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Trim29

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https://www.readbyqxmd.com/read/29038422/trim29-promotes-dna-virus-infections-by-inhibiting-innate-immune-response
#1
Junji Xing, Ao Zhang, Hua Zhang, Jin Wang, Xian Chang Li, Mu-Sheng Zeng, Zhiqiang Zhang
Many double-stranded DNA viruses, such as Epstein-Barr virus, can establish persistent infection, but the underlying virus-host interactions remain poorly understood. Here we report that in human airway epithelial cells Epstein-Barr virus induces TRIM29, a member of the TRIM family of proteins, to inhibit innate immune activation. Knockdown of TRIM29 in airway epithelial cells enhances type I interferon production, and in human nasopharyngeal carcinoma cells results in almost complete Epstein-Barr virus clearance...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28815294/diallyl-trisulfide-inhibits-proliferation-invasion-and-angiogenesis-of-glioma-cells-by-inactivating-wnt-%C3%AE-catenin-signaling
#2
Qingxia Tao, Cuiying Wu, Ruxiang Xu, Lijun Niu, Jiazhen Qin, Ning Liu, Peng Zhang, Chong Wang
Aberrant activation of Wnt/β-catenin signaling leads to increased cell proliferation and survival and promotes the development of various human tumors, including glioma, one of the most common primary brain tumors. The treatment efficacy of many anticancer drugs remains limited or unsatisfactory and it is urgently necessary to develop effective and low-toxicity anticancer drugs or strategies, especially for glioma. Here, we report that diallyl trisulfide suppresses survival, migration, invasion and angiogenesis in glioma cells...
August 17, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28731167/high-expression-of-trim29%C3%A2-atdc-contributes-to-poor-prognosis-and-tumor-metastasis-by-inducing-epithelial%C3%A2-mesenchymal-transition-in-osteosarcoma
#3
Si-Xiang Zeng, Qing-Chun Cai, Chi-Hua Guo, Li-Qiang Zhi, Xing Dai, Dang-Feng Zhang, Wei Ma
The association of TRIM29 overexpression with cancer progression and poor clinical prognosis has been reported in the context of several types of cancers. In the present study, we investigated the prognostic relevance of TRIM29 and its involvement in the progression of human osteosarcoma. To the best of our knowledge, this is the first study to demonstrate a major role of TRIM29 in osteosarcoma. Our results showed that the expression of TRIM29 in osteosarcoma tissues was much higher than that in normal bone tissues...
July 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28678327/lncrna625-modulates-prostate-cancer-cells-proliferation-and-apoptosis-through-regulating-the-wnt-%C3%AE-catenin-pathway-by-targeting-mir-432
#4
J-B Li, F Liu, B-P Zhang, W-K Bai, W Cheng, Y-H Zhang, L-J Yu
OBJECTIVE: Prostate cancer (PCa) is the second leading contributor to male malignancy-associated death in developed countries. The study aimed to evaluate the effects of lncRNA625/miR-432 on the prostate cancer cells and the underlying molecular mechanism. PATIENTS AND METHODS: The cell proliferation was detected using the MTT and colony formation, and cells apoptosis and cell cycle were analyzed with the flow cytometry. Luciferase reporter assay was carried out to detect the correlation between miR-432 and TRIM29 and PYGO2...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28216417/expression-profiling-of-clinical-specimens-supports-the-existence-of-neural-progenitor-like-stem-cells-in-basal-breast-cancers
#5
Alex Panaccione, Yan Guo, Wendell G Yarbrough, Sergey V Ivanov
BACKGROUND: We previously characterized in salivary adenoid cystic carcinoma (ACC) a novel population of cancer stem cells (CSCs) marked by coexpression of 2 stemness genes, sex-determining region Y (SRY)-related HMG box-containing factor 10 (SOX10) and CD133. We also reported that in ACC and basal-like breast carcinoma (BBC), a triple-negative breast cancer subtype, expression of SOX10 similarly demarcates a highly conserved gene signature enriched with neural stem cell genes. On the basis of these findings, we hypothesized that BBC might be likewise driven by SOX10-positive (SOX10(+))/CD133(+) cells with neural stem cell properties...
July 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28186089/adenovirus-mediated-tipe2-overexpression-inhibits-gastric-cancer-metastasis-via-reversal-of-epithelial-mesenchymal-transition
#6
H Yin, X Huang, M Tao, Q Hu, J Qiu, W Chen, J Wu, Y Xie
Tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TNFAIP8L2; also termed TIPE2) has been shown to be involved in both the immune-negative modulation and cancer. We previously found that TIPE2 is lost in human gastric cancer, and TIPE2 restoration suppresses gastric cancer growth by induction of apoptosis and impairment of protein kinase B (PKB/AKT) and extracellular signal-regulated kinase-1/2 (ERK1/2) signaling. However, its correlation with epithelial-mesenchymal transition (EMT) in gastric cancer is largely elusive...
April 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28098872/trim29-promotes-progression-of-thyroid-carcinoma-via-activating-p13k-akt-signaling-pathway
#7
Jinkai Xu, Zongyu Li, Qinghua Su, Jun Zhao, Jiancang Ma
Thyroid cancer (TC) is a common malignancy of the endocrine system. Abnormal expression of tripartite motif-containing 29 (TRIM29) has been reported to promote tumorigenesis and predict poor prognosis in several human malignancies. The aim of this study was to assess the involvement of TRIM29 in the significance and prognosis of TC. Fifty-six tumor samples and their clinicopathological para-meters were obtained from TC patients; the expression level of TRIM29 was detected by RT-qPCR and western blotting. TRIM29 expression was knocked down by small interfering RNA (siRNA) among TT, TPC-1, and K1 cells to investigate the biological role of TRIM29 in TC cells...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28054302/microrna-761-induces-aggressive-phenotypes-in-triple-negative-breast-cancer-cells-by-repressing-trim29-expression
#8
Guang-Cheng Guo, Jia-Xiang Wang, Ming-Li Han, Lian-Ping Zhang, Lin Li
PURPOSE: Despite advances that have been made in systemic chemotherapy, the prognosis of advanced triple-negative breast cancer (TNBC) patients is still poor. The identification of key factors governing TNBC development is considered imperative for the development of novel effective therapeutic approaches. Previously, it has been reported that microRNA (miR)-761 may act as either a tumor suppressor or as an oncogene in different types of cancer. Here, we aimed at assessing the biological role of this miRNA in TNBC...
April 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/27849197/corrigendum-identification-of-a-role-for-trim29-in-the-control-of-innate-immunity-in-the-respiratory-tract
#9
Junji Xing, Leiyun Weng, Bin Yuan, Zhuo Wang, Li Jia, Rui Jin, Hongbo Lu, Xian Chang Li, Yong-Jun Liu, Zhiqiang Zhang
No abstract text is available yet for this article.
November 16, 2016: Nature Immunology
https://www.readbyqxmd.com/read/27695001/identification-of-a-role-for-trim29-in-the-control-of-innate-immunity-in-the-respiratory-tract
#10
Junji Xing, Leiyun Weng, Bin Yuan, Zhuo Wang, Li Jia, Rui Jin, Hongbo Lu, Xian Chang Li, Yong-Jun Liu, Zhiqiang Zhang
The respiratory tract is heavily populated with innate immune cells, but the mechanisms that control such cells are poorly defined. Here we found that the E3 ubiquitin ligase TRIM29 was a selective regulator of the activation of alveolar macrophages, the expression of type I interferons and the production of proinflammatory cytokines in the lungs. We found that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while challenge of Trim29(-/-) mice with Haemophilus influenzae resulted in lethal lung inflammation due to massive production of proinflammatory cytokines by macrophages...
December 2016: Nature Immunology
https://www.readbyqxmd.com/read/27535224/the-breast-cancer-tumor-suppressor-trim29-is-expressed-via-atm-dependent-signaling-in-response-to-hypoxia
#11
Muzaffer Dükel, W Scott Streitfeld, Tsz Ching Chloe Tang, Lindsey R F Backman, Lingbao Ai, W Stratford May, Kevin D Brown
Reduced ATM function has been linked to breast cancer risk, and the TRIM29 protein is an emerging breast cancer tumor suppressor. Here we show that, in cultured breast tumor and non-tumorigenic mammary epithelial cells, TRIM29 is up-regulated in response to hypoxic stress but not DNA damage. Hypoxia-induced up-regulation of TRIM29 is dependent upon ATM and HIF1α and occurs through increased transcription of the TRIM29 gene. Basal expression of TRIM29 is also down-regulated in cells expressing diminished levels of ATM, and findings suggest that this occurs through basal NF-κB activity as knockdown of the NF-κB subunit RelA suppresses TRIM29 abundance...
October 7, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27430345/rna-interference-against-trim29-inhibits-migration-and-invasion-of-colorectal-cancer-cells
#12
Weihong Xu, Bin Xu, Yiting Yao, Xiaoling Yu, Hua Cao, Jun Zhang, Jie Liu, Huiming Sheng
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Tripartite motif-containing 29 (TRIM29) is a member of TRIM proteins family, which plays diverse physiological and pathological roles in humans. Recent studies found that TRIM29 expressed highly in CRC and promoted cell growth in vitro. However, its function in the metastasis of CRC has not been studied. In the present study, we confirmed the previous report that TRIM29 was upregulated in CRC tissues and high levels of TRIM29 expression were associated with poor overall survival of patients...
September 2016: Oncology Reports
https://www.readbyqxmd.com/read/27145374/identification-of-nasopharyngeal-carcinoma-metastasis-related-biomarkers-by-itraq-combined-with-2d-lc-ms-ms
#13
Zhen Chen, Lu Long, Kun Wang, Facai Cui, Lepan Zhu, Ya Tao, Qiong Wu, Manlin Xiang, Yunlai Liang, Shiyang Qiu, Zhiqiang Xiao, Bin Yi
To identify metastasis-related proteins in nasopharyngeal carcinoma (NPC), iTRAQ-tagging combined with 2D LC-MS/MS analysis was performed to identify the differentially expressed proteins (DEPs) in high metastatic NPC 5-8F cells and non-metastatic NPC 6-10B cells, and qRT-PCR and Western blotting were used to confirm DEPs. As a result, 101 DEPs were identified by proteomics, and 12 DEPs were selectively validated. We further detected expression of three DEPs (RAN, SQSTM1 and TRIM29) in a cohort of NPC tissue specimens to assess their value as NPC metastatic biomarkers, and found that combination of RAN, SQSTM1 and TRIM29 could discriminate metastatic NPC from non-metastatic NPC with a sensitivity of 88% and a specificity of 91%...
June 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27081037/trim29-overexpression-is-associated-with-poor-prognosis-and-promotes-tumor-progression-by-activating-wnt-%C3%AE-catenin-pathway-in-cervical-cancer
#14
Rui Xu, Jingye Hu, Tiansong Zhang, Chao Jiang, Hui-Yun Wang
Dysregulation of TRIM29 has been reported to be involved in tumorigenesis, but the role of TRIM29 in cervical cancer is unclear. In this study, we first examined TRIM29 expression and found that TRIM29 mRNA and protein expression was upregulated in cervical cancer tissues when compared with the matched adjacent cervical tissues. We further detected TRIM29 protein with immunohistochemistry in 150 paraffin-embedded samples from early-stage cervical cancer patients. The results showed that high expression of TRIM29 was significantly associated with pelvic lymph node metastasis (p=0...
May 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/26987391/trim29-overexpression-promotes-proliferation-and-survival-of-bladder-cancer-cells-through-nf-%C3%AE%C2%BAb-signaling
#15
Shu-Tao Tan, Sheng-Ye Liu, Bin Wu
PURPOSE: TRIM29 overexpression has been reported in several human malignancies and showed correlation with cancer cell malignancy. The aim of the current study is to examine its clinical significance and biological roles in human bladder cancer tissues and cell lines. MATERIALS AND METHODS: A total of 102 cases of bladder cancer tissues were examined for TRIM29 expression by immunohistochemistry. siRNA and plasmid transfection were performed in 5637 and BIU-87 cell lines...
October 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/26872369/upregulated-trim29-promotes-proliferation-and-metastasis-of-nasopharyngeal-carcinoma-via-pten-akt-mtor-signal-pathway
#16
Xiao-Min Zhou, Rui Sun, Dong-Hua Luo, Jian Sun, Mei-Yin Zhang, Meng-He Wang, Yang Yang, Hui-Yun Wang, Shi-Juan Mai
Tripartite motif-containing 29 (TRIM29) has been reported to be dysregulated in human cancers. Up-regulation of TRIM29 was first observed in NPC cell lines by a genome-wide transcriptome analysis in our previous study. However, its expression biological function and clinical significance in nasopharyngeal carcinoma (NPC) remain unclear. In this study, TRIM29 expression was validated by qRT-PCR and immunohistochemistry in 69 NPC samples. Notably, TRIM29 protein expression was significantly and positively correlated with the tumor size, clinical stage and metastasis...
March 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/26838517/early-evidence-for-the-role-of-trim29-in-multiple-cancer-models
#17
Shigetsugu Hatakeyama
No abstract text is available yet for this article.
July 2016: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/26622835/tripartite-motif-containing-29-as-a-novel-biomarker-in-non-small-cell-lung-cancer
#18
Xiaoming Song, Chunhai Fu, Xudong Yang, Dongfeng Sun, Xianqi Zhang, Jiandong Zhang
Tripartite motif-containing 29 (TRIM29) is a member of the tripartite motif (TRIM) protein family. TRIM29 has been reported to be deregulated in a number of cancer types, suggesting the oncogenic function of TRIM29. However, its clinical significance in non-small cell lung cancer (NSCLC) has not been fully elucidated. In the present study, the TRIM29 expression status was investigated by immunohistochemical analysis in paraffin-embedded specimens obtained from 320 patients with surgically resected NSCLC, treated between 2000 and 2007...
October 2015: Oncology Letters
https://www.readbyqxmd.com/read/26599082/trim59-promotes-the-proliferation-and-migration-of-non-small-cell-lung-cancer-cells-by-upregulating-cell-cycle-related-proteins
#19
Weihua Zhan, Tianyu Han, Chenfu Zhang, Caifeng Xie, Mingxi Gan, Keyu Deng, Mingui Fu, Jian-Bin Wang
TRIM protein family is an evolutionarily conserved gene family implicated in a number of critical processes including inflammation, immunity, antiviral and cancer. In an effort to profile the expression patterns of TRIM superfamily in several non-small cell lung cancer (NSCLC) cell lines, we found that the expression of 10 TRIM genes including TRIM3, TRIM7, TRIM14, TRIM16, TRIM21, TRIM22, TRIM29, TRIM59, TRIM66 and TRIM70 was significantly upregulated in NSCLC cell lines compared with the normal human bronchial epithelial (HBE) cell line, whereas the expression of 7 other TRIM genes including TRIM4, TRIM9, TRIM36, TRIM46, TRIM54, TRIM67 and TRIM76 was significantly down-regulated in NSCLC cell lines compared with that in HBE cells...
2015: PloS One
https://www.readbyqxmd.com/read/26471361/atdc-trim29-drives-invasive-bladder-cancer-formation-through-mirna-mediated-and-epigenetic-mechanisms
#20
Phillip L Palmbos, Lidong Wang, Huibin Yang, Yin Wang, Jacob Leflein, McKenzie L Ahmet, John E Wilkinson, Chandan Kumar-Sinha, Gina M Ney, Scott A Tomlins, Stephanie Daignault, Lakshmi P Kunju, Xue-Ru Wu, Yair Lotan, Monica Liebert, Mats E Ljungman, Diane M Simeone
Bladder cancer is a common and deadly malignancy but its treatment has advanced little due to poor understanding of the factors and pathways that promote disease. ATDC/TRIM29 is a highly expressed gene in several lethal tumor types, including bladder tumors, but its role as a pathogenic driver has not been established. Here we show that overexpression of ATDC in vivo is sufficient to drive both noninvasive and invasive bladder carcinoma development in transgenic mice. ATDC-driven bladder tumors were indistinguishable from human bladder cancers, which displayed similar gene expression signatures...
December 1, 2015: Cancer Research
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