Deanna L Kelly, Matthew Glassman, Ikwunga Wonodi, Gopal Vyas, Charles M Richardson, Evaristus Nwulia, Heidi J Wehring, Taiwo Oduguwa, Marie Mackowick, Maria Mananita S Hipolito, Olawunmi Peters, Narayan Rai, Jaeboon Park, Adeola O Adebayo, David A Gorelick, Elaine Weiner, Fang Liu, Ann Marie Kearns, Heather A Adams, Raymond C Love, Shuo Chen, Ayodeji Olaniyan, Nicholas Ambulos, Darius McKoy, Madhulika C Nallani, Sophie Lanzkron, Mulu Mengistab, Brian Barr, Erica Davis, Rahman Lawal, Robert W Buchanan, Richard Adebayo
INTRODUCTION: Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, but it is markedly underutilized, particularly in the US Black population, partly because of concern over clozapine-associated low absolute neutrophil count (ANC). People of African descent have a lower normative ANC range than the White population, which is associated with a specific "ACKR1-null" ("Duffy null") CC genotype (SNP rs2814778) on the ACKR1 gene, termed benign ethnic neutropenia (BEN)...
August 24, 2023: Schizophrenia Research