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https://www.readbyqxmd.com/read/27926981/efficacy-of-allergen-immunotherapy-in-reducing-the-likelihood-of-developing-new-allergen-sensitizations-a-systematic-review
#1
REVIEW
Danilo Di Bona, Antonella Plaia, Maria Stefania Leto-Barone, Simona La Piana, Luigi Macchia, Gabriele Di Lorenzo
BACKGROUND: Guidelines and position papers indicate that allergen immunotherapy (AIT) is the only disease-modifying treatment, including prevention of the onset of new allergen sensitizations. However, this preventive effect was shown by only a few observational studies. Our aim was to systematically review the efficacy of AIT in preventing the onset of new allergen sensitizations. METHODS: Computerized bibliographic searches of MEDLINE, EMBASE, and the Cochrane Library (through June 2015) were supplemented with manual searches of reference lists...
December 7, 2016: Allergy
https://www.readbyqxmd.com/read/27926795/tumour-budding-evaluated-in-biopsy-specimens-is-a-useful-predictor-of-prognosis-in-patients-with-cn0-early-stage-oral-squamous-cell-carcinoma
#2
Mai Seki, Takaaki Sano, Satoshi Yokoo, Tetsunari Oyama
AIMS: Oral squamous cell carcinoma (OSCC) prognosis depends on lymph node metastasis (LNM). We recently reported that tumour budding is a good predictive factor for LNM in squamous cell carcinoma of the tongue and floor of the mouth (FOM). Our aim was to evaluate whether tumour budding is a good prognostic factor in OSCC. METHODS AND RESULTS: We examined conventional histopathological assessment and a new factor, tumour budding, in 209 cases of OSCC in incisional biopsy specimens...
December 7, 2016: Histopathology
https://www.readbyqxmd.com/read/27926786/nut-midline-carcinoma-of-the-larynx-an-international-series-and-review-of-the-literature
#3
Henrik Hellquist, Christopher A French, Justin A Bishop, Andrés Coca-Pelaz, Evan J Propst, António Paiva Correia, Bo-Yee Ngan, Ronald Grant, Nicole A Cipriani, David Vokes, Rui Henrique, Fernando Pardal, Jose Ramon Vizcaino, Alessandra Rinaldo, Alfio Ferlito
AIMS: NUT midline carcinoma (NMC) is a rare undifferentiated and aggressive carcinoma that characteristically locates to the midline of the head and neck, and mediastinum. NMC is characterised by chromosomal rearrangements of the gene encoding nuclear protein in testis, NUT, at 15q14. The BRD4 gene on 19q13 is the most common translocation partner forming a fusion oncogene, BRD4-NUT. By the end of 2014, the International NUT Midline Carcinoma Registry had 48 patients treated for NMC. Laryngeal NMC are exceedingly rare and we report a case series of seven cases...
December 7, 2016: Histopathology
https://www.readbyqxmd.com/read/27926656/what-is-new-in-global-women-s-health-part-1-best-articles-from-the-past-year
#4
Amy M Autry, Scott M Petersen
This month we focus on current research in global women's health in obstetrics and gynecology. Drs. Autry and Petersen discuss six recent publications, which are concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in Box 1 on this page, along with direct links to the abstracts.
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926614/clinical-coordination-in-accountable-care-organizations-a-qualitative-study
#5
Valerie A Lewis, Karen Schoenherr, Taressa Fraze, Aleen Cunningham
BACKGROUND: Accountable care organizations (ACOs) are becoming a common payment and delivery model. Despite widespread interest, little empirical research has examined what efforts or strategies ACOs are using to change care and reduce costs. Knowledge of ACOs' clinical efforts can provide important context for understanding ACO performance, particularly to distinguish arenas where ACOs have and have not attempted care transformation. PURPOSE: The aim of the study was to understand ACOs' efforts to change clinical care during the first 18 months of ACO contracts...
December 6, 2016: Health Care Management Review
https://www.readbyqxmd.com/read/27926541/major-unanswered-questions-in-the-clinical-gout-field
#6
Lisa K Stamp
PURPOSE OF REVIEW: Although gout is one of the most common forms of inflammatory arthritis, it has been relatively neglected until recently. Despite progress in many areas of pathophysiology and genetics of gout and the development of new urate lowering therapies, there remain a number of unanswered clinical questions. With the resurgence of interest in gout it is important to recognize key aspects of gout management that remain challenging and require further research. RECENT FINDINGS: The unanswered clinical issues outlined in this review are basic aspects of gout management that clinicians treating people with gout face on a daily basis and include when urate lowering therapy should be commenced, the most appropriate target serum urate, use of prophylaxis when starting urate lowering therapy and the most appropriate urate lowering therapy, particularly for those with chronic kidney disease...
December 6, 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27925832/twitter-as-a-tool-for-health-research-a-systematic-review
#7
Lauren Sinnenberg, Alison M Buttenheim, Kevin Padrez, Christina Mancheno, Lyle Ungar, Raina M Merchant
BACKGROUND: Researchers have used traditional databases to study public health for decades. Less is known about the use of social media data sources, such as Twitter, for this purpose. OBJECTIVES: To systematically review the use of Twitter in health research, define a taxonomy to describe Twitter use, and characterize the current state of Twitter in health research. SEARCH METHODS: We performed a literature search in PubMed, Embase, Web of Science, Google Scholar, and CINAHL through September 2015...
January 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27925673/systematic-reviews-of-mechanisms-for-financing-family-planning-findings-implications-and-future-agenda
#8
Craig L Lissner, Moazzam Ali
The article describes an international collaboration that systematically reviewed the evidence on financing mechanisms for family planning/contraception, assessed the strength of and summarized the evidence, identified research gaps, and proposed a new research agenda to address the gaps. The review found that the evidence base is weak owing to the paucity of studies, diversity in findings, and variations in intervention, study design, and outcome measures. Of more than 17,000 papers reviewed only 38 met the eligibility criteria...
December 2016: Studies in Family Planning
https://www.readbyqxmd.com/read/27925486/real-talk-developing-a-computer-delivered-sexual-health-program-for-black-men-who-have-sex-with-men
#9
Charles Klein, Carmela Lomonaco
HIV disproportionately affects Black men who have sex with men (MSM), yet there are few evidence-based programs that respond to the diverse realities of Black MSM communities. This article examines the development of Real Talk, a new harm reduction-based, sexual health intervention for Black MSM. We first analyze the key themes from our formative research: (1) stigma, discrimination, and intersectionalities in the lives of Black MSM, (2) the importance of safe spaces and community provided by health promotion programs, and (3) moving beyond condoms in sexual health messaging...
December 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/27925402/two-new-oxygen-containing-biomarkers-isolated-from-the-chinese-maoming-oil-shale-by-silica-gel-column-chromatography-and-preparative-gas-chromatography
#10
Xiangyun Zhang, Hong Lu, Jing Liao, Caiming Tang, Guoying Sheng, Ping'an Peng
Two biomarkers, 5,9-dimethyl-6-isopropyl-2-decanone (1) and 4,9,11-trimethyl-6-isopropyl-2-dodecanone (2), were isolated from Chinese Maoming Oil Shale by silica gel column chromatography and preparative gas chromatography. Their structures were elucidated by using spectroscopic techniques. This article is protected by copyright. All rights reserved.
December 7, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27925389/the-long-term-immunological-effects-of-alloferon-and-its-analogues-in-the-mealworm-tenebrio-molitor
#11
Elżbieta Czarniewska, Arkadiusz Urbański, Szymon Chowański, Mariola Kuczer
The subject of this paper is a search for the long-term immunological effects of alloferon and 3 structural analogues of alloferon, which were earlier characterised by the highest pro-apoptotic activity in Tenebrio molitor. The differences in the actions of these peptides on immune response were observed. Alloferon increased nodulation and significantly phenoloxidase activity in the haemolymph of experimentally infected T. molitor. However, [Phe(p-NH2 )(1) ]- and [Phe(p-OMe)(1) ]-alloferon strongly inhibited cellular and humoral defense of the mealworm against Staphylococcus aureus infection...
December 7, 2016: Insect Science
https://www.readbyqxmd.com/read/27925362/ns5a-inhibitors-for-the-treatment-of-hepatitis-c-infection
#12
Stefano Gitto, Nesrine Gamal, Pietro Andreone
Today, we are witnessing a new era for the treatment of hepatitis C with excellent rates of virologic response and very good safety profiles. Among the many classes of direct acting antivirals, the inhibitors of non-structural protein 5A are particularly interesting. NS5A is phosphorylated protein with a relevant role in viral replication. HCV-NS5A inhibitors show high potency, very good safety profile and high barrier to resistance. The amazing in vitro effectiveness of this class is associated with great efficacy in clinical trials in combination protocols with antivirals of other classes, with sustained virological response (SVR) obtained in more than 90% of patients...
December 7, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27925332/left-atrial-appendage-closure-with-the-new-occlutech%C3%A2-device-first-in-man-experience-and-neurological-outcome
#13
Barbara Bellmann, Steffen Schnupp, Peter Kühnlein, Christian Javernik, Caroline Kleinecke, Andreas Rillig, Ulf Landmesser, Johannes Brachmann, Jai-Wun Park
AIMS: Percutaneous left atrial appendage closure (LAAC) is a valuable treatment option for stroke prevention in patients with atrial fibrillation and a HAS-BLED-Score ≥ 3. Determinants of procedural safety events and neurological outcome of the patients with the Occlutech Device (OD) are not established yet. METHODS AND RESULTS: Between 2012 and 2016, 30 patients underwent LAAC using the OD. This is a prospective, study. Neurological examination and transesophageal echocardiography was performed directly before and after the procedure and after 1, 3 and 12 months...
December 7, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27925287/treatment-sequence-matters-anabolic-and-antiresorptive-therapy-for-osteoporosis
#14
Felicia Cosman, Jeri W Nieves, David Dempster
The majority of osteoporosis medications are antiresorptive agents, which reduce the rate of bone remodeling. Within this group are the bisphosphonates, which inhibit protein prenylation in the mature osteoclast, reducing osteoclast capacity to resorb bone(1) and denosumab, a monoclonal antibody to rank ligand that inhibits osteoclast formation, function and survival(2) . Although several new anabolic agents are in development(3-5) , teriparatide is currently the only available anabolic therapy for osteoporosis in the United States, with the addition of only PTH(1-84) in the EU [referred to as PTH)...
December 7, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27925263/improved-consistency-in-2d-gel-electrophoresis-sheep-plasma-as-a-test-case
#15
Stuart Brown, Gillian Norris
Two-dimensional gel electrophoresis is a well proven proteomic technique, however sample specific optimization can often be necessary in order to get consistent quantitation. In particular, plasma samples are often smeared on 2D gels which makes spot matching difficult. A variety of different sample preparation and 2D methods were tested using sheep plasma, and it was found that lowering sample pH prior to precipitation, using a long voltage gradient for isoelectric focusing and the inclusion of carrier ampholytes in the electrode wicks, improved both the quality and consistency of spot resolution...
December 7, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27925205/generation-of-insulin-producing-cells-from-human-induced-pluripotent-stem-cells-using-a-stepwise-differentiation-protocol-optimized-with-platelet-rich-plasma
#16
Seyed Ehsan Enderami, Yousef Mortazavi, Masoud Soleimani, Samad Nadri, Alireza Biglari, Reyhaneh Nassiri Mansour
Studies on patient-specific human-induced pluripotent stem cells (hiPSCs) as well as a series of autologous growth factors presumably will reveal their many benefits for cell base replacement therapy in type 1 diabetes mellitus (TIDM) patients in the future. For this purpose, we established a multistep protocol by adding platelet-rich plasma (PRP) that induce the hiPSCs into insulin-producing cells (IPCs). We present here a differentiation protocol consisting of five stages in two groups including protocol with PRP and without PRP...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27925201/vascular-inter-regulation-of-inflammation-molecular-and-cellular-targets-for-cns-therapy
#17
REVIEW
Marta Machado-Pereira, Tiago Santos, Liliana Bernardino, Raquel Ferreira
Angiogenesis and inflammation are clearly interconnected and interdependent processes that are dysregulated in a series of systemic and brain pathologies. Herein, key aspects regarding endothelial cell function and tissue remodelling that are particularly affected or aggravated by inflammation are presented. Most importantly, the cellular and molecular mechanisms involved in the vascular regulation of the inflammatory processes occurring in several brain disorders and how they impact on disease/injury progression are detailed, highlighting potential targets for therapy...
December 7, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27925194/sv40-infection-of-mesenchymal-stromal-cells-from-wharton-s-jelly-drives-the-production-of-inflammatory-and-tumoral-mediators
#18
Carolina Cason, Giuseppina Campisciano, Nunzia Zanotta, Erica Valencic, Serena Delbue, Ramona Bella, Manola Comar
The Mesenchymal Stromal Cells from umbilical cord Wharton's jelly (WJSCs) are a source of cells with high potentiality for the treatment of human immunological disorders. Footprints of the oncogenic viruses Simian Virus 40 (SV40) and JC Virus (JCPyV) have been recently detected in human WJSCs specimens. The aim of this study is to evaluate if WJSCs can be efficiently infected by these Polyomaviruses and if they can potentially exert tumoral activity. Cell culture experiments indicated that WJSCs could sustain both SV40 and JCPyV infections...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27925185/effects-of-carbocysteine-and-beclomethasone-on-histone-acetylation-deacetylation-processes-in-cigarette-smoke-exposed-bronchial-epithelial-cells
#19
E Pace, S Di Vincenzo, M Ferraro, L Siena, G Chiappara, P Dino, P Vitulo, A Bertani, F Saibene, L Lanata, M Gjomarkaj
Histone deacetylase expression/activity may control inflammation, cell senescence, and responses to corticosteroids. Cigarette smoke exposure, increasing oxidative stress, may negatively affect deacetylase expression/activity. The effects of cigarette smoke extracts (CSE), carbocysteine, and beclomethasone dipropionate on chromatin remodelling processes in human bronchial epithelial cells are largely unknown. The present study was aimed to assess the effects of cigarette smoke, carbocysteine, and beclomethasone dipropionate on histone deacetylase 3 (HDAC3) expression/activity, N-CoR (nuclear receptor corepressor) expression, histone acetyltransferases (HAT) (p300/CBP) expression, p-CREB and IL-1 m-RNA expression, neutrophil chemotaxis...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27925183/changing-socioeconomic-inequalities-in-cancer-incidence-and-mortality-cohort-study-with-54-million-person-years-follow-up-1981-2011
#20
Andrea M Teng, June Atkinson, George Disney, Nick Wilson, Tony Blakely
Cancer is increasingly responsible for the mortality gap between high and low socioeconomic position groups in high-income countries. This study investigates which cancers are contributing more to socioeconomic gaps in mortality and how this changes over time. New Zealand census data from 1981, 1986, 1991, 1996, 2001, and 2006, were linked to three to five years of subsequent mortality and cancer registrations, resulting in 54 and 42 million years of follow-up cancer incidence and mortality respectively. Age- and ethnicity-standardised cancer mortality rates and the slope index of inequality (SII) by income were calculated...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
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