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https://www.readbyqxmd.com/read/29029261/selective-enhancement-of-domoic-acid-toxicity-in-primary-cultures-of-cerebellar-granule-cells-by-lowering-extracellular-na-concentration
#1
Anabel Pérez-Gómez, David Cabrera-García, Davide Warm, Ann M Marini, Javier Salas Puig, Maria Teresa Fernández-Sánchez, Antonello Novelli
Domoic acid (DOM) is an excitatory amino acid analog of kainic acid (KA) that acts through glutamic acid (GLU) receptors, inducing a fast and potent neurotoxic response. Here we present evidence for an enhancement of excitotoxicity following exposure of cultured cerebellar granule cells to DOM in the presence of lower than physiological Na+ concentrations. The concentration of DOM that reduced by 50% neuronal survival was ̴ 3 µM in Na+-free conditions and 16 µM in presence of a physiological concentration of extracellular Na+...
September 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29029245/host-transcription-profile-in-nasal-epithelium-and-whole-blood-of-hospitalised-children-under-two-years-of-age-with-respiratory-syncytial-virus-infection
#2
Lien Anh Ha Do, Johann Pellet, H Rogier van Doorn, Anh Tuan Tran, Bach Hue Nguyen, Thi Thu Loan Tran, Quynh Huong Tran, Quoc Bao Vo, Nguyen Anh Tran Dac, Hong Nhien Trinh, Thi Thanh Hai Nguyen, Bao Tinh Le Binh, Huu Mai Khanh Nguyen, Minh Tien Nguyen, Quang Tung Thai, Thanh Vu Vo, Ngoc Quang Minh Ngo, Thi Kim Huyen Dang, Ngoc Huong Cao, Thu Van Tran, Lu Viet Ho, Bertrand De Meulder, Charles Auffray, Jorrit-Jan Hofstra, Jeremy Farrar, Juliet E Bryant, Menno de Jong, Martin L Hibberd
Most insights into the cascade of immune events following acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. Here we investigated host gene expression profiles in nasopharyngeal swabs (NP) and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalised patients <2 years old with lower respiratory tract infections (LRTI). RSV infection induced strong and persistent innate immune responses including interferon signaling and pathways related to chemokine/cytokine signaling in both compartments...
September 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029213/recovery-kinetics-of-radiographic-and-implant-related-revision-patients-following-adult-spinal-deformity-surgery
#3
Peter G Passias, Cyrus M Jalai, Virginie Lafage, Gregory W Poorman, Shaleen Vira, Samantha R Horn, Justin K Scheer, D Kojo Hamilton, Breton G Line, Shay Bess, Frank J Schwab, Christopher P Ames, Douglas C Burton, Robert A Hart, Eric O Klineberg
BACKGROUND: Prior studies have observed similar health-related quality of life (HRQL) in revisions and nonrevision (NR) patients following adult spinal deformity (ASD) correction. However, a novel comparison approach may allow better comparisons in spine outcomes groups. OBJECTIVE: To determine if ASD revisions for radiographic and implant-related complications undergo a different recovery than NR patients. METHODS: Inclusion: ASD patients with complete HRQL (Oswestry Disability Index, Short-Form-36 version 2 (SF-36), Scoliosis Research Society [SRS]-22) at baseline, 6 wk, 1 yr, 2 yr...
October 6, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29028864/predicting-cognitive-functioning-activities-of-daily-living-and-participation-6-months-after-mild-to-moderate-stroke
#4
Madison Bertolin, Ryan Van Patten, Taylor Greif, Robert Fucetola
Objective: Predicting neurocognitive and functional outcomes in stroke is an important clinical task, especially in rehabilitation settings. We assessed acute predictors of cognitive and functional outcomes 6 months after mild to moderate stroke. Methods: We conducted a retrospective analysis of acute clinical data and 6-month follow-up telephone interviews for 498 mild to moderate stroke patients. Predictors were sociodemographic variables, the National Institute of Health Stroke Scale (NIHSS), basic physical measures, the Mesulam Cancellation Test, the Short Blessed Test (SBT), Trails A/B, and the Boston Naming Test...
September 25, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29028554/recovery-capital-pathways-modelling-the-components-of-recovery-wellbeing
#5
Ivan Cano, David Best, Michael Edwards, John Lehman
BACKGROUND: In recent years, there has been recognition that recovery is a journey that involves the growth of recovery capital. Thus, recovery capital has become a commonly used term in addiction treatment and research yet its operationalization and measurement has been limited. Due to these limitations, there is little understanding of long-term recovery pathways and their clinical application. METHODS: We used the data of 546 participants from eight different recovery residences spread across Florida, USA...
September 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29027934/angiotensin-i-converting-enzyme-ace-inhibitory-activity-antioxidant-properties-phenolic-content-and-amino-acid-profiles-of-fucus-spiralis-l-protein-hydrolysate-fractions
#6
Lisete Paiva, Elisabete Lima, Ana Isabel Neto, José Baptista
Food protein-derived hydrolysates with multi-bioactivities such as antihypertensive and antioxidant properties have recently received special attention since both activities can play significant roles in preventing cardiovascular diseases. This study reports, for the first time, the angiotensin I-converting enzyme (ACE)-inhibition and antioxidant properties of ultrafiltrate fractions (UF) with different molecular weight ranges (<1, 1-3 and ≥3 kDa) obtained from Fucus spiralis protein hydrolysate (FSPH) digested with cellulase-bromelain...
October 13, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29027362/impact-of-extraction-methods-on-the-detectable-protein-complement-of-metaproteomic-analyses-of-marine-sediments
#7
Lars Wöhlbrand, Christoph Feenders, Jessica Nachbaur, Holger Freund, Bert Engelen, Heinz Wilkes, Hans-Jürgen Brumsack, Ralf Rabus
Metaproteomic analysis targets proteins, the catalytic entities in the habitat, thereby providing direct insights into the metabolic activity of the community studied. A major challenge still remaining for metaproteomics is the effective and comprehensive extraction of proteins from environmental samples, due to their high complexity with respect to organismic diversity and abundance range. Moreover, in certain habitats, the inherent matrix may interfere with protein extraction. In recent years, several studies reported different protein extraction methods for soils known for their complex geochemistry, but only two analyzed marine sediments that generally comprise different though similarly complex geochemistry...
October 13, 2017: Proteomics
https://www.readbyqxmd.com/read/29027245/epac-induced-ryanodine-receptor-type-2-activation-inhibits-sodium-currents-in-atrial-and-ventricular-murine-cardiomyocytes
#8
Haseeb Valli, Shiraz Ahmad, Sujan Sriharan, Lydia D Dean, Andrew A Grace, Kamalan Jeevaratnam, Hugh R Matthews, Christopher L-H Huang
Acute RyR2 activation by exchange protein directly activated by cAMP (Epac) reversibly perturbs myocyte Ca(2+) homeostasis, slows myocardial action potential conduction, and exerts pro-arrhythmic effects. Loose patch-clamp studies, preserving in vivo extracellular and intracellular conditions, investigated Na(+) current in intact cardiomyocytes in murine atrial and ventricular preparations following Epac activation. Depolarising steps to varying test voltages activated typical voltage-dependent Na(+) currents...
October 12, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29026447/epigenome-alterations-in-aortic-valve-stenosis-and-its-related-left-ventricular-hypertrophy
#9
REVIEW
Igor Gošev, Martina Zeljko, Željko Đurić, Ivana Nikolić, Milorad Gošev, Sanja Ivčević, Dino Bešić, Zoran Legčević, Frane Paić
Aortic valve stenosis is the most common cardiac valve disease, and with current trends in the population demographics, its prevalence is likely to rise, thus posing a major health and economic burden facing the worldwide societies. Over the past decade, it has become more than clear that our traditional genetic views do not sufficiently explain the well-known link between AS, proatherogenic risk factors, flow-induced mechanical forces, and disease-prone environmental influences. Recent breakthroughs in the field of epigenetics offer us a new perspective on gene regulation, which has broadened our perspective on etiology of aortic stenosis and other aortic valve diseases...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29026331/poorly-controlled-postoperative-pain-prevalence-consequences-and-prevention
#10
REVIEW
Tong J Gan
This review provides an overview of the clinical issue of poorly controlled postoperative pain and therapeutic approaches that may help to address this common unresolved health-care challenge. Postoperative pain is not adequately managed in greater than 80% of patients in the US, although rates vary depending on such factors as type of surgery performed, analgesic/anesthetic intervention used, and time elapsed after surgery. Poorly controlled acute postoperative pain is associated with increased morbidity, functional and quality-of-life impairment, delayed recovery time, prolonged duration of opioid use, and higher health-care costs...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29025768/action-potential-shortening-and-impairment-of-cardiac-function-by-ablation-of-slc26a6
#11
Padmini Sirish, Hannah A Ledford, Valeriy Timofeyev, Phung N Thai, Lu Ren, Hyo Jeong Kim, Seojin Park, Jeong Han Lee, Gu Dai, Maryam Moshref, Choong-Ryoul Sihn, Wei Chun Chen, Maria Valeryevna Timofeyeva, Zhong Jian, Rafael Shimkunas, Leighton T Izu, Nipavan Chiamvimonvat, Ye Chen-Izu, Ebenezer N Yamoah, Xiao-Dong Zhang
BACKGROUND: Intracellular pH (pHi) is critical to cardiac excitation and contraction; uncompensated changes in pHi impair cardiac function and trigger arrhythmia. Several ion transporters participate in cardiac pHi regulation. Our previous studies identified several isoforms of a solute carrier Slc26a6 to be highly expressed in cardiomyocytes. We show that Slc26a6 mediates electrogenic Cl(-)/HCO3(-) exchange activities in cardiomyocytes, suggesting the potential role of Slc26a6 in regulation of not only pHi, but also cardiac excitability...
October 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29025427/adaptive-hybrid-robotic-system-for-rehabilitation-of-reaching-movement-after-a-brain-injury-a-usability-study
#12
F Resquín, J Gonzalez-Vargas, J Ibáñez, F Brunetti, I Dimbwadyo, L Carrasco, S Alves, C Gonzalez-Alted, A Gomez-Blanco, J L Pons
BACKGROUND: Brain injury survivors often present upper-limb motor impairment affecting the execution of functional activities such as reaching. A currently active research line seeking to maximize upper-limb motor recovery after a brain injury, deals with the combined use of functional electrical stimulation (FES) and mechanical supporting devices, in what has been previously termed hybrid robotic systems. This study evaluates from the technical and clinical perspectives the usability of an integrated hybrid robotic system for the rehabilitation of upper-limb reaching movements after a brain lesion affecting the motor function...
October 12, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29024852/the-cation-selective-exhaustive-injection-and-sweeping-capillary-electrophoresis-method-for-the-analysis-of-chlorpheniramine-enantiomers-in-rat-plasma
#13
Yaqi Yao, Li Zhou, Meng Li, Xingjie Guo
Chlorpheniramine is a potent antihistaminic administered as a racemic mixture, while its clinical activity is mainly associated with the S-enantiomer. In this study, a sensitive and rapid on-line preconcentration capillary electrophoresis (CE) method, cation-selective exhaustive injection (CSEI) and sweeping method was established and validated for the analysis of two chlorpheniramine enantiomers. Parameters influencing separation and enhancement efficiency were investigated, including cyclodextrin (CD) types and concentration, background electrolyte pH, type and content of organic modifier, injection time of water plug, injection time and voltage of sample...
September 18, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29024690/sodium-channel-current-loss-of-function-in-induced-pluripotent-stem-cell-derived-cardiomyocytes-from-a-brugada-syndrome-patient
#14
Elisabet Selga, Franziska Sendfeld, Rebecca Martinez-Moreno, Claire N Medine, Olga Tura-Ceide, Sir Ian Wilmut, Guillermo J Pérez, Fabiana S Scornik, Ramon Brugada, Nicholas L Mills
Brugada syndrome predisposes to sudden death due to disruption of normal cardiac ion channel function, yet our understanding of the underlying cellular mechanisms is incomplete. Commonly used heterologous expression models lack many characteristics of native cardiomyocytes and, in particular, the individual genetic background of a patient. Patient-specific induced pluripotent stem (iPS) cell-derived cardiomyocytes (iPS-CM) may uncover cellular phenotypical characteristics not observed in heterologous models...
October 9, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29024389/in-vivo-properties-of-the-disaggregase-function-of-j-proteins-and-hsc70-in-caenorhabditis-elegans-stress-and-aging
#15
Janine Kirstein, Kristin Arnsburg, Annika Scior, Anna Szlachcic, D Lys Guilbride, Richard I Morimoto, Bernd Bukau, Nadinath B Nillegoda
Protein aggregation is enhanced upon exposure to various stress conditions and aging, which suggests that the quality control machinery regulating protein homeostasis could exhibit varied capacities in different stages of organismal lifespan. Recently, an efficient metazoan disaggregase activity was identified in vitro, which requires the Hsp70 chaperone and Hsp110 nucleotide exchange factor, together with single or cooperating J-protein co-chaperones of classes A and B. Here, we describe how the orthologous Hsp70s and J-protein of Caenorhabditis elegans work together to resolve protein aggregates both in vivo and in vitro to benefit organismal health...
October 10, 2017: Aging Cell
https://www.readbyqxmd.com/read/29023563/influence-of-platinum-harmonized-textile-on-neuromuscular-systemic-and-subjective-recovery
#16
Fridolin Zinke, Patrick Bakenecker, Daniel Hahn
The clothing manufacturer Venex Life-Science tracks the strategy to enhance recovery process through implementing platinum harmonized technology (PHT) into their Venex® Regeneration Wear. The proposed mechanisms of the regeneration wear are an increase of parasympathetic activity and an increase of the temperature due far-infrared radiation. The purpose of this study was to investigate potential effects of Venex regeneration wear on the recovery of neuromuscular, systemic and subjective parameters following exercise...
2017: PloS One
https://www.readbyqxmd.com/read/29023478/regeneration-of-glycocalyx-by-heparan-sulfate-and-sphingosine-1-phosphate-restores-inter-endothelial-communication
#17
Solomon A Mensah, Ming J Cheng, Homa Homayoni, Brian D Plouffe, Arthur J Coury, Eno E Ebong
Vasculoprotective endothelium glycocalyx (GCX) shedding plays a critical role in vascular disease. Previous work demonstrated that GCX degradation disrupts endothelial cell (EC) gap junction connexin (Cx) proteins, likely blocking interendothelial molecular transport that maintains EC and vascular tissue homeostasis to resist disease. Here, we focused on GCX regeneration and tested the hypothesis that vasculoprotective EC function can be stimulated via replacement of GCX when it is shed. We used EC with [i] intact heparan sulfate (HS), the most abundant GCX component; [ii] degraded HS; or [iii] HS that was restored after enzyme degradation, by cellular self-recovery or artificially...
2017: PloS One
https://www.readbyqxmd.com/read/29023330/heart-rate-variability-and-training-load-among-national-collegiate-athletic-association-division-1-college-football-players-throughout-spring-camp
#18
Andrew A Flatt, Michael R Esco, Jeff R Allen, James B Robinson, Ryan L Earley, Michael V Fedewa, Amy Bragg, Clay M Keith, Jonathan E Wingo
Flatt, AA, Esco, MR, Allen, JR, Robinson, JB, Earley, RL, Fedewa, MV, Bragg, A, Keith, CM, and Wingo, JE. Heart rate variability and training load among National Collegiate Athletic Association Division 1 college football players throughout spring camp. J Strength Cond Res XX(X): 000-000, 2017-The purpose of this study was to determine whether recovery of cardiac-autonomic activity to baseline occurs between consecutive-day training sessions among positional groups of a collegiate football team during Spring camp...
October 10, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29023249/priming-with-1-hz-rtms-over-contralesional-leg-motor-cortex-does-not-increase-the-rate-of-regaining-ambulation-within-3-months-of-stroke-a-randomized-controlled-trial
#19
Ying-Zu Huang, Li-Fong Lin, Kwang-Hwa Chang, Chaur-Jong Hu, Tsan-Hon Liou, Yen-Nung Lin
BACKGROUND: The potential benefits of repetitive transcranial magnetic stimulation (rTMS), applied either alone or as a combination treatment, on recovery of lower extremities after stroke have been insufficiently studied. OBJECTIVE: To evaluate the effect of priming with 1-Hz rTMS over contralesional leg motor area with a double cone coil prior physical therapy (PT) on regaining ambulation. METHODS: Thirty-eight subacute stroke patients with significant leg disabilities were randomly assigned into the experimental (E) group or control (C) group to receive a 15-min real or sham 1-Hz rTMS, respectively, over the contralesional motor cortex representing the quadriceps muscle followed by 45-min PT for 15 sessions over 3 weeks...
October 10, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29023174/subjective-responses-to-sprint-interval-exercise-in-adults-with-and-without-exercise-induced-bronchoconstriction
#20
Joshua Good, Shilpa Dogra
OBJECTIVE: Little is known of the subjective response to exercise that involves short "all out" bursts of effort, separated by recovery periods (sprint interval exercise (SPRINT)) among adults with exercise-induced bronchoconstriction (EIBC). The purpose of this study was to compare subjective responses to SPRINT and moderate intensity continuous exercise (MOD) among adults with EIBC, and to compare these responses between adults with EIBC and those without EIBC. METHODS: Eight adults (22...
October 12, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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