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Active recovery

Vipin Arora, Thomas J Martin, Carol A Aschenbrenner, Kenichiro Hayashida, Susy A Kim, Renee A Parker, James C Eisenach, Christopher M Peters
Psychosocial factors such as anxiety, depression and catastrophizing, commonly associated with established chronic pain, also may be associated with an increased risk of chronic postsurgical pain (CPSP) when present preoperatively. We used a repeat social defeat (RSD) paradigm to induce psychosocial stress in rodents prior to incisional surgery of the paw. Mixed effects growth curve models were utilized to examine resolution of mechanical hypersensitivity in rats for four weeks following surgery. Eight days following surgery, immunohistochemistry was conducted to examine glial activation as well as evoked neuronal activation in the spinal cord...
April 22, 2018: Neuroscience
E I Jasso-Villagomez, M Garcia-Lorenzana, J C Almanza-Perez, M A Fortis-Barrera, G Blancas-Flores, R Roman-Ramos, L A Prado-Barragan, F J Alarcon-Aguilar
Ulomoides dermestoides is a beetle traditionally consumed to treat diabetes. In this study, we performed a composition analysis of U. dermestoides to obtain the principal fractions, which were used to assess the effect on glycemia, liver and pancreatic architecture, and PPARγ and GLUT4 expression. Normal mice and alloxan-induced diabetic mice were administered fractions of chitin, protein or fat, and the acute hypoglycemic effect was evaluated. A subacute study involving daily administration of these fractions to diabetic mice was also performed over 30 days, after which the liver and pancreas were processed by conventional histological techniques and stained with hematoxylin and eosin to evaluate morphological changes...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Ayinuer Reheman, Haji Akber Aisa, Qing Ling Ma, Dilaram Nijat, Rahima Abdulla
By merging a high-performance liquid chromatography diode array detector (HPLC-DAD) method with high-performance thin-layer chromatography (HPTLC), an assay was developed for chemical fingerprinting and quantitative analysis of traditional medicine Majun Mupakhi ELA (MME), and constituent compounds were identified using HPLC coupled with UHPLC-DAD-Quadrupole-Orbitrap-MS method. In addition, the antioxidant capacity of MME was assessed based on the ability of components to scavenge radicals using in vitro method...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Toshikazu Suenaga, Shohei Riya, Masaaki Hosomi, Akihiko Terada
Nitrous oxide (N2 O)-reducing bacteria, which reduce N2 O to nitrogen in the absence of oxygen, are phylogenetically spread throughout various taxa and have a potential role as N2 O sinks in the environment. However, research on their physiological traits has been limited. In particular, their activities under microaerophilic and aerobic conditions, which severely inhibit N2 O reduction, remain poorly understood. We used an O2 and N2 O micro-respirometric system to compare the N2 O reduction kinetics of four strains, i...
2018: Frontiers in Microbiology
Yana O Mukhamedshina, Elvira R Akhmetzyanova, Alexander A Kostennikov, Elena Y Zakirova, Luisa R Galieva, Ekaterina E Garanina, Alexander A Rogozin, Andrey P Kiassov, Albert A Rizvanov
The use of stem and progenitor cells to restore damaged organs and tissues, in particular, the central nervous system, is currently considered a most promising therapy in regenerative medicine. At the same time, another approach aimed at stimulating regeneration with the use of stem cells encapsulated into a biopolymer matrix and capable of creating a specific microenvironment for the implanted cells similar to the natural extracellular matrix is under active development. Here, we study effects of the application of adipose-derived mesenchymal stem cells (AD-MSCs) combined with a fibrin matrix on post-traumatic reactions in the spinal cord in rats...
2018: Frontiers in Pharmacology
Raquel Carvalho, Elsa Azevedo, Paulo Marques, Nuno Dias, João José Cerqueira
RATIONALE, AIMS, AND OBJECTIVES: Upper limb recovery is one of the main concerns of stroke neurorehabilitation. Neuroplasticity might underlie such recovery, particularly in the chronic phase. The purpose of this study was to assess the effect of physiotherapy based on problem-solving in recovering arm function in chronic stroke patients and explore its neuroplastic changes. METHODS: A small sample research design with a n of 3 using a pre-post test design was carried out...
April 25, 2018: Journal of Evaluation in Clinical Practice
Wan-Kyu Ko, Seong Jun Kim, Min-Jae Jo, Hyemin Choi, Donghyun Lee, Il Keun Kwon, Soo-Hong Lee, In-Bo Han, Seil Sohn
The aim of this study was to investigate the anti-inflammatory effects by ursodeoxycholic acid (UDCA) in rats with a spinal cord injury (SCI). A moderate mechanical compression injury was imposed on adult Sprague-Dawley (SD) rats. The post-injury locomotor functions were assessed using the Basso, Beattie, and Bresnahan (BBB) locomotor scale and the tissue volume of the injured region was analyzed using hematoxylin and eosin staining. The pro-inflammatory factors were evaluated by immunofluorescence (IF) staining, a quantitative real-time polymerase chain reaction (qRT-PCR), and enzyme-linked immunosorbent assay (ELISA)...
March 20, 2018: Molecular Neurobiology
S Kalafatakis, S Braekevelt, A Lymperatou, A Zarebska, C Hélix-Nielsen, L Lange, I V Skiadas, H N Gavala
Forward osmosis (FO) is a low energy-intensive process since the driving force for water transport is the osmotic pressure difference, Δπ, between the feed and draw solutions, separated by the FO membrane, where πdraw  > πfeed . The potential of FO in wastewater treatment and desalination have been extensively studied; however, regeneration of the draw solution (thereby generating clean water) requires application of an energy-intensive process step like reverse osmosis (RO). In this study, the potential of applying FO for direct water recirculation from diluted fermentation effluent to concentrated feedstock, without the need for an energy-intensive regeneration step (e...
April 24, 2018: Bioprocess and Biosystems Engineering
Zhen Zhou, Shuang Ma, Jie Liu, Qiao-Rong Ji, Cheng-Zhu Cao, Xiao-Na Li, Feng Tang, Wei Zhang
The present study is aimed to explore the effects of endogenous carbon monoxide on the ischemia-reperfusion in rats. Wistar rats were intraperitoneally injected with protoporphyrin cobalt chloride (CoPP, an endogenous carbon monoxide agonist, 5 mg/kg), zinc protoporphyrin (ZnPP, an endogenous carbon monoxide inhibitor, 5 mg/kg) or saline. Twenty-four hours after injection, the myocardial ischemia-reperfusion model was made by Langendorff isolated cardiac perfusion system, and cardiac function parameters were collected...
April 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
Pan Liu, Jan Wysocki, Tomokazu Souma, Minghao Ye, Veronica Ramirez, Bisheng Zhou, Lisa D Wilsbacher, Susan E Quaggin, Daniel Batlle, Jing Jin
Angiotensin-converting enzyme 2 (ACE2) is a carboxypeptidase that potently degrades angiotensin II to angiotensin 1-7. Previous studies showed that injection of the enzymatic ectodomain of recombinant ACE2 (rACE2) markedly increases circulatory levels of ACE2 activity, and effectively lowered blood pressure in angiotensin II-induced hypertension. However, due to the short plasma half-life of rACE2, its therapeutic potential for chronic use is limited. To circumvent this, we generated a chimeric fusion of rACE2 and the Ig fragment Fc segment to increase its plasma stability...
April 21, 2018: Kidney International
Yong Beom Kim, Sangseok Lee, Hey Ran Choi, Junyong In, Young Jin Chang, Ha Jung Kim, Young Jin Ro, Hong-Seuk Yang
Background: Several types of receptors are found at neuromuscular presynaptic membranes. Presynaptic inhibitory A1 and facilitatory A2A receptors mediate different modulatory functions on acetylcholine release. This study investigated whether adenosine A1 receptor agonist contributes to the first twitch tension (T1) of train-of-four (TOF) stimulation depression and TOF fade during rocuronium-induced neuromuscular blockade, and sugammadex-induced recovery. Methods: Phrenic nerve-diaphragm tissues were obtained from 30 adult Sprague-Dawley rats...
April 25, 2018: Korean Journal of Anesthesiology
Andrei Mocan, Alina Diuzheva, Simone Carradori, Vasil Andruch, Chiara Massafra, Cadmiel Moldovan, Cristian Sisea, Jacobus P Petzer, Anél Petzer, Susi Zara, Guya Diletta Marconi, Gokhan Zengin, Gianina Crișan, Marcello Locatelli
In the present work, fourteen cultivars of Prunus domestica were analysed to investigate their phenolic pattern with the purpose of using the leaves as potential resources of bioactive compounds in the pharmaceutical and food industry. Microwave-assisted extraction (MAE), dispersive liquid-liquid microextraction and sugaring-out liquid-liquid extraction techniques were optimized in order to obtain an exhaustive multi-component panel of phenolic compounds. The best phenolic-enriched recovery was achieved using MAE in water:methanol (30:70), and this procedure was further applied for quantitative analysis of phenolic compounds in real samples...
April 21, 2018: Food and Chemical Toxicology
Cong Wang, Xudong Gao, Ramesh Kumar Santhanam, Zhongqin Chen, Yue Chen, Leilei Xu, Chunli Wang, Nicola Ferri, Haixia Chen
In the present study, the antioxidant activity, anti-glycation activity, α-amylase, α-glucosidase inhibitory activity of polysaccharides from Inonotus obliquus (UIOPS) and its chromium (III) complex (UIOPC) were investigated. Their protective effects against H2 O2 -induced oxidative damages in hepatic L02 cells were also assessed. Results demonstrated that UIOPC and UIOPS exhibited remarkable DPPH scavenging activity, ferric reducing power and hemolysis inhibitory activity. UIOPC also showed significant inhibitory capacity on α-amylase and α-glucosidase than UIOPS (P < 0...
April 21, 2018: Food and Chemical Toxicology
Masateru Magotani, Aya Nakamura, Haruka Ikegami, Saori Kunii, Yuji Mishina, Koichi Morimoto, Satoshi Kishigami
Transgenic animals provide attractive systems for the production of valuable recombinant proteins. Previous studies indicate that milk is a suitable source of secreted recombinant proteins. In the current study, we examine whether excrement can be another source of recombinant proteins by using transgenic mice ubiquitously-expressing green fluorescent protein (GFP) as a model. We found that the surface of excrement from GFP-transgenic mice was fluorescent, and the supernatant after centrifugation of an excrement suspension was rich in undegraded, actively fluorescing GFP...
April 21, 2018: Biochemical and Biophysical Research Communications
Rebecca Vaudreuil, Luis Avila, Joke Bradt, Paul Pasquina
PURPOSE: Music therapy has a long history of treating the physiological, psychological, and neurological injuries of war. Recently, there has been an increase in the use of music therapy and other creative arts therapies in the care of combat injured service members returning to the United States from Iraq and Afghanistan, especially those with complex blast-related injuries. This case report describes the role of music therapy in the interdisciplinary rehabilitation of a severely injured service member...
April 24, 2018: Disability and Rehabilitation
Yuxin Qian, Fan Qi, Qi Chen, Qiang Zhang, Zhongqian Qiao, Si Zhang, Ting Wei, Qian Yu, Shan Yu, Zhengwei Mao, Changyou Gao, Yiru Ding, Yanyong Cheng, Chenyu Jin, Hexin Xie, Runhui Liu
Methicillin-resistant Staphylococcus aureus (MRSA) has been one of the major nosocomial pathogens to cause frequent and serious infections that are associated with various biomedical surfaces. This study demonstrated that surface modified with host defense peptide-mimicking β-peptide polymer, has surprisingly high bactericidal activities against Escherichia coli ( E. coli) and MRSA. As surface-tethered β-peptide polymers cannot move freely to adopt the collaborative interactions with bacterial membrane and are too short to penetrate the cell envelop, we proposed a mode of action by diffusing away the cell membrane-stabilizing divalent ions, Ca2+ and Mg2+ ...
April 24, 2018: ACS Applied Materials & Interfaces
Amy E Settle, Laura Berstis, Shuting Zhang, Nicholas Rorrer, Haiming Hu, Ryan Richards, Gregg Beckham, Michael Crowley, Derek Vardon
cis,cis-Muconic acid is a platform biobased chemical that can be upgraded to drop-in commodity and novel monomers. Among the possible drop-in products, dimethyl terephthalate can be synthesized via esterification, isomerization, Diels-Alder cycloaddition, and dehydrogenation. The isomerization of cis,cis-dimethyl muconate (ccDMM) to the trans,trans-form (ttDMM) can be catalyzed by iodine; however, studies have yet to address (i) the mechanism and reaction barriers unique to DMM, and (ii) the influence of solvent, potential for catalyst recycle, and recovery of high-purity ttDMM...
April 16, 2018: ChemSusChem
Uğur Çetiner, Andriy Anishkin, Sergei Sukharev
Adaptive desensitization and inactivation are common properties of most ion channels and receptors. The mechanosensitive channel of small conductance MscS, which serves as a low-threshold osmolyte release valve in most bacteria, inactivates not from the open, but from the resting state under moderate tensions. This mechanism enables the channel to respond differently to slow tension ramps versus abruptly applied stimuli. In this work, we present a reconstruction of the energy landscape for MscS transitions based on patch current kinetics recorded under special pressure protocols...
April 23, 2018: European Biophysics Journal: EBJ
Daniel Gomes, Miguel Gama, Lucília Domingues
Background: In spite of the continuous efforts and investments in the last decades, lignocellulosic ethanol is still not economically competitive with fossil fuels. Optimization is still required in different parts of the process. Namely, the cost effective usage of enzymes has been pursued by different strategies, one of them being recycling. Results: Cellulase recycling was analyzed on recycled paper sludge (RPS) conversion into bioethanol under intensified conditions...
2018: Biotechnology for Biofuels
Shengming Sun, Zhongbao Guo, Hongtuo Fu, Xianping Ge, Jian Zhu, Zhimin Gu
Hypoxia represents a major physiological challenge for prawns and is a problem in aquaculture. Therefore, an understanding of the metabolic response mechanism of economically important prawn species to hypoxia and re-oxygenation is essential. However, little is known about the intrinsic mechanisms by which the oriental river prawn Macrobrachium nipponense copes with hypoxia at the metabolic level. In this study, we conducted gas chromatography-mass spectrometry-based metabolomics studies and assays of energy metabolism-related parameters to investigate the metabolic mechanisms in the hepatopancreas of M...
2018: Frontiers in Physiology
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