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https://www.readbyqxmd.com/read/29454005/a-quest-to-find-good-primers-for-gene-expression-analysis-of-candida-albicans-from-clinical-samples
#1
Gabriela C Alonso, Ana C Pavarina, Tábata V Sousa, Marlise I Klein
Biofilm production contributes to several human diseases, including oral candidiasis. Among the Candida species, Candida albicans is the most prevalent. The expression of virulence genes is implicated in the pathogenic potential of Candida biofilms. However, the evaluation of microbial gene expression from in vivo biofilm samples is not trivial, specifically, assessment via quantitative PCR (qPCR) can be a challenge because of several species present in clinical samples. Hence, the necessity of primers specificity...
February 14, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29453968/lipoprotein-lipase-biosynthesis-regulatory-factors-and-its-role-in-atherosclerosis-and-other-diseases
#2
REVIEW
Ping-Ping He, Ting Jiang, Xin-Ping OuYang, Ya-Qin Liang, Jie-Qiong Zou, Yan Wang, Qian-Qian Shen, Li Liao, Xi-Long Zheng
Lipoprotein lipase (LPL) is a rate-limiting enzyme that catalyzes hydrolysis of the triglyceride (TG) core of circulating TG-rich lipoproteins including chylomicrons (CM), low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL). A variety of parenchymal cells can synthesize and secrete LPL. Recent studies have demonstrated that complicated processes are involved in LPL biosynthesis, secretion and transport. The enzyme activity of LPL is regulated by many factors, such as apolipoproteins, angiopoietins, hormones and miRNAs...
February 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29453925/impact-of-opioid-therapy-on-gonadal-hormones-focus-on-buprenorphine
#3
REVIEW
Anjali Varma, Mamta Sapra, Ali Iranmanesh
Objective The USA is in the midst of an opioid crisis. Understanding the impact of opioids and commonly used treatments for opioid dependence is essential for clinicians and researchers in order to educate and treat the nation's growing population with opioid use disorders. As a relatively new treatment for opioid dependence, buprenorphine is gaining popularity to the extent of becoming not only a preferred approach to the maintenance of opiate addiction, but also an option for chronic pain management. The purpose of this report is to review the available evidence on the endocrine effects of buprenorphine, particularly as it relates to the hypothalamic-pituitary-gonadal (HPG) axis, which is controversial and not fully defined...
February 17, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29453901/shedding-light-on-aberrant-interactions-a-review-of-modern-tools-for-studying-protein-aggregates
#4
REVIEW
Franziska Kundel, Laura Tosatto, Daniel R Whiten, David C Wirthensohn, Mathew H Horrocks, David Klenerman
The link between protein aggregation and neurodegenerative disease is well established. However, given the heterogeneity of species formed during the aggregation process, it is difficult to delineate details of the molecular events involved in generating pathological aggregates from those producing soluble monomers. As aberrant aggregates are possible pharmacological targets for the treatment of neurodegenerative diseases, the need to observe and characterise soluble oligomers has pushed traditional biophysical techniques to their limits, leading to the development of a plethora of new tools capable of detecting soluble oligomers with high precision and specificity...
February 17, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29453887/coronary-artery-disease-in-heart-transplantation-new-concepts-for-an-old-disease
#5
REVIEW
Mandy Langstraat, Kyra J S Musters, Olivier Manintveld, Marco Masetti, Luciano Potena
BACKGROUND: Cardiac allograft vasculopathy (CAV) remains one of the main long-term complications after heart transplantation. We performed a systematic review focused on articles published in the previous 6 years to reappraise the novel evidences supporting risk-factors, pathology, prevention and treatment of CAV. METHODS: We identified a search string for a literature search on PubMed. We excluded articles specifically focused on diagnosis/biomarkers/imaging only or complications of other diseases...
February 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29453884/daratumumab-resistance-is-frequent-in-advanced-stage-multiple-myeloma-patients-irrespectively-of-cd38-expression-and-is-related-to-dismal-prognosis
#6
M Pick, V Vainstein, N Goldschmidt, D Lavie, D Libster, A Gural, S Grisariu, B Avni, D Ben Yehuda, M E Gatt
OBJECTIVE: Daratumumab is a promising new anti-myeloma agent. We report a single center "real world" series of multiple myeloma (MM) and amyloidosis (AL) patients treated with daratumumab. METHODS: Forty-one patients were included: 7 second line MM, 30 heavily pretreated (median number of therapies of 5) advanced MM, and 4 with AL. RESULTS: Second line patients and advanced AL showed high rate of durable overall responses. However, advanced MM patients had a dismal prognosis with an ORR of 36%, and a short median progression free and overall survival of 2...
February 17, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29453854/cost-effective-innovations-in-low-resource-settings
#7
Olivia H Chang, Jeffrey P Wilkinson
As health technologies are slowly adapted in low resource settings, the support modalities, equipment and supplies that allow these advances to be implemented are often not fully considered. It is not uncommon to install a new computed tomography scan machine in a hospital in sub-Saharan Africa only to suffer extensive downtime from unreliable electricity supply or unavailability of contrast agents (Essential Health Technologies WHO 2011). Countless expensive high-tech devices sit idle in low resource settings for lack of proper disposables and properly trained health care professionals...
February 17, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29453850/the-role-of-the-immune-system-in-kidney-disease
#8
REVIEW
Josefine Tecklenborg, David Clayton, Stefan Siebert, Shana M Coley
The immune system and the kidneys are closely linked. In health the kidneys contribute to immune homeostasis, while components of the immune system mediate many acute forms of renal disease and play a central role in progression of chronic kidney disease. A dysregulated immune system can have either direct or indirect renal effects. Direct immune-mediated kidney diseases are usually a consequence of autoantibodies directed against a constituent renal antigen, such as collagen IV in anti-glomerular basement membrane disease...
February 17, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29453823/paeoniflorin-ameliorates-collagen-induced-arthritis-via-suppressing-nf-%C3%AE%C2%BAb-signaling-pathway-in-osteoclast-differentiation
#9
Haiyan Xu, Li Cai, Lili Zhang, Guojue Wang, Rongli Xie, Yongshuai Jiang, Yuanyang Yuan, Hong Nie
Paeoniflorin (PF), extracted from the root of Paeonia lactiflora Pall, exhibits anti-inflammation properties in several autoimmune diseases. Osteoclast, the only somatic cell with bone resorbing capacity, was the direct cause of bone destruction in rheumatoid arthritis (RA) and its mouse model, such as collagen induced arthritis(CIA). The objective of this study is to estimate the effect of PF on CIA mice, and explore the mechanism of PF on bone destruction. We demonstrated that PF treatment significantly ameliorated CIA via inflammatory response inhibition and bone destruction suppression...
February 17, 2018: Immunology
https://www.readbyqxmd.com/read/29453815/the-use-of-chitosan-porous-3d-scaffolds-embedded-with-resolvin-d1-to-improve-in-vivo-bone-healing
#10
Daniela P Vasconcelos, Madalena Costa, Nuno Neves, José H Teixeira, Daniel M Vasconcelos, Susana G Santos, Artur P Águas, Mário A Barbosa, Judite N Barbosa
The aim of this study was to investigate the effect chitosan (Ch) porous 3D scaffolds embedded with resolvin D1 (RvD1), an endogenous pro-resolving lipid mediator, on bone tissue healing. These scaffolds previous developed by us have demonstrated to have immunomodulatory properties namely in the modulation of the macrophage inflammatory phenotypic profile in an in vivo model of inflammation. Herein, results obtained in an in vivo rat femoral defect model demonstrated that two months after Ch+RvD1 scaffolds implantation, an increase in new bone formation, in bone trabecular thickness, and in collagen type I and Coll I/Coll III ratio were observed...
February 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29453548/-big-data-from-clinical-routine
#11
REVIEW
U Mansmann
BACKGROUND: Over the past 100 years, evidence-based medicine has undergone several fundamental changes. Through the field of physiology, medical doctors were introduced to the natural sciences. Since the late 1940s, randomized and epidemiological studies have come to provide the evidence for medical practice, which led to the emergence of clinical epidemiology as a new field in the medical sciences. Within the past few years, big data has become the driving force behind the vision for having a comprehensive set of health-related data which tracks individual healthcare histories and consequently that of large populations...
February 16, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29453504/financing-the-primary-care-behavioral-health-model
#12
Dennis S Freeman, Lesley Manson, Jeff Howard, Joel Hornberger
The PCBH model of integrated care blends behavioral health professionals into the primary care team, thereby enhancing the scope of primary care and expanding the range of services provided to the patient. Despite promising evidence in support of the model and a growing number of advocates and practitioners of PCBH integration, current reimbursement policies are not always favorable. As the nation's healthcare system transitions to value-based payment models, new financing strategies are emerging which will further support the viability of PCBH integration...
February 16, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29452779/management-of-female-stress-urinary-incontinence-a-care-pathway-and-update
#13
REVIEW
Giampiero Capobianco, Massimo Madonia, Sonia Morelli, Francesco Dessole, Davide De Vita, Pier Luigi Cherchi, Salvatore Dessole
Stress urinary incontinence (SUI) is a condition characterized by an involuntary loss of urine occurring as result of an increase in intra-abdominal pressure due to effort or exertion or on sneezing or coughing. Estimates of its prevalence in the female population range from 10% to 40%. A literature search of the Medline, Cochrane library, EMBASE, NLH, ClinicalTrials.gov and Google Scholar databases was done up to July 2017, restricted to English-language articles, using terms related to SUI, medical therapy, surgical therapy and treatment options...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29452610/the-plasma-membrane-calcium-pumps-the-old-and-the-new
#14
REVIEW
Asma Zaidi, Mercy Adewale, Lauren McLean, Paul Ramlow
The plasma membrane Ca 2+ -ATPase (PMCA) pumps play a critical role in the maintenance of calcium (Ca 2+ ) homeostasis, crucial for optimal neuronal function and cell survival. Loss of Ca 2+ homeostasis is a key precursor in neuronal dysfunction associated with brain aging and in the pathogenesis of neurodegenerative disorders. In this article, we review evidence showing age-related changes in the PMCAs in synaptic plasma membranes (SPMs) and lipid raft microdomains isolated from rat brain. Both PMCA activity and protein levels decline progressively with increasing age...
January 10, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29452560/health-care-efficiencies-consolidation-and-alternative-models-vs-health-care-and-antitrust-regulation-irreconcilable-differences
#15
Michael W King
Despite the U.S. substantially outspending peer high income nations with almost 18% of GDP dedicated to health care, on any number of statistical measurements from life expectancy to birth rates to chronic disease, 1 the U.S. achieves inferior health outcomes. In short, Americans receive a very disappointing return on investment on their health care dollars, causing economic and social strain. 2 Accordingly, the debates rage on: what is the top driver of health care spending? Among the culprits: poor communication and coordination among disparate providers, paperwork required by payors and regulations, well-intentioned physicians overprescribing treatments, drugs and devices, outright fraud and abuse, and medical malpractice litigation...
November 2017: American Journal of Law & Medicine
https://www.readbyqxmd.com/read/29452517/a-decade-of-the-clinical-trials-transformation-initiative-what-have-we-accomplished-what-have-we-learned
#16
P Tenaerts, L Madre, M Landray
The Clinical Trials Transformation Initiative reflects on 10 years of working to improve the quality and efficiency of clinical trials. This article highlights many of the Clinical Trials Transformation Initiative's accomplishments and offers examples of the impact that the Clinical Trials Transformation Initiative has had on the clinical trials enterprise. After conducting more than 25 projects and issuing recommendations for specific strategies to improve the design and execution of clinical trials, some common themes and lessons learned have emerged...
February 2018: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29452171/evolution-of-model-specific-relative-growth-rate-its-genesis-and-performance-over-fisher-s-growth-rates
#17
Arijit Pal, Amiya Ranjan Bhowmick, Farhana Yeasmin, Sabyasachi Bhattacharya
Growth curve models play an instrumental role to quantify the growth of biological processes and have immense practical applications across disciplines. In the modelling approach, the absolute growth rate and relative growth rate (RGR) are two most commonly used measures of growth rates. RGR is empirically estimated by Fisher (1921) assuming exponential growth between two consecutive time points and remains invariant under any choice of the underlying growth model. In this article, we propose a new measure of RGR, called modified RGR, which is sensitive to the choice of underlying growth law...
February 13, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29451715/transitions-in-sex-determination-and-sex-chromosomes-across-vertebrate-species
#18
Matthew W Pennell, Judith E Mank, Catherine L Peichel
Despite the prevalence of sexual reproduction across eukaryotes, there is a remarkable diversity of sex determination mechanisms. The underlying causes of this diversity remain unclear, and it is unknown if there are convergent trends in the directionality of turnover in sex determination mechanisms. We used the recently assembled Tree of Sex database to assess patterns in the evolution of sex determination systems in the remarkably diverse vertebrate clades of teleost fish, squamate reptiles, and amphibians...
February 16, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29451710/salvisertin-a-a-new-hexacyclic-triterpenoid-and-other-bioactive-terpenes-from-salvia-deserta-root
#19
Yin-Ru Wang, Yun Yu, Shu-Ming Li, Wei Liu, Wei Li, Susan L Morris-Natschke, Masuo Goto, Kuo-Hsiung Lee, Xue-Feng Huang
Using various chromatographic methods, a new hexacyclic triterpenoid, 2β, 3β, 24β-trihydroxy-12, 13-cyclo-taraxer-l4-en-28oic acid (1), together with ten known compounds, 2α, 3α, 23- trihydroxyurs-12, 20(30)-dien-28oic acid (2), 6, 7-dehydroroyleanone (3), horminone (4), 7-O-methylhorminone (5), sugiol (6), demethylcryptojaponol (7), 14-deoxycoleon U (8), 5, 6-didehydro-7-hydroxy-taxodone (9), ferruginol (10) and dichroanone (11), were isolated from the roots of Salvia deserta. Their structures were identified on the basis of spectroscopic analysis and comparison with the reported data...
February 16, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29451335/mesenchymal-stem-cells-protect-against-hypoxia-ischemia-brain-damage-by-enhancing-autophagy-through-bdnf-mtor-signaling-pathway
#20
Zhen Zheng, Li Zhang, Yi Qu, Guoguang Xiao, Shiping Li, Shan Bao, Richard Lu, Dezhi Mu
Hypoxic-ischemic encephalopathy (HIE) is a serious disease for neonates. However, present therapeutic strategies are not effective enough for treating HIE. Previous study showed that mesenchymal stem cells (MSCs) can exert neuroprotective effects for brain damage, but its mechanism remains elusive. Using in-vitro co-culture of rat cortical primary neurons and MSCs in HI conditions, we demonstrated that MSCs help increase BDNF and autophagy markers (LC3II and Beclin1) in the cultures and decrease cells death (LDH levels)...
February 16, 2018: Stem Cells
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