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Pulmonary adenocarcinoma and metastasis and therapy

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https://www.readbyqxmd.com/read/27829227/targeted-therapy-of-multiple-liver-metastases-after-resected-solitary-gastric-metastasis-and-primary-pulmonary-adenocarcinoma
#1
Ling-Yu Ding, Ke-Jun Liu, Zhe-Long Jiang, Hai-Ying Wu, Shi-Xi Wu
Gastric metastases from lung adenocarcinoma are rare and usually asymptomatic. A 61-year-old woman was referred to our department because of a right lower pulmonary mass found on a chest X-ray film in August 2012. Right lower lobectomy was performed for pulmonary adenocarcinoma. Four months later, she developed epigastric discomfort. A fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) scan showed a malignancy at the cardias of the stomach. A biopsy diagnosed poorly differentiated carcinoma and a gastric carcinoma was suspected...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27784458/-trend-analysis-and-clinicopathological-characteristics-of-198-young-patients-with-advanced-lung-adenocarcinoma
#2
Y F Li, Y Wang, J L Li, X Z Hao, X S Hu, H Y Wang
Objective: The aim of this study was to analyze the trend of incidence, clinicopathological characteristics and therapy of young (less than 40 years old) patients with advanced lung adenocarcinoma, and to identify the prognostic factors. Methods: The clinical data of 198 young patients with advanced lung adenocarcinoma were collected from the Cancer hospital and Institute of Chinese academy of Medical Sciences from January 2001 to June 2012. To analyze the trend of incidence, clinicopathological characteristics and therapy and evaluate the independent prognostic factors affecting survival time with Cox proportional hazards model...
October 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27747151/a-long-term-survivor-of-non-small-cell-lung-cancer-harboring-concomitant-egfr-mutation-and-alk-translocation
#3
Fumio Imamura, Takako Inoue, Madoka Kimura, Kazumi Nishino, Toru Kumagai
In January 2003, a 55-year old, non-smoking woman visited our hospital to undergo treatment for T4N0M0 pulmonary adenocarcinoma of the left lung. Until death in October 2015, she received over 20 lines of treatment including a second line therapy with gefitinib, which showed long response. In March 2014, she noticed the left axillar lymph node swelling. Aspiration cytology of the lymph node revealed the presence of adenocarcinoma harboring EGFR exon 19 deletion (Ex19del) but not T790M. Concomitant ALK translocation of variant 1 was also detected...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27628491/intensity-modulated-radiation-therapy-may-improve-local-regional-tumor-control-for-locally-advanced-non-small-cell-lung-cancer-compared-with-three-dimensional-conformal-radiation-therapy
#4
Jingbo Wang, Zongmei Zhou, Jun Liang, Qinfu Feng, Zefen Xiao, Zhouguang Hui, Xiaozhen Wang, Jima Lv, Dongfu Chen, Hongxing Zhang, Zhe Ji, Jianzhong Cao, Lipin Liu, Wei Jiang, Yu Men, Cai Xu, Jiangrong Dai, Weibo Yin, Luhua Wang
BACKGROUND: Consistent results are lacking as regards the comparative effectiveness of intensity-modulated radiotherapy (IMRT) versus three-dimensional conformal radiotherapy (3DCRT) in patients with locally advanced non-small cell lung cancer (LA-NSCLC). PATIENTS AND METHODS: Patients treated with definitive radiotherapy (RT) between 2002 and 2010 were retrospectively reviewed. Overall survival (OS), local-regional progression-free survival (LRPFS), distant metastasis-free survival (DMFS), and progression-free survival (PFS) were compared among patients irradiated with different techniques...
September 14, 2016: Oncologist
https://www.readbyqxmd.com/read/27118646/-analysis-of-the-role-of-pet-ct-suvmax-in-prognosis-and-its-correlation-with-%C3%A2-clinicopathological-characteristics-in-resectable-lung-squamous-cell-carcinoma
#5
Hongliang Ren, Wengui Xu, Jian You, Xiuyu Song, Hui Huang, Ning Zhao, Xiubao Ren, Xinwei Zhang
BACKGROUND: Lung cancer is the leading cause of cancer death in men and women in the world, more than one-half of cases are diagnosed at a advanced stage, and the overall 5-year survival rate for lung cancer is 18%. Lung cancer is divided into non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC). Approximately 80%-85% of cases are NSCLC which includes three main types: adenocarcinoma (40%), squamous cell carcinoma (SCC) (20%-30%), and large cell carcinoma (10%). Although therapies that target driver mutations in adenocarcinomas are showing some promise, they are proving ineffective in smoking-related SCC...
April 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/26943447/a-case-of-metastatic-carcinoma-of-anal-fistula-caused-by-implantation-from-rectal-cancer
#6
Rina Takahashi, Ryosuke Ichikawa, Singo Ito, Kosuke Mizukoshi, Shun Ishiyama, Kiichi Sgimoto, Yutaka Kojima, Michitoshi Goto, Yuichi Tomiki, Takashi Yao, Kazuhiro Sakamoto
This case involved an 80-year-old man who was seen for melena. Further testing revealed a tubular adenocarcinoma 50 mm in size in the rectum. In addition, an anal fistula was noted behind the anus along with induration. A biopsy of tissue from the external (secondary) opening of the fistula also revealed adenocarcinoma. Nodules suspected of being metastases were noted in both lung fields. The patient was diagnosed with rectal cancer, a cancer arising from an anal fistula, and a metastatic pulmonary tumor, and neoadjuvant chemotherapy was begun...
December 2015: Surgical Case Reports
https://www.readbyqxmd.com/read/26787633/minimally-invasive-strategy-for-mediastinal-staging-of-patients-with-lung-cancer
#7
Jolanta Hauer, Artur Szlubowski, Katarzyna Żanowska, Lucyna Rudnicka-Sosin, Łukasz Trybalski, Zbigniew Grochowski, Tomasz Gil, Janusz Włodarczyk, Janusz Warmus, Piotr Kocoń, Tomasz Smęder, Jarosław Kużdżał
INTRODUCTION: The exclusion of mediastinal involvement in patients with non-small cell lung cancer is essential for choosing an appropriate therapy. OBJECTIVES: The aim of the study was to analyze the ability of a new minimally invasive strategy combining positron emission tomography (PET), endobronchial ultrasound needle aspiration (EBUS-NA), and endoscopic ultrasound needle aspiration (EUS-NA) to exclude mediastinal nodal metastases of non-small cell lung cancer...
2015: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/26782034/-specific-types-of-bladder-cancer
#8
S Bertz, A Hartmann, R Knüchel-Clarke, N T Gaisa
Bladder cancer shows rare variants and special subtypes with diverse prognostic importance and therefore may necessitate different therapeutic approaches. For pathologists it is important to histologically diagnose and specify such variants. Nested variants of urothelial carcinoma with inconspicuous, well-formed tumor cell nests present with an aggressive course. The plasmacytoid variant, which morphologically resembles plasma cells is associated with a shorter survival time and a high frequency of peritoneal metastasis...
February 2016: Der Pathologe
https://www.readbyqxmd.com/read/26765420/case-report-bazex-syndrome-associated-with-pulmonary-adenocarcinoma
#9
Jing Zhao, Xilin Zhang, Zhuo Chen, Jian-Hua Wu
Bazex syndrome, a rare paraneoplastic syndrome characterized by psoriasiform eruptions, palmoplantar keratosis, and symmetric onychodystrophy, is most prevalent with squamous cell carcinomas of the upper aerodigestive tract.Here, we reported an uncommon case of Bazex syndrome about an 83-year-old man with pulmonary adenocarcinoma and osseous metastasis, Physical examination found psoriasiform eruptions on the nose, cheeks, ears, knees, and the dorsa of interphalangeal joints, along with plantar keratosis and symmetric onychodystrophy involving hands and feet...
January 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26491347/advanced-lung-adenocarcinoma-with-spinal-cord-metastasis-successfully-treated-with-second-egfr-tki-treatment-a-case-report-and-literature-review
#10
Xiaoyan Li, Hui Yang, Jing Zhao, Hongjun Gao
Lung adenocarcinoma can be accompanied by epidermal growth factor receptor (EGFR) mutation. As a consequence, targeted therapy based on screening of tyrosine-kinase inhibitors (TKIs) is necessary. Spinal cord metastasis of lung cancer is a serious clinical problem. Here, we report a case of lung adenocarcinoma with severe spinal cord metastasis that was successfully treated with a second administration of an EGFR-TKI. Magnetic resonance imaging showed spinal cord metastasis to the cervical vertebrae. The patient received a second administration of an EGFR-TKI (150 mg/day erlotinib)...
2015: OncoTargets and Therapy
https://www.readbyqxmd.com/read/26458633/the-effect-of-bevacizumab-for-bone-scintigraphy-imaging-a-case-report
#11
LETTER
Takamitsu Asano, Osamu Takakuwa, Ken Maeno, Tetsuya Oguri, Akio Niimi
A 65-year-old man presented with pulmonary nodules and a right humeral fracture. The 99mTc-hydroxy-methylene-diphosphonate (HMDP) bone scintigraphy showed high-intensity radioisotope (RI) uptake by a tumor of the right arm. Adenocarcinoma of the lung with an epidermal growth factor receptor (EGFR) mutation was diagnosed on pathological examination of the computed tomography (CT)-guided needle biopsy of the right humerus. Although, gefitinib therapy was initiated, the tumor progressed. The patient was then treated with second-line chemotherapy including bevacizumab...
July 2015: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/26238818/stereotactic-body-radiotherapy-for-second-pulmonary-nodules-after-operation-for-an-initial-lung-cancer
#12
Kinji Nishiyama, Ken Kodama, Teruki Teshima, Hirohito Tada
OBJECTIVE: A second lung cancer is occasionally observed in patients who underwent surgical resection of the index lung cancer. The purpose of this study is to evaluate stereotactic body radiation therapy for second lung cancer. METHODS: Fifty-one medically inoperable patients who underwent stereotactic body radiation therapy for second lung cancer were the subjects: 31 cases of multiple primary lung cancer and 20 of pulmonary metastasis from the index cancer. Clinical stage was T1a in 27 patients, T1b in 13 patients and T2a in 11 patients, and 70% of subjects had impaired respiratory function...
October 2015: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26207006/survival-outcomes-for-oligometastasis-in-resected-non-small-cell-lung-cancer
#13
Yoshihisa Shimada, Hisashi Saji, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
BACKGROUND: We investigated the factors associated with post-recurrence survival and the treatment for non-small-cell lung cancer patients with postoperative distant recurrence, especially oligometastasis. METHODS: We reviewed the data of 272 patients with distant recurrence who underwent resection of non-small-cell lung cancer from January 2000 through December 2011. RESULTS: The type of distant recurrence was classified as oligometastasis (n = 76, 28%) or polymetastasis (n = 196, 72%)...
October 2015: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/26059540/cripto-1-as-a-novel-therapeutic-target-for-triple-negative-breast-cancer
#14
Nadia P Castro, Natalie D Fedorova-Abrams, Anand S Merchant, Maria Cristina Rangel, Tadahiro Nagaoka, Hideaki Karasawa, Malgorzata Klauzinska, Stephen M Hewitt, Kajal Biswas, Shyam K Sharan, David S Salomon
Triple-negative breast cancer (TNBC) presents the poorest prognosis among the breast cancer subtypes and no current standard therapy. Here, we performed an in-depth molecular analysis of a mouse model that establishes spontaneous lung metastasis from JygMC(A) cells. These primary tumors resembled the triple-negative breast cancer (TNBC) both phenotypically and molecularly. Morphologically, primary tumors presented both epithelial and spindle-like cells but displayed only adenocarcinoma-like features in lung parenchyma...
May 20, 2015: Oncotarget
https://www.readbyqxmd.com/read/25943541/solitary-pulmonary-metastasis-from-prostate-cancer-with-neuroendocrine-differentiation-a-case-report-and-review-of-relevant-cases-from-the-literature
#15
REVIEW
Toshiya Maebayashi, Katsumi Abe, Takuya Aizawa, Masakuni Sakaguchi, Naoya Ishibash, Shoko Fukushima, Taku Honma, Yoshiaki Kusumi, Tsuyoshi Matsui, Nozomu Kawata
BACKGROUND: Solitary lung metastasis from prostate cancer is rare. There are few reports of such cases with neuroendocrine differentiation. CASE PRESENTATION: A 50-year-old man presented to our hospital with a chief complaint of dysuria. Histological examination revealed prostate cancer, which was classified as cT4 N0 M0, stage IV adenocarcinoma. Since the patient was at high risk, endocrine and radiation therapies were started. One year after starting radiation therapy, the patient developed bloody sputum...
2015: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25926247/bronchial-pulmonary-adenocarcinoma-subtyping-relates-with-different-molecular-pathways
#16
Vítor Sousa, Bruno Bastos, Maria Silva, Ana Maria Alarcão, Lina Carvalho
Lung cancer is one of the most common cancers in the world with a high mortality rate. We analyzed 45 surgical samples of the adenocarcinoma, 13 with lymph node metastasis. APC, BCL2, chromogranin A, CK 5/6/18 (LP34), CK20, CK7, cyclin D1, EGFR, ERCC1, HER2, Ki67, LRP, MRP, P53, RB and TTF1 expressions were evaluated by immunohistochemistry (IHC). Higher Ki67, APC, ERCC1 expressions and lower TTF1 expression were identified in advanced stages (IIA and IIIA) of adenocarcinomas, which reflect a more aggressive, less differentiated, possibly a non-TRU adenocarcinoma...
September 2015: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/25806349/a-61-year-old-man-with-cough-and-white-sputum
#17
Yanwen Yao, Jie Yin, Xinwu Xiao, Tangfeng Lv, Wenkui Sun, Yong Song
A 61-year-old man with cough and white sputum had an abnormal pulmonary mass in the left lower lobe in the computed tomography (CT) imaging. According to the lung cancer multidisciplinary team (MDT) discussion, the patient took the left lower lobe resection and lymphadenectomy and finally diagnosed as left lung adenocarcinoma with TNM stage IIIA (pT3N2M0). After four cycles of postoperative chemotherapy with pemetrexed and nedaplatin and 10-month release, a solitary pulmonary nodule (SPN) appeared in the middle lobe of right lung in CT scanning...
February 2015: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/25731425/-report-of-a-successful-case-of-multidisciplinary-therapy-for-a-patient-with-lung-and-liver-metastasis-from-rectal-adenocarcinoma
#18
Terumasa Yamada, Chiwan Kim, Tomo Nakagawa, Kazuya Hiraoka, Ken Konishi, Shunji Endo, Masaki Okuyama, Kazuyuki Oda, Masanobu Hayakawa, Amane Yamauchi, Junichi Nishijima
A strategy of multidisciplinary therapy is considered necessary for the longer survival of a patient diagnosed with advanced colorectal cancer. We report a successful multi-disciplinary therapy case of a 70's-year-old male who received pulmonary resection for metastatic lung cancer twice after primary resection for rectal cancer. Solitary metastatic liver cancer with portal vein tumor thrombus (PVTT) was diagnosed 5 years and 4 months after primary surgery. Although systemic chemotherapy was started immediately, disease control was poor and local pulmonary recurrence appeared...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/25731358/-a-case-report-of-metastatic-anal-fistula-cancer-treated-with-neoadjuvant-chemotherapy
#19
REVIEW
Akihiro Murata, Satoshi Takatsuka, Hiroji Shinkawa, Ryoji Kaizaki, Takaaki Hori, Teruyuki Ikehara
A 69-year-old man with perianal pain was diagnosed with an anal fistula and a rectal tumor by magnetic resonance imaging and pulmonary tuberculosis by computed tomography. A colonoscopy confirmed the presence of a circular mass in the rectum 6 cm from the anal verge. Histological examination revealed a moderately differentiated adenocarcinoma. Initially, seton drainage was used to improve the perianal pain. After 2 months of anti-tuberculosis therapy, the patient underwent low anterior resection for the rectal cancer...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/25702675/lung-cancer-presenting-as-a-metastasis-to-the-tibial-bones-a-case-report
#20
Lorena Gurrieri, Alessandra Longhi, Antonio Braghetti
AIMS AND BACKGROUND: Bone metastasis below the knee from primary lung cancer is rare. Discussion of such cases in a multidisciplinary team is important to establish the correct treatment approach. CASE REPORT: We analyzed the diagnostic pathway of a 53-year-old female patient with a 5-month history of pain in the right foot. The patient underwent several radiological examinations for the pain. An initial diagnosis of osteoporotic syndrome was made, followed by a diagnosis of primary sarcoma...
March 20, 2015: Tumori
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