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Depression and inflammation

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https://www.readbyqxmd.com/read/28748390/mir-27b-3p-mir-181a-1-3p-and-mir-326-5p-are%C3%A2-involved-in-the-inhibition-of-macrophage-activation-in-chronic-liver-injury
#1
Weiyang Li, Na Chang, Lei Tian, Jingjing Yang, Xiaofang Ji, Jieshi Xie, Lin Yang, Liying Li
Macrophages are central players in inflammation, which leads to liver injury. It has been reported that continuous macrophage activation initiates this process. Our previous data show that the anti-inflammatory factor, 15-deoxy-Δ(12, 14)-prostaglandin J2 (15d-PGJ2), inhibits bone marrow (BM)-derived macrophage (BMM) migration and inflammatory cytokine production. However, the underlying mechanism of 15d-PGJ2 inhibited BMM activation is still unclear. Here, we evaluate the role of 15d-PGJ2/PPARγ axis in BMM activation...
July 26, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28747511/autologous-minced-muscle-grafts-improve-endogenous-fracture-healing-and-muscle-strength-after-musculoskeletal-trauma
#2
Brady J Hurtgen, Catherine L Ward, Chrissy M Leopold Wager, Koyal Garg, Stephen M Goldman, Beth E P Henderson, Todd O McKinley, Sarah M Greising, Joseph C Wenke, Benjamin T Corona
The deleterious impact of concomitant muscle injury on fracture healing and limb function is commonly considered part of the natural sequela of orthopedic trauma. Recent reports suggest that heightened inflammation in the surrounding traumatized musculature is a primary determinant of fracture healing. Relatedly, there are emerging potential therapeutic approaches for severe muscle trauma (e.g., volumetric muscle loss [VML] injury), such as autologous minced muscle grafts (1 mm(3) pieces of muscle; GRAFT), that can partially prevent chronic functional deficits and appear to have an immunomodulatory effect within VML injured muscle...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28740415/the-extracellular-matrix-of-eggshell-displays-anti-inflammatory-activities-through-nf-%C3%AE%C2%BAb-in-lps-triggered-human-immune-cells
#3
Tram T Vuong, Sissel B Rønning, Henri-Pierre Suso, Ralf Schmidt, Kristian Prydz, Marlene Lundström, Anders Moen, Mona E Pedersen
Avian eggshell membrane (ESM) is a natural biomaterial that has been used as an alternative natural bandage on burned and cut skin injuries for >400 years in Asian countries, and is available in large quantities from egg industries. Our aim was to characterize ESM that was separated and processed from egg waste, and to study whether this material possesses anti-inflammatory properties, making it suitable as an ingredient in industrial production of low cost wound healing products. Our results show that the processed ESM particles retain a fibrous structure similar to that observed for the native membrane, and contain collagen, and carbohydrate components such as hyaluronic acid and sulfated glycosaminoglycans, as well as N-glycans, mostly with uncharged structures...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28738849/immune-suppression-of-igg-response-against-dairy-proteins-in-major-depression
#4
Leszek Rudzki, Dariusz Pawlak, Krystyna Pawlak, Napoleon Waszkiewicz, Aleksandra Małus, Beata Konarzewska, Mirosława Gałęcka, Anna Bartnicka, Lucyna Ostrowska, Agata Szulc
BACKGROUND: Interactions between the digestive system, brain functions and immunoglobulin G (IgG) mediated immunity against food antigens became recently a topic of growing interest in psychiatry research. Psychological stress can activate hypothalamic-pituitary-adrenal axis (HPA) with subsequent hypercortisolemia. It can also influence intestinal permeability and dynamics of IgG response. Major depression can by accompanied either by activation of inflammatory response or by immune suppression (e...
July 24, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28738770/effects-of-resveratrol-and-other-polyphenols-on-the-most-common-brain-age-related-diseases
#5
Fiorella Sarubbo, David Moranta, Victor Jose Asensio, Antonio Miralles, Susana Esteban
With the global increase in the elderly population, modern societies must meet the challenge to find strategies to reduce the consequences of aging process; thereby decreasing the incidence of age-related neurodegenerative diseases. Over the last two decades, oxidative stress and recently inflammation, have been pointed out as the leading causes of brain aging. As a suggested treatment, the consumption or administration of antioxidant and anti-inflammatory molecules, such as polyphenols, present in food, is recommended as a beneficial strategy for preventing brain aging and several brain age-related diseases...
July 24, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28738351/major-depression-as-a-neuroprogressive-prelude-to-dementia-what-is-the-evidence
#6
Brian E Leonard
Epidemiological studies implicate chronic depression as a predisposing factor for dementia in later life. However, the link is incompletely understood and controversial. The aim of this review is to consider some of the biological factors that contribute to neuroprogressive brain dysfunction in late life as a consequence of prolonged, low-grade inflammation in the course of depressive episodes. As chronic inflammation is known to precipitate increased apoptosis of neurons and astrocytes, this could be a contributing factor to brain dysfunction...
2017: Modern Trends in Pharmacopsychiatry
https://www.readbyqxmd.com/read/28732807/pharmacology-and-toxicology-of-%C3%AE-and-%C3%AE-asarone-a-review-of-preclinical-evidence
#7
REVIEW
Ranjithkumar Chellian, Vijayapandi Pandy, Zahurin Mohamed
BACKGROUND: Asarone is one of the most researched phytochemicals and is mainly present in the Acorus species and Guatteria gaumeri Greenman. In preclinical studies, both α- and β-asarone have been reported to have numerous pharmacological activities and at the same time, many studies have also revealed the toxicity of α- and β-asarone. PURPOSE: The purpose of this comprehensive review is to compile and analyze the information related to the pharmacokinetic, pharmacological, and toxicological studies reported on α- and β-asarone using preclinical in vitro and in vivo models...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28730748/extracellular-signal-regulated-kinase-activation-in-the-spinal-cord-contributes-to-visceral-hypersensitivity-induced-by-craniofacial-injury-followed-by-stress
#8
Y-J Zhao, J-H Li, B Hu, Y Wang, X-F Chang, R J Traub, D-Y Cao
BACKGROUND: We previously developed an animal model to examine mechanisms that underlie the emergence of visceral hypersensitivity modeling pain characteristics of temporomandibular disorder (TMD) patients with comorbid irritable bowel syndrome (IBS). In ovariectomized (OVx) rats with estradiol (E2) replacement, visceral hypersensitivity developed subsequent to masseter muscle inflammation followed by repeated forced swim (FS) stress. The purpose of this study was to investigate whether activation of extracellular signal-regulated kinase (ERK) in the spinal cord contributes to visceral hypersensitivity in this overlapping pain model...
July 21, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28728805/associations-of-c-reactive-protein-and-psychological-distress-are-modified-by-antidepressants-supporting-an-inflammatory-depression-subtype-findings-from-ukhls
#9
Amanda Hughes, Meena Kumari
BACKGROUND: Clinical evidence increasingly suggests inflammation may be important specifically for an etiologically distinct depression subtype, characterised by resistance to antidepressant medication. However, epidemiological investigations of the relationship of inflammation with depression and psychological distress have failed to acknowledge these developments, which may have resulted in bias or masking of associations driven by the subtype. This may have contributed to inconsistent results in epidemiological studies, and equivocal support for an inflammation-depression link...
July 17, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28726780/foxq1-regulates-senescence-associated-inflammation-via-activation-of-sirt1-expression
#10
Pan Wang, Cuicui Lv, Tao Zhang, Junling Liu, Jin Yang, Fangxia Guan, Tianpei Hong
Cellular senescence is an initial barrier to tumor development that prevents the proliferation of premalignant cells. However, some of the features of senescent cells seem to promote tumor progression via senescence-associated secretory phenotype (SASP). Here, we demonstrated that the protein level of forkhead box Q1 (FOXQ1), which highly overexpresses in several kinds of tumors, was significantly downregulated during both replicative and oncogene-induced senescence. Moreover, overexpression of FOXQ1 delayed senescence, whereas FOXQ1 silence led to premature senescence in human fibroblasts...
July 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28724431/biological-embedding-of-childhood-adversity-from-physiological-mechanisms-to-clinical-implications
#11
REVIEW
Anne E Berens, Sarah K G Jensen, Charles A Nelson
BACKGROUND: Adverse psychosocial exposures in early life, namely experiences such as child maltreatment, caregiver stress or depression, and domestic or community violence, have been associated in epidemiological studies with increased lifetime risk of adverse outcomes, including diabetes, heart disease, cancers, and psychiatric illnesses. Additional work has shed light on the potential molecular mechanisms by which early adversity becomes "biologically embedded" in altered physiology across body systems...
July 20, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28721154/obesity-and-inflammation-the-linking-mechanism-and-the-complications
#12
Mohammed S Ellulu, Ismail Patimah, Huzwah Khaza'ai, Asmah Rahmat, Yehia Abed
Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. As a risk factor, inflammation is an imbedded mechanism of developed cardiovascular diseases including coagulation, atherosclerosis, metabolic syndrome, insulin resistance, and diabetes mellitus...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28719808/activated-neuro-oxidative-and-neuro-nitrosative-pathways-at-the-end-of-term-are-associated-with-inflammation-and-physio-somatic-and-depression-symptoms-while-predicting-outcome-characteristics-in-mother-and-baby
#13
Chutima Roomruangwong, Decio Sabbatini Barbosa, Andressa Keiko Matsumoto, André de Souza Nogueira, Buranee Kanchanatawan, Sunee Sirivichayakul, André F Carvalho, Sebastien Duleu, Michel Geffard, Estefania Gastaldello Moreira, Michael Maes
OBJECTIVES: To examine oxidative & nitrosative stress (O&NS) biomarkers at the end of term in relation to perinatal affective symptoms, neuro-immune biomarkers and pregnancy-related outcome variables. METHODS: We measured plasma advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical trapping antioxidant parameter (TRAP), -sulfhydryl (-SH), peroxides (LOOH) and paraoxonase (PON)1 activity in pregnant women with and without prenatal depression and non-pregnant controls...
July 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28716590/lumbar-muscle-inflammation-alters-spinally-mediated-locomotor-recovery-induced-by-training-in-a-mouse-model-of-complete-spinal-cord-injury
#14
Renaud Jeffrey-Gauthier, Mathieu Piché, Hugues Leblond
Locomotor networks after spinal cord injury (SCI) are shaped by training-activated proprioceptive and cutaneous inputs. Nociception from injured tissues may alter these changes but has largely been overlooked. The objective of the present study was to ascertain whether lumbar muscle inflammation hinders locomotion recovery in a mouse model of complete SCI. Lower limb kinematics during treadmill training was assessed before and after complete SCI at T8 (2, 7, 14, 21 and 28days post-injury). Locomotor recovery was compared in 4 groups of CD1 mice: control spinal mice; spinal mice with daily locomotor training; spinal mice with lumbar muscle inflammation (Complete Freund's Adjuvant (CFA) injection); and spinal mice with locomotor training and CFA...
July 15, 2017: Neuroscience
https://www.readbyqxmd.com/read/28715724/toxoplasma-gondii-infection-and-common-mental-disorders-in-the-finnish-general-population
#15
Jaana Suvisaari, Minna Torniainen-Holm, Maija Lindgren, Tommi Härkänen, Robert H Yolken
OBJECTIVE: We investigated whether T. gondii seropositivity is associated with 12-month depressive, anxiety and alcohol use disorders and current depressive symptoms and whether inflammation, measured by C-reactive protein (CRP) level, explains these associations. METHOD: Health 2000 study (BRIF8901), conducted in years 2000-2001, is based on a nationally representative sample of Finns aged 30 and above, with 7112 participants and 88.6% response rate. DSM-IV depressive, anxiety and alcohol use disorders were assessed with the Composite International Diagnostic Interview and depressive symptoms with the Beck Depressive Inventory (BDI-21)...
July 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28713238/targeting-cognitive-impairment-in-multiple-sclerosis-the-road-toward-an-imaging-based-biomarker
#16
Jeroen Van Schependom, Guy Nagels
Multiple Sclerosis (MS) is a neuro-degenerative and -inflammatory disease leading to physical and cognitive impairment, pathological fatigue and depression, and affecting patients' quality of life and employment status. The combination of inflammation, demyelination, and neurodegeneration leads to the emergence of MS lesions, reduced white and gray matter brain volumes, a reduced conduction velocity and microstructural changes in the so-called Normal Appearing White Matter (NAWM). Currently, there are very limited options to treat cognitive impairment and its origin is only poorly understood...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28712427/depression-inflammation-and-epidermal-growth-factor-receptor-egfr-status-in-metastatic-non-small-cell-lung-cancer-a-pilot-study
#17
Jamie M Jacobs, Lara Traeger, Justin Eusebio, Naomi M Simon, Lecia V Sequist, Joseph A Greer, Jennifer S Temel, William F Pirl
OBJECTIVE: Patients with stage IV non-small cell lung cancer (NSCLC) have high risk for depressive symptoms and major depressive disorder (MDD); however, those with epidermal growth factor receptor (EGFR) mutations may have decreased risk. The biological underpinning of this relationship is unknown. We examined differences in depression severity and MDD in patients with newly diagnosed stage IV NSCLC based on EGFR mutation status, and examined proinflammatory cytokines and growth factors known to play a role in cancer progression and depression...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28712413/sleep-disturbance-and-kynurenine-metabolism-in-depression
#18
Hyong Jin Cho, Jonathan Savitz, Robert Dantzer, T Kent Teague, Wayne C Drevets, Michael R Irwin
OBJECTIVE: Although the interrelationships between sleep disturbance, inflammation, and depression have been found, molecular mechanisms that link these conditions are largely unknown. Kynurenine metabolism is hypothesized to be a key mechanism that links inflammation and depression. Inflammation activates the kynurenine pathway, leading to increases in 3-hydroxykynurenine (3HK) and quinolinic acid (QA), potentially neurotoxic metabolites, and decreases in kynurenic acid (KynA), a potentially neuroprotective compound...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28709566/selected-comorbidities-of-atopic-dermatitis-atopy-neuropsychiatric-and-musculoskeletal-disorders
#19
Jonathan I Silverberg
Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease with substantial morbidity and quality of life impairment. There are a number of comorbid health problems that occur in patients with AD, aside from the cutaneous signs and symptoms. Chronic pruritus and inflammation can lead to sleep disturbances and mental health symptoms, which are not mutually exclusive. AD is associated with and may predispose to higher risk of other atopic disorders, including asthma and hay fever. Persons with AD appear to be at higher risk for multiple neuropsychiatric disorders, including depression, attention-deficit/hyperactivity disorder, speech disorders in childhood, headaches, and seizures...
July 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28708885/pioglitazone-ameliorates-glomerular-nlrp3-inflammasome-activation-in-apolipoprotein-e-knockout-mice-with-diabetes-mellitus
#20
Yao Wang, Bo Yu, Li Wang, Ming Yang, Zhiyin Xia, Wei Wei, Fengyu Zhang, Xiaochen Yuan
OBJECTIVE: The NLRP3 inflammasome plays an important role in the pathogenesis of inflammation in diabetic nephropathy (DN). Pioglitazone (PIO) has been found to exert an anti-inflammatory effect in patients with diabetes mellitus, but it is still unclear whether PIO exhibits a similar effect in DN. We aimed to explore the effect and underlying mechanism of PIO on DN, as well as investigate if NLRP3 is a pharmacologic target of PIO. METHODS: We divided 48 apolipoprotein E (apoE) (-/-) mice into 4 groups: apoE (-/-), apoE (-/-) with PIO, diabetic apoE (-/-), and diabetic apoE (-/-) with PIO...
2017: PloS One
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