Pedro C Rodriguez, Xitllaly Popa, Odeth Martínez, Silvia Mendoza, Eduardo Santiesteban, Tatiana Crespo, Rosa M Amador, Ricardo Fleytas, Soraida C Acosta, Yanine Otero, Gala N Romero, Ana de la Torre, Mireysi Cala, Lina Arzuaga, Loisel Vello, Delmairis Reyes, Niurka Futiel, Teresa Sabates, Mauricio Catala, Yoanna I Flores, Beatriz Garcia, Carmen Viada, Patricia Lorenzo-Luaces, Maria A Marrero, Liuba Alonso, Jenelin Parra, Nadia Aguilera, Yaisel Pomares, Patricia Sierra, Gryssell Rodríguez, Zaima Mazorra, Agustin Lage, Tania Crombet, Elia Neninger
PURPOSE: EGFR is a well-validated target for patients with non-small cell lung cancer (NSCLC). CIMAvax-EGF is a therapeutic cancer vaccine composed of human recombinant EGF conjugated to a carrier protein and Montanide ISA51 as adjuvant. The vaccine is intended to induce antibodies against self EGFs that block EGF-EGFR interaction. EXPERIMENTAL DESIGN: To evaluate overall survival, safety, immunogenicity, and EGF concentration in serum after CIMAvax-EGF, a randomized phase III trial was done in patients with advanced NSCLC...
August 1, 2016: Clinical Cancer Research