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pulmonary adenocarcinoma & brain metastases

Guang Han, Jianping Bi, Wenyong Tan, Xueyan Wei, Xiaohong Wang, Xiaofang Ying, Xiaofang Guo, Xiaoyi Zhou, Desheng Hu, Weining Zhen
Lung adenocarcinomas are more commonly associated with brain metastases (BM). Epidermal growth factor receptor (EGFR) mutations have been demonstrated to be both predictive and prognostic for patients with lung adenocarcinoma. We aimed to explore the potential association between EGFR mutation and the risk of BM in pulmonary adenocarcinoma patients. Data of 234 patients from 2007 to 2014 were retrospectively reviewed. A total of 108 patients had EGFR mutations in the entire cohort. Among them, 76 patients developed BM during their disease course...
July 29, 2016: Oncotarget
Yazan Abdeen, Sawsan Amireh, Alpa Patel, Moh'd Al-Halawani, Hamid Shaaban, Richard Miller
CONTEXT: According to the recent World Health Organization reports, lung cancer has become the most common type of malignancy and the leading cause of death from cancer. Lung cancer frequently metastasizes to hilar lymphnodes, brain, adrenal glands, bone, but rarely to skin. CASE REPORT: We report a case of a 72-year-old male with a past medical history of pulmonary fibrosis and no prior history of smoking who presented to the emergency room for progressive dyspnea over three weeks...
May 2016: North American Journal of Medical Sciences
Jennifer Shih, Babar Bashir, Karen S Gustafson, Mark Andrake, Roland L Dunbrack, Lori J Goldstein, Yanis Boumber
Next-generation sequencing of primary and metachronous metastatic cancer lesions may impact patient care. We present a case of relapsed metastatic breast cancer with a dominant pulmonary lesion originally identified as lung adenocarcinoma. A 72-year-old, never-smoker woman with a protracted cough was found to have a large lung mass and regional lymphadenopathy on a chest CT. Lung mass biopsy showed adenocarcinoma with focal TTF-1 (thyroid transcription factor 1) positivity, favoring a lung primary. In addition to stereotactic brain radiation for cerebral metastases, she was started on carboplatin/pemetrexed...
August 2015: Journal of the National Comprehensive Cancer Network: JNCCN
Yoshihisa Shimada, Hisashi Saji, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
BACKGROUND: We investigated the factors associated with post-recurrence survival and the treatment for non-small-cell lung cancer patients with postoperative distant recurrence, especially oligometastasis. METHODS: We reviewed the data of 272 patients with distant recurrence who underwent resection of non-small-cell lung cancer from January 2000 through December 2011. RESULTS: The type of distant recurrence was classified as oligometastasis (n = 76, 28%) or polymetastasis (n = 196, 72%)...
October 2015: Asian Cardiovascular & Thoracic Annals
Halit Diri, Melih Kiziltepe, Sulbiye Karaburgu, Mehmet Sait Koc, Ersin Ozaslan, Fatih Tanriverdi
Adrenal incidentalomas are found incidentally during a radiologic examination performed for indications other than an adrenal disease, and 15% of them are bilateral adrenal masses. This study describes a 51-year-old male smoker patient admitted with diabetes mellitus. An abdominal ultrasonography performed due to his anemia revealed bilateral adrenal masses. His chest X-ray showed abnormal 10 cm opacity at the right upper lung, and brain, thorax, and abdomen CT scans showed multiple lesions compatible with lung cancer metastases...
2015: Case Reports in Endocrinology
David Ladrón de Guevara H, Francisca Furnaro L, Sebastián Yévenes A, José Miguel Clavero R, David Lazo P, Patricio Rodríguez D, Antonio Piottante B, Raúl Pefaur D, Claudio Pardo B
BACKGROUND: PET/CT (Positron Emission Tomography/Computed Tomography) is widely used in nodal and metastatic staging of lung cancer patients. AIM: To analyze PET/CT detection of metastatic disease in patients with lung cancer. MATERIAL AND METHODS: We reviewed retrospectively F18Fluorodeoxyglucose PET/CT scans performed between December 2008 and December 2013. We selected 143 patients aged 30 to 92 years (63% males) with confirmed lung cancer referred for staging, with no previous treatment...
January 2015: Revista Médica de Chile
Clemens Seidel, Rolf-Dieter Kortmann
No abstract text is available yet for this article.
February 2015: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Yingjie Xiu, Lili Jiang, Weiping Liu
Pulmonary blastoma is a rare series of malignant lung tumor, which contains three categories: classic biphasic pulmonary blastoma, pluropulmonary blastoma, and well-differentiated fetal adenocarcinoma. In this study, a 19-year old female suffering with classic biphasic pulmonary blastoma and metastases in brain and axilla was presented with special interest in clinicopathological presentations, immunohistochemical features, and molecular characterizations. However, this case was misdiagnosed initially with small biopsy specimen...
2015: International Journal of Clinical and Experimental Pathology
Kornelia Holzmann, Roland Kropfmüller, Herwig Schinko, Stephan Bogner, Franz Fellner, Wolfgang Arzt, Bernd Lamprecht
In the 26th week of gestation, a 29-year-old pregnant office employee was referred to the pulmonary department of Linz General Hospital (AKH) under the suspicion of tuberculosis. She complained of a cough with intermittent hemoptysis and pain in the thoracic spine from which she had been suffering the past 9 weeks. A plain chest X-ray showed a dense infiltrate on the right side and multiple smaller shadows in both lungs. Laboratory testing revealed anemia, leukocytosis, and an increase of C-reactive protein...
August 2015: Wiener Klinische Wochenschrift
Wei Zhang, Chao Yu, Bin Huang, Feng-Liang Zhou, Hai-Dong Huang, Qiang Li
Thrombocytosis is commonly observed in patients exhibiting a variety of malignancies, including pulmonary, gastrointestinal and hepatic cancer. In the present study, the correlation between distant metastasis and thrombocytosis was retrospectively reviewed in 308 cases of histopathologically confirmed pulmonary adenocarcinoma. The patients were classified as having thrombocytosis or not, based on their platelet counts upon diagnosis; thrombocytosis was documented in 82/308 patients (26.6%). A log-rank test indicated a statistically significant difference in survival between patients exhibiting thrombocytosis compared with patients not exhibiting thrombocytosis (P<0...
February 2015: Oncology Letters
Dhruv Lowe, Shreya Sinha, Arunpreet Kahlon
Cancer Student/Resident Case Report Posters IIISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Leptomeningeal carcinomatosis is a rare but grave consequence of advanced cancers with median overall survival of 2-3 months. Patients can present with a broad range of symptoms, hence, diagnosis requires a high index of suspicion.CASE PRESENTATION: We present a case of a 71 year old female with h/o ovarian cancer s/p TAH-BSO, pulmonary adenocarcinoma s/p left lung lobectomy who presented to the hospital with a one month history of intermittent lightheadedness and headaches...
October 1, 2014: Chest
Nirosshan Thiruchelvam, Jaskirat Randhawa, Hamed Daw, Timothy Spiro, Abdo Haddad
SESSION TITLE: Cancer Student/Resident Case Report Posters IISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Pancoast tumor is defined as a neoplasm located at the apical pleuropulmonary groove. The majority of the tumors are non small cell lung cancers (NSCLCs). CASE PRESENTATION: A 44 year old male with 20 pack year history of smoking who presented with headache, axillary chest wall discomfort and numbness in the medial aspect of the left forearm for 2 weeks...
October 1, 2014: Chest
Dong Soo Lee, Seung Joon Kim, Jin Hyoung Kang, Sook Hee Hong, Eun Kyoung Jeon, Young Kyoon Kim, Ie Ryoung Yoo, Jae Gil Park, Hong Seok Jang, Hyo Chun Lee, Yeon Sil Kim
BACKGROUND: This study aimed to clarify the clinical associations between serum carcinoembryonic antigen (CEA) levels and whole-body metastatic distribution in stage IV NSCLC patients. METHODS: This study analyzed 377 eligible patients between June 2007 and December 2012. All patients enrolled in the study were newly diagnosed with stage IV NSCLC and had records of pre-treatment serum CEA levels. The serum CEA levels were categorized as normal (< 5 ng/ml) or abnormal (≥ 5 ng/ml) to reveal clinically correlated factors with abnormal serum CEA levels...
2014: Journal of Cancer
Giorgio Fratus, Fabio Tagliabue, Pierpaolo Mariani, Enrico Coppola Bottazzi, Luisella Spinelli, Lorenzo Novellino
UNLABELLED: Lung cancer is the most common neoplasm diagnosed worldwide. Metastatic presentation of the disease is frequent. Apart from the usual sites of metastatic disease (bone, adrenals, liver, brain), a particular site for metastases is represented by skin. The case we report is about a 66 year-old man with cutaneous metastasis from lung cancer. A 66 year-old man, with a previous history of abdominal aortic aneurism, chronic obstructive pulmonary disease, cardiopathy, diabetes mellitus, was admitted to our institution for left lower lobe lung cancer...
2014: Annali Italiani di Chirurgia
Jy Ming Chiang, Pao Shiu Hsieh, Jinn Shiun Chen, Reiping Tang, Jeng Fu You, Chien Yuh Yeh
BACKGROUND: Rectal cancer patients have a higher incidence of pulmonary metastases than those with colon cancer. This study aimed to examine the effects of rectal cancer level on recurrence patterns in rectal cancer patients. METHODS: Patients with T3/T4 rectal cancers who underwent surgery between 2002 and 2006 were recruited in this study. All the patients were followed up on until death. Recurrence patterns and survival rates were calculated in relation to clinical variables...
2014: World Journal of Surgical Oncology
W Schreiner, S Semrau, R Fietkau, H Sirbu
OBJECTIVE: The therapeutic strategies for oligometastatic non-small cell lung cancer have changed over the last decade from palliative to curative intent. The role of surgery in this multimodal treatment in selected patients remains a subject for open discussion. METHODS: Data of 34 patients with one or two metastases treated from January 1998 to January 2013 were retrospectively analysed. RESULTS: The mean age was 59.7 (± 10.1) years. The male vs...
June 2014: Zentralblatt Für Chirurgie
Valeria Barresi, Giovanni Branca, Maria Caffo, Rosario Caltabiano, Antonio Ieni, Enrica Vitarelli, Salvatore Lanzafame, Giovanni Tuccari
Despite ongoing clinical trials, the efficacy of anti-angiogenic drugs for the treatment of brain metastases (BM) is still questionable. The lower response rate to anti-angiogenic therapy in the presence of BM than in metastatic disease involving other sites suggests that BM may be insensitive to these drugs, although the biological reasons underlining this phenomenon are still to be clarified. With the aim of assessing whether the targets of anti-angiogenic therapies are actually present in BM, in the present study, we analyzed the microvessel density (MVD), a measure of neo-angiogenesis, and the vascular phenotype (mature vs...
2014: International Journal of Molecular Sciences
Daichi Fujimoto, Hiroyuki Ueda, Ryoko Shimizu, Ryoji Kato, Takehiro Otoshi, Takahisa Kawamura, Koji Tamai, Yumi Shibata, Takeshi Matsumoto, Kazuma Nagata, Kyoko Otsuka, Atsushi Nakagawa, Kojiro Otsuka, Nobuyuki Katakami, Keisuke Tomii
Mutated epidermal growth factor receptor (EGFR) and signaling pathways were associated with multiple brain and intra-pulmonary metastases, oncogenic progression and metastasis. However, features of metastasis to other organs and the independent prognostic influence of metastatic lesions were not elucidated in patients with lung cancer harboring EGFR mutations. Between January 2007 and April 2012, we treated 277 patients diagnosed with stage IV lung adenocarcinoma. Studied were 246 patients with available tumor EGFR mutation data who also underwent radiographic evaluation of lung, abdominal, brain, and bone metastases...
June 2014: Clinical & Experimental Metastasis
Yon Ju Ryu, Eun Mi Chun, Soon Nam Lee, Sung Shin Shim
Gefitinib is regarded as a relatively safe agent for the treatment of an advanced non-small cell lung cancer (NSCLC). Pulmonary toxicity such as interstitial lung disease associated with gefitinib is uncommon with an estimated all time incidence around 1% worldwide. Moreover, a case of gefitinib associated with pulmonary cystic changes has not been reported yet. In this report we present a case of progressive multiple air cystic changes in both lungs in a patient with NSCLC and intrapulmonary metastases who underwent a gefitinib therapy...
March 2014: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
M Straub, A Muselier, A Bron, C Creuzot-Garcher
We report the case of a 53-year-old patient referred by his ophthalmologist for a red, painful eye. On exam, he demonstrated findings of granulomatous uveitis with ocular hypertension (38 mm Hg) and a whitish, vascularized iris tumor with invasion of the irido-corneal angle. As our first hypothesis was an iris metastasis, a systemic work-up was carried out, which revealed moderately differentiated broncho-pulmonary carcinoma with multiple metastases (brain, cerebellum and adrenal). Emergency radio-chemotherapy was initiated, and the outcome was good, with rapid regression of the iris metastasis and good efficacy against the primary cancer...
February 2014: Journal Français D'ophtalmologie
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