Jessica Cusato, Carla Cafasso, Miriam Antonucci, Alice Palermiti, Alessandra Manca, Gian Paolo Caviglia, Marta Vernero, Angelo Armandi, Giorgio Maria Saracco, Antonio D'Avolio, Davide Giuseppe Ribaldone
Although the role of vitamin D (VD) in the pathogenesis and progression of Crohn's disease (CD) is known, the association between single-nucleotide polymorphisms (SNPs) of genes linked to vitamin D pathway and CD risk is still under study. Furthermore, no significant association has been previously found between these SNPs and perianal CD (pCD), a severe phenotypic manifestation of CD that may present as perianal fistula, abscess, and recto-vaginal fistula. Among the mechanisms involved in its pathogenesis, local inflammation and intestinal microbiota alteration are recognized...
January 30, 2024: Biomedicines