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Tim Hewett

J Moore, T Price, S Carruthers, S Selva-Nayagam, A Luck, M Thomas, P Hewett
AIM: The aim was to determine whether the addition of additional cycles of chemotherapy during the 'wait period' following neoadjuvant chemoradiotherapy for rectal cancer improves the pathological complete response (pCR) rate. METHOD: Rectal cancer patients were randomly allocated either to a standard 10 week wait period before surgery (standard chemoradiotherapy, SCRT) or to receive three cycles of fluorouracil based chemotherapy following chemoradiotherapy during a similar 10 week wait (extended chemoradiotherapy, XCRT)...
November 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Chi-un Choe, Jan Lewerenz, Gerry Fischer, Tracy F Uliasz, Michael Graham Espey, Friedhelm C Hummel, Stephen Bruce King, Edzard Schwedhelm, Rainer H Böger, Christian Gerloff, Sandra J Hewett, Tim Magnus, Sonia Donzelli
Nitroxyl (HNO) donor compounds function as potent vasorelaxants, improve myocardial contractility and reduce ischemia-reperfusion injury in the cardiovascular system. With respect to the nervous system, HNO donors have been shown to attenuate NMDA receptor activity and neuronal injury, suggesting that its production may be protective against cerebral ischemic damage. Hence, we studied the effect of the classical HNO-donor, Angeli's salt (AS), on a cerebral ischemia/reperfusion injury in a mouse model of experimental stroke and on related in vitro paradigms of neurotoxicity...
September 2009: Journal of Neurochemistry
Letha Y Griffin, Marjorie J Albohm, Elizabeth A Arendt, Roald Bahr, Bruce D Beynnon, Marlene Demaio, Randall W Dick, Lars Engebretsen, William E Garrett, Jo A Hannafin, Tim E Hewett, Laura J Huston, Mary Lloyd Ireland, Robert J Johnson, Scott Lephart, Bert R Mandelbaum, Barton J Mann, Paul H Marks, Stephen W Marshall, Grethe Myklebust, Frank R Noyes, Christopher Powers, Clarence Shields, Sandra J Shultz, Holly Silvers, James Slauterbeck, Dean C Taylor, Carol C Teitz, Edward M Wojtys, Bing Yu
The incidence of noncontact anterior cruciate ligament injuries in young to middle-aged athletes remains high. Despite early diagnosis and appropriate operative and nonoperative treatments, posttraumatic degenerative arthritis may develop. In a meeting in Atlanta, Georgia (January 2005), sponsored by the American Orthopaedic Society for Sports Medicine, a group of physicians, physical therapists, athletic trainers, biomechanists, epidemiologists, and other scientists interested in this area of research met to review current knowledge on risk factors associated with noncontact anterior cruciate ligament injuries, anterior cruciate ligament injury biomechanics, and existing anterior cruciate ligament prevention programs...
September 2006: American Journal of Sports Medicine
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