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https://www.readbyqxmd.com/read/29450530/screening-for-ovarian-cancer-updated-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#1
Jillian T Henderson, Elizabeth M Webber, George F Sawaya
Importance: Ovarian cancer is relatively rare but the fifth-leading cause of cancer mortality among United States women. Objective: To systematically review evidence on benefits and harms of ovarian cancer screening among average-risk women to inform the United States Preventive Services Task Force. Data Sources: MEDLINE, PubMed, Cochrane Collaboration Registry of Controlled Trials; studies published in English from January 1, 2003, through January 31, 2017; ongoing surveillance in targeted publications through November 22, 2017...
February 13, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29436617/ripk4-pebp1-axis-promotes-pancreatic-cancer-cell-migration-and-invasion-by-activating-raf1-mek-erk-signaling
#2
Zi-Hao Qi, Hua-Xiang Xu, Shi-Rong Zhang, Jin-Zhi Xu, Shuo Li, He-Li Gao, Wei Jin, Wen-Quan Wang, Chun-Tao Wu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
Pancreatic cancer is a lethal disease with a high metastatic potential. In our previous study, we identified a specific subgroup of patients with pancreatic cancer with a serum signature of carcinoembryonic antigen (CEA)+/cancer antigen (CA)125+/CA19-9 ≥1,000 U/ml. In this study, by using high-throughput screening analysis, we found that receptor-interacting protein kinases 4 (RIPK4) may be a key molecule involved in the high metastatic potential of this subgroup of patients with pancreatic cancer. A high RIPK4 expression predicted a poor prognosis and promoted pancreatic cancer cell migration and invasion via the RAF1/MEK/ERK pathway...
February 7, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29401246/anti-napi2b-antibody-drug-conjugate-lifastuzumab-vedotin-dnib0600a-compared-to-pegylated-liposomal-doxorubicin-in-patients-with-platinum-resistant-ovarian-cancer-in-a-randomized-open-label-phase-ii-study
#3
S Banerjee, A M Oza, M J Birrer, E P Hamilton, J Hasan, A Leary, K N Moore, B Mackowiak-Matejczyk, J Pikiel, I Ray-Coquard, P Trask, K Lin, E Schuth, A Vaze, Y Choi, J C Marsters, D J Maslyar, V Lemahieu, Y Wang, E W Humke, J F Liu
Background: Lifastuzumab vedotin (LIFA) is a humanized anti-NaPi2b monoclonal antibody conjugated to a potent anti-mitotic agent, monomethyl auristatin E (MMAE), which inhibits cell division by blocking the polymerization of tubulin. This study is the first to compare an antibody-drug-conjugate (ADC) to standard-of-care in ovarian cancer (OC) patients. Patients and Methods: Platinum-resistant OC patients were randomized to receive LIFA (2.4 mg/kg, intravenously, every 3 weeks [Q3W]), or pegylated liposomal doxorubicin (PLD) (40 mg/m2, intravenously, Q4W)...
February 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29400023/diagnostic-value-of-integrated-%C3%A2-%C3%A2-f-fluoro-2-deoxyglucose-positron-emission-tomography-computed-tomography-in-recurrent-epithelial-ovarian-cancer-accuracy-of-patient-selection-for-secondary-cytoreduction-in-134-patients
#4
Young Jae Lee, Yong Man Kim, Phill Seung Jung, Jong Jin Lee, Jeong Kon Kim, Young Tak Kim, Joo Hyun Nam
OBJECTIVE: The aim of this study was to evaluate the diagnostic value of integrated ¹⁸F-fluoro-2-deoxyglucose-positron emission tomography/computed tomography (¹⁸F-FDG-PET/CT) for suspected recurrence of epithelial ovarian cancer (EOC) with non-disseminated lesions. METHODS: We retrospectively reviewed the medical records of recurrent EOC patients who underwent secondary cytoreduction from January 2000 to December 2013. A total of 134 patients underwent secondary cytoreduction after imaging with either ¹⁸F-FDG-PET/CT or contrast-enhanced computed tomography (CECT)...
February 1, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29400011/clinical-outcomes-of-patients-with-clear-cell-and-endometrioid-ovarian-cancer-arising-from-endometriosis
#5
E Sun Paik, Tae Joong Kim, Chel Hun Choi, Byoung Gie Kim, Duk Soo Bae, Jeong Won Lee
OBJECTIVE: The aim of this investigation is to compare outcomes of patients according to the presence of cancer arising from endometriosis in ovarian clear cell carcinoma (CCC) and endometrioid carcinoma (EC). METHODS: This study retrospectively investigated 224 CCC and EC patients treated in Samsung Medical Center from 2001 to 2015 to identify cancer arising from endometriosis according to Sampson and Scott criteria. Propensity score matching was performed to compare patients arising from endometriosis to patients without endometriosis (ratio 1:1) according to stage, age, lymph node metastasis (LNM), cancer antigen (CA)-125 level, and residual status after debulking surgery...
December 11, 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29391043/precise-preoperative-diagnosis-of-struma-ovarii-with-pseudo-meigs-syndrome-mimicking-ovarian-cancer-with-the-combination-of-131i-scintigraphy-and-18f-fdg-pet-case-report-and-review-of-the-literature
#6
Sayaka Fujiwara, Hideaki Tsuyoshi, Toshiya Nishimura, Nozomu Takahashi, Yoshio Yoshida
BACKGROUND: Struma ovarii is a rare ovarian neoplasm that often appears malignant on conventional imaging. Pseudo-Meigs' syndrome with ascites, pleural effusion, and elevated serum CA 125 levels is much rarer and leads to misdiagnosis of ovarian cancer and unnecessary extended surgery. CASE PRESENTATION: A 50-year-old woman with abdominal distention and dyspnoea was referred to our hospital. Ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) showed a polycystic ovarian tumor with a solid component, pleural effusion, and massive ascites with negative cytology...
February 2, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29390326/the-application-of-18f-fdg-pet-ct-in-ovarian-immature-teratomas-when-pathological-examination-results-contradict-clinical-observations-a-case-report
#7
Manni Wang, Shaoxiong Jiang, Yiwen Zhang, Chong Jiang, Fan Xia, Weiliang Lyu, Xuelei Ma
RATIONALE: Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) could reveal potential lymph node involvement and assisted locating sample sites for pathological examinations. PATIENT CONCERNS: Help choose the right treatment strategies for patients. To better stage immature ovarian teratomas with 18F-FDG PET/CT when lymphatic metastasis is suspected while lymph node biopsy results are negative. DIAGNOSES: The ultimate pathological diagnosis was left ovarian cancer, an immature teratoma (IMT) Grade 1...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29387174/cancer-antigen-125-and-risk-of-atrial-fibrillation-a-systematic-review-and-meta-analysis
#8
Angel Cheung, Mengqi Gong, Roberto Bellanti, Sadeq Ali-Hasan-Al-Saegh, Guangping Li, Eulàlia Roig, Julio Núñez, Thomas D Stamos, Mehmet Birhan Yilmaz, Kaya Hakki, William K K Wu, Sunny Hei Wong, Wing Tak Wong, George Bazoukis, Konstantinos Lampropoulos, Lah Ah Tse, Jichao Zhao, Gregory Y H Lip, Adrian Baranchuk, Martin C S Wong, Tong Liu, Gary Tse
Background: Cancer antigen-125 (Ca-125) is traditionally recognised as a tumour marker and its role in cardiovascular diseases has been studied only in recent years. Whether Ca-125 is elevated in patients with atrial fibrillation (AF) and its levels predict the risk of AF remains controversial. Therefore, we conducted a systematic review and meta-analysis of the association between Ca-125 levels and AF. Methods: PubMed and EMBASE databases were searched until 1 June 2017 for studies that evaluated the association between Ca-125 and AF...
2018: Heart Asia
https://www.readbyqxmd.com/read/29380107/prognostic-role-of-mesenteric-lymph-nodes-involvement-in-patients-undergoing-posterior-pelvic-exenteration-during-radical-or-supra-radical-surgery-for-advanced-ovarian-cancer
#9
Roberto Berretta, Vito Andrea Capozzi, Giulio Sozzi, Lavinia Volpi, Valentina Ceni, Mauro Melpignano, Giovanna Giordano, Federico Marchesi, Michela Monica, Maurizio Di Serio, Matteo Riccò, Marcello Ceccaroni
PURPOSE: The aim of this retrospective study is to analyze the prognostic role and the practical implication of mesenteric lymph nodes (MLN) involvements in advanced ovarian cancer (AOC). METHODS: A total of 429 patients with AOC underwent surgery between December 2007 and May 2017. We included in the study 83 patients who had primary (PDS) or interval debulking surgery (IDS) for AOC with bowel resection. Numbers, characteristics and surgical implication of MLN involvement were considered...
January 27, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29378033/cervical-cancer-markers-epigenetics-and-micrornas
#10
Vishuda Laengsri, Usanee Kerdpin, Chotiros Plabplueng, Lertyot Treeratanapiboon, Pornlada Nuchnoi
Gynecologic malignant neoplasms are a severe health problem among female patients, of which cervical cancer (CC), in particular, is a common disease leading to high mortality rates. Despite extensive attempts by researchers to solve the molecular mystery of CC, the mechanisms of its pathogenesis remain unclear. Tumor markers used in the clinical laboratory, such as squamous cell carcinoma (SCC), cancer antigen (CA)-125, and CA19-9, provide some help in diagnosing patients with CC. However, finding new molecular markers with high sensitivity and specificity is necessary...
January 25, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29360690/predicting-6-and-12-month-risk-of-mortality-in-patients-with-platinum-resistant-advanced-stage-ovarian-cancer-prognostic-model-to-guide-palliative-care-referrals
#11
Jonathan Foote, Micael Lopez-Acevedo, Gregory Samsa, Paula S Lee, Arif H Kamal, Angeles Alvarez Secord, Laura J Havrilesky
OBJECTIVE: Predictive models are increasingly being used in clinical practice. The aim of the study was to develop a predictive model to identify patients with platinum-resistant ovarian cancer with a prognosis of less than 6 to 12 months who may benefit from immediate referral to hospice care. METHODS: A retrospective chart review identified patients with platinum-resistant epithelial ovarian cancer who were treated at our institution between 2000 and 2011. A predictive model for survival was constructed based on the time from development of platinum resistance to death...
February 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29359457/the-levonorgestrel-releasing-intrauterine-system-is-associated-with-a-reduction-in-dysmenorrhoea-and-dyspareunia-a-decrease-in-ca-125-levels-and-an-increase-in-quality-of-life-in-women-with-suspected-endometriosis
#12
Nese Yucel, Erdem Baskent, Burcin Karamustafaoglu Balci, Gokhan Goynumer
BACKGROUND AND AIMS: The aim of this study was to investigate the effectiveness of a levonorgestrel-releasing intrauterine device (LNG-IUS) in the symptomatic relief of pain in women with endometriosis and additionally, to assess the changes in women's life quality and serum cancer antigen (CA) 125 levels. MATERIALS AND METHODS: All women who had an LNG-IUS inserted for the treatment of dysmenorrhea, chronic pelvic pain or both for more than six months over a two-year period were included in the study...
January 23, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29340789/fully-sialylated-alpha-chain-of-complement-4-binding-protein-a2160-a-novel-prognostic-marker-for-epithelial-ovarian-carcinoma
#13
Koji Matsuo, Kazuhiro Tanabe, Masae Ikeda, Takeo Shibata, Hiroshi Kajiwara, Masaki Miyazawa, Mariko Miyazawa, Masaru Hayashi, Masako Shida, Takeshi Hirasawa, Lynda D Roman, Mikio Mikami
PURPOSE: Fully sialylated alpha-chain of complement 4-binding protein (A2160) is a member of the glycoprotein family and has recently been identified as a diagnostic biomarker for epithelial ovarian cancer. This study examined the utility of A2160 as a prognostic biomarker for this disease. METHODS: This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I-IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014...
January 16, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29335251/goblet-cell-carcinomas-of-the-appendix-rare-but-aggressive-neoplasms-with-challenging-management
#14
Ashley Kieran Clift, Oskar Kornasiewicz, Panagiotis Drymousis, Omar Faiz, Harpreet Wasan, James Kinross, Thomas Cecil, Andrea Frilling
Goblet cell carcinomas (GCC) are a rare, aggressive sub-type of appendiceal tumours with neuroendocrine features, and controversy exists with regards to therapeutic strategy. We undertook a retrospective review of GCC patients surgically treated at two tertiary referral centres. Clinical and histopathological data were extracted from a prospectively maintained database. Survival analyses utilised Kaplan-Meier methodology. Twenty-one patients were identified (9 females). Median age at diagnosis was 55years (range 32-77)...
January 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29324533/multicenter-clinicopathological-study-of-high-grade-serous-carcinoma-presenting-as-primary-peritoneal-carcinoma
#15
Shinichi Komiyama, Yoshihiro Nishijima, Haruhiro Kondo, Hiroyuki Nomura, Satoshi Yamaguchi, Masayuki Futagami, Hiroharu Arai, Yoshihito Yokoyama, Nao Suzuki, Mikio Mikami, Kaneyuki Kubushiro, Daisuke Aoki, Yasuhiro Udagawa, Ryuichiro Nishimura
OBJECTIVE: We conducted a multicenter clinicopathological study to characterize patients with high-grade serous carcinoma presenting as primary peritoneal carcinoma (clinical PPC). METHODS: At 9 sites in Japan, patients with clinical PPC diagnosed according to Gynecologic Oncology Group criteria were enrolled retrospectively. The Gynecologic Oncology Group criteria allow for minor ovarian involvement by high-grade serous carcinoma. There was no systematic detailed histopathological review of the fallopian tubes to determine whether they were involved by serous carcinoma...
January 12, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29313279/a-phase-1-study-of-parp-inhibitor-abt-767-in-advanced-solid-tumors-with-brca1-2-mutations-and-high-grade-serous-ovarian-fallopian-tube-or-primary-peritoneal-cancer
#16
Diane A J van der Biessen, Jourik A Gietema, Maja J A de Jonge, Ingrid M E Desar, Martha W den Hollander, Matthew Dudley, Martin Dunbar, Robert Hetman, Camille Serpenti, Hao Xiong, Rajendar K Mittapalli, Kirsten M Timms, Peter Ansell, Christine K Ratajczak, Stacie Peacock Shepherd, Carla M L van Herpen
Purpose This phase 1 study examined safety, pharmacokinetics (PK), and efficacy of the poly(ADP-ribose) polymerase (PARP) inhibitor ABT-767 in patients with advanced solid tumors and BRCA1/2 mutations or with high-grade serous ovarian, fallopian tube, or primary peritoneal cancer. Methods Patients received ABT-767 monotherapy orally until disease progression or unacceptable toxicity. Dose was escalated from 20 mg once daily to 500 mg twice daily (BID). Dose-limiting toxicities, recommended phase 2 dose (RP2D), food effect, objective response rate, and biomarkers predicting response were determined...
January 8, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29312729/diagnostic-accuracy-of-tumor-markers-for-malignant-pleural-effusion-a-derivation-and-validation-study
#17
Kan Zhai, Wen Wang, Yao Wang, Jing-Yuan Liu, Qiong Zhou, Huan-Zhong Shi
Background: The utility of tumor markers (TMs) for differentiating malignant pleural effusion (MPE) from benign pleural effusion (BPE) has been a subject of controversy. The majority of published studies are single center designed and lack validation. We performed a derivation and validation study in China to evaluate the diagnostic value of carcinoembryonic antigen (CEA) as well as carbohydrate antigen (CA) 15-3, CA 19-9 and CA 125 to differentiate between MPE and BPE. Methods: Three hundred and twenty seven pleural effusion (PE) and paired serum samples were collected from consecutive patients with MPE or BPE in Beijing (174 patients, derivation) and Wuhan (153 patients, validation) during the same period...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29306249/biomarker-and-shear-stress-in-secondary-pediatric-pulmonary-hypertension
#18
Ayhan Pektaş, Rana Olguntürk, Serdar Kula, Erman Çilsal, Ayşe Deniz Oğuz, Fatma Sedef Tunaoğlu
Background/aim: Endothelial dysfunction, tissue damage, inflammation, and microthrombosis are involved in the pathogenesis of pulmonary hypertension (PH), which may be present as a complication of congenital heart diseases. This study aims to identify how indicators of endothelial dysfunction (shear stress), tissue damage (brain natriuretic peptide and troponin T), inflammation (C-reactive protein (CRP)), and microthrombosis (D-dimer and von Willebrand factor) are altered in children with congenital left-to-right shunting...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29289320/ultrasensitive-flexible-fet-type-aptasensor-for-ca-125-cancer-marker-detection-based-on-carboxylated-multiwalled-carbon-nanotubes-immobilized-onto-reduced-graphene-oxide-film
#19
Samira Mansouri Majd, Abdollah Salimi
The development of a novel flexible and ultrasensitive aptasensor based on carboxylated multiwalled carbon nanotubes (MWCNTs)/ reduced graphene oxide-based field effect transistor (FET) has been reported for label-free detection of the ovarian cancer antigen (CA125). The fabricated sensor has a straightforward design based on the noncovalent attachment of MWCNTs/aptamer conjugated onto few layers reduced graphene oxide nanosheets and its integration with poly-methyl methacrylate (PMMA) as a suitable platform for designing flexible field-effect transistors...
February 13, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29278633/tumor-marker-ca-125-in-the-diagnosis-of-active-pulmonary-tuberculosis-a-study-of-adults-in-mostar-b-h
#20
Marijana Mikačić, Ivan Vasilj, Marina Vasilj, Danijel Bevanda, Mario Šimović, Kristina Galić
BACKGROUND: Tumor marker CA 125 is found in normal mesothelial lung cells and normal bronchial epithelial cells. If destruction of these cells occurs due to inflammation or tumour, CA 125 will be released, and increased in the serum. SUBJECTS AND METHODS: From November 2008 to May 2009 a study analysing CA 125 levels in serum samples from patients who are hospitalized at the Pulmology Department of University Hospital Mostar. Standard laboratory tests, X-ray, sputum examination to BK, and tumour marker CA 125 were performed in all patients...
December 2017: Psychiatria Danubina
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