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https://www.readbyqxmd.com/read/29224258/progressive-osseous-heteroplasia-in-a-chinese-infant-and-a-novel-mutation-in-the-gnas-gene
#1
Shi-De Zhang, Zhuang-Li Xie, Ke-Qing Zhang, Karina Nht, Jing-Jun Zhao
Progressive osseous heteroplasia(POH,OMIM 166350) is a rare inherited disease that begins with skin ossification and proceeds into the deeper connective tissues. Most cases of POH are caused by heterozygous inactivating mutations of GNAS gene. Herein, we report a new sporadic case of atypical POH and its underlying genetic basis. This article is protected by copyright. All rights reserved.
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29224247/cortisol-and-blood-pressure-levels-decreased-in-fathers-during-the-first-hour-of-skin-to-skin-contact-with-their-premature-babies
#2
Natalia Varela, Réjean Tessier, George Tarabulsy, Tamarha Pierce
AIM: Premature birth is an extremely stressful experience. In 2013 to 2014 we explored the physiological stress responses of fathers during their first skin-to-skin contact with their new baby. METHODS: We recruited 49 fathers whose partners had given birth to a premature baby of up to 33 weeks and three days. The study, in the neonatal intensive care unit (NICU) of a Quebec hospital, measured the physiological stress responses of the fathers before and after they first experienced skin-to-skin contact with their new baby...
December 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29224244/a-histopathological-classification-system-of-tyr-nrasq61k-murine-melanocytic-lesions-a-reproducible-simplified-classification
#3
Pierre Sohier, Léa Legrand, Zackie Aktary, Christine Grill, Véronique Delmas, Florence Bernex, Edouard Reyes-Gomez, Lionel Larue, Béatrice Vergier
Genetically engineered mouse models offer essential opportunities to investigate the mechanisms of initiation and progression in melanoma. Here we report a new simplified histopathology classification of mouse melanocytic lesions in Tyr::NRASQ61K derived models, using an interactive decision tree that produces homogeneous categories. Reproducibility for this classification system was evaluated on a panel of representative cases of murine melanocytic lesions by pathologists and basic scientists. Reproducibility, measured as inter-rater agreement between evaluators using a modified Fleiss' kappa statistic revealed a very good agreement between observers...
December 10, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29224243/discovery-of-a-novel-thermostable-zn2-dependent-alcohol-dehydrogenase-from-chloroflexus-aurantiacus-through-conserved-domains-mining
#4
Christoph Loderer, David Wagner, Frances Morgenstern, Antje Spieß, Marion B Ansorge-Schumacher
AIMS: The purpose of the study was to demonstrate feasibility of the Conserved Domains Database (CDD) for identification of novel biocatalysts with desirable properties from a class of well-characterized biocatalysts. METHODS AND RESULTS: The thermostable ADH from Sulfolobus solfataricus with a broad substrate range was applied as a template for the search for novel thermostable ADHs via Conserved Domains Database. From the resulting hits, a putative ADH gene from the thermophilic organism Chloroflexus aurantiacus was cloned and expressed in E...
December 10, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29224214/facial-swelling-and-foreign-body-granulomatous-reaction-to-hyaluronic-acid-filler-in-the-setting-of-neratinib
#5
Brian P Hibler, Bernice Y Yan, Michael A Marchetti, Shabnam Momtahen, Klaus J Busam, Anthony M Rossi
Cosmetic injection of dermal fillers is common, with late complications increasingly recognized. Herein, we report a granulomatous reaction to hyaluronic acid filler occurring during the use of neratinib. A woman in her fifties, with metastatic adenocarcinoma of unknown primary involving the skin and bones, was referred for new-onset facial swelling. Notable past medical history included progression of disease on carboplatin/paclitaxel and a hemithyroidectomy for papillary thyroid cancer. This article is protected by copyright...
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29223966/advancing-point-of-care-diagnostics-for-the-control-and-prevention-of-stis-the-way-forward
#6
Igor Toskin, Karel Blondeel, Rosanna W Peeling, Carolyn Deal, James Kiarie
WHO recognises the global impact of sexually transmitted infections (STIs) on global public health and individual sexual and reproductive health and well-being. As a component of the WHO Global Health Sector Strategy for the control and prevention of STIs, there has been a growing recognition of the importance of integrating point-of-care tests (POCTs) into overall strategic planning. The process of integrating STI POCTs, in addition to providing a definitive diagnosis and appropriate treatment in a single visit, also includes innovative delivery options, such as on-site delivery, community-based testing (including screening), as well as self-testing at home after purchase of a test online or over-the-counter...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223960/systematic-reviews-of-point-of-care-tests-for-the-diagnosis-of-urogenital-chlamydia-trachomatis-infections
#7
REVIEW
Helen Kelly, Cordelia E M Coltart, Nitika Pant Pai, Jeffrey D Klausner, Magnus Unemo, Igor Toskin, Rosanna W Peeling
BACKGROUND: WHO estimates that 131 million new cases of urogenital Chlamydia trachomatis (CT) infections occur globally every year. Most infections are asymptomatic. Untreated infection in women can lead to severe complications. Screening and treatment of at-risk populations is a priority for prevention and control. OBJECTIVES: To summarise systematic reviews of the performance characteristics of commercially available point-of-care tests (POCT) for screening and diagnosis of urogenital CT infection...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223847/funding-breakthrough-therapies-a-systematic-review-and-recommendation
#8
REVIEW
E Hanna, M Toumi, C Dussart, B Borissov, O Dabbous, K Badora, P Auquier
BACKGROUND: Advanced therapy medicinal products (ATMPs) are innovative therapies likely associated with high prices. Payers need guidance to create a balance between ensuring patient access to breakthrough therapies and maintaining the financial sustainability of the healthcare system. OBJECTIVE: The aims of this study were to identify, define, classify and compare the approaches to funding high-cost medicines proposed in the literature, to analyze their appropriateness for ATMP funding and to suggest an optimal funding model for ATMPs...
December 2, 2017: Health Policy
https://www.readbyqxmd.com/read/29223732/a-comparison-of-4d-flow-mri-derived-wall-shear-stress-with-computational-fluid-dynamics-methods-for-intracranial-aneurysms-and-carotid-bifurcations-a-review
#9
REVIEW
Jeremy Szajer, Kevin Ho-Shon
BACKGROUND: 4D flow MRI is a relatively quick method for obtaining wall shear stress (WSS) in vivo, a hemodynamic parameter which has shown promise in risk stratification for rupture of cerebrovascular diseases such as intracranial aneurysms and atherosclerotic plaques. The accuracy of such measurements is still largely unknown. OBJECTIVE: To quantify the accuracy of 4D flow MRI-derived wall shear stress values for intracranial aneurysms and carotid bifurcations...
December 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29223581/toward-new-forms-of-meal-sharing-collective-habits-and-personal-diets
#10
Estelle Masson, Sandrine Bubendorff, Christèle Fraïssé
This article sheds light on the fact that the commensality remains a fundamental aspect of eating in French culture. However, at the same time, the expansion of the individualization and medicalization of the act of eating during the latest decades impacted the social representations of food. We will first place dietary practices into a general context in which the relationship to food tends to be individualised and in which health-related issues remain an important aspect of the discourse about food on internet...
December 6, 2017: Appetite
https://www.readbyqxmd.com/read/29223209/nurse-led-initiatives-to-implement-universal-screening-for-perinatal-emotional-complications
#11
Marissa Tenenbaum Potter
Perinatal emotional complications are the most common pregnancy complications in the United States. This article reviews three recent studies that illustrate the prevalence of and risk factors for perinatal emotional complications and sheds light on the inconsistency of screening by health care providers in acute care and outpatient settings. Also presented is an example of nurse-led quality improvement initiatives aimed at implementing universal screening in a rural New England county, which resulted in 100% screening with the Edinburgh Postnatal Depression Scale across health care facilities within the community, as well as a system-wide change in the approach to identifying and treating perinatal emotional complications...
December 2017: Nursing for Women's Health
https://www.readbyqxmd.com/read/29223193/quality-indicators-for-evaluating-prehospital-emergency-care-a-scoping-review
#12
Ian Howard, Peter Cameron, Lee Wallis, Maaret Castren, Veronica Lindstrom
Introduction Historically, the quality and performance of prehospital emergency care (PEC) has been assessed largely based on surrogate, non-clinical endpoints such as response time intervals or other crude measures of care (eg, stakeholder satisfaction). However, advances in Emergency Medical Services (EMS) systems and services world-wide have seen their scope and reach continue to expand. This has dictated that novel measures of performance be implemented to compliment this growth. Significant progress has been made in this area, largely in the form of the development of evidence-informed quality indicators (QIs) of PEC...
December 10, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29223137/sysmex-uf-1000i-flow-cytometer-to-screen-urinary-tract-infections-the-uriscam-multicentre-study
#13
O Herráez, M A Asencio, R Carranza, M M Jarabo, M Huertas, O Redondo, A Arias, S Jiménez-Álvarez, S Solís, P Zamarrón, M S Illescas, M A Galán
The new Sysmex UF-1000i analyzer - which incorporates bacteria morphology distinction - allows to automatically screen samples to be cultured at microbiology laboratories. We have evaluated the feasibility and accuracy of Sysmex UF-1000i to screen urine tract infections (UTIs). A total amount of 2,468 urine samples from six Spanish hospitals were analysed. Demographic and clinical data such as age, gender, source and sample type, preserving conditions, cytometer parameters (bacteria, leucocytes, and bacteria morphology) as well as urine culture results (gold standard) were recorded...
December 9, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29222999/the-symbolic-affordances-of-a-video-mediated-gaze-in-emergency-psychiatry
#14
Marianne V Trondsen, Aksel Tjora, Alex Broom, Graham Scambler
While mental illness is a significant health challenge worldwide, the availability of specialists is limited, especially in rural areas and for psychiatric emergencies. Although tele-psychiatry, via real-time videoconferencing (VC), is used to provide consultative services in areas that lack psychiatrists, there are a paucity of studies on the use of VC for psychiatric emergencies. We examine how VC matters for patient involvement and professional practice in the first Norwegian emergency tele-psychiatric service...
December 2, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29222962/east-meets-west-historical-investigation-of-non-operative-biliary-interventions
#15
EDITORIAL
Takao Itoi, Todd H Baron
Endoscopic retrograde cholangiopancreatography (ERCP) has become an established procedure not only for diagnosis using direct opacification, but also for various therapeutic interventions within the pancreaticobiliary system. This concept, "non-operative and intraluminal retrograde approach to the ampulla of Vater", which is the outlet for both the pancreatic duct and bile duct, was first described by radiologists Rabinov and Simon in 1965 [1]. They performed cannulation and injection of the ampulla of Vater by intubation using a new instrument through the mouth under television fluoroscopic control...
December 9, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29222951/neuronal-pas-domain-protein-4-npas4-controls-neuronal-homeostasis-in-pentylenetetrazole-induced-epilepsy-through-the-induction-of-homer1a
#16
Wei Shan, Taku Nagai, Motoki Tanaka, Norimichi Itoh, Yoko Furukawa-Hibi, Toshitaka Nabeshima, Masahiro Sokabe, Kiyofumi Yamada
Neuronal intrinsic homeostatic scaling-down of excitatory synapse has been implicated in epilepsy pathogenesis to prevent the neuronal circuits from hyper-excitability. Recent findings suggest a role for neuronal PAS domain protein 4 (Npas4), an activity-dependent neuron-specific transcription factor in epileptogenesis, however, the underlying mechanism by which Npas4 regulates epilepsy remains unclear. We herein propose that limbic seizure activity up-regulates Npas4-homer1a signaling in the hippocampus, thereby contributing to epileptogenesis in mice...
December 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29222950/tolerance-design-of-patient-specific-range-qa-using-the-dmaic-framework-in-proton-therapy
#17
Jeong-Eun Rah, Dongho Shin, Ryan P Manger, Tae Hyun Kim, Do Hoon Oh, Dae Yong Kim, Gwe-Ya Kim
PURPOSE: To implement the DMAIC (Define-Measure-Analyze-Improve-Control) can be used for customizing the patient-specific QA by designing site-specific range tolerances. METHODS: The DMAIC framework (process flow diagram, cause and effect, Pareto chart, control chart, and capability analysis) were utilized to determine the steps that need focus for improving the patient-specific QA. The patient-specific range QA plans were selected according to 7 treatment site groups, a total of 1437 cases...
December 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/29222948/force-coordination-strategies-in-on-water-single-sculling-are-asymmetries-related-to-better-rowing-performance
#18
John Warmenhoven, Richard Smith, Conny Draper, Andrew Harrison, Norma Bargary, Stephen Cobley
Asymmetries of the rowing stroke cycle have been assessed with reference to kinematics and foot-force measures in laboratory testing environments. It remains unclear how asymmetries in propulsive kinetic measures are related to on-water rowing performance. A new approach for the evaluation of both global and local asymmetries across the entire movement was used to assess the continuous role of asymmetries and whether these change according to level of competitive representation. Twenty seven highly skilled female rowers (national and international competition level), rowing at 32 strokes per minute in a single scull boat were evaluated...
December 9, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29222911/current-and-future-therapeutic-regimens-for-non-alcoholic-fatty-liver-disease-nafld-and-non-alcoholic-steatohepatitis-nash
#19
REVIEW
Zobair M Younossi, Rohit Loomba, Mary E Rinella, Elisabetta Bugianesi, Giulio Marchesini, Brent A Neuschwander-Tetri, Lawrence Serfaty, Francesco Negro, Stephen H Caldwell, Vlad Ratziu, Kathleen E Corey, Scott L Friedman, Manal F Abdelmalek, Stephen A Harrison, Arun J Sanyal, Joel E Lavine, Philippe Mathurin, Michael R Charlton, Naga P Chalasani, Quentin M Anstee, Kris V Kowdley, Jacob George, Zachary D Goodman, Keith Lindor
NASH/NAFLD is rapidly becoming one of top causes of cirrhosis, hepatocellular carcinoma and indication for liver transplantation. Except for life style modification through diet and exercise, there are currently no other approved treatments for NASH/NAFLD. Although weight loss can be effective, it is hard to achieve and sustain. In contrast, bariatric surgery can improve metabolic conditions associated with NAFLD and has been shown to improve liver histology. In order to have approved regimens for treatment of NASH/NAFLD, a number of issues that must be addressed...
December 9, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29222879/prevalence-cause-and-diagnosis-of-lactose-intolerance-in-children-aged-1-5-years-a-systematic-review-of-1995-2015-literature
#20
Louise Harvey, Thomas Ludwig, Alice Qian Hou, Quak Seng Hock, Michelle Ln Tan, Seksit Osatakul, Jacques Bindels, Leilani Muhardi
BACKGROUND AND OBJECTIVES: To assess the prevalence, etiology, diagnosis of primary and secondary lactose intolerance (LI), including age of onset, among children 1-5 years of age. Suspected/perceived lactose intolerance can lead to dietary restrictions which may increase risk of future health issues. METHODS AND STUDY DESIGN: MEDLINE, CAB Abstract, and Embase were searched for articles published from January 1995-June 2015 related to lactose intolerance in young children...
2018: Asia Pacific Journal of Clinical Nutrition
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