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https://www.readbyqxmd.com/read/29458059/modest-enhancement-of-sensory-axon-regeneration-in-the-sciatic-nerve-with-conditional-co-deletion-of-pten-and-socs3-in-the-dorsal-root-ganglia-of-adult-mice
#1
Zachary R Gallaher, Oswald Steward
Axons within the peripheral nervous system are capable of regeneration, but full functional recovery is rare. Recent work has shown that conditional deletion of two key signaling inhibitors of the PI3K and Jak/Stat pathways-phosphatase and tensin homolog (PTEN) and suppressor of cytokine signaling-3 (SOCS3), respectively-promotes regeneration of normally non-regenerative central nervous system axons. Moreover, in studies of optic nerve regeneration, co-deletion of both PTEN and SOCS3 has an even greater effect...
February 16, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29457902/multicolor-luminescence-switching-and-controllable-thermally-activated-delayed-fluorescence-turn-on-turn-off-in-carbazole-quinoxaline-carbazole-triads
#2
Ramin Pashazadeh, Piotr Henryk Pander, Algirdas Lazauskas, Fernando B Dias, Juozas Vidas Grazulevicius
In this work we report a series of thermally activated delayed fluorescence (TADF) molecules with mechanochromic luminescence (MCL) properties and reversible TADF turn on/off properties in solid state that are induced by the transition between amorphous and crystalline states. Additionally, multicolor altering through external stimulus is demonstrated. All the studied compounds exhibited recovery of the initial states associated with narrower emission spectra. TADF OLEDs fabricated by solution processing rendered high external quantum efficiency up to 10...
February 19, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29457559/functional-outcomes-of-inpatient-rehabilitation-in-very-elderly-patients-with-stroke-differences-across-three-age-groups
#3
Hitoshi Mutai, Tomomi Furukawa, Ayumi Wakabayashi, Akihito Suzuki, Tokiji Hanihara
Background As the population continues to age rapidly, clarifying the factors affecting the prognosis in very elderly stroke patients is essential to enhance the quality of their rehabilitation. Objectives To compare the functional recovery of elderly stroke patients classified into three age groups and to identify the predictors of functional recovery in the very elderly following acute inpatient rehabilitation. Methods Observational study: We collected data on 461 stroke patients in the neurology and neurosurgery ward and classified them into three age groups (65-74, 75-84, and ≥ 85 years)...
February 19, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29457414/-clinical-research-of-popliteal-cyst-excision-combined-with-debridement-of-the-knee-under-arthroscopy-with-local-anesthesia
#4
Ji Li, Zhong-Li Li, Hao Zhang, Ke-Tao Wang, Yi-Meng Yang, Xiang-Zheng Su
OBJECTIVE: To evaluate the clinical effects of popliteal cyst excision combined with debridement of the knee under arthroscopy with local anesthesia. METHODS: From February 2009 to August 2014, 52 patients with popliteal cysts were treated in our hospital, including 34 males and 18 females with an average age of 43.6 years old ranging from 14 to 62 years old; 29 cases were on the right knee and 23 on the left knee. Preoperative diagnosis was performed according to MRI findings and to determine whether other knee disorders were associated with the disease, 52 patients were diagnosed as popliteal cyst before operation; 23 cases of simple meniscus injury or cartilage injury, 18 cases of osteoarthritis, 7 cases of cruciate ligament injury, 2 cases of gouty arthritis, 1 case of rheumatoid arthritis, 1 case of pigmented villonodular arthritis...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457411/-effect-of-hip-fracture-at-different-sites-in-elderly-patients-on-prognosis
#5
Cheng Peng, Xiao-Wei Wang, Shao-Guang Li, Zhi Liu, Tian-Sheng Sun, Jian-Zheng Zhang
OBJECTIVE: To determine the effect of site of fracture on the prognosis for patients of elderly hip fracture. METHODS: From January 2012 to December 2014, 667 patients with hip fractures were divided into femoral neck fracture group and intertrochanteric fracture group according to the site of fracture. There were 304 cases of intertrochanteric fracture, including 96 males and 208 females, with an average age of (80.33±7.94) years old. There were 217 cases of femoral neck fracture, including 74 males and 143 females, with an average age of (79...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457350/reactivating-catalytic-surface-insights-into-the-role-of-hot-holes-in-plasmonic-catalysis
#6
Tianhuan Peng, Junjian Miao, Zhaoshuai Gao, Linjuan Zhang, Yi Gao, Chunhai Fan, Di Li
Surface plasmon resonance of coinage metal nanoparticles is extensively exploited to promote catalytic reactions via harvesting solar energy. Previous efforts on elucidating the mechanisms of enhanced catalysis are devoted to hot electron-induced photothermal conversion and direct charge transfer to the adsorbed reactants. However, little attention is paid to roles of hot holes that are generated concomitantly with hot electrons. In this work, 13 nm spherical Au nanoparticles with small absorption cross-section are employed to catalyze a well-studied glucose oxidation reaction...
February 19, 2018: Small
https://www.readbyqxmd.com/read/29456505/deletion-of-trace-amine-associated-receptor-1-attenuates-behavioral-responses-to-caffeine
#7
Michael D Schwartz, Jeremiah B Palmerston, Diana L Lee, Marius C Hoener, Thomas S Kilduff
Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic activity. Selective TAAR1 full and partial agonists exhibit similar pro-cognitive, antidepressant- and antipsychotic-like properties in rodents and non-human primates, suggesting TAAR1 as a novel target for the treatment of neurological and psychiatric disorders. We previously reported that TAAR1 partial agonists are wake-promoting in rats and mice, and that TAAR1 knockout (KO) and overexpressing mice exhibit altered sleep-wake and EEG spectral composition...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29456456/developing-and-evaluating-an-instrument-to-measure-recovery-after-intensive-care-the-rain-instrument
#8
Ingegerd Bergbom, Veronika Karlsson, Mona Ringdal
Background: Measuring and evaluating patients' recovery, following intensive care, is essential for assessing their recovery process. By using a questionnaire, which includes spiritual and existential aspects, possibilities for identifying appropriate nursing care activities may be facilitated. The study describes the development and evaluation of a recovery questionnaire and its validity and reliability. Methods: A questionnaire consisting of 30 items on a 5-point Likert scale was completed by 169 patients (103 men, 66 women), 18 years or older (m=69, SD 12...
2018: BMC Nursing
https://www.readbyqxmd.com/read/29456203/effect-of-vitamin-e-on-reversibility-of-renal-function-following-discontinuation-of-colistin-in-rats-histological-and-biochemical-investigations
#9
Zohra Ghlissi, Ahmed Hakim, Hela Mnif, Rim Kallel, Khaled Zeghal, Tahiya Boudawara, Zouheir Sahnoun
This study was carried out to evaluate spontaneous renal regeneration after stopping colistin methanesulfonate (CMS), which induces tubular damage, and the curative effect of Vitamin E (vit E) in rats. Animals were given the following: sterile saline (n = 6), 300,000 IU/kg/ day of CMS (n = 24), or 450,000 IU/kg/day of CMS (n = 24) for seven days. Each CMS group was subdivided into four subgroups (n = 6) and sacrificed as follows: (i) 12 h after stopping CMS, (ii) two weeks after stopping CMS, (iii) two weeks after stopping treatment with vit E, and (iv) two weeks after stopping treatment with olive oil...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29455915/fatty-acid-composition-enzyme-activities-and-metallothioneins-in-donax-trunculus-mollusca-bivalvia-from-polluted-and-reference-sites-in-the-gulf-of-annaba-algeria-pattern-of-recovery-during-transplantation
#10
Amina Rabei, Aziz Hichami, Hayet Beldi, Sandrine Bellenger, Naim Akhtar Khan, Noureddine Soltani
The gulf of Annaba, the most important touristic and economic coastal zone located in Northeast Algeria, is contaminated by several pollutants from urban, agricultural, harbor and industrial activities. Elevated levels of heavy metals were detected in a locally prevalent edible mollusk Donax trunculus (Bivalvia, Donacidae) widely used as a sentinel species for the assessment of marine pollution. The present work aims to measure the difference between two localities, one being full of different pollutants (Sidi Salem) and the other being relatively clean (El Battah) and to evaluate the ability of D...
February 15, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29455576/central-infusion-of-igf-1-increases-hippocampal-neurogenesis-and-improves-neurobehavioral-function-following-traumatic-brain-injury
#11
Shaun W Carlson, Kathryn E Saatman
Traumatic brain injury (TBI) produces neuronal dysfunction and cellular loss that can culminate in lasting impairments in cognitive and motor abilities. Therapeutic agents that promote repair and replenish neurons after TBI hold promise in improving recovery of function. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice; however, the translational neurogenic potential of exogenously administered IGF-1 after TBI remains unknown...
February 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29455497/-clinical-research-of-treating-the-avulsed-fracture-of-humerus-greater-tuberosity-using-an-arthroscopic-double-row-suture-anchor-fixation-technique
#12
Ji Li, Wei-Xiong Liao, Hao Zhang, Yi-Meng Yang, Ke-Tao Wang, Zhong-Li Li
OBJECTIVE: To evaluate the early clinical effects of treating the avulsed fracture of humerus greater tuberosity using the double-row suture anchor fixation technique. METHODS: Total 20 patients with the avulsed fracture of the greater tuberosity of the humerus were treated from September 2009 to January 2013. There were 12 males and 7 females, with an average age of 46.8 years old(24 to 69 years old). Eleven patients had injuries on right shoulder joint and 8 patients had injuries on left side...
August 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455454/oxidative-capacity-varies-along-the-length-of-healthy-human-tibialis-anterior
#13
Andreas Boss, Linda Heskamp, Vincent Breukels, Lauren J Bains, Mark J van Uden, Arend Heerschap
The rate of phosphocreatine (PCr) recovery (kPCr ) after exercise, characterizing muscle oxidative capacity, is traditionally assessed with unlocalized31 P magnetic resonance spectroscopy (MRS) using a single surface coil. However, because of intramuscular variation in fibre type and oxygen supply, kPCr may be non-uniform within muscles. We tested this along the length of the tibialis anterior (TA) muscle in 10 male volunteers. For this purpose we employed a 3T MR system with a31 P/1 H volume transmit coil combined with a home-built31 P phased-array receive probe, consisting of 5 coil elements covering the TA muscle length...
February 18, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29455302/patient-experiences-of-a-physiotherapy-led-multidisciplinary-rehabilitative-intervention-after-successful-treatment-for-oesophago-gastric-cancer
#14
A E Bennett, L O'Neill, D Connolly, E M Guinan, L Boland, S L Doyle, J O'Sullivan, J V Reynolds, J Hussey
PURPOSE: To qualitatively explore the perceived impact of a 12-week rehabilitative intervention for oesophago-gastric cancer survivors on their physical, mental and social wellbeing. METHODS: Of the 21 participants who completed the intervention, 19 took part in a semi-structured focus group interview. Four audio-taped focus groups were held, ranging in size from two to eight participants. Focus groups were transcribed and analysed using a descriptive qualitative approach...
February 18, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29455153/the-recovery-of-estuarine-quality-and-the-perceived-increase-of-cultural-ecosystem-services-by-beach-users-a-case-study-from-northern-spain
#15
Sarai Pouso, María C Uyarra, Ángel Borja
In Europe, the quality of coastal bathing waters improved considerably in the last decades, mainly due to the more demanding legislation and the adoption of water sanitation plans. In the Nerbioi estuary (North Spain), the Wastewater Treatment Plan implemented between 1990 and 2001 resulted on an abrupt decrease in microbial concentration; thus, complying with bathing waters legislation and allowing recreational activities again in the three beaches of the estuary. However, little is known about how improvements in bathing waters influences the provision of cultural ecosystem services and human well-being...
February 15, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29455091/an-uplc-ms-ms-method-to-determine-ct-707-and-its-two-metabolites-in-plasma-of-alk-positive-advanced-non-small-cell-lung-cancer-patients
#16
Cheng Cui, Pei Hu, Ji Jiang, Fansheng Kong, Hong Luo, Qian Zhao
CT-707, a mutant-selective inhibitor of an important cancer target, anaplastic lymphoma kinase (ALK), is designed to be a targeted therapeutic agent for non-small cell lung cancer (NSCLC) patients harboring ALK active and crizotinib resistant mutations. A rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the determination of CT-707 and its two metabolites (M1 and M2) in human plasma. The samples were purified by solid phase extraction (SPE) and separated on a BEH C18 column (2...
January 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29454943/research-of-a-new-metal-chelating-carrier-preparation-and-papain-immobilization
#17
Yan-Jie Gu, Min-Liang Zhu, Yan-Li Li, Chun-Hua Xiong
A new type of magnetic metal chelating carrier (PCMM-IDA-Cu2+ ) was prepared for the immobilization of papain, using chitosan as raw material, nano Fe3 O4 as magnetic material, SiO2 as porogen, iminodiacetic acid (IDA) as a chelating ligand, and binding with transition metal ion (Cu2+ ). The resulting products were well characterized by optical microscopy, scanning electron microscopy (SEM), vibrating sample magnetometer (VSM), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA)...
February 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29454629/postoperative-pain-and-analgesia-administration-in-children-after-urological-outpatient-procedures
#18
A Schröder, F A Campbell, W A Farhat, J L Pippi Salle, D J Bägli, A J Lorenzo, M A Koyle
INTRODUCTION: There are limited data about pain patterns, analgesic requirements and factors predicting opioid requirements of children undergoing outpatient urologic surgery. This prospective study aimed to assess recovery profiles and pain medication requirements. METHODS: Patients between 6 months and 12 years of age were recruited prospectively between December 2013 and June 2014. Demographic and operative characteristics were collected. Following discharge home, the parents were asked to administer both acetaminophen and ibuprofen Q6H at a weight-adjusted dose, based on a schedule, until the end of postoperative day 2, and to administer the medication as required on postoperative day 3...
January 31, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29454544/mapping-the-spatiotemporal-evolution-of-solute-transport-in-articular-cartilage-explants-reveals-how-cartilage-recovers-fluid-within-the-contact-area-during-sliding
#19
Brian T Graham, Axel C Moore, David L Burris, Christopher Price
The interstitial fluid within articular cartilage shields the matrix from mechanical stresses, reduces friction and wear, enables biochemical processes, and transports solutes into and out of the avascular extracellular matrix. The balanced competition between fluid exudation and recovery under load is thus critical to the mechanical and biological functions of the tissue. We recently discovered that sliding alone can induce rapid solute transport into buried cartilage contact areas via a phenomenon termed tribological rehydration...
February 8, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29454354/cerebrospinal-fluid-level-of-nogo-receptor-1-antagonist-lateral-olfactory-tract-usher-substance-lotus-correlates-inversely-with-the-extent-of-neuroinflammation
#20
Keita Takahashi, Hideyuki Takeuchi, Yuji Kurihara, Hiroshi Doi, Misako Kunii, Kenichi Tanaka, Haruko Nakamura, Ryoko Fukai, Atsuko Tomita-Katsumoto, Mikiko Tada, Yuichi Higashiyama, Hideto Joki, Shigeru Koyano, Kohtaro Takei, Fumiaki Tanaka
BACKGROUND: Although inflammation in the central nervous system is responsible for multiple neurological diseases, the lack of appropriate biomarkers makes it difficult to evaluate inflammatory activities in these diseases. Therefore, a new biomarker reflecting neuroinflammation is required for accurate diagnosis, appropriate therapy, and comprehension of pathogenesis of these neurological disorders. We previously reported that the cerebrospinal fluid (CSF) concentration of lateral olfactory tract usher substance (LOTUS), which promotes axonal growth as a Nogo receptor 1 antagonist, negatively correlates with disease activity in multiple sclerosis, suggesting that variation in LOTUS reflects the inflammatory activities and is a useful biomarker to evaluate the disease activity...
February 17, 2018: Journal of Neuroinflammation
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