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https://www.readbyqxmd.com/read/28096645/peri-and-post-menopausal-women-with-complex-adnexal-masses-ascites-and-raised-ca-125-is-it-ovarian-cancer-or-tuberculosis
#1
Rashmi Bagga, Tanuja Muthyala, Subhas Chandra Saha, Shalini Gainder, Pradip Kumar Saha, Radhika Srinivasan, Arvind Rajwanshi, Nalini Gupta
Pelvic and peritoneal tuberculosis may resemble advanced ovarian cancer due to the presence of ascites, complex adnexal masses, peritoneal deposits and raised CA-125 level, especially in peri- and postmenopausal women. Other common features among women with these two conditions are abdominal pain and distension, weight loss and reduced appetite. As the treatment of pelvic-peritoneal tuberculosis is completely different from that of ovarian cancer, it is important to reach a correct diagnosis. Sometimes women with pelvic-peritoneal tuberculosis may be subjected to a laparotomy for suspected ovarian cancer which is likely to increase their morbidity...
October 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28087476/phospholipase-d-mrna-expression-and-clinical-role-in-high-grade-serous-carcinoma
#2
Keren Harel-Dassa, Saul Yedgar, Claes G Tropé, Ben Davidson, Reuven Reich
This objective of this study was to analyze the expression and clinical role of phospholipase D (PLD) in high-grade serous carcinoma (HGSC). PLD1 and PLD2 isoform expression was studied in 125 HGSC specimens (73 effusions, 28 ovarian tumors, 24 solid metastases) using quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR). Expression levels were analyzed for association with clinicopathologic parameters, including chemoresponse, and survival. PLD1 and PLD2 isoforms were found in the majority of specimens at all anatomic sites and their levels were strongly positively related (P<...
January 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28086838/clinical-characteristics-of-genital-chlamydia-infection-in-pelvic-inflammatory-disease
#3
Sung Taek Park, Suk Woo Lee, Min Jeong Kim, Young Mo Kang, Hye Min Moon, Chae Chun Rhim
BACKGROUND: Chlamydia infection in acute pelvic inflammatory disease (PID) is associated with serious complications including ectopic pregnancy, tubal infertility, Fitz-Hugh-Curtis syndrome and tubo-ovarian abscess (TOA). This study compared clinical and laboratory data between PID with and without chlamydia infection. METHODS: The medical records of 497 women who were admitted with PID between 2002 and 2011 were reviewed. The patients were divided into two groups (PID with and without chlamydia infection), which were compared in terms of the patients' characteristics, clinical presentation, and laboratory findings, including inflammatory markers...
January 13, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28067948/preoperative-assessment-of-lymph-node-metastasis-in-endometrial-cancer-a-korean-gynecologic-oncology-group-study
#4
Sokbom Kang, Joo-Hyun Nam, Duk-Soo Bae, Jae-Weon Kim, Moon-Hong Kim, Xiaojun Chen, Jae-Hong No, Jong-Min Lee, Jae-Hoon Kim, Hidemich Watari, Seok Mo Kim, Sung Hoon Kim, Seok Ju Seong, Ki Tae Kim, Seung Cheol Kim, Jong-Hyeok Kim, Myung-Cheol Lim, Jung-Yun Lee, Sang-Young Ryu, Bingyi Yang, Byoung-Gie Kim
BACKGROUND: Previously proposed criteria for preoperatively identifying endometrial cancer patients at low risk for lymph node metastasis remain to be verified. For this purpose, a prospective, multicenter observational study was performed. METHODS: Eligible patients with histologically confirmed endometrial cancer underwent magnetic resonance imaging (MRI) and serum cancer antigen 125 (CA 125) testing before surgery. The following criteria were used to identify low-risk patients: 1) endometrioid-type cancer, 2) no evidence of deep myometrial invasion on MRI, 3) no enlarged lymph nodes on MRI, 4) no suspicious metastasis out of the uterine corpus, and 5) serum CA 125 levels less than 35 U/mL...
January 1, 2017: Cancer
https://www.readbyqxmd.com/read/28050796/anastomosing-hemangioma-of-the-ovary-a-clinicopathological-study-of-six-cases-with-stromal-luteinization
#5
Pavel Dundr, Kristýna Němejcová, Jan Laco, Helena Skálová, Lenka Bauerová, Radoslav Matěj, Daniela Fischerová
We report six cases of anastomosing hemangioma of the ovary. All lesions were unilateral and arose in 43 to 81 year old females. In all but one patient, the tumor was asymptomatic and represented incidental finding. The exception was a tumor associated with massive ascites and elevated CA 125. The tumors were, on cut section, spongy and dark violet in color. The size of tumors ranged from 0.5 to 3.5 cm. All lesions showed the same histological features and consisted of capillary sized anastomosing vessels with sinusoid-like pattern intermingled with sporadic medium sized vessels...
January 3, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28008424/correlation-of-ca-125-serum-level-and-clinico-pathological-characteristic-of-patients-with-endometriosis
#6
Mojgan Karimi-Zarchi, Najmeh Dehshiri-Zadeh, Leili Sekhavat, Fahime Nosouhi
BACKGROUND: Cancer antigen 125 (CA-125) is a glycoprotein biomarker that is used in women with pelvic masses such as endometriosis and maybe is useful in practice of patients suspicious to endometriosis. OBJECTIVE: The aim of this study was to evaluate the association between preoperative serum CA-125 levels and clinic pathological characteristic in women with endometriosis, and find out the best serum CA-125 levels cut-off in pre and post menopause women. MATERIALS AND METHODS: Serum CA-125 levels in 87 women aged 21-54 years suspected to endometriosis with pelvic pain, dysmenorrhea, or dyspareunia were measured preoperatively...
November 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28006994/the-role-of-human-epididymis-secretory-protein-e4-in-patients-with-endometrial-cancer-and-premalignant-endometrial-lesions
#7
Setenay Arzu Yılmaz, Sündüz Özlem Altınkaya, Özlem Seçilmiş Kerimoglu, Aybike Tazegül Pekin, Fikret Akyürek, Tolgay Tuyan Ilhan, Nilgün Benzer, Ali Unlu, Hasan Yuksel, Cetin Celik
We evaluated the concentrations of human epididymis secretory protein E4 (HE4) and Ca-125 in relation to clinicopathologic features in patients with endometrial cancer and premalignant endometrial lesions. Women with abnormal uterine bleeding (n = 167) who underwent endometrial sampling were divided into four groups. Group 1: endometrial cancer (n = 68), group 2: atypical endometrial hyperplasia (n = 12), group 3: endometrial hyperplasia without atypia (n = 39) and group 4: controls (n = 48)...
December 22, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28003762/biomarkers-in-pancreatic-adenocarcinoma-current-perspectives
#8
REVIEW
Douglas S Swords, Matthew A Firpo, Courtney L Scaife, Sean J Mulvihill
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with a 5-year survival rate of 7.7%. Most patients are diagnosed at an advanced stage not amenable to potentially curative resection. A substantial portion of this review is dedicated to reviewing the current literature on carbohydrate antigen (CA 19-9), which is currently the only guideline-recommended biomarker for PDAC. It provides valuable prognostic information, can predict resectability, and is useful in decision making about neoadjuvant therapy...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27997533/exploratory-analysis-of-tp53-mutations-in-circulating-tumour-dna-as-biomarkers-of-treatment-response-for-patients-with-relapsed-high-grade-serous-ovarian-carcinoma-a-retrospective-study
#9
Christine A Parkinson, Davina Gale, Anna M Piskorz, Heather Biggs, Charlotte Hodgkin, Helen Addley, Sue Freeman, Penelope Moyle, Evis Sala, Karen Sayal, Karen Hosking, Ioannis Gounaris, Mercedes Jimenez-Linan, Helena M Earl, Wendi Qian, Nitzan Rosenfeld, James D Brenton
BACKGROUND: Circulating tumour DNA (ctDNA) carrying tumour-specific sequence alterations may provide a minimally invasive means to dynamically assess tumour burden and response to treatment in cancer patients. Somatic TP53 mutations are a defining feature of high-grade serous ovarian carcinoma (HGSOC). We tested whether these mutations could be used as personalised markers to monitor tumour burden and early changes as a predictor of response and time to progression (TTP). METHODS AND FINDINGS: We performed a retrospective analysis of serial plasma samples collected during routine clinical visits from 40 patients with HGSOC undergoing heterogeneous standard of care treatment...
December 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27995729/is-serum-level-of-nestin-useful-in-detecting-epithelial-ovarian-cancer
#10
Veysel Sal, Ilker Kahramanoglu, Tugan Bese, Fuat Demirkiran, Nigar Sofiyeva, Zeynep Soyman, Sinem Durmus, Remisa Gelisgen, Macit Arvas, Hafize Uzun
AIM: The aim of the present study was to evaluate the usefulness of nestin as a discriminative marker between benign and malignant ovarian tumors. METHODS: During the 1 year from January 2015 through December 2015, a nonconsecutive series of 80 patients (40 malignant, 40 benign) who underwent surgery for an adnexal mass were enrolled in the study. Intraoperative frozen section evaluation was performed if there was a suspicion in diagnosis. Statistical analyses were performed using spss ver...
December 19, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27994689/random-assay-in-radioimmunoassay-feasibility-and-application-compared-with-batch-assay
#11
Jung Min Lee, Hwan Hee Lee, Sohyun Park, Tae Sung Kim, Seok-Ki Kim
PURPOSE: The batch assay has been conventionally used for radioimmunoassay (RIA) because of its technical robustness and practical convenience. However, it has limitations in terms of the relative lag of report time due to the necessity of multiple assays in a small number of samples compared with the random assay technique. In this study, we aimed to verify whether the random assay technique can be applied in RIA and is feasible in daily practice. METHODS: The coefficients of variation (CVs) of eight standard curves within a single kit were calculated in a CA-125 immunoradiometric assay (IRMA) for the reference of the practically ideal CV of the CA-125 kit...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27987404/diagnostic-accuracy-of-cancer-antigen-125-ca125-for-endometriosis-in-symptomatic-women-a-multi-center-study
#12
Martin Hirsch, James M N Duffy, Christine S Deguara, Colin J Davis, Khalid S Khan
STUDY OBJECTIVE: To assess the diagnostic accuracy of serum Cancer Antigen 125 (CA 125)≥30units/milliliter (u/ml) for diagnosing endometriosis in symptomatic women. STUDY DESIGN: Prospective observational cohort study including patients with symptoms of pelvic pain or subfertility undergoing elective diagnostic laparoscopy at two tertiary referral hospitals. We excluded patients suspected to have other gynecological pathology. We evaluated the accuracy of serum CA 125 (index test) with histologically confirmed endometriosis (reference standard)...
December 5, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27986748/clinical-use-of-programmed-cell-death-1-pd-1-and-its-ligand-pd-l1-expression-as-discriminatory-and-predictive-markers-in-ovarian-cancer
#13
Jayanta Chatterjee, Wei Dai, Nor Haslinda Abd Aziz, Pei Yun Teo, John Wahba, David L Phelps, Christian J Maine, Lynsey Whilding, Roberto Dina, Giorgia Trevisan, Kirsty Flower, Andrew Jt George, Sadaf Ghaem-Maghami
Purpose We aimed to establish whether PD-1 and PD-L1 expression, in ovarian cancer (OC) tumour tissue and blood, could be used as biomarkers for discrimination of tumour histology and prognosis of OC. Experimental Design Immune cells were separated from blood, ascites and tumour tissue obtained from women with suspected OC and studied for the differential expression of possible immune biomarkers using flow cytometry. PD-L1 expression on tumour associated inflammatory cells was assessed by immunohistochemistry and tissue microarray...
December 16, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27931751/phase-ii-study-of-irinotecan-in-combination-with-bevacizumab-in-recurrent-ovarian-cancer
#14
Fernanda Musa, Bhavana Pothuri, Stephanie V Blank, Huichung T Ling, James L Speyer, John Curtin, Leslie Boyd, Xiaochun Li, Judith D Goldberg, Franco Muggia, Amy Tiersten
OBJECTIVES: To evaluate the efficacy and safety of irinotecan and bevacizumab in recurrent ovarian cancer. The primary objective was to estimate the progression free survival (PFS) rate at 6months. Secondary objectives included estimation of overall survival (OS), objective response rate (ORR), duration of response, and an evaluation of toxicity. METHODS: Recurrent ovarian cancer patients with no limit on prior treatments were eligible. Irinotecan 250mg/m2 (amended to 175mg/m2 after toxicity assessment in first 6 patients) and bevacizumab 15mg/kg were administered every 3weeks until progression or toxicity...
December 5, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27916269/optimizing-the-treatment-of-ovarian-cancer-neoadjuvant-chemotherapy-and-interval-debulking-versus-primary-debulking-surgery-for-epithelial-ovarian-cancers-likely-to-have-suboptimal-resection
#15
Sarah E Gill, Michaela E McGree, Amy L Weaver, William A Cliby, Carrie L Langstraat
OBJECTIVE: To: a) identify prognostic factors in patients with epithelial ovarian cancer treated with neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS), and b) compare post-surgical survival between patients treated with NACT/IDS for presumed unresectable disease and stage IIIC/IV patients who underwent suboptimal primary debulking surgery (PDS). METHODS: This was a retrospective study of consecutive stage IIIC or IV patients undergoing IDS after NACT at Mayo Clinic from January 2007 to December 2013...
December 1, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27913927/the-number-of-cycles-of-neoadjuvant-chemotherapy-is-associated-with-prognosis-of-stage-iiic-iv-high-grade-serous-ovarian-cancer
#16
Xia Xu, Fei Deng, Mengmeng Lv, Xiaoxiang Chen
OBJECTIVE: No consensus exists on the number of chemotherapy cycles to be administered before and after interval debulking surgery (IDS) in patients with advanced stage epithelial ovarian cancer. The present study aims to explore the optimal number of cycles of neoadjuvant chemotherapy (NAC) and post-operation chemotherapy to treat the International Federation of Gynecology and Obstetrics stage IIIc-IV high-grade serous ovarian cancer (HG-SOC). MATERIALS AND METHODS: A total of 129 IIIc-IV stage HG-SOC cases were retrospectively analyzed...
December 3, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27912779/ascites-regression-following-neoadjuvant-chemotherapy-in-prediction-of-treatment-outcome-among-stage-iiic-to-iv-high-grade-serous-ovarian-cancer
#17
Xia Xu, Fei Deng, Mengmeng Lv, Binhui Ren, Wenwen Guo, Xiaoxiang Chen
BACKGROUND: No consensus exists on the outcome-related factors of interval debulking surgery (IDS) in patients with advanced high-grade serous ovarian cancer (HG-SOC) who underwent neoadjuvant chemotherapy (NAC). This study aimed to explore the optimal timing for IDS and the prognosis-associated factors of International Federation of Gynecology and Obstetrics stage IIIc to IV HG-SOC patients. METHODS: A total of 160 IIIc to IV stage HG-SOC patients were retrospectively analyzed...
December 2, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27912770/endometriosis-associated-clear-cell-carcinoma-arising-in-caesarean-section-scar-a-case-report-and-review-of-the-literature
#18
Gabriella Ferrandina, Eleonora Palluzzi, Francesco Fanfani, Stefano Gentileschi, Anna Lia Valentini, Maria Vittoria Mattoli, Ilaria Pennacchia, Giovanni Scambia, Gianfranco Zannoni
BACKGROUND: Malignant transformation has been reported in approximately 1% of the endometriosis cases; herein, we report a case of clear cell endometrial carcinoma arising from endometriosis foci located within a caesarean section scar. CASE PRESENTATION: In November 2014, a Caucasian, 44-year-old woman was transferred to our institution because of severe respiratory failure due to massive lung embolism and rapid enlargement of a subcutaneous suprapubic mass. Abdomino-pelvic magnetic resonance showed a 10...
December 3, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27903809/the-bimanual-ovarian-palpation-examination-in-the-prostate-lung-colorectal-and-ovarian-cancer-screening-trial-performance-and-complications
#19
Maryam Doroudi, Barnett S Kramer, Paul F Pinsky
OBJECTIVE: To provide evidence about the performance characteristics and consequences of bimanual ovarian palpation. SETTING AND METHODS: The Prostate, Lung, Colorectal and Ovarian cancer screening trial randomized 154,900 individuals to either an intervention or control arm. Enrolled eligible participants were aged 55-74, had no history of trial cancers, and no current treatment for cancer. Intervention arm women received CA-125 tests and transvaginal ultrasound...
November 30, 2016: Journal of Medical Screening
https://www.readbyqxmd.com/read/27898751/-investigating-the-predictive-value-of-rmi-and-roma-indices-in-patients-with-ovarian-tumors-of-uncertain-dignity
#20
Géza Krascsenits, Boglárka Balázs, Anna Dudnyikova, Katalin Purcsi, Enikõ Orosz, Imre Pete
We were investigating the predictive value of RMI and ROMA indices in patients with ovarian tumors of uncertain dignity, in order to determine whether these methods are suitable for the early detection of ovarian malignancy. Our study included 162 patients treated at the Gynecological Department of the National Institute of Oncology (Budapest, Hungary). These patients were diagnosed with ovarian tumor of uncertain dignity, and were admitted to our Department with the purpose of gynecological surgery. Each of them had CA-125, HE4 blood tests and ultrasound scan in order to calculate RMI and ROMA indices and to study their effectiveness...
November 29, 2016: Magyar Onkologia
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