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https://www.readbyqxmd.com/read/29202810/trajectories-of-body-mass-index-among-canadian-seniors-and-associated-mortality-risk
#1
Meng Wang, Yanqing Yi, Barbara Roebothan, Jennifer Colbourne, Victor Maddalena, Guang Sun, Peizhong Peter Wang
BACKGROUND: This study aims to characterize the heterogeneity in BMI trajectories and evaluate how different BMI trajectories predict mortality risk in Canadian seniors. METHODS: Data came from the Canadian National Population Health Survey (NPHS, 1994-2011) and 1480 individuals aged 65-79 years with at least four BMI records were included in this study. Group-based trajectory model was used to identify distinct subgroups of longitudinal trajectories of BMI measured over 19 years for men and women...
December 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29160159/reported-habitual-intake-of-breakfast-and-selected-foods-in-relation-to-overweight-status-among-seven-to-nine-year-old-swedish-children
#2
Bente B Nilsen, Agneta Yngve, Celia Monteagudo, Richard Tellström, Henrik Scander, Bo Werner
AIM: The aim of this study was to examine the reported frequency of breakfast intake and selected food and beverages in the investigated group of Swedish children in comparison with recommended intakes. Furthermore, the study analyses these food habits and some demographic and lifestyle factors in relation to overweight and obesity. METHODS: This cross-sectional study builds on data collected in 2008 and 2010. Measured anthropometric data and parent questionnaire data were collected...
August 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29142292/urinary-volatile-organic-compounds-in-overweight-compared-to-normal-weight-children-results-from-the-italian-i-family-cohort
#3
Rosaria Cozzolino, Beatrice De Giulio, Pasquale Marena, Antonella Martignetti, Kathrin Günther, Fabio Lauria, Paola Russo, Matteo Stocchero, Alfonso Siani
Accumulating evidence shows that urinary volatile organic compounds (VOCs) could be perturbed in many physiological and pathological states, including several diseases and different dietary exposures. Few studies investigated the urinary metabolic signature associated to excess body weight and obesity in adult populations, while a different VOCs profile was found in exhaled breath in obese as compared to lean children. Aim of this study was to evaluate the VOCs profile in the urine of 21 overweight/obese (OW/Ob) and 28 normal-weight (NW) children belonging to the Italian cohort of the I...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29096069/exercise-training-and-weight-loss-not-always-a-happy-marriage-single-blind-exercise-trials-in-females-with-diverse-bmi
#4
Matthew Jackson, Fardin Fatahi, Kholoud Alabduljader, Charlotte Jelleyman, Jonathan P Moore, Hans-Peter Kubis
Individuals show high variability in body weight responses to exercise training. Expectations and motivation towards effects of exercise on body weight might influence eating behaviour and could conceal regulatory mechanisms. We conducted two single-blind exercise trials (4 weeks (study 1) and 8 weeks (study 2)) with concealed objectives and exclusion of individuals with weight loss intention. Circuit exercise training programs (3 times a week (45-90 min), intensity 50-90% VO2peak, for 4 and 8 weeks) were conducted...
November 2, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29090684/neuroactive-steroids-and-affective-symptoms-in-women-across-the-weight-spectrum
#5
Laura E Dichtel, Elizabeth A Lawson, Melanie Schorr, Erinne Meenaghan, Margaret Lederfine Paskal, Kamryn T Eddy, Graziano Pinna, Marianela Nelson, Ann M Rasmusson, Anne Klibanski, Karen K Miller
3α-5α-Tetrahydroprogesterone, a progesterone metabolite also known as allopregnanolone, and 5α-androstane-3α,17β-diol, a testosterone metabolite also known as 3α-androstanediol, are neuroactive steroids and positive GABAA receptor allosteric modulators. Both anorexia nervosa (AN) and obesity are complicated by affective co-morbidities and hypothalamic-pituitary-gonadal dysregulation. However, it is not known whether neuroactive steroid levels are abnormal at the extremes of the weight spectrum. We hypothesized that serum allopregnanolone and 3α-androstanediol levels would be decreased in AN compared to healthy controls (HC) and negatively associated with affective symptoms throughout the weight spectrum, independent of body mass index (BMI)...
November 1, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29068700/silibinin-reduces-the-impact-of-obesity-on-invasive-liver-cancer
#6
C Miethe, H Nix, R Martin, A R Hernandez, R S Price
Obesity is associated with non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Obesity and metabolic abnormalities resulting in low-grade inflammation can increase the risk of developing NASH and HCC. NASH, a risk factor for HCC, is characterized by increased inflammation, lipid accumulation, and liver injury. Obesogenic proteins modulate signaling pathways that induce physiological changes including lipogenesis, ROS, and inflammation. Silibinin, a polyphenol in milk thistle seed, has been shown to have anti-inflammatory properties...
October 25, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28989878/prevalence-of-metabolic-syndrome-markers-among-women-at-1-year-postpartum-as-per-prepregnancy-body-mass-index-status-a-longitudinal-study
#7
Neha A Kajale, Vaman Khadilkar, Shashi A Chiplonkar, Raja Padidela, Anuradha V Khadilkar
INTRODUCTION: Maternal body composition (BC) changes during lactation. Increased prepregnancy obesity is associated with poor obstetric outcomes. The aim was to study changes in maternal BC postpartum (PP) to 1-year PP with reference to their prepregnancy body mass index (BMI) status. METHODS: The study design was a 1-year follow-up study. Sixty-five apparently healthy primiparous women (28.6 ± 3.4 years delivered full-term infants) were randomly selected from December 2010 to June 2013 and postclassified on the basis of their prepregnancy BMI status...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28988759/predictors-of-obesity-and-overweight-in-preschoolers-the-role-of-parenting-styles-and-feeding-practices
#8
H Melis Yavuz, Bilge Selcuk
Childhood obesity/overweight (OB/OW) displayed a rapid increase and high prevalence in the last few decades in preschool-aged children, which raised health concerns across the world and motivated researchers to investigate the factors that underlie childhood obesity. The current study examined parenting styles and child-feeding practices as potential predictors for OB/OW in preschool children, controlling for child's temperament, which has been shown to be linked with OB/OW. The sample included 61 normal weight (NW) and 61 obese/overweight (OB/OW) Turkish pre-schoolers (M age = 62...
January 1, 2018: Appetite
https://www.readbyqxmd.com/read/28965494/the-impacts-of-maternal-iron-deficiency-and-being-overweight-during-pregnancy-on-neurodevelopment-of-the-offspring
#9
Staffan K Berglund, Francisco J Torres-Espínola, Luz García-Valdés, Mª Teresa Segura, Cristina Martínez-Zaldívar, Carmen Padilla, Ricardo Rueda, Miguel Pérez García, Harry J McArdle, Cristina Campoy
Both maternal Fe deficiency (ID) and being overweight or obese (Ow/Ob, BMI≥25 kg/m2) may negatively affect offspring brain development. However, the two risk factors correlate and their independent effects on infant neurodevelopment are unclear. PREOBE is a prospective observational study that included 331 pregnant Spanish women, of whom 166 had pre-gestational Ow/Ob. Fe status was analysed at 34 weeks and at delivery, and babies were assessed using Bayley III scales of neurodevelopment at 18 months. In confounder-adjusted analyses, maternal ID at 34 weeks was associated with lower composite motor scores at 18 months (mean 113·3 (sd 9·9) v...
October 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28965443/effect-of-body-mass-index-on-surgical-outcomes-after-posterior-spinal-fusion-for-adolescent-idiopathic-scoliosis
#10
Rafael De la Garza Ramos, Jonathan Nakhla, Rani Nasser, Jacob F Schulz, Taylor E Purvis, Daniel M Sciubba, Merritt D Kinon, Reza Yassari
OBJECTIVE Obesity is an increasing public health concern in the pediatric population. The purpose of this investigation was to examine the impact of body mass index (BMI) on 30-day outcomes after posterior spinal fusion for adolescent idiopathic scoliosis (AIS). METHODS The American College of Surgeons National Surgical Quality Improvement Program Pediatric database (2013 and 2014) was reviewed. Patients 10-18 years of age who had undergone fusion of 7 or more spinal levels for AIS were included. Thirty-day outcomes (complications, readmissions, and reoperations) were compared based on patient BMI per age- and sex-adjusted growth charts as follows: normal weight (NW; BMI < 85th percentile), overweight (OW; BMI 85th-95th percentile), and obese (OB; BMI > 95th percentile)...
October 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28938412/renal-metabolic-programming-is-linked-to-the-dynamic-regulation-of-a-leptin-klf15-axis-and-akt-ampk%C3%AE-signaling-in-male-offspring-of-obese-dams
#11
Philipp Kasper, Christina Vohlen, Katharina Dinger, Jasmine Mohr, Eva Hucklenbruch-Rother, Ruth Janoschek, Jessica Köth, Jan Matthes, Sarah Appel, Jörg Dötsch, Miguel A Alejandre Alcazar
Childhood obesity is associated with renal diseases. Maternal obesity is a risk factor linked to increased adipocytokines and metabolic disorders in the offspring. Therefore, we studied the impact of maternal obesity on renal-intrinsic insulin and adipocytokine signaling and on renal function and structure. To induce maternal obesity, female mice were fed a high-fat diet (HFD) or a standard diet (SD; control group) prior to mating, during gestation, and throughout lactation. A third group of dams was fed HFD only during lactation (HFD-Lac)...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28919382/overweight-and-obesity-in-new-caledonian-adults-results-from-measured-and-adjusted-self-reported-anthropometric-data
#12
Philippe Corsenac, Isabella Annesi-Maesano, Damian Hoy, Adam Roth, Bernard Rouchon, Isabelle Capart, Richard Taylor
AIMS: To estimate the overweight (OW) and obesity (Ob) prevalence and associated socio-demographic risk factors in New Caledonian adults aged 18-67years. METHODS: From a randomly selected cross-sectional population survey, self-reported (n=2513) and measured (n=736) height and weight data were collected. Separate linear regression analyses for measured weight and height were performed, using cases with both self-reported weight and height and socio-demographic variables...
June 22, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28911136/protein-rich-food-ingestion-stimulates-mitochondrial-protein-synthesis-in-sedentary-young-adults-of-different-bmis
#13
COMPARATIVE STUDY
Joseph W Beals, Richard W A Mackenzie, Stephan van Vliet, Sarah K Skinner, Brandon A Pagni, Grace M Niemiro, Alexander V Ulanov, Zhong Li, Anna C Dilger, Scott A Paluska, Michael De Lisio, Nicholas A Burd
Context: Excess fat mass may diminish the anabolic potency of protein-rich food ingestion to stimulate muscle protein subfractional synthetic responses. However, the impact of adiposity on mitochondrial protein synthesis (MPS) rates after protein-rich food ingestion has not been thoroughly examined in vivo in humans. Objective: We compared basal and postprandial MPS and markers of muscle inflammation [toll-like receptor 4 (TLR4) and myeloid differentiation primary response protein 88 (MyD88) protein content] in young adults with different body mass indices (BMIs)...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28870230/pre-pregnancy-weight-gestational-weight-gain-and-the-gut-microbiota-of-mothers-and-their-infants
#14
Maggie A Stanislawski, Dana Dabelea, Brandie D Wagner, Marci K Sontag, Catherine A Lozupone, Merete Eggesbø
BACKGROUND: Recent evidence supports that the maternal gut microbiota impacts the initial infant gut microbiota. Since the gut microbiota may play a causal role in the development of obesity, it is important to understand how pre-pregnancy weight and gestational weight gain (GWG) impact the gut microbiota of mothers at the time of delivery and their infants in early life. In this study, we performed 16S rRNA gene sequencing on gut microbiota samples from 169 women 4 days after delivery and from the 844 samples of their infants at six timepoints during the first 2 years of life...
September 4, 2017: Microbiome
https://www.readbyqxmd.com/read/28864012/maternal-obesity-and-gestational-weight-gain-are-modestly-associated-with-umbilical-cord-dna-methylation
#15
Keshari M Thakali, Jennifer B Faske, Arjun Ishwar, Maria P Alfaro, Mario A Cleves, Thomas M Badger, Aline Andres, Kartik Shankar
INTRODUCTION: Maternal obesity (OB) and excessive gestational weight gain (GWG) are strong independent contributors that augment obesity risk in offspring. However, direct evidence of epigenetic changes associated with maternal habitus remains sparse. METHODS: We utilized Bisulfite Amplicon Sequencing (BSAS) to conduct targeted DNA methylation association analysis of maternal obesity and excessive GWG with DNA methylation of select metabolism-related and imprinted genes...
September 2017: Placenta
https://www.readbyqxmd.com/read/28834553/efficacy-of-exenatide-on-weight-loss-metabolic-parameters-and-pregnancy-in-overweight-obese-polycystic-ovary-syndrome
#16
Xin Liu, Ying Zhang, Si-Yuan Zheng, Rong Lin, Yi-Juan Xie, Hui Chen, Yong-Xiong Zheng, En Liu, Lin Chen, Jia-He Yan, Wei Xu, Ting-Ting Mai, Yi Gong
CONTEXT: Weight loss remains one of the most important arms in obese patients with polycystic ovary syndrome (PCOS). Further studies are needed to identify the best treatment. OBJECTIVE: To evaluate the effects of exenatide (EXE) on reproductive and metabolic function in overweight/obese (OW/OB) PCOS. DESIGN: This is a 24-week open-label prospective, randomized, clinical study. PATIENTS AND MEASUREMENTS: This study randomized 176 OW/OB women diagnosed with PCOS to receive either EXE 10 μg BID (n = 88) or metformin (MET) 1000 mg BID (n = 88) for the first 12 weeks...
August 23, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28834246/magnetic-resonance-imaging-reveals-elevated-aortic-pulse-wave-velocity-in-obese-and-overweight-adolescents
#17
J E Caterini, L Banks, G D Wells, B Cifra, C Slorach, B W McCrindle, M Seed
The aortic pulse wave velocity (PWV) measured via cardiac magnetic resonance (CMR) can be used to non-invasively assess changes in arterial stiffness and potential underlying vascular dysfunction. This technique could unmask early arterial dysfunction in overweight and obese youth at risk for cardiovascular disease. We sought to determine the association between vascular stiffness, percentage body fat, body mass index (BMI), and cardiac function in adolescents across the weight spectrum through both CMR and standard applanation tonometry (AT)-based PWV measurements...
August 23, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28821636/twenty-four-hour-rhythmicity-of-circulating-metabolites-effect-of-body-mass-and-type-2-diabetes
#18
Cheryl M Isherwood, Daan R Van der Veen, Jonathan D Johnston, Debra J Skene
Metabolic profiling of individuals with type 2 diabetes mellitus (T2DM) has previously been limited to single-time-point samples, ignoring time-of-day variation. Here, we tested our hypothesis that body mass and T2DM affect daily rhythmicity and concentrations of circulating metabolites across a 24-h day in 3 age-matched, male groups-lean, overweight/obese (OW/OB), and OW/OB with T2DM-in controlled laboratory conditions, which were not confounded by large meals. By using targeted liquid chromatography/mass spectrometry metabolomics, we quantified 130 plasma metabolites every 2 h over 24 h, and we show that average metabolite concentrations were significantly altered by increased body mass (90 of 130) and T2DM (56 of 130)...
August 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28821510/social-and-somatic-determinants-of-underweight-overweight-and-obesity-at-5-years-of-age-a-norwegian-regional-cohort-study
#19
Hilde Mjell Donkor, Jacob Holter Grundt, Pétur Benedikt Júlíusson, Geir Egil Eide, Jørgen Hurum, Robert Bjerknes, Trond Markestad
OBJECTIVE: To identify associations between the weight groups underweight (UW), overweight (OW) and obesity (OB) at 5 years of age and exposures related to pregnancy, anthropometric measures at birth, sociodemographic factors, and family health, anthropometric measures and habits. DESIGN: Regional cohort study. SETTING: Oppland County, Norway. METHODS: Pregnancy data were obtained from a prospective perinatal register for children born in the county, and weight and height were measured by midwives at birth and by public health nurses at 5 years...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28755804/a-new-index-to-simplify-the-screening-of-hypertension-in-overweight-or-obese-youth
#20
MULTICENTER STUDY
P Di Bonito, G Valerio, L Pacifico, C Chiesa, C Invitti, A Morandi, C Maffeis, M R Licenziati, M Manco, E Miraglia Del Giudice, M G Baroni, S Loche, G Tornese, M Tomat, G de Simone
BACKGROUND AND AIMS: Hypertension (HTH) is a frequent complication in pediatric obesity. To simplify the screening of HTH in overweight/obese (Ow/Ob) youth, we compared the performance of a new index (High Blood Pressure index, HBPi) with respect to the standard criteria of the IV Report [systolic BP (SBP) and/or diastolic BP (DBP) ≥95th percentile for age, gender and height]. We also compared the performance of HBPi with other simplified indices such as the BP/height ratio and the absolute height-specific BP thresholds...
September 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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