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Depression and inflammation

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https://www.readbyqxmd.com/read/28449562/longer-telomere-length-of-t-lymphocytes-in-patients-with-early-and-chronic-psychosis
#1
Yin Cui, Vishwanath Vasudev Prabhu, Thong Ba Nguyen, Subramaniam Mohana Devi, Young-Chul Chung
Objective: To investigate pathological conditions that act as sources of pro-inflammatory cytokines and cytotoxic substances to examine telomere length (TL) in patients with either early (duration of illness [DI] ≤5 years) or chronic (DI >5 years) psychosis using T lymphocytes. Methods: Based on these factors and the important role that T lymphocytes play in inflammation, the present study measured the TL of T lymphocytes in patients with either early or chronic psychosis...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28445888/differential-effects-of-inflammatory-and-psychosocial-stress-on-mood-hypothalamic-pituitary-adrenal-axis-and-inflammation-in-remitted-depression
#2
Peter Niemegeers, Peter De Boer, Glenn J H Dumont, Filip Van Den Eede, Erik Fransen, Stephan J Claes, Manuel Morrens, Bernard G C Sabbe
BACKGROUND/AIMS: Major depressive disorder (MDD) is highly recurrent. This may be due to increased stress sensitivity after remission. Both inflammatory and psychosocial stressors are implicated in the pathogenesis of MDD, but the additive or differential effect is unclear. METHODS: We conducted a single-blind placebo-controlled study to investigate the effects of inflammatory stress (i.e., typhoid vaccination), psychosocial stress (i.e., Trier Social Stress Test [TSST]), or a combination of both in women (25-45 years old) with (partially) remitted recurrent MDD (n = 21) and healthy female controls (n = 18)...
April 27, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28444658/comparing-the-immune-genomic-effects-of-vilazodone-and-paroxetine-in-late-life-depression-a-pilot-study
#3
Harris Eyre, Prabha Siddarth, Natalie Cyr, Hongyu Yang, Steve Cole, Malcolm Forbes, Helen Lavretsky
Vilazodone is a novel antidepressant agent that combines selective serotonin (5-HT) reuptake inhibitor (SSRI) activity and 5-HT(1A) receptor partial agonist activity. A pilot study was conducted to compare vilazodone (novel compound) and paroxetine (gold standard) on antidepressant effects, tolerability, and inflammation and immune modulation. A 12-week, double-blind, randomized clinical trial was conducted with 56 nondemented older adults diagnosed with major depressive disorder (MDD). Between-group differences in mood, tolerability, and safety, as well as genomic markers of inflammation and immune modulation, were examined...
April 25, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28442354/the-influence-of-stress-on-neuroinflammation-and-alterations-in-brain-structure-and-function-in-major-depressive-disorder
#4
REVIEW
Yong-Ku Kim, Eunsoo Won
Major depressive disorder (MDD) is a condition which has often been associated with chronic stress. The sympathetic nervous system is continuously activated without the normal counteraction of the parasympathetic nervous system under the influence of chronic stress. As a result, epinephrine and norepinephrine levels are increased, and acetylcholine levels are decreased, which in turn can increase the levels of pro-inflammatory cytokines. Peripheral inflammatory responses can access the brain, with neuroinflammation contributing to the increase in neurotoxic kynurenine pathway metabolites such as 3-hydroxykynurenine, 3-hydroxyanthranilic acid and quinolinic acid, and decrease in neuroprotective metabolites such as kynurenic acid...
April 22, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28441923/lowered-pon1-activities-are-strongly-associated-with-depression-and-bipolar-disorder-recurrence-of-hypo-mania-and-depression-increased-disability-and-lowered-quality-of-life
#5
Estefania Gastaldello Moreira, Dalmo Guilherme Correia, Kamila Landucci Bonifácio, Juliana Brum de Moraes, Fernanda Liboni Cavicchioli, Carolina Sampaio Nunes, Sandra Odebrecht Vargas Nunes, Heber Odebrecht Vargas, Décio Sabbatini Barbosa, Michael Maes
BACKGROUND: Mood disorders (MD) frequently co-exist with cardiovascular disease (CVD) and immune-inflammatory and oxidative stress are important shared pathophysiological pathways. Even though there is an extensive investigation of the enzyme paraoxonase 1 (PON1) as a biomarker of susceptibility for CVD, there are only few reports studying PON1 in MD. OBJECTIVES: To determine the association between PON1 activities as well as functional genotypes and MD diagnosis, clinical characteristics and outcomes...
April 26, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28440737/heart-rate-variability-depression-in-porcine-peritonitis-induced-sepsis-without-organ-failure
#6
Dagmar Jarkovska, Lenka Valesova, Jiri Chvojka, Jan Benes, Vojtech Danihel, Jitka Sviglerova, Lukas Nalos, Martin Matejovic, Milan Stengl
Depression of heart-rate variability (HRV) in conditions of systemic inflammation has been shown in both patients and experimental animal models and HRV has been suggested as an early indicator of sepsis. The sensitivity of HRV-derived parameters to the severity of sepsis, however, remains unclear. In this study we modified the clinically relevant porcine model of peritonitis-induced sepsis in order to avoid the development of organ failure and to test the sensitivity of HRV to such non-severe conditions. In 11 anesthetized, mechanically ventilated and instrumented domestic pigs of both sexes, sepsis was induced by fecal peritonitis...
May 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28438472/shared-metabolic-and-immune-inflammatory-oxidative-and-nitrosative-stress-pathways-in-the-metabolic-syndrome-and-mood-disorders
#7
REVIEW
Luiz Gustavo Piccoli de Melo, Sandra Odebrecht Vargas Nunes, George Anderson, Heber Odebrecht Vargas, Décio Sabbattini Barbosa, Piotr Galecki, André F Carvalho, Michael Maes
This review examines the shared immune-inflammatory, oxidative and nitrosative stress (IO&NS) and metabolic pathways underpinning metabolic syndrome (MetS), bipolar disorder (BD) and major depressive disorder (MDD). Shared pathways in both MetS and mood disorders are low grade inflammation, including increased levels of pro-inflammatory cytokines and acute phase proteins, increased lipid peroxidation with formation of malondialdehyde and oxidized low density lipoprotein cholesterol (LDL-c), hypernitrosylation, lowered levels of antioxidants, most importantly zinc and paraoxonase (PON1), increased bacterial translocation (leaky gut), increased atherogenic index of plasma and Castelli risk indices; and reduced levels of high-density lipoprotein (HDL-c) cholesterol...
April 21, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28438331/-the-intestinal-microbiota-a-new-player-in-depression
#8
M Meyrel, L Varin, B Detaint, F Mouaffak
Depression is the leading cause of disability in the world according to the World Health Organization. The effectiveness of the available antidepressant therapies is limited. Data from the literature suggest that some subtypes of depression may be associated with chronic low grade inflammation. The uncovering of the role of intestinal microbiota in the development of the immune system and its bidirectional communication with the brain have led to growing interest on reciprocal interactions between inflammation, microbiota and depression...
April 21, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28433943/acute-lung-injury-leads-to-depression-like-symptoms-through-upregulation-of-neutrophilic-and-neuronal-nadph-oxidase-signaling-in-a-murine-model
#9
Ahmed Nadeem, Nahid Siddiqui, Naif O Al-Harbi, Sabry M Attia, Shakir D AlSharari, Sheikh F Ahmad
There is an increased prevalence of comorbid major depressive disorders with a number of inflammatory conditions which is thought to result from activation of the immune system. Acute lung injury (ALI) in humans has been also shown to be associated with depression previously. However, no study has explored the mechanism behind ALI-induced depression. NADPH oxidase (NOX-2) derived reactive oxygen species (ROS) are associated with neuropsychiatric disorders including depression. ROS generation via NOX-2 is also shown to be involved in the pathogenesis of ALI...
April 20, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28433458/linking-the-biological-underpinnings-of-depression-role-of-mitochondria-interactions-with-melatonin-inflammation-sirtuins-tryptophan-catabolites-dna-repair-and-oxidative-and-nitrosative-stress-with-consequences-for-classification-and-cognition
#10
REVIEW
George Anderson
The pathophysiological underpinnings of neuroprogressive processes in recurrent major depressive disorder (rMDD) are reviewed. A wide array of biochemical processes underlie MDD presentations and their shift to a recurrent, neuroprogressive course, including: increased immune-inflammation, tryptophan catabolites (TRYCATs), mitochondrial dysfunction, aryl hydrocarbonn receptor activation, and oxidative and nitrosative stress (O&NS), as well as decreased sirtuins and melatonergic pathway activity. These biochemical changes may have their roots in central, systemic and/or peripheral sites, including in the gut, as well as in developmental processes, such as prenatal stressors and breastfeeding consequences...
April 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28430117/fluvastatin-therapy-could-not-decrease-progression-of-paroxysmal-atrial-fibrillation-in-non-valvular-disease-patients
#11
Qiang Tan, Shuangyue Zhang, Xiaoyi Zou, Jun Zhao, Jia Hao, Qian Sun
OBJECTIVE: This study aimed to evaluate whether fluvastatin therapy could decrease the probability of atrial fibrillation (AF) progression from paroxysmal AF to permanent AF and decrease the recurrence frequency of AF. METHODS: Analyses were performed using two-tailed Student's t test or Mann-Whitney U tests. Categorical variables were compared with the χ2 statistics or Fisher's exact test. Patients with paroxysmal AF were randomized case-control, prospective into either the fluvastatin group (n=61) or control group (n=57)...
April 10, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28429885/intravenous-self-administration-of-benzydamine-a-non-steroidal-anti-inflammatory-drug-with-a-central-cannabinoidergic-mechanism-of-action
#12
Riccardo Avvisati, Maria Meringolo, Emiliana Stendardo, Elisa Malavasi, Silvia Marinelli, Aldo Badiani
Benzydamine (BZY) is a non-steroidal anti-inflammatory drug used for the topical treatment of inflammations of the oral and vaginal mucosae. Virtually nothing is known about the central pharmacological actions of BZY. Yet there are reports of voluntary systemic overdosage of BZY in drug addicts, resulting in a euphoric, hallucinatory state. In the present study, we investigated the reinforcing properties of BZY in a rat self-administration paradigm. We found that BZY has a powerful reinforcing effect and that this effect is greatly facilitated in animals that already had substance experience, having previously self-administered heroin and cocaine, indicating cross sensitization between BZY and other common drugs of abuse...
April 21, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28422706/adult-hippocampal-neurogenesis-an-important-target-associated-with-antidepressant-effects-of-exercise
#13
Lina Sun, Qingshan Sun, Jinshun Qi
Depression is a prevalent devastating mental disorder that affects the normal life of patients and brings a heavy burden to whole society. Although many efforts have been made to attenuate depressive/anxiety symptoms, the current clinic antidepressants have limited effects. Scientists have long been making attempts to find some new strategies that can be applied as the alternative antidepressant therapy. Exercise, a widely recognized healthy lifestyle, has been suggested as a therapy that can relieve psychiatric stress...
April 19, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28419913/depression-and-anxiety-both-associate-with-serum-level-of-hs-crp-a-gender-stratified-analysis-in-a-population-based-study
#14
Maryam Tayefi, Mojtaba Shafiee, Seyyed Mohammad Reza Kazemi-Bajestani, Habibolah Esmaeili, Susan Darroudi, Samaneh Khakpouri, Maryam Mohammadi, Zahra Ghaneifar, Mahmoud Reza Azarpajouh, Mohsen Moohebati, Alireza Heidari-Bakavoli, Mohammad Reza Parizadeh, Mohsen Nematy, Mohammad Safarian, Mahmoud Ebrahimi, Gordon A Ferns, Naghmeh Mokhber, Majid Ghayour-Mobarhan
BACKGROUND: Depression and anxiety are two important mood disorders that are frequently associated with chronic diseases such as cardiovascular diseases (CVDs). Hyper-inflammation is related to both CVDs and psychological conditions such as depression and anxiety. Therefore, inflammation may partially explain the relationship between depression and cardiovascular disease. OBJECTIVE: The objective of this study was to perform a gender-stratified examination of the association between symptoms of depression/anxiety disorders and serum hs-CRP and inflammation linked conditions in a large Iranian population...
April 2, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28418288/immunopsychiatry-important-facts
#15
G M Khandaker, R Dantzer, P B Jones
Accumulating evidence indicate a role for the immune system particularly inflammation and autoimmunity in the aetiology of major psychiatric disorders such as depression and schizophrenia. In this paper, we discuss some of the key advances in immunopsychiatry in order to highlight to psychiatrists and other health professionals how an increased understanding of this field might enhance our knowledge of illness mechanism and approaches to treatment. We present a brief overview of clinical research that link inflammation and autoimmunity with depression and psychosis, including potential role of inflammation in treatment response, current evidence for the effectiveness of immune-modulating treatment for depression and psychosis, and possible role of inflammation in common physical comorbidities for these disorders such as coronary heart disease and diabetes mellitus...
April 18, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28415997/dusuqing-granules-dsq-suppress-inflammation-in-klebsiella-pneumonia-rat-via-nf-%C3%AE%C2%BAb-mapk-signaling
#16
Xue Mei, Hao-Xun Wang, Jian-Sheng Li, Xiao-Hui Liu, Xiao-Fan Lu, Ya Li, Wei-Yu Zhang, Yan-Ge Tian
BACKGROUND: Dusuqing granules (DSQ) have been used in the treatment of bacterial pneumonia clinically, with remarkable benefits. This study was initiated to explore the effects of DSQ on pulmonary inflammation by regulating nuclear factor (NF)-κB/mitogen-activated protein kinase (MAPK) signaling in bacterial pneumonia rats. METHODS: Rat model was duplicated with Klebsiella pneumonia by a one-time intratracheal injection. Rats were randomized into control, model, DSQ and levofloxacin (LVX) groups...
April 17, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28415673/camp-pka-creb-bdnf-signaling-pathway-in-hippocampus-mediates-cyclooxygenase-2-induced-learning-memory-deficits-of-rats-subjected-to-chronic-unpredictable-mild-stress
#17
Ying Luo, Shengnan Kuang, Huan Li, Dongzhi Ran, Junqing Yang
To investigate the mechanism of cyclooxygenase 2 (COX2) in learning and memory impairments in rats subjected to chronic unpredictable mild stress (CUMS), meloxicam was used intragastrically to inhibit the activity of cyclooxygenase 2. Moreover, cyclooxygenase 2 over-expressing or RNA interfere lentivirus was injected intraventricularly to increase or decrease the enzyme's expression, respectively. The body weights and sucrose consumption were used to analyze depressive behaviors, while the Morris water maze and step-down-type passive avoidance tests were carried out to evaluate the learning-memory functions...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412530/indoles-as-therapeutics-of-interest-in-medicinal-chemistry-bird-s-eye-view
#18
REVIEW
Navriti Chadha, Om Silakari
Indoles constitute extensively explored heterocyclic ring systems with wide range of applications in pathophysiological conditions that is, cancer, microbial and viral infections, inflammation, depression, migraine, emesis, hypertension, etc. Presence of indole nucleus in amino acid tryptophan makes it prominent in phytoconstituents such as perfumes, neurotransmitters, auxins (plant hormones), indole alkaloids etc. The interesting molecular architecture of indole makes them suitable candidates for the drug development...
April 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28411047/immunodepression-after-cpb-cytokine-dynamics-and-clinics-after-pediatric-cardiac-surgery-a-prospective-trial
#19
Georgia Justus, Christoph Walker, Lisa-Maria Rosenthal, Felix Berger, Oliver Miera, Katharina Rose Luise Schmitt
BACKGROUND: Corrective surgery for congenital heart defects is known to trigger a severe immune reaction. There has been extensive research on the effects of inflammation after cardiopulmonary bypass (CPB). Interestingly, monocytes are observed to be non-responsive to stimulation with lipopolysaccharide (LPS) under these conditions, indicating a state of immunodepression, which lays the ground for second hit infections after cardiosurgery with CPB. OBJECTIVES: The aim of this prospective study was to analyze immunodepression after pediatric cardiopulmonary bypass and to differentiate the effects of monocytic anergy on postoperative outcome...
April 11, 2017: Cytokine
https://www.readbyqxmd.com/read/28410273/up-regulation-of-intracellular-calcium-handling-underlies-the-recovery-of-endotoxemic-cardiomyopathy-in-mice
#20
Justin C Morse, Joanne Huang, Natasha Khona, Edward J Miller, Deborah A Siwik, Wilson S Colucci, Ion A Hobai
BACKGROUND: In surviving patients, sepsis-induced cardiomyopathy is spontaneously reversible. In the absence of any experimental data, it is generally thought that cardiac recovery in sepsis simply follows the remission of systemic inflammation. Here the authors aimed to identify the myocardial mechanisms underlying cardiac recovery in endotoxemic mice. METHODS: Male C57BL/6 mice were challenged with lipopolysaccharide (7 μg/g, intraperitoneally) and followed for 12 days...
April 14, 2017: Anesthesiology
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