keyword
MENU ▼
Read by QxMD icon Read
search

sabrina

keyword
https://www.readbyqxmd.com/read/29150549/psychometric-validation-of-the-needs-assessment-tool-progressive-disease-in-interstitial-lung-disease
#1
Miriam J Johnson, Armita Jamali, Joy Ross, Caroline Fairhurst, Jason Boland, Carla Reigada, Simon Paul Hart, Gunn Grande, David C Currow, Athol U Wells, Sabrina Bajwah, Thanos Papadopoulos, J Martin Bland, Janelle Yorke
The inter-rater/test-retest reliability and construct validity of a palliative care needs assessment tool in interstitial lung disease (NAT:PD-ILD) were tested using NAT:PD-ILD-guided video-recorded consultations, and NAT:PD-ILD-guided consultations, and patient and carer-report outcomes (St George's Respiratory Questionnaire (SGRQ)-ILD, Carer Strain Index (CSI)/Carer Support Needs Assessment Tool (CSNAT)). 11/16 items reached at least fair inter-rater agreement; 5 items reached at least moderate test-retest agreement...
November 17, 2017: Thorax
https://www.readbyqxmd.com/read/29150335/camptothecin-psammaplin-a-hybrids-as-topoisomerase-i-and-hdac-dual-action-inhibitors
#2
Raffaella Cincinelli, Loana Musso, Roberto Artali, Mario Guglielmi, Erminia Bianchino, Francesco Cardile, Fabiana Colelli, Claudio Pisano, Sabrina Dallavalle
Recent studies have demonstrated enhanced anticancer effects of combination therapy consisting of camptothecin derivatives and HDAC inhibitors. To exploit this synergy in a single active compound, we designed new dual-acting multivalent molecules simultaneously targeting topoisomerase I and HDAC. In particular, a selected compound containing a camptothecin and the psammaplin A scaffold showed a broad spectrum of antiproliferative activity, with IC50 values in the nanomolar range. Preliminary in vivo results indicated a strong antitumor activity on human mesothelioma primary cell line MM473 orthotopically xenografted in CD-1 nude mice and very high tolerability...
November 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29149770/a-multicenter-retrospective-medical-record-review-of-x-linked-myotubular-myopathy-the-recensus-study
#3
Alan H Beggs, Barry J Byrne, Sabine de Chastonay, Tmirah Haselkorn, Imelda Hughes, Emma S James, Nancy L Kuntz, Jennifer Simon, Lindsay C Swanson, Michele L Yang, Zi-Fan Yu, Sabrina W Yum, Suyash Prasad
INTRODUCTION: X-linked myotubular myopathy (XLMTM), characterized by severe hypotonia, weakness, respiratory distress, and early mortality, is rare and natural history studies are few. METHODS: RECENSUS is a multicenter chart review of male XLMTM patients characterizing disease burden and unmet medical needs. Data were collected between September 2014 and June 2016. RESULTS: Analysis included 112 patients at six clinical sites. Most recent patient age recorded was ≤18 months for 40 patients and >18 months for 72 patients...
November 17, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29149592/dynamics-under-the-telomeric-bridge
#4
Sabrina Pisano, Eric Gilson, Marie-Josèphe Giraud-Panis
In this issue of Molecular Cell, Kim et al. (2017) have studied the structure and organization of the shelterin protein complex protecting telomeres in Schizosaccharomyces pombe and humans and discovered an allosteric structural transition that drives the formation of the shelterin complex and participates in telomere length regulation.
November 16, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29148401/vitamin-d-and-systemic-lupus-erythematous-a-review-of-immunological-and-clinical-aspects
#5
REVIEW
Francesca Dall'Ara, Maurizio Cutolo, Laura Andreoli, Angela Tincani, Sabrina Paolino
OBJECTIVES: To review the relationships between vitamin D status and systemic lupus erythematosus (SLE) concerning immunological, clinical aspects and possible effects of supplementation in disease modulation. METHODS: The literature was reviewed up to January 2017 for studies regarding the epidemiology, pathogenesis, immunological aspects, clinical implications and supplementation strategies. The focus was mainly on studies with implications on every day clinical practice...
November 14, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29146634/knowledge-attitudes-and-intention-regarding-mhealth-in-generation-y-evidence-from-a-population-based-cross-sectional-study-in-chakaria-bangladesh
#6
M Shafiqur Rahman, Syed Hanifi, Fatema Khatun, Mohammad Iqbal, Sabrina Rasheed, Tanvir Ahmed, Shahidul Hoque, Tamanna Sharmin, Nazib-Uz Zaman Khan, Shehrin Shaila Mahmood, Abbas Bhuiya
BACKGROUND AND OBJECTIVES: mHealth offers a new opportunity to ensure access to qualified healthcare providers. Therefore, to better understand its potential in Bangladesh, it is important to understand how young people use mobile phones for healthcare. Here we examine the knowledge, attitudes and intentions to use mHealth services among young population. DESIGN: Population based cross sectional household survey. SETTING AND PARTICIPANTS: A total of 4909 respondents, aged 18 years and above, under the Chakaria Health and Demographic Surveillance System (HDSS) area, were interviewed during the period November 2012 to April 2013...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146164/magnetic-resonance-imaging-validation-of-tibial-tubercle-transfer-distance-in-the-fulkerson-osteotomy-a-clinical-and-cadaveric-study
#7
Joseph N Liu, Douglas N Mintz, Joseph T Nguyen, Jacqueline M Brady, Sabrina M Strickland, Beth E Shubin Stein
PURPOSE: To validate the medialization and anteriorization distances, and the osteotomy angle of anteromedialization tibial tubercle osteotomies using postoperative axial imaging. METHODS: From March 2004 to August 2015, 117 consecutive patients who underwent anteromedialization osteotomies of the tibial tubercle by a single surgeon were identified. Only patients with pre- and postoperative magnetic resonance imaging (MRI) studies were included. Using MRI multiplanar reformats, distances that the tibial tubercle was translated medially (medialization) and anteriorly (anteriorization) were measured...
November 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29143551/independent-validation-of-the-icu-requirement-score-in-a-cohort-of-acutely-poisoned-adults
#8
Regina Böll, Katrin Romanek, Sabrina Schmoll, Raphael Stich, Armin Ott, Jochen Stenzel, Stefanie Geith, Florian Eyer, Christian Rabe
OBJECTIVE: To independently validate the predictive value of the intensive care requirement score (IRS) in unselected poisoned patients. DESIGN: Retrospective chart review. PATIENTS AND METHODS: Five hundred and seventeen out of 585 admissions for acute intoxications could be analyzed. Eleven were excluded for a condition already requiring intensive care unit (ICU) support at admission (e.g., preclinical intubation). A further 57 admissions were excluded due to missing data...
November 16, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29143165/structure-of-monomeric-interleukin-8-and-its-interactions-with-the-n-terminal-binding-site-i-of-cxcr1-by-solution-nmr-spectroscopy
#9
Sabrina Berkamp, Sang Ho Park, Anna A De Angelis, Francesca M Marassi, Stanley J Opella
The structure of monomeric human chemokine IL-8 (residues 1-66) was determined in aqueous solution by NMR spectroscopy. The structure of the monomer is similar to that of each subunit in the dimeric full-length protein (residues 1-72), with the main differences being the location of the N-loop (residues 10-22) relative to the C-terminal α-helix and the position of the side chain of phenylalanine 65 near the truncated dimerization interface (residues 67-72). NMR was used to analyze the interactions of monomeric IL-8 (1-66) with ND-CXCR1 (residues 1-38), a soluble polypeptide corresponding to the N-terminal portion of the ligand binding site (Binding Site-I) of the chemokine receptor CXCR1 in aqueous solution, and with 1TM-CXCR1 (residues 1-72), a membrane-associated polypeptide that includes the same N-terminal portion of the binding site, the first trans-membrane helix, and the first intracellular loop of the receptor in nanodiscs...
November 15, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/29142133/human-adenovirus-infection-causes-the-cellular-mkrn1-e3-ubiquitin-ligase-degradation-involving-the-viral-core-protein-pvii
#10
Raviteja Inturi, Kwangchol Mun, Katrin Singethan, Sabrina Schreiner, Tanel Punga
Human adenoviruses (HAdVs) are common human pathogens encoding a highly abundant histone-like core protein VII, which is involved in nuclear delivery and protection of viral DNA as well as in sequestering immune danger signals in infected cells. The molecular details of how protein VII acts as a multifunctional protein have remained to a large extent enigmatic. Here we report the identification of several cellular proteins interacting with the precursor pVII protein. We show that the cellular E3 ubiquitin ligase MKRN1 is a novel precursor pVII interacting protein in HAdV-C5-infected cells...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29141992/letter-to-the-editor-diabetes-insipidus-is-an-unfavorable-prognostic-factor-for-response-to-glucocorticoids-in-patients-with-autoimmune-hypophysitis
#11
Sabrina Chiloiro, Laura De Marinis
As primary autoimmune hypophysitis represents a rare disease and, recently, two monocentric Italian series of affected patients have been described,with several similarities, we think that discussing the similarities and the differences of these two series would contribute in improving knowledge on this very rare disease.
November 15, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29141986/arfgap1-restricts-mycobacterium-tuberculosis-entry-by-controlling-the-actin-cytoskeleton
#12
Ok-Ryul Song, Christophe J Queval, Raffaella Iantomasi, Vincent Delorme, Sabrina Marion, Romain Veyron-Churlet, Elisabeth Werkmeister, Michka Popoff, Isabelle Ricard, Samuel Jouny, Nathalie Deboosere, Frank Lafont, Alain Baulard, Edouard Yeramian, Laurent Marsollier, Eik Hoffmann, Priscille Brodin
The interaction of Mycobacterium tuberculosis (Mtb) with pulmonary epithelial cells is critical for early stages of bacillus colonization and during the progression of tuberculosis. Entry of Mtb into epithelial cells has been shown to depend on F-actin polymerization, though the molecular mechanisms are still unclear. Here, we demonstrate that mycobacterial uptake into epithelial cells requires rearrangements of the actin cytoskeleton, which are regulated by ADP-ribosylation factor 1 (Arf1) and phospholipase D1 (PLD1), and is dependent on the M3 muscarinic receptor (M3R)...
November 15, 2017: EMBO Reports
https://www.readbyqxmd.com/read/29141965/food-groups-and-risk-of-hypertension-a-systematic-review-and-dose-response-meta-analysis-of-prospective-studies
#13
REVIEW
Lukas Schwingshackl, Carolina Schwedhelm, Georg Hoffmann, Sven Knüppel, Khalid Iqbal, Violetta Andriolo, Angela Bechthold, Sabrina Schlesinger, Heiner Boeing
The aim of this systematic review and meta-analysis was to summarize the evidence on the relation of the intakes of 12 major food groups, including whole grains, refined grains, vegetables, fruits, nuts, legumes, eggs, dairy, fish, red meat, processed meat, and sugar-sweetened beverages (SSBs) with the risk of hypertension. PubMed, Scopus, and Web of Science were searched systematically until June 2017 for prospective studies having quantitatively investigated the above-mentioned foods. We conducted meta-analysis on the highest compared with the lowest intake categories and linear and nonlinear dose-response meta-analyses to analyze the association...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29141960/rapid-molecular-assays-to-study-human-centromere-genomics
#14
Rafael Contreras-Galindo, Sabrina Fischer, Anjan K Saha, John D Lundy, Patrick W Cervantes, Mohamad Mourad, Claire Wang, Brian Qian, Manhong Dai, Fan Meng, Arul Chinnaiyan, Gilbert S Omenn, Mark H Kaplan, David M Markovitz
The centromere is the structural unit responsible for the faithful segregation of chromosomes. Although regulation of centromeric function by epigenetic factors has been well-studied, the contributions of the underlying DNA sequences have been much less well defined, and existing methodologies for studying centromere genomics in biology are laborious. We have identified specific markers in the centromere of 23 of the 24 human chromosomes that allow for rapid PCR assays capable of capturing the genomic landscape of human centromeres at a given time...
November 15, 2017: Genome Research
https://www.readbyqxmd.com/read/29141920/parathyroid-hormone-related-protein-modulates-mice-mesangial-cells-inflammation-and-blunts-apoptosis-by-enhancing-cox-2-expression
#15
Mazène Hochane, Denis Raison, Catherine Coquard, Claire Béraud, Audrey Bethry, Sabrina Danilin, Thierry Massfelder, Mariette Barthelmebs
Mesangial cell (MC) injury is a prominent feature of glomerulonephritis. Activated MC secretes inflammatory mediators which induce cell apoptosis. Parathyroid hormone-related peptide (PTHrP) is a locally active cytokine that enhances cell survival and is upregulated by pro-inflammatory factors in many cell types. The aim of this study was to analyze the regulation of PTHrP expression by inflammatory cytokines, and to evaluate whether PTHrP itself acts as a pro-inflammatory and/or survival factor on male murine MC in primary culture...
November 15, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29141804/validity-and-reproducibility-of-the-italian-version-of-the-patient-determined-disease-steps-scale-in-people-with-multiple-sclerosis
#16
Luigi Lavorgna, Maddalena Sparaco, Sabrina Esposito, Robert W Motl, Antonio Gallo, Alvino Bisecco, Gioacchino Tedeschi, Simona Bonavita
No abstract text is available yet for this article.
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141700/can-a-customer-relationship-management-program-improve-recruitment-for-primary-care-research-studies
#17
Sharon Johnston, Sabrina T Wong, Stephanie Blackman, Leena W Chau, Anne M Grool, William Hogg
BACKGROUND: Recruiting family physicians into primary care research studies requires researchers to continually manage information coming in, going out, and coming in again. In many research groups, Microsoft Excel and Access are the usual data management tools, but they are very basic and do not support any automation, linking, or reminder systems to manage and integrate recruitment information and processes. OBJECTIVE: We explored whether a commercial customer relationship management (CRM) software program - designed for sales people in businesses to improve customer relations and communications - could be used to make the research recruitment system faster, more effective, and more efficient...
November 16, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29141021/correction-targeting-neutrophils-to-prevent-malaria-associated-acute-lung-injury-acute-respiratory-distress-syndrome-in-mice
#18
Michelle K Sercundes, Luana S Ortolan, Daniela Debone, Paulo V Soeiro-Pereira, Eliane Gomes, Elizabeth H Aitken, Antonio Condino-Neto, Momtchilo Russo, Maria R D' Império Lima, José M Alvarez, Silvia Portugal, Claudio R F Marinho, Sabrina Epiphanio
[This corrects the article DOI: 10.1371/journal.ppat.1006054.].
November 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29140997/topical-anaesthesia-reduces-sensitivity-of-castration-wounds-in-neonatal-piglets
#19
Sabrina Lomax, Charissa Harris, Peter A Windsor, Peter J White
The aim of this study was to do determine the efficacy of the topical anaesthetic Tri-Solfen® in the amelioration of the pain of castration in piglets. The trial was conducted over a three day period, and blocked across six litters with 12 piglets treated on days one and two, and 16 on day three. The piglets were randomly allocated by weight and litter to 1 of 4 treatment groups: (i) sham castration (SHAM; n = 10); (ii) surgical castration with no anaesthetic intervention (CAST; n = 10); (iii) surgical castration with post-operative topical anaesthesia (TRI; n = 10); (iv) surgical castration with a pre-operative intra-testicular lignocaine hydrochloride injection (LIG; n = 10)...
2017: PloS One
https://www.readbyqxmd.com/read/29140107/a-cross-sectional-study-of-ethnicity-based-differences-in-treatment-seeking-for-symptoms-of-acute-coronary-syndrome
#20
Emma Iacoe, Pamela A Ratner, Sabrina T Wong, Martha H Mackay
BACKGROUND: Patient-related delays in acquiring medical care for symptoms of acute coronary syndrome remain unacceptably long. Many clinical and sociodemographic characteristics associated with treatment-seeking delay are known; however, ethnicity has not been extensively evaluated. OBJECTIVE: The purpose of this study was to examine ethnicity-based differences in the time-to-treatment-seeking intervals of patients experiencing symptoms of acute coronary syndrome...
November 1, 2017: European Journal of Cardiovascular Nursing
keyword
keyword
63680
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"