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https://www.readbyqxmd.com/read/29017382/which-factors-are-associated-with-the-recurrence-of-endometrioma-after-cystectomy
#1
Mehmet Küçükbaş, Meryem Kurek Eken, Gülşah İlhan, Taylan Şenol, Dilşad Herkiloğlu, Bilge Kapudere
Endometrioma is the most common form of endometriosis and is a sign of wide-spread disease in symptomatic patients. Medical treatment options can be successful in endometrioma smaller than 1 cm, but ineffective for growing and symptomatic endometriomas. Conservative surgical interventions that preserve fertility, such as laparoscopic removal or destruction of endometriotic tissue or aspiration of cystic content are typically used to treat the condition. One of the most frustrating aspects of endometrioma treatment is disease recurrence...
October 10, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28991928/clinical-significance-of-pretreatment-serum-levels-of-vegf-and-its-receptors-il-8-and-their-prognostic-value-in-type-i-and-ii-endometrial-cancer-patients
#2
Beata Kotowicz, Malgorzata Fuksiewicz, Joanna Jonska-Gmyrek, Alicja Berezowska, Jakub Radziszewski, Mariusz Bidzinski, Maria Kowalska
OBJECTIVES: The study aimed to assess the usefulness of the determination of cytokines: IL-8, VEGF and its soluble receptors: VEGF-R1, VEGF-R2 in patients with endometrial cancer (EC). MATERIAL/METHODS: The study group consisted of 118 patients with EC subjected to surgical treatment. Before the treatment we determined the serum levels of cytokines IL-8, and VEGF as well as VEGFR1 and VEGFR2 receptors. For comparison, the concentration of CA 125 was also measured...
2017: PloS One
https://www.readbyqxmd.com/read/28991564/imaging-and-screening-of-ovarian-cancer
#3
REVIEW
Kathryn P Lowry, Susanna I Lee
Ovarian cancer has a high mortality, attributed to its typically advanced stage at detection. Despite much effort to identify an effective approach for ovarian cancer screening, to date no screening test has proven to reduce ovarian cancer mortality. The natural history of ovarian cancer is reviewed as well as data from the largest trials of ovarian cancer screening. Currently, no North American society recommends routine ovarian cancer screening; some societies recommend consideration of screening with pelvic ultrasound and CA-125 in women at high risk, although its use in this setting is not supported by data demonstrating a mortality benefit...
November 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28989069/the-role-of-biomarkers-in-dilated-cardiomyopathy-assessment-of-clinical-severity-and-reverse-remodeling
#4
Sandra Amorim, Manuel Campelo, Brenda Moura, Elisabete Martins, João Rodrigues, Isaac Barroso, Margarida Faria, Tiago Guimarães, Filipe Macedo, José Silva-Cardoso, Maria Júlia Maciel
INTRODUCTION: Biomarkers in dilated cardiomyopathy (DCM) reflect various pathobiological processes, including neurohormonal activation, oxidative stress, matrix remodeling, myocyte injury and myocyte stretch. We assessed the role of biomarkers in clinical and echocardiographic parameters and in left ventricular (LV) reverse remodeling (LVRR). METHODS: In this prospective study of 50 DCM patients (28 men, aged 59±10 years) with LV ejection fraction (LVEF) <40%, LVRR was defined as an increase of >10 U in LVEF after optimal medical therapy...
October 5, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28984773/ovarian-torsion-of-mixed-epithelial-tumor-misdiagnosed-as-a-malignancy-in-postmenopausal-woman-a-case-report
#5
Hyeji Jeon, Aeli Ryu, Hui-Gyeong Seo, Si-Hyong Jang
RATIONALE: Adnexal torsion is 1 of the most common emergency gynecological disease. It is more often diagnosed in reproductive age, but rarely in postmenopausal women. The clinical symptoms of adnexal torsion are nonspecific in postmenopausal women. Epithelial ovarian tumors are common in adults, and the risk of malignancy increases with age, especially after menopause. So, it is difficult to diagnose adnexal torsion precisely compared with reproductive women, and most cases of adnexal torsion with postmenopausal women are diagnosed as a malignancy preoperatively...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28978897/serum-ca-125-level-after-neoadjuvant-chemotherapy-is-predictive-of-prognosis-and-debulking-surgery-outcomes-in-advanced-epithelial-ovarian-cancer
#6
Tomohiko Matsuhashi, Toshiyuki Takeshita, Akihito Yamamoto, Rieko Kawase, Takashi Yamada, Keisuke Kurose, Daisuke Doi, Katsuyuki Konnai, Ryo Onose, Hisamori Kato
Recently, neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS) has been recommended for selected patients with International Federation of Gynecology and Obstetrics (FIGO) stage III or IV disease and bulky tumors. The aim of this study was to evaluate associations between post-NACT serum CA 125 levels, surgical outcomes, and clinical outcomes in patients with advanced epithelial ovarian cancer. We retrospectively analyzed 107 patients with FIGO stage III or IV ovarian cancer who were treated with NACT-IDS at the Gynecology Department of Kanagawa Cancer Center between January 2001 and December 2012...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28971141/malignant-brenner-tumor-of-the-ovary-review-and-case-report
#7
Susan M Lang, Anne M Mills, Leigh A Cantrell
Ovarian neoplasms are a heterogeneous group of tumors with varying incidence in the general population. The most common are the surface epithelial tumors which include transitional cell tumors. Transitional cell tumors include both transitional cell carcinoma and Brenner tumor. The vast majority of Brenner tumors are benign, often incidental findings; however, malignant Brenner tumors (MBT) do occasionally occur. MBT present similarly to other ovarian neoplasms with abdominal pain and bulk symptoms. On imaging, these tumors demonstrate nonspecific findings...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28935762/effect-of-different-anesthetic-methods-on-cellular-immune-functioning-and-the-prognosis-of-patients-with-ovarian-cancer-undergoing-oophorectomy
#8
Xin-Rui Han, Xin Wen, Yan-Yi Li, Shao-Hua Fan, Zi-Feng Zhang, Hong Li, Xing-Feng Sun, Gui-Qi Geng, Shen Sun, Shao-Qiang Huang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
This study aimed to explore the effects of different anesthetic methods on cellular immune function and prognosis of patients with ovarian cancer (OC) undergoing oophorectomy. A total of 167 patients who received general anesthesia (GA) treatment (GA group) and 154 patients who received combined general/epidural anesthesia (GEA) treatment (GEA group) were collected retrospectively. Each group selected 124 patients that met the inclusion and exclusion criteria for further study. ELISA and radioimmunoassay were employed to detect levels of IL-2, TNF-α and CA-125...
September 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28935270/preoperative-c-reactive-protein-serum-levels-as-a-predictive-diagnostic-marker-in-patients-with-adnexal-masses
#9
Elisabeth Reiser, Stefanie Aust, Veronika Seebacher, Alexander Reinthaller, Samir Helmy-Bader, Richard Schwameis, Christoph Grimm, Stephan Polterauer
OBJECTIVE: To evaluate C-reactive protein (CRP) serum levels as a preoperative predictive marker for ovarian cancer in patients with adnexal masses. METHODS: CRP serum levels of 1843 adnexal masses and subsequent surgery were investigated (patients with benign ovarian tumors: n=1423; borderline tumor of the ovary [BTO]: n=83; EOC: n=337). Test characteristics and predictive values of CRP serum levels were investigated by univariate analysis and multivariate binary logistic regression models...
September 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28925274/-a-case-report-of-peritoneal-tuberculosis-the-diagnostic-role-of-pet-ct-and-laparoscopy
#10
H Macháčková, R Pilka, S Losse, M Žurková, V Lošťáková, T Tichý, Y Lovečková
OBJECTIVE: We present a case of peritoneal tuberculosis of young woman with focus on difficult diagnosis of this low incidence disease in developed countries. DESIGN: Case report. SETTING: Department of Gynaecology and Obstetrics, Faculty Hospital, Olomouc. Department of Obstetric and Gynaecology, Nový Jičín Hospital. Department of Pulmonary Diseases and Tuberculosis, Faculty Hospital, Olomouc. Department of Pathology nad Molecular Medicine, Faculty Hospital, Olomouc...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28911827/single-site-robot-assisted-laparoscopic-staging-surgery-for-presumed-clinically-early-stage-ovarian-cancer
#11
Ji Geun Yoo, Woo Jin Kim, Keun Ho Lee
STUDY OBJECTIVE: To present the demonstration of Robotic-assisted laparoendoscopic single-site(R-LESS) staging surgery in presumed clinically early stage ovarian cancer. DESIGN: A step-by-step presentation of the procedure using video (Canadian Task Force classification III). SETTING: A university hospital. INTERVENTION: A 29-year-old woman was referred from a local clinic for an 8x6cm sized left ovarian tumor suggesting malignancy...
September 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28901315/serum-expression-level-of-squamous-cell-carcinoma-antigen-highly-sensitive-c-reactive-protein-and-ca-125-as-potential-biomarkers-for-recurrence-of-cervical-cancer
#12
Suyang Guo, Bo Yang, Hongli Liu, Yuzhi Li, Shengze Li, Ling Ma, Jian Liu, Wei Guo
OBJECTIVE: The aim of this study was to evaluate the serum expression levels of squamous cell carcinoma antigen (SCC-Ag), highly sensitive C-reactive protein (hs-CRP), and CA-125 as potential serum biomarkers for recurrence of cervical cancer. METHODS: Eighty-six cervical cancer patients who received radical treatment were retrospectively included in this study from February 2011 to January 2014. Of the included 86 cases, 23 were recurred within the 36 months (recurrence group [RG]) and other 63 patients did not (non-RG [NRG])...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28899828/borderline-ovarian-tumor-in-the-pediatric-and-adolescent-population-a-case-series-and-literature-review
#13
Krista J Childress, Ninad Mohan Patil, Jodi A Muscal, Jennifer E Dietrich, Rajkumar Venkatramani
STUDY OBJECTIVE: To determine the diagnosis, management, and outcome for children and adolescents with borderline ovarian tumor (BOT), To provide a review of the literature on BOT in children and adolescents. DESIGN: A retrospective cohort study of females under age 21 diagnosed with BOT between January 2001 and May 2016. SETTING: Texas Children's Hospital, Houston, Texas PARTICIPANTS: Fourteen patients (ages 12 to 18) diagnosed with BOT. MAIN OUTCOME MEASURES: Clinical presentation, pre-operative characteristics, surgical technique, cancer stage, histology, treatment, recurrence...
September 9, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28893024/diagnostic-performance-of-serum-human-epididymis-protein-4-in-endometrial-carcinoma-a-pilot-study
#14
Rupali Dewan, Abhinav Dewan, Swati Hare, Mausumi Bhardwaj, Krati Mehrotra
INTRODUCTION: Endometrial Cancer (EC) is a common female malignant disorder. To date, there are no specific tumour markers for EC that may be routinely used in clinical practice for diagnosis. AIM: To evaluate the diagnostic performance of the serum Human Epididymis protein 4 (HE4) as biomarker for EC and to determine its association with clinicopathological variables. MATERIALS AND METHODS: The study population included 60 postmenopausal women with a diagnosis of EC and 60 healthy postmenopausal female subjects (control group)...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28853527/-low-grade-ovarian-cancer
#15
REVIEW
Yakir Segev, Anis Kaldawy, Ron Auslender, Ofer Lavie
According to the new and reproducible grading system of the MD Anderson Cancer Center (MDACC), low grade serous cancer (LGSC) differs greatly from the commonly known high grade serous cancer (HGSC). Pathology speaking, LGSC has less mitotic index; the grade of nuclear atypia is low to intermediate. Genetically speaking, these tumors tend to show mutation in the mitogen-activated protein kinase (MAPK) pathway, mainly in the KRAS and BRAF genes, resulting in uncontrolled proliferation; however, it seems that the presence of this mutation might be related to a better prognosis compared to their absence...
August 2017: Harefuah
https://www.readbyqxmd.com/read/28845842/an-adolescent-with-an-asymptomatic-adnexal-cyst-to-worry-or-not-to-worry-medical-versus-surgical-management-options
#16
Vincenzo De Sanctis, Ashraf T Soliman, Heba Elsedfy, Nada A Soliman, Rania Elalaily, Salvatore Di Maio, Alaa Y Ahmed, Giuseppe Millimaggi
Paraovarian cysts or paratubal cysts (PTCs) arise from either the mesothelium or from paramesonephric remnants. These present as either adnexal mass or as an incidental finding. Diagnosis is usually established on ultrasound and it is important to differentiate these from ovarian cysts. Typically PCTs appear as simple cysts by ultrasound and are indistinguishable from ovarian cysts if one does not recognize the extraovarian location. Occasionally, PTCs have internal echoes due to hemorrhage. PTCs are usually asymptomatic and benign...
August 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28845013/-progress-in-preoperative-evaluation-methods-regarding-cytoreduction-in-patients-with-advanced-ovarian-cancer
#17
Jinyang Liu, Keqiang Zhang
Primary cytoreductive surgery followed by platinum-based chemotherapy represents the standard treatment for patients with advanced ovarian cancer. But some patients with advanced ovarian cancer still have suboptimal residual disease after the primary debulking surgery. Neoadjuvant chemotherapy has been suggested as an alternative strategy to achieve no residual disease. It is important to find methods to estimate the likelihood that cytoreductive surgery will leave no residual disease. A number of studies have evaluated the use of serologic markers (such as CA-125), imaging modalities (such as CT, PETCT, MRI), and laparoscopic surgery to determine which patients are ideal predictors for neoadjuvant chemotherapy...
July 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28842710/preoperative-prognostic-nutritional-index-is-a-powerful-predictor-of-prognosis-in-patients-with-stage-iii-ovarian-cancer
#18
Weiwei Zhang, Bin Ye, Weijiang Liang, Yazhou Ren
Many established inflammation- and nutrition-related factors have been investigated as potential independent prognostic factors in various cancers, including the C-reactive protein/albumin ratio (CAR), lymphocyte/monocyte ratio (LMR), modified Glasgow prognostic score (mGPS), body mass index (BMI), and prognostic nutritional index (PNI). This study was performed to estimate the prognostic value of these factors in predicting survival and platinum resistance in ovarian cancer (OC), especially according to stage...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28837575/development-of-a-tool-for-prediction-of-ovarian-cancer-in-patients-with-adnexal-masses-value-of-plasma-fibrinogen
#19
Veronika Seebacher, Stefanie Aust, David D'Andrea, Christoph Grimm, Elisabeth Reiser, Denise Tiringer, Hannah Von Mersi, Stephan Polterauer, Alexander Reinthaller, Samir Helmy-Bader
OBJECTIVE: To develop a tool for individualized risk estimation of presence of cancer in women with adnexal masses, and to assess the added value of plasma fibrinogen. STUDY DESIGN: We performed a retrospective analysis of a prospectively maintained database of 906 patients with adnexal masses who underwent cystectomy or oophorectomy. Uni- and multivariate logistic regression analyses including pre-operative plasma fibrinogen levels and established predictors were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28835604/spontaneously-ruptured-paraovarian-tumor-of-borderline-malignancy-with-extremely-elevated-serum-carbohydrate-antigen-125-ca125-levels-a-comparison-of-the-imaging-and-pathological-features
#20
Akiko Kajiyama, Hiromi Edo, Chiaki Takeya, Kaneyuki Kubushiro, Toshiaki Oharaseki, Tatsuya Gomi
BACKGROUND Paraovarian cysts are common and are generally benign; however, they are frequently misdiagnosed as being of ovarian origin. Conversely, paraovarian tumors of borderline malignancy are extremely rare. Especially, no cases of spontaneous rupture have been reported, and all previous reports had normal serum carbohydrate antigen (CA) 125 level. As for imaging findings, the presence of papillary projections in the lumen of paraovarian tumors does not always indicate malignancy or benignancy, which makes the preoperative distinction difficult...
August 24, 2017: American Journal of Case Reports
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