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https://www.readbyqxmd.com/read/28655142/systematic-reviews-guidance-relevant-for-studies-of-older-people
#1
Susan D Shenkin, Jennifer K Harrison, Tim Wilkinson, Richard M Dodds, John P A Ioannidis
Systematic reviews and meta-analyses are increasingly common. This article aims to provide guidance for people conducting systematic reviews relevant to the healthcare of older people. An awareness of these issues will also help people reading systematic reviews to determine whether the results will influence their clinical practice. It is essential that systematic reviews are performed by a team which includes the required technical and clinical expertise. Those performing reviews for the first time should ensure they have appropriate training and support...
June 24, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28655027/zolpidem-for-the-treatment-of-neurologic-disorders-a-systematic-review
#2
Martin N Bomalaski, Edward S Claflin, Whitney Townsend, Mark D Peterson
Importance: Given its selective action on the ω1 subtype of the γ-aminobutyric acid A receptor, zolpidem tartrate presents a potential treatment mechanism for other neurologic disorders. Objective: To synthesize studies that used zolpidem to treat neurologic disorders. Evidence Review: Eligibility criteria included any published English-language article that examined the use of zolpidem for noninsomnia neurologic disorders in humans for all dates up to March 20, 2015...
June 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28654930/understanding-the-inter-disciplinary-and-institutional-diversity-of-citizen-science-a-survey-of-current-practice-in-germany-and-austria
#3
Lisa Pettibone, Katrin Vohland, David Ziegler
Citizen science has become more popular in recent years, quickly taking on a variety of potentially conflicting characteristics: a way to collect massive data sets at relatively low cost, a way to break science out of the ivory tower and better engage the public, an approach to educate lay people in scientific methods. But the extent of current citizen science practice-the types of actors and scientific disciplines who take part-is still poorly understood. This article builds on recent surveys of citizen science in PLOS One by analyzing citizen science practice in Germany and Austria through the projects on two online platforms...
2017: PloS One
https://www.readbyqxmd.com/read/28654906/p53-p63-and-p73-in-the-wonderland-of-s-cerevisiae
#4
REVIEW
Olivier Billant, Marc Blondel, Cécile Voisset
Since its discovery in 1979, p53 has been on the forefront of cancer research. It is considered a master gene of cancer suppression and is found mutated in around 50% of all human tumors. In addition, the progressive identification of p53-related transcription factors p63 and p73 as well as their multiple isoforms have added further layers of complexity to an already dense network. Among the numerous models used to unravel the p53 family mysteries, S. cerevisiae has been particularly useful. This seemingly naive model allows the expression of a functional human p53 and thus the assessment of p53 intrinsic transcriptional activity...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654727/using-the-noncode-database-resource
#5
Li Xiyuan, Bu Dechao, Sun Liang, Wu Yang, Fang Shuangsang, Li Hui, Luo Haitao, Luo Chunlong, Fang Wenzheng, Chen Runsheng, Zhao Yi
NONCODE is a comprehensive database that aims to present the most complete collection and annotation of non-coding RNAs, especially long non-coding RNAs (lncRNA genes), and thus NONCODE is essential to modern biological and medical research. Scientists are producing a flood of new data from which new lncRNA genes and lncRNA-disease relationships are continually being identified. NONCODE assimilates such information from a wide variety of sources including published articles, RNA-seq data, micro-array data and databases on genetic variation (dbSNP) and genome-wide associations (GWAS)...
June 27, 2017: Current Protocols in Bioinformatics
https://www.readbyqxmd.com/read/28654621/measuring-provider-performance-for-physicians-participating-in-the-merit-based-incentive-payment-system
#6
Lee Squitieri, Kevin C Chung
In 2017, the Centers for Medicare and Medicaid Services began requiring all eligible providers to participate in the Quality Payment Program or face financial reimbursement penalty. The Quality Payment Program outlines two paths for provider participation: the Merit-Based Incentive Payment System and Advanced Alternative Payment Models. For the first performance period beginning in January of 2017, the Centers for Medicare and Medicaid Services estimates that approximately 83 to 90 percent of eligible providers will not qualify for participation in an Advanced Alternative Payment Model and therefore must participate in the Merit-Based Incentive Payment System program...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654611/evidence-based-medicine-alloplastic-breast-reconstruction
#7
Peter A Lennox, Esta S Bovill, Sheina A Macadam
LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Understand the different advances that have resulted in improved outcomes in implant-based reconstruction. 2. Gain knowledge about specific techniques that have evolved rapidly in recent years and how to implement these. 3. Gain an understanding of controversies associated with alloplastic reconstruction. 4. Recognize undesirable outcomes in implant-based breast reconstruction and understand strategies for correction...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654610/what-s-new-in-syndromic-craniosynostosis-surgery
#8
Jesse A Taylor, Scott P Bartlett
LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Understand the role of prenatal screening and counseling of parents of unborn children with syndromic craniosynostosis. 2. Recognize the genetic abnormalities, craniofacial phenotype, associated anomalies, and challenges associated with each of the five major forms of syndromic craniosynostosis. 3. Identify the pros and cons associated with timing and types of cranial vault remodeling techniques in this patient population...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654446/sepsis-in-obstetrics-pathophysiology-and-diagnostic-definitions
#9
Sheryl E Parfitt, Mary L Bogat, Sandra L Hering, Cheryl Roth
In spite of many medical breakthroughs, sepsis continues to be challenging to identify, treat, and successfully resolve, including among the obstetric population. Sepsis is the result of an overactive, complex inflammatory response that is not completely understood. Currently there are no nationally agreed-upon criteria for systemic inflammatory response syndrome or sepsis in pregnant or peripartum women, as the physiologic changes of pregnancy have not been taken into consideration.This article is the first in a series of three that discuss the importance of sepsis and septic shock in pregnancy...
July 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28654303/imaging-and-dosimetry-for-radium-223-the-potential-for-personalized-treatment
#10
Glenn D Flux
Radium-223 ((223)Ra) offers a new option for the treatment of bone metastases from prostate cancer. As cancer treatment progresses towards personalization, the potential for an individualized approach is exemplified in treatments with radiotherapeutics due to the unique ability to image in vivo the uptake and retention of the therapeutic agent. This is unmatched in any other field of medicine. Currently, (223)Ra is administered according to standard fixed administrations, modified according to patient weight...
June 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28654218/unlocking-the-potential-of-organ-donation
#11
EDITORIAL
J M Smits
In the 8th century AD, under the reign of the Abbasid caliph Harun al-Rashid, the House of Wisdom was inaugurated in Baghdad.(1) This was a center of learning and transmission of classical wisdom, where scholars from all parts of the world gathered to learn and to transmit all the world's knowledge. So it is an ancient, albeit brilliant, concept to bring together all the beautiful minds and by exchanging and confronting opinions and ideas, gain new knowledge. This article is protected by copyright. All rights reserved...
June 27, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28654217/dual-labelled-antibodies-for-flow-and-mass-cytometry-a-new-tool-for-cross-platform-comparison-and-enrichment-of-target-cells-for-mass-cytometry
#12
EDITORIAL
Sabine Baumgart, Axel R Schulz, Anette Peddinghaus, Silke Stanislawiak, Sarah Gillert, Heike Hirseland, Susanne Krauthäuser, Christian Dose, Henrik E Mei, Andreas Grützkau
Antibody conjugates applicable in both conventional flow and mass cytometry would offer interesting options for cross-platform comparison, as well as the enrichment of rare target cells by conventional flow cytometry (FC) sorting prior to deep phenotyping by mass cytometry (MC). Here, we introduce a simple method to generate dual fluorochrome/metal-labelled antibodies by consecutive orthogonal labelling. First we compared different fluorochrome-conjugated antibodies specific for CD4, such as FITC, Vio667, VioGreen or VioBlue for their compatibility with the conventional secondary MAXPAR(®) labelling protocol...
June 27, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28654210/do-plant-eating-insect-lineages-pass-through-phases-of-host-use-generalism-during-speciation-and-host-switching-phylogenetic-evidence
#13
Nate B Hardy
The Oscillation Hypothesis posits that plant-eating insect diversity is generated by cycles of diet breadth expansion and contraction. Although at any given time most plant-eating insect species are host specialists, host use evolution and speciation tend to entail a phase of generalism. The main evidence for this comes from comparative phylogenetic studies, but with mixed support. Here, I review and add to this evidence. I show that some of the original work that inspired the Oscillation Hypothesis is flawed in a way that leads to spurious inferences about trends in the evolution of diet diversity...
June 27, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28654205/driving-toward-precision-medicine-for-acute-leukemias-are-we-there-yet
#14
Clement Chung, Hilary Ma
Despite recent progress in the understanding of the molecular basis of acute leukemias, treatment options for these diseases have not shown significant changes over the last few decades. In this review, we present a nonexhaustive key summary of the current cytogenetic and molecular changes associated with acute leukemias in disease prognostication and potential targeted therapies. An emerging paradigm is that many genetic or molecular alterations target similar signal transduction, transcriptional, and epigenetic pathways...
June 27, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28654194/ecogenetics-an-r-package-for-the-management-and-exploratory-analysis-of-spatial-data-in-landscape-genetics
#15
Leandro G Roser, Laura I Ferreyra, Beatriz O Saidman, Juan C Vilardi
The integration of ecology and genetics has become established in recent decades, in hand with the development of new technologies, whose implementation is allowing an improvement of the tools used for data analysis. In a landscape genetics context, integrative management of population information from different sources can make spatial studies involving phenotypic, genotypic and environmental data simpler, more accessible and faster. Tools for exploratory analysis of autocorrelation can help to uncover the spatial genetic structure of populations and generate appropriate hypotheses in searching for possible causes and consequences of their spatial processes...
June 27, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28653762/critical-updates-in-the-7-th-edition-of-the-american-society-for-apheresis-guidelines
#16
Tina S Ipe, Huy P Pham, Lance A Williams
The 7(th) edition of the American Society for Apheresis (ASFA) guidelines was composed by an international physicians committee, and includes 14 new diseases, and 2 new indications for diseases described in the former guidelines. Several indications have either changed names or were excluded from this edition. The guidelines are developed after taking into account documented evidence, either supporting or negating use of apheresis technology in the treatment of diseases. Based on this evidence, the committee revises, updates and includes or excludes disease entities/indications in the guidelines...
June 27, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28653756/a-zinc-oxide-modified-hydroxyapatite-based-cement-facilitated-new-crystalline-stoichiometric-and-amorphous-apatite-precipitation-on-dentine
#17
M Toledano, M C Pérez-Álvarez, F S Aguilera, E Osorio, I Cabello, M Toledano-Osorio, R Osorio
AIM: To evaluate the remineralization ability of two endodontic sealer cements. METHODOLOGY: Mid-coronal dentine surfaces were subjected to: i) 37% phosphoric acid (PA) or ii) 0.5 M ethylenediaminetetraacetic acid (EDTA) conditioning prior to the application of two experimental hydroxyapatite-based cements, containing sodium hydroxide (calcypatite) or zinc oxide (oxipatite), respectively. Samples were stored in simulated body fluid for 24 h or 21 d. Remineralization of the dentine surfaces were studied by Raman spectroscopy (mapping with K-means cluster and hierarchical cluster analysis) was undertaken were done...
June 27, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28653746/discovery-of-the-oldest-record-of-nitellopsis-obtusa-charophyceae-charophyta-in-north-america
#18
Kenneth G Karol, Robin S Sleith
Studies of the colonization and spread of invasive species improves our understanding of key concepts in population biology as well as informs control and prevention efforts. The characean green alga Nitellopsis obtusa (starry stonewort) is rare in its native Eurasian range but listed by the United States Geological Survey (USGS) as an aggressive invasive in North America. First documented in North America in 1978 from New York, U.S.A., it has since been reported from numerous inland lakes from Minnesota to Vermont, and from Lake Ontario and inland lakes in southern Ontario, Canada...
June 27, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28653664/compulsive-seekers-our-take-two-clinicians-perspective-on-a-new-animal-model-of-addiction
#19
David H Epstein, William J Kowalczyk
Neuropsychopharmacology accepted article preview online, 27 June 2017. doi:10.1038/npp.2017.132.
June 27, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28653598/identifying-attributes-of-food-literacy-a-scoping-review
#20
Elsie Azevedo Perry, Heather Thomas, H Ruby Samra, Shannon Edmonstone, Lyndsay Davidson, Amy Faulkner, Lisa Petermann, Elizabeth Manafò, Sharon I Kirkpatrick
OBJECTIVE: An absence of food literacy measurement tools makes it challenging for nutrition practitioners to assess the impact of food literacy on healthy diets and to evaluate the outcomes of food literacy interventions. The objective of the present scoping review was to identify the attributes of food literacy. DESIGN: A scoping review of peer-reviewed and grey literature was conducted and attributes of food literacy identified. Subjects included in the search were high-risk groups...
June 27, 2017: Public Health Nutrition
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