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https://www.readbyqxmd.com/read/28811946/are-all-mutations-the-same-a-rare-case-report-of-coexisting-mutually-exclusive-kras-and-braf-mutations-in-a-patient-with-metastatic-colon-adenocarcinoma
#1
Anusha Vittal, Akshay Middinti, Anup Kasi Loknath Kumar
29-year-old Hispanic woman presented to the clinic with complaints of abdominal pain, nausea, fatigue, and constipation. Laboratory tests indicated the presence of iron deficiency anemia and transaminitis. Imaging evaluation revealed marked hepatomegaly with multiple hepatic metastases and pelvic lymphadenopathy. Biopsy of the hepatic lesions showed adenocarcinoma positive for pan-cytokeratin, CMA5.2, villin, and CDX2. She was positive for tumor markers CA 19-9, CA-125, and CEA. Upon further evaluation, she was found to have colorectal cancer positive for KRAS and BRAF mutations...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28808611/red-snappers-and-red-herrings-pelvic-tuberculosis-causing-elevated-ca-125-and-mimicking-advanced-ovarian-cancer-a-case-report-and-literature-review
#2
Johnnie Alphonse Yates, Olivia Ann Collis, Thanasak Sueblinvong, Tarquin Kamakana Collis
Female genital tuberculosis (FGTB) is a form of extra-pulmonary tuberculosis that has been primarily described in developing countries, where it is an important cause of infertility, ectopic pregnancy, and miscarriage. FGTB is rare in the United States and because its clinical presentation is non-specific and often insidious, FGTB may be misdiagnosed as a gynecologic malignancy or endometriosis. The tendency of tuberculosis to dramatically increase serum CA 125 levels contributes to the potential for FGTB to be mistaken for ovarian cancer in particular...
August 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28808503/prognostic-efficacy-of-inflammation-based-markers-in-patients-with-curative-colorectal-cancer-resection
#3
Özgür Akgül, Erdinç Çetinkaya, Metin Yalaza, Sabri Özden, Mesut Tez
AIM: To evaluate the prognostic significance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and prognostic nutritional index (PNI) and other clinicopathological factors in patients undergoing curative resection of colon cancer. METHODS: 183 patients with histologically proven colorectal cancer who had undergone potentially curative resection between 2010 and 2016 at Ankara Numune Training and Research Hospital were retrospectively analyzed and clinicopathological characteristics included age, sex, tumor type, grade, size and localization, the number of metastatic and total number of lymph nodes removed, vascular and perineural invasion of the tumor, TNM stages, tumor marker levels (CEA, CA19-9, AFP, CA-125, CA15-3), complete blood counts, albumin levels, overall survival (months), NLR, PLR, LMR and PNI ratios were retrospectively reviewed and analyzed from the electronic database...
July 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28806987/a-prospective-study-to-evaluate-the-risk-malignancy-index-and-its-diagnostic-implication-in-patients-with-suspected-ovarian-mass
#4
Santosh Kumar Dora, Atal Bihari Dandapat, Benudhar Pande, Jatindra Prasad Hota
BACKGROUND: There is no universal screening method for discrimination between benign and malignant adnexal masses yet. Various authors have tried tumor markers, imaging studies, cytology but no one yet is a definite method for screening of cancer ovary, for which a combined diagnostic modality has come to practice in form of RMI. With this background we conducted our study "Evaluation of risk malignancy index and its diagnostic value in patients with adnexal masses". METHODS: The aim of the study was to determine the effectiveness of risk of malignancy index (RMI-3) in preoperative discrimination between benign and malignant masses and also to reveal the most suitable cut off value...
August 14, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28805195/-the-plasma-levels-and-diagnostic-utility-of-matrix-metalloproteinase-9-and-ca-125-in-cervical-cancer-patients
#5
Emilia Lubowicka, Ewa Gacuta, Monika Zajkowska, Edyta Katarzyna Głażewska, Andrzej Przylipiak, Lech Chrostek, Monika Zbucka-Krętowska, Sławomir Ławicki
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes, involved in the degradation of extracellular matrix components. The physiological function of MMP-9 is associated with regulation of immune processes, embryogenesis, reproduction and wound healing. MMP-9 also plays a critical role in tumor invasion, degrading the basement membrane, what is observed in different types of cancers: breast, gastrointestinal, and gynecological. AIM: The aim of this study was to investigate the plasma levels and diagnostic utility of MMP-9 and CA 125 in cervical cancer patients...
July 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28801321/massive-ascites-pelvic-mass-elevated-ca-125-and-weight-loss-think-outside-the-ovaries
#6
Jehan Khalid Mohammed Musleh, Mohammed Almulhem, Nourah Hasan Al Qahtani
A 44-year-old woman presented with 3 months' history of painless progressive abdominal distension and weight loss of more than 15 kg. Clinically a pelviabdominal mass with ascites was detected. CT scan of the pelvis and abdomen showed a subserosal leiomyoma with huge amount of ascites. Cancer Antigen (CA)-125 was 546 kU/L. Exploratory laparotomy with myomectomy was done and this was followed by dramatic improvement postoperatively.
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28800507/ultrasensitive-electrochemiluminescence-immunoassay-for-simultaneous-determination-of-ca125-and-ca15-3-tumor-markers-based-on-pamam-sulfanilic-acid-ru-bpy-3-2-and-pamam-cdte-cds-nanocomposite
#7
Bahareh Babamiri, Rahman Hallaj, Abdollah Salimi
A multiplex ultrasensitive electrochemiluminescence (ECL) immunoassay was developed for the simultaneous determination of two different tumor markers, cancer antigen 153 (CA 15-3) and cancer antigen 125 (CA 125) using polyamidoamine dendrimer-quantum dots (PAMAM-QDs) and PAMAM-sulfanilic acid-Ru(bpy)3(2+) as the signal probes and Fe3O4-SiO2 as a magnetic bead. The CdTe@CdS- QDs and Ru(bpy)3(2+) at the presence of tripropyl amine (TPA) as coreactant generate ECL at an applied voltage of + 1.2V (vs Ag/AgCl) in two different wavelengths 500 and 620nm, respectively...
July 28, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28797156/-expression-and-significance-of-ikk%C3%AE%C2%B5-in-the-specimens-and-cells-of-epithelial-ovarian-cancer
#8
L Pang, J C Gao, P X Zhang, Q Sun, W J Qi, H L Gao, H W Guan, H Shi
Objective: To examine the expressions of IKKε protein in the specimens and cells of epithelial ovarian cancer and investigate the effect of IKKε inhibitor on cell proliferation and apoptosis. Methods: (1) A total of 118 cases of patients with the median age of 59 who have accepted surgical treatment due to ovarian cancer in the First Affiliated Hospital of Dalian Medical University from January 2006 to April 2013 were selected. Twenty cases of patients with the median age of 55 who have accepted hysterectomy and salpingo-oophorectomy due to uterine leiomyoma during the same period were selected as the control...
July 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28791273/significant-elevation-in-serum-ca-125-and-ca-19-9-levels-with-torsion-of-the-hydrosalpinx-in-a-postmenopausal-woman
#9
Ji Hye Kim, Hyo Jin Jung, Seung Hun Song
Isolated torsion of the fallopian tube in postmenopausal women is rare. In this case report, we detail the case of a 53-year-old patient who presented with adenomyosis and a left hydrosalpinx with high levels of CA 125 and CA 19-9. The isolated torsion of the left hydrosalpinx was observed during the operation. The serum levels of CA 125 and CA 19-9 were reduced from 129.62 and 348 to 58.2 and 12.41 U/mL, respectively, after total laparoscopic hysterectomy with salpingectomy. On radiologic evaluation, there were no other factors that may have influenced the increase in serum levels of CA 125 and CA 19-9 in this patient, which were reduced after operation...
July 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28790096/paraneoplastic-cerebellar-degeneration-secondary-to-ovarian-carcinosarcoma-a-cerebellar-conundrum
#10
Julian David Birch, Arup Sen, Katherine Rowland, Tatyana Viner
We present a case of an elderly female patient who presented with a 6-month history of progressive slurred speech, vertigo, unsteadiness and falls. She underwent an extensive battery of neurological and cardiovascular investigations, none of which demonstrated a diagnostic cause for her symptoms. She was referred to the stroke and neurology teams and was started on treatment for presumed anxiety. As her symptoms continued to progress, she was referred to the falls service. Following a multidisciplinary team discussion, she was reviewed by the consultant geriatrician who felt this may be due to a malignancy so the consultant geriatrician arranged blood testsand CT scan of her chest, abdomen and pelvis...
August 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28763368/veliparib-monotherapy-to-patients-with-brca-germ-line-mutation-and-platinum-resistant-or-partially-platinum-sensitive-relapse-of-epithelial-ovarian-cancer-a-phase-i-ii-study
#11
Karina Dahl Steffensen, Parvin Adimi, Anders Jakobsen
OBJECTIVE: A new treatment principle, which seems to radically change the treatment approach in ovarian cancer (OC), has developed over the past few years. Poly(ADP-ribose) polymerase inhibitors work by interfering with mechanisms important to DNA damage repair. Cancer cells that already have defects in the BRCA genes are particularly sensitive to treatment with poly(ADP-ribose) polymerase inhibitors. The main purpose of this study was to investigate the effect of veliparib in patients with known BRCA1/2 mutations and with a platinum-resistant or intermediate sensitive relapse of OC...
August 1, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28762064/nomogram-with-potential-clinical-use-to-predict-lymph-node-metastasis-in-endometrial-cancer-patients-diagnosed-incidentally-by-postoperative-pathological-assessment
#12
Salih Taşkın, Yavuz Emre Şükür, Bulut Varlı, Kazibe Koyuncu, Mehmet Murat Seval, Can Ateş, Selcen Yüksel, Mete Güngör, Fırat Ortaç
PURPOSE: To determine the clinical and pathological risk factors for lymph node metastasis (LNM) in patients with endometrial cancer and to create a nomogram to predict LNM in patients without surgical staging. METHODS: All patients with endometrial adenocarcinoma who were treated surgically at a university based gynecologic oncology clinic between January 2011 and December 2014 were recruited. Women with endometrial adenocarcinoma who were surgically staged including lymphadenectomy were included in the study...
July 31, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28756722/the-role-of-novel-biomarker-he4-in-the-diagnosis-prognosis-and-follow-up-of-ovarian-cancer-a-systematic-review
#13
Giuseppe Scaletta, Francesco Plotti, Daniela Luvero, Stella Capriglione, Roberto Montera, Andrea Miranda, Salvatore Lopez, Corrado Terranova, Carlo De Cicco Nardone, Roberto Angioli
Ovarian cancer is the leading cause of death from gynecologic cancers, in fact, >80% of cases are diagnosed as advanced-stage disease associated with a high mortality rate (<40% of women cured). A systematic review was performed to estimate the role of HE4 in the diagnosis, prognosis and follow-up of ovarian tumors. Areas covered: A comprehensive search of the literature from January 1952 to August 2016 was conducted using the terms 'ovarian tumor' and 'ovarian cancer' combined with 'HE4' and 'human epididymis protein 4'...
August 3, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28752542/steady-relentless-progress-towards-effective-safe-screening-for-early-detection-of-cancer-of-the-ovary
#14
Ian Jacobs
The quest for early detection of ovarian cancer (OC), in the hope of reducing mortality, began as soon as the correlation between stage and survival were documented >50 years ago. Research commenced in earnest in the 1980s when the CA 125 test became available(1) and ultrasound technology was able to image the ovary(2) . The challenges were quickly recognised. Alongside acceptability, compliance and cost two issues needed addressing before large randomised trials with mortality as an end point could be justified...
July 28, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28751117/single-agent-trabectedin-in-heavily-pretreated-patients-with-recurrent-ovarian-cancer
#15
Jean-Philippe Adam, Feriel Boumedien, Nathalie Letarte, Diane Provencher
PURPOSE: In 2012, due to a shortage of pegylated liposomal doxorubicin, single agent trabectedin was proposed as an alternative of treatment to our patients with recurrent ovarian cancer (ROC) at our center. The aim of this retrospective study was to evaluate efficacy and tolerability of trabectedin in this context. PATIENTS AND METHODS: This retrospective study included all patients who received intravenous trabectedin 1.3mg/m(2) over 3h every 3weeks for ROC between January 2012 and December 2015 at the Centre hospitalier de l'Université de Montreal...
July 21, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28735628/novel-algorithm-including-ca-125-he4-and-body-mass-index-in-the-diagnosis-of-endometrial-cancer
#16
Tamara Knific, Joško Osredkar, Špela Smrkolj, Irena Tonin, Katja Vouk, Andrej Blejec, Snježana Frković Grazio, Tea Lanišnik Rižner
OBJECTIVES: To evaluate the diagnostic and prognostic potential of preoperative serum CA-125 and HE4 levels in patients with endometrial cancer. METHODS: Prospective case-control study of 133 women who underwent surgical treatment at the University Medical Centre Ljubljana (64 patients with endometrial cancer, 69 control patients with prolapsed uterus or myoma). Serum CA-125 and HE4 levels were determined using electrochemiluminescent assays. RESULTS: Serum CA-125 and HE4 levels were significantly higher in patients with endometrial cancer, compared to the controls (p=2...
July 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28724319/cerebral-hemorrhage-as-the-initial-manifestation-in-patients-with-systemic-cancer
#17
Gelun Huang, Li Chen, Chao Qin, Daobin Cheng, Qiuhong Lu, Lixia Yu, Zhijian Liang
BACKGROUND: Cerebral hemorrhage as well as ischemic stroke is one of the common complications among patients with cancer. Ischemic stroke could be the initial manifestation in some patients with cancer. Meanwhile, some patients with cancer also could present cerebral hemorrhage as the initial manifestation, and further studies are required to determine whether these patients have their unique clinical features. AIM: To investigate the clinical features and underlying pathogenesis of concealed systemic cancer patients with cerebral hemorrhage as the initial manifestation...
August 1, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28710703/igg4-related-disease-involving-polyserous-effusions-with-elevated-serum-interleukin-6-levels-a-case-report-and-literature-review
#18
Xiang Tong, Min Bai, Weiya Wang, Qingbing Han, Panwen Tian, Hong Fan
Immunoglobulin G4-related disease (IgG4-RD) is a recently described immune-mediated fibroinflammatory disease with a characteristic histopathologic appearance that can affect various organs. We report a 43-year-old Chinese female patient with IgG4-RD involving polyserous effusions with reports of worsening exertional dyspnea for 3 months. Laboratory blood tests revealed that serum interleukin (IL)-6, carbohydrate antigens (CA-199 and CA-125), and alpha-fetoprotein levels were significantly increased, but serum IgG4 levels were normal...
August 2017: Immunologic Research
https://www.readbyqxmd.com/read/28700426/coexisting-primary-ovarian-and-omental-hydatid-disease-mimicking-an-ovarian-neoplasm-a-case-report
#19
Emre E Tas, Gulin F Yegin Akcay, Fatma Yildirim, Filiz Yavuz
Hydatid disease is a parasitic infection that most commonly affects the liver and lungs, although the disease can arise in any part of the body. Cysts may mimic many benign and malignant conditions. The diagnosis cannot be confirmed preoperatively in all cases. A 44-yr-old menopausal woman was admitted to the department of gynecology with complaints of abdominal distention. A fixed abdominopelvic mass was identified. Radiology revealed a 20-cm mass with branched septations and solid components. CA-125 level was 55 kU/L, and Risk of Malignancy Index-2 score was 880...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28698755/primary-fallopian-tube-carcinoma-a-case-report-and-literature-review
#20
Meral Rexhepi, Elizabeta Trajkovska, Hysni Ismaili, Florin Besimi, Nagip Rufati
BACKGROUND: Primary fallopian tube carcinoma (PFTC) is a rare tumour of the female genital tract with an incidence of 0.1-1.8% of all genital malignancies, and it is very difficult to diagnose preoperatively, because of its non-specific symptomatology. In most cases, it is an intraoperative finding or a histopathological diagnosis. It is a tumour that histologically and clinically resembles epithelial ovarian cancer. CASE PRESENTATION: We are reporting a case of a 62-year-old, postmenopausal women with primary fallopian tube carcinoma of the right fallopian tube in stage IA...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
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