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Junji Xing, Leiyun Weng, Bin Yuan, Zhuo Wang, Li Jia, Rui Jin, Hongbo Lu, Xian Chang Li, Yong-Jun Liu, Zhiqiang Zhang
The respiratory tract is heavily populated with innate immune cells, but the mechanisms that control such cells are poorly defined. Here we found that the E3 ubiquitin ligase TRIM29 was a selective regulator of the activation of alveolar macrophages, the expression of type I interferons and the production of proinflammatory cytokines in the lungs. We found that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while challenge of Trim29(-/-) mice with Haemophilus influenzae resulted in lethal lung inflammation due to massive production of proinflammatory cytokines by macrophages...
October 3, 2016: Nature Immunology
Muzaffer Dükel, W Scott Streitfeld, Tsz Ching Chloe Tang, Lindsey R F Backman, Lingbao Ai, W Stratford May, Kevin D Brown
Reduced ATM function has been linked to breast cancer risk and the TRIM29 protein is an emerging breast cancer tumor suppressor. Here we show that, in cultured breast tumor and non-tumorigenic mammary epithelial cells, TRIM29 is upregulated in response to hypoxic stress but not DNA damage. Hypoxia-induced upregulation of TRIM29 is dependent upon ATM and HIF1α, and occurs through increased transcription of the TRIM29 gene. Basal expression of TRIM29 is also downregulated in cells expressing diminished levels of ATM and findings suggest this occurs through basal NF-κB activity as knockdown of the NF-κB subunit RelA suppresses TRIM29 abundance...
August 17, 2016: Journal of Biological Chemistry
Weihong Xu, Bin Xu, Yiting Yao, Xiaoling Yu, Hua Cao, Jun Zhang, Jie Liu, Huiming Sheng
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Tripartite motif-containing 29 (TRIM29) is a member of TRIM proteins family, which plays diverse physiological and pathological roles in humans. Recent studies found that TRIM29 expressed highly in CRC and promoted cell growth in vitro. However, its function in the metastasis of CRC has not been studied. In the present study, we confirmed the previous report that TRIM29 was upregulated in CRC tissues and high levels of TRIM29 expression were associated with poor overall survival of patients...
September 2016: Oncology Reports
Zhen Chen, Lu Long, Kun Wang, Facai Cui, Lepan Zhu, Ya Tao, Qiong Wu, Manlin Xiang, Yunlai Liang, Shiyang Qiu, Zhiqiang Xiao, Bin Yi
To identify metastasis-related proteins in nasopharyngeal carcinoma (NPC), iTRAQ-tagging combined with 2D LC-MS/MS analysis was performed to identify the differentially expressed proteins (DEPs) in high metastatic NPC 5-8F cells and non-metastatic NPC 6-10B cells, and qRT-PCR and Western blotting were used to confirm DEPs. As a result, 101 DEPs were identified by proteomics, and 12 DEPs were selectively validated. We further detected expression of three DEPs (RAN, SQSTM1 and TRIM29) in a cohort of NPC tissue specimens to assess their value as NPC metastatic biomarkers, and found that combination of RAN, SQSTM1 and TRIM29 could discriminate metastatic NPC from non-metastatic NPC with a sensitivity of 88% and a specificity of 91%...
June 7, 2016: Oncotarget
Rui Xu, Jingye Hu, Tiansong Zhang, Chao Jiang, Hui-Yun Wang
Dysregulation of TRIM29 has been reported to be involved in tumorigenesis, but the role of TRIM29 in cervical cancer is unclear. In this study, we first examined TRIM29 expression and found that TRIM29 mRNA and protein expression was upregulated in cervical cancer tissues when compared with the matched adjacent cervical tissues. We further detected TRIM29 protein with immunohistochemistry in 150 paraffin-embedded samples from early-stage cervical cancer patients. The results showed that high expression of TRIM29 was significantly associated with pelvic lymph node metastasis (p=0...
May 10, 2016: Oncotarget
Shu-Tao Tan, Sheng-Ye Liu, Bin Wu
Purpose: TRIM29 overexpression has been reported in several human malignancies and showed correlation with cancer cell malignancy. The aim of the current study is to examine its clinical significance and biological roles in human bladder cancer tissues and cell lines. Materials and Methods: A total of 102 cases of bladder cancer tissues were examined for TRIM29 expression by immunohistochemistry. siRNA and plasmid transfection were performed in 5637 and BIU-87 cell lines...
March 11, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Xiao-Min Zhou, Rui Sun, Dong-Hua Luo, Jian Sun, Mei-Yin Zhang, Meng-He Wang, Yang Yang, Hui-Yun Wang, Shi-Juan Mai
Tripartite motif-containing 29 (TRIM29) has been reported to be dysregulated in human cancers. Up-regulation of TRIM29 was first observed in NPC cell lines by a genome-wide transcriptome analysis in our previous study. However, its expression biological function and clinical significance in nasopharyngeal carcinoma (NPC) remain unclear. In this study, TRIM29 expression was validated by qRT-PCR and immunohistochemistry in 69 NPC samples. Notably, TRIM29 protein expression was significantly and positively correlated with the tumor size, clinical stage and metastasis...
March 22, 2016: Oncotarget
Shigetsugu Hatakeyama
No abstract text is available yet for this article.
July 2016: Expert Opinion on Therapeutic Targets
Xiaoming Song, Chunhai Fu, Xudong Yang, Dongfeng Sun, Xianqi Zhang, Jiandong Zhang
Tripartite motif-containing 29 (TRIM29) is a member of the tripartite motif (TRIM) protein family. TRIM29 has been reported to be deregulated in a number of cancer types, suggesting the oncogenic function of TRIM29. However, its clinical significance in non-small cell lung cancer (NSCLC) has not been fully elucidated. In the present study, the TRIM29 expression status was investigated by immunohistochemical analysis in paraffin-embedded specimens obtained from 320 patients with surgically resected NSCLC, treated between 2000 and 2007...
October 2015: Oncology Letters
Weihua Zhan, Tianyu Han, Chenfu Zhang, Caifeng Xie, Mingxi Gan, Keyu Deng, Mingui Fu, Jian-Bin Wang
TRIM protein family is an evolutionarily conserved gene family implicated in a number of critical processes including inflammation, immunity, antiviral and cancer. In an effort to profile the expression patterns of TRIM superfamily in several non-small cell lung cancer (NSCLC) cell lines, we found that the expression of 10 TRIM genes including TRIM3, TRIM7, TRIM14, TRIM16, TRIM21, TRIM22, TRIM29, TRIM59, TRIM66 and TRIM70 was significantly upregulated in NSCLC cell lines compared with the normal human bronchial epithelial (HBE) cell line, whereas the expression of 7 other TRIM genes including TRIM4, TRIM9, TRIM36, TRIM46, TRIM54, TRIM67 and TRIM76 was significantly down-regulated in NSCLC cell lines compared with that in HBE cells...
2015: PloS One
Phillip L Palmbos, Lidong Wang, Huibin Yang, Yin Wang, Jacob Leflein, McKenzie L Ahmet, John E Wilkinson, Chandan Kumar-Sinha, Gina M Ney, Scott A Tomlins, Stephanie Daignault, Lakshmi P Kunju, Xue-Ru Wu, Yair Lotan, Monica Liebert, Mats E Ljungman, Diane M Simeone
Bladder cancer is a common and deadly malignancy but its treatment has advanced little due to poor understanding of the factors and pathways that promote disease. ATDC/TRIM29 is a highly expressed gene in several lethal tumor types, including bladder tumors, but its role as a pathogenic driver has not been established. Here we show that overexpression of ATDC in vivo is sufficient to drive both noninvasive and invasive bladder carcinoma development in transgenic mice. ATDC-driven bladder tumors were indistinguishable from human bladder cancers, which displayed similar gene expression signatures...
December 1, 2015: Cancer Research
Huibin Yang, Phillip L Palmbos, Lidong Wang, Evelyn H Kim, Gina M Ney, Chao Liu, Jayendra Prasad, David E Misek, Xiaochun Yu, Mats Ljungman, Diane M Simeone
Induction of DNA damage by ionizing radiation (IR) and/or cytotoxic chemotherapy is an essential component of cancer therapy. The ataxia telangiectasia group D complementing gene (ATDC, also called TRIM29) is highly expressed in many malignancies. It participates in the DNA damage response downstream of ataxia telangiectasia-mutated (ATM) and p38/MK2 and promotes cell survival after IR. To elucidate the downstream mechanisms of ATDC-induced IR protection, we performed a mass spectrometry screen to identify ATDC binding partners...
November 6, 2015: Journal of Biological Chemistry
Chunxiao Liu, Xiaoxi Huang, Shengcai Hou, Bin Hu, Hui Li
BACKGROUND: TRIM29 belongs to the tripartite motif (TRIM) protein family. It has been reported to be a tumor suppressor or have oncogenic function in many cancer types. The aim of this study was to investigate whether downregulation of TRIM29 by small interfering ribonucleic acid (siRNA) could inhibit cell proliferation and invasion and increase chemosensitivity to cisplatin in human lung squamous cancer NCI-H520 cells in vitro. METHODS: We transformed TRIM29 siRNA into NCI-H520 cells...
January 2015: Thoracic Cancer
Feng Qiu, Jian-Ping Xiong, Jun Deng, Xiao-Jun Xiang
Tripartite motif-containing 29 (TRIM29) belongs to TRIM family of transcription factors and may function as an oncogene or a tumor suppressor depending on the tumor types. Overexpression of TRIM29 is frequently observed in gastric cancer but the underlying mechanisms remain largely unknown. In the present study, we investigated the function of TRIM29 in gastric cancer-derived cell line MGC803. RNAi-mediated silencing of TRIM29 resulted in significantly reduced cell proliferation and colony formation, as well as G1-S cell cycle arrest and apoptosis...
2015: International Journal of Clinical and Experimental Pathology
Yasushi Masuda, Hidehisa Takahashi, Shigeo Sato, Chieri Tomomori-Sato, Anita Saraf, Michael P Washburn, Laurence Florens, Ronald C Conaway, Joan W Conaway, Shigetsugu Hatakeyama
Although DNA double-strand break (DSB) repair is mediated by numerous proteins accumulated at DSB sites, how DNA repair proteins are assembled into damaged chromatin has not been fully elucidated. Here we show that a member of the tripartite motif protein family, TRIM29, is a histone-binding protein responsible for DNA damage response (DDR). We found that TRIM29 interacts with BRCA1-associated surveillance complex, cohesion, DNA-PKcs and components of TIP60 complex. The dynamics of the TRIM29-containing complex on H2AX nucleosomes is coordinated by a cross-talk between histone modifications...
2015: Nature Communications
Yasushi Masuda, Hidehisa Takahashi, Shigetsugu Hatakeyama
Cell invasion and adhesion play an important role in cancer metastasis and are orchestrated by a complicated network of transcription factors including p63. Here, we show that a member of the tripartite motif protein family, TRIM29, is required for regulation of the p63-mediated pathway in cervical cancer cells. TRIM29 knockdown alters the adhesion and invasion activities of cervical cancer cells. TRIM29 knockdown and overexpression cause a significant decrease and increase of TAp63α expression, respectively...
October 2015: Biochimica et Biophysica Acta
Nan Jiang, Wen-Jie Chen, Jian-Wen Zhang, Chi Xu, Xian-Cheng Zeng, Tong Zhang, Yang Li, Guo-Ying Wang
Sustained cell growth and proliferation, one of the hallmarks of cancer, is considered to responsible for cancer-related deaths by disorganizing the balance of growth promotion and growth limitation. Aberrant activation of the Wnt/β-catenin signaling pathway leads to cell proliferation, growth and survival, and promotes the development of various human tumors, including hepatocellular carcinoma. Elucidating the molecular mechanism of this abnormality in hepatocellular carcinoma carcinogenesis may improve diagnostic and therapeutic strategies for this malignancy...
April 10, 2015: Oncotarget
Young Seok Lee, Seung Won Ryu, Se Jong Bae, Tae Hwan Park, Kang Kwon, Yun Hee Noh, Sung Young Kim
Anthracyclines are among the most effective and commonly used chemotherapeutic agents. However, the development of acquired anthracycline resistance is a major limitation to their clinical application. The aim of the present study was to identify differentially expressed genes (DEGs) and biological processes associated with the acquisition of anthracycline resistance in human breast cancer cells. We performed a meta-analysis of publically available microarray datasets containing data on stepwise-selected, anthracycline‑resistant breast cancer cell lines using the RankProd package in R...
April 2015: Oncology Reports
Lidong Wang, Huibin Yang, Ethan V Abel, Gina M Ney, Phillip L Palmbos, Filip Bednar, Yaqing Zhang, Jacob Leflein, Meghna Waghray, Scott Owens, John E Wilkinson, Jayendra Prasad, Mats Ljungman, Andrew D Rhim, Marina Pasca di Magliano, Diane M Simeone
The initiation of pancreatic ductal adenocarcinoma (PDA) is linked to activating mutations in KRAS. However, in PDA mouse models, expression of oncogenic mutant KRAS during development gives rise to tumors only after a prolonged latency or following induction of pancreatitis. Here we describe a novel mouse model expressing ataxia telangiectasia group D complementing gene (ATDC, also known as TRIM29 [tripartite motif 29]) that, in the presence of oncogenic KRAS, accelerates pancreatic intraepithelial neoplasia (PanIN) formation and the development of invasive and metastatic cancers...
January 15, 2015: Genes & Development
Thomas M Harris, Peicheng Du, Nicole Kawachi, Thomas J Belbin, Yanhua Wang, Nicolas F Schlecht, Thomas J Ow, Christian E Keller, Geoffrey J Childs, Richard V Smith, Ruth Hogue Angeletti, Michael B Prystowsky, Jihyeon Lim
CONTEXT: Global proteomic analysis of oral cavity squamous cell carcinoma was performed to identify changes that reflect patient outcomes. OBJECTIVES: To identify differentially expressed proteins associated with patient outcomes and to explore the use of imaging mass spectrometry as a clinical tool to identify clinically relevant proteins. DESIGN: Two-dimensional separation of digested peptides generated from 43 specimens with high-resolution mass spectrometry identified proteins associated with disease-specific death, distant metastasis, and loco-regional recurrence...
April 2015: Archives of Pathology & Laboratory Medicine
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