is generally ineffective at PD symptom management...
2021: Frontiers in Human Neuroscience
#32
JOURNAL ARTICLE
Kamyar Kalantar-Zadeh, Peter A McCullough, Sanjay Kumar Agarwal, Srinivasan Beddhu, Mona Boaz, Annette Bruchfeld, Philippe Chauveau, Jing Chen, Patricia de Sequera, Nieltje Gedney, Thomas A Golper, Malini Gupta, Tess Harris, Lori Hartwell, Vassilios Liakopoulos, Joel D Kopple, Csaba P Kovesdy, Iain C Macdougall, Johannes F E Mann, Donald Molony, Keith C Norris, Jeffrey Perlmutter, Connie M Rhee, Leonardo V Riella, Steven D Weisbord, Carmine Zoccali, David Goldsmith
A recently published nomenclature by a "Kidney Disease Improving Global Outcomes" (KDIGO) Consensus Conference suggested that the word "kidney" should be used in medical writings instead of "renal" or "nephro" when referring to kidney disease and kidney health. Whereas the decade-old move to use "kidney" more frequently should be supported when communicating with the public-at-large, such as the World Kidney Day, or in English speaking countries in communications with patients, care-partners, and non-medical persons, our point of view is that "renal" or "nephro" should not be removed from scientific and technical writings...
June 2021: Journal of Nephrology
#33
JOURNAL ARTICLE
Lisa A Campbell, Jenna R LaFreniere, Mhd Hasan Almekdash, David D Perlmutter, Huaxin Song, Patricia J Kelly, Rohali Keesari, Kay Leigh Shannon
Incivilities are pervasive among workers in healthcare institutions. Previously identified effects include deterioration of employee physical and mental health, absenteeism, burnout, and turnover, as well as reduced patient safety and quality of care. This study documented factors related to organizational civility at an academic health sciences center (AHSC) as the basis for future intervention work. We used a cross-sectional research design to conduct an online survey at four of five campuses of an AHSC. Using the Organizational Civility Scale (OCS), we assessed differences across gender, race (White and non-White) and job type (faculty or staff) in the eleven subscales (frequency of incivility, perceptions of organizational climate, existence of civility resources, importance of civility resources, feelings about current employment, employee satisfaction, sources of stress, coping strategies, overall levels of stress/coping ability, and overall civility rating)...
2021: PloS One
#34
JOURNAL ARTICLE
Jeanne P Vu, Ha Yeon Lee, Qiyu Chen, Elizabeth Cisneros, Richard L Barbano, Christopher G Goetz, Joseph Jankovic, Hyder A Jinnah, Joel S Perlmutter, Brian D Berman, Mark I Appelbaum, Glenn T Stebbins, Cynthia L Comella, David A Peterson
BACKGROUND: Although head tremor (HT) and pain are prevalent in cervical dystonia (CD), their joint relationship to phenotypic features of focal dystonia remains unclear. OBJECTIVES: We examined how severity of HT and pain are associated with age of CD onset and duration, and whether HT subtypes ("jerky" or "regular") exhibit distinct relationships between severity of HT and pain. METHODS: The severity of HT and pain were assessed with the Toronto Western Spasmodic Torticollis Rating Scale in retrospective review of 188 CD patients recruited through the Dystonia Coalition...
May 2021: Journal of Neurology
#35
JOURNAL ARTICLE
Elizabeth Cisneros, Glenn T Stebbins, Qiyu Chen, Jeanne P Vu, Casey N Benadof, Zheng Zhang, Richard L Barbano, Susan H Fox, Christopher G Goetz, Joseph Jankovic, Hyder A Jinnah, Joel S Perlmutter, Charles H Adler, Stewart A Factor, Stephen G Reich, Ramon Rodriguez, Lawrence L Severt, Natividad P Stover, Brian D Berman, Cynthia L Comella, David A Peterson
OBJECTIVES: To investigate hypothesized sources of error when quantifying the effect of the sensory trick in cervical dystonia (CD) with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS-2), test strategies to mitigate them, and provide guidance for future research on the sensory trick. METHODS: Previous analyses suggested the sensory trick (or "alleviating maneuver", AM) item be removed from the TWSTRS-2 because of its poor clinimetric properties. We hypothesized three sources of clinimetric weakness for rating the AM: 1) whether patients were given sufficient time to demonstrate their AM; 2) whether patients' CD was sufficiently severe for detecting AM efficacy; and 3) whether raters were inadvertently rating the item in reverse of scale instructions...
December 15, 2020: Journal of the Neurological Sciences
#36
JOURNAL ARTICLE
David S May, Linda R van Dillen, Gammon M Earhart, Kerri S Rawson, Joel S Perlmutter, Ryan P Duncan
Subthalamic nucleus deep brain stimulation (STN-DBS) and levodopa are common treatment strategies for Parkinson's disease (PD). However, the specific effects of these treatment strategies on balance and its components remain unclear. This cross-sectional study of people with PD and STN-DBS compared balance in the treated state (ON-medication/ON-stimulation) and untreated state (OFF-medication/OFF-stimulation) using the Balance Evaluation Systems Test (BESTest). Total BESTest scores from the treated and untreated states were compared to assess overall balance...
September 30, 2020: Brain Sciences
#37
JOURNAL ARTICLE
Joshua Olson, David S Perlmutter, Peter T S DeVore, Jason T Chou
A real-time jitter meter is used to measure and digitally sample the pulse-to-pulse timing error in a laser pulse train. The jitter meter is self-referenced using a single-pulse delay line interferometer and measures timing jitter using optical heterodyne detection between two frequency channels of the pulse train. Jitter sensitivity down to 3×10-10 f s 2 / H z at 500 MHz has been demonstrated with a pulse-to-pulse noise floor of 1.6 fs. As a proof of principle, the digital correction of the output of a high-frequency photonic analog-to-digital converter (PADC) is demonstrated with an emulated jitter signal...
September 15, 2020: Optics Letters
#38
JOURNAL ARTICLE
Noelle E Carlozzi, Nicholas R Boileau, Matthew W Roché, Rebecca E Ready, Joel S Perlmutter, Kelvin L Chou, Stacey K Barton, Michael K McCormack, Julie C Stout, David Cella, Jennifer A Miner, Jane S Paulsen
BACKGROUND: The majority of persons with Huntington disease (HD) experience mental health symptoms. Patient-reported outcome (PRO) measures are capable of capturing unobservable behaviors and feelings relating to mental health. The current study aimed to test the reliability and responsiveness to self-reported and clinician-rated change over time of Neuro-QoL and PROMIS mental health PROs over the course of a 24-month period. METHODS: At baseline, 12-months, and 24-months, 362 participants with premanifest or manifest HD completed the Neuro-QoL Depression computer adaptive test (CAT), PROMIS Depression short form (SF), Neuro-QoL Anxiety CAT, PROMIS Anxiety SF, PROMIS Anger CAT and SF, Neuro-QoL Emotional/Behavioral Dyscontrol CAT and SF, Neuro-QoL Positive Affect and Well-Being CAT and SF, and Neuro-QoL Stigma CAT and SF...
August 19, 2020: Quality of Life Research
#39
RANDOMIZED CONTROLLED TRIAL
Douglas Yee, Angela M DeMichele, Christina Yau, Claudine Isaacs, W Fraser Symmans, Kathy S Albain, Yunn-Yi Chen, Gregor Krings, Shi Wei, Shuko Harada, Brian Datnow, Oluwole Fadare, Molly Klein, Stefan Pambuccian, Beiyun Chen, Kathi Adamson, Sharon Sams, Paulette Mhawech-Fauceglia, Anthony Magliocco, Mike Feldman, Mara Rendi, Husain Sattar, Jay Zeck, Idris T Ocal, Ossama Tawfik, Lauren Grasso LeBeau, Sunati Sahoo, Tuyethoa Vinh, A Jo Chien, Andres Forero-Torres, Erica Stringer-Reasor, Anne M Wallace, Lajos Pusztai, Judy C Boughey, Erin D Ellis, Anthony D Elias, Janice Lu, Julie E Lang, Hyo S Han, Amy S Clark, Rita Nanda, Donald W Northfelt, Qamar J Khan, Rebecca K Viscusi, David M Euhus, Kirsten K Edmiston, Stephen Y Chui, Kathleen Kemmer, John W Park, Minetta C Liu, Olufunmilayo Olopade, Brian Leyland-Jones, Debasish Tripathy, Stacy L Moulder, Hope S Rugo, Richard Schwab, Shelly Lo, Teresa Helsten, Heather Beckwith, Patricia Haugen, Nola M Hylton, Laura J Van't Veer, Jane Perlmutter, Michelle E Melisko, Amy Wilson, Garry Peterson, Adam L Asare, Meredith B Buxton, Melissa Paoloni, Julia L Clennell, Gillian L Hirst, Ruby Singhrao, Katherine Steeg, Jeffrey B Matthews, Smita M Asare, Ashish Sanil, Scott M Berry, Laura J Esserman, Donald A Berry
Importance: Pathologic complete response (pCR) is a known prognostic biomarker for long-term outcomes. The I-SPY2 trial evaluated if the strength of this clinical association persists in the context of a phase 2 neoadjuvant platform trial. Objective: To evaluate the association of pCR with event-free survival (EFS) and pCR with distant recurrence-free survival (DRFS) in subpopulations of women with high-risk operable breast cancer treated with standard therapy or one of several novel agents...
September 1, 2020: JAMA Oncology
#40
JOURNAL ARTICLE
Katherine Fay, Mathew R P Sapiano, Runa Gokhale, Raymund Dantes, Nicola Thompson, David E Katz, Susan M Ray, Lucy E Wilson, Rebecca Perlmutter, Joelle Nadle, Deborah Godine, Linda Frank, Geoff Brousseau, Helen Johnston, Wendy Bamberg, Ghinwa Dumyati, Deborah Nelson, Ruth Lynfield, Malini DeSilva, Marion Kainer, Alexia Zhang, Valerie Ocampo, Monika Samper, Rebecca Pierce, Lourdes Irizarry, Marla Sievers, Meghan Maloney, Anthony Fiore, Shelley S Magill, Lauren Epstein
Importance: Current information on the characteristics of patients who develop sepsis may help in identifying opportunities to improve outcomes. Most recent studies of sepsis epidemiology have focused on changes in incidence or have used administrative data sets that provided limited patient-level data. Objective: To describe sepsis epidemiology in adults. Design, Setting, and Participants: This retrospective cohort study reviewed the medical records, death certificates, and hospital discharge data of adult patients with sepsis or septic shock who were discharged from the hospital between October 1, 2014, and September 30, 2015...
July 1, 2020: JAMA Network Open
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