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https://www.readbyqxmd.com/read/27926617/robotic-approaches-for-the-rehabilitation-of-upper-limb-recovery-after-stroke-a-systematic-review-and-meta-analysis
#1
Chao Zhang, Cecilia W P Li-Tsang, Ricky K C Au
This systematic review with a meta-analysis of studies was carried out to evaluate the effectiveness of robotic training (RT) and conventional training (CT) in improving the motor recovery of paretic upper limbs in stroke patients. Numerous electronic databases were searched from January 2000 to May 2016. Finally, 13 randomized-controlled trials fulfilled the inclusion criteria and were included in the three meta-analyses. The first meta-analysis carried out for those studies using RT for stroke patients indicated a significant improvement in the RT groups...
December 6, 2016: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/27925861/modeling-heavy-ion-impairment-of-hippocampal-neurogenesis-after-acute-and-fractionated-irradiation
#2
Eliedonna Cacao, Francis A Cucinotta
Radiation-induced impairment of neurogenesis in the hippocampal dentate gyrus is a concern due to its reported association with cognitive detriments after radiotherapy for brain cancers and the possible risks to astronauts chronically exposed to space radiation. Here, we have extended our recent work in a mouse model of impaired neurogenesis after exposure to low-linear energy transfer (LET) heavy ion radiation. To our knowledge, this is the first report of a predictive mathematical model of radiation-induced changes to neurogenesis for a variety of radiation types after acute or fractionated irradiation...
December 7, 2016: Radiation Research
https://www.readbyqxmd.com/read/27925844/a-two-dose-heterologous-prime-boost-vaccine-regimen-eliciting-sustained-immune-responses-to-ebola-zaire-could-support-a-preventive-strategy-for-future-outbreaks
#3
Georgi Shukarev, Benoit Callendret, Kerstin Luhn, Macaya Douoguih, The Ebovac Consortium
The consequences of the 2013-16 Ebola Zaire virus disease epidemic in West Africa were grave. The economies, healthcare systems and communities of Guinea, Sierra Leone and Liberia were devastated by over 18 months of active Ebola virus transmission, followed by sporadic resurgences potentially related to sexual transmission by survivors with viral persistence in body fluids following recovery. The need to develop and implement strategies to prevent and mitigate future outbreaks is now beyond dispute. The potential for unpredictable outbreaks of indeterminate duration, and control challenges posed by the possibility of sporadic re-emergence, mean that implementation of an effective vaccination programme for outbreak containment necessitates a vaccine providing durable immunity...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925633/shock-wave-enhances-angiogenesis-through-vegfr2-activation-and-recycling
#4
Tien-Hung Huang, Cheuk-Kwan Sun, Yi-Ling Chen, Ching-Jen Wang, Tsung-Cheng Yin, Mel S Lee, Hon-Kan Yip
Although low-energy shock wave (SW) is adopted to treat ischemic diseases because of its pro-angiogenic properties, the underlying mechanism remains unclear. This study aimed at testing whether SW-induced angiogenesis may be through endothelial vascular endothelial growth factor receptor 2 (VEGFR2) signaling and trafficking. Phosphorylation of VEGFR2-Akt-eNOS axis and production of nitric oxide (NO) were determined in human umbilical vein endothelial cells (HUVECs) treated with SW. Carotid artery in ob/ob mice was treated with SW before evaluation with sprouting assay...
December 6, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/27925273/biochemical-response-of-the-africanized-honeybee-exposed-to-fipronil
#5
Thaisa C Roat, Stephan M Carvalho, Mário S Palma, Osmar Malaspina
Bees are recognized worldwide for their social, economic, and environmental value; however, they have been seriously threatened in recent decades by diseases and by high levels of pesticide use. The susceptibility of bees to insecticides makes them an important terrestrial model for assessing environmental quality, and various biomarkers have been developed for these assessments. The present study aimed to evaluate the activity of the enzymes acetylcholinesterase (AChE), carboxylesterase (CaE), and glutathione S-transferase (GST) in Africanized honeybees exposed to fipronil...
December 7, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27925241/vertebral-subluxation-repair-in-a-pet-goat
#6
Sara Nannarone, Enrico Bellezza, Yves P Moens, Paula Larenza Menzies
OBJECTIVES: To describe the perioperative management, including surgery, anesthesia, metabolic derangements, and physiotherapy, in a goat referred for paraparesis secondary to a road traffic accident. STUDY DESIGN: Case report. ANIMALS: 2-year-old mixed breed dwarf 44 kg female pet goat. METHODS: Clinical examination showed symptoms of early compensatory stages of shock, paraparesis with hyperextension of the thoracic limbs, pain on palpation of the thoracolumbar spine, increased patellar reflexes of both pelvic limbs without superficial sensitivity, but preserved deep pain sensation...
December 7, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27925210/effects-of-steam-microwave-blanching-and-different-drying-processes-on-drying-characteristics-and-quality-attributes-of-thunbergia-laurifolia-linn-leaves
#7
Traiphop Phahom, Singhanat Phoungchandang, William L Kerr
BACKGROUND: Dried Thunbergia laurifolia leaves are usually prepared using tray drying, resulting in products that have lost substantial amounts of bioactive compounds and antioxidant activity. The maturity of the raw material, blanching techniques and drying methods were investigated in order to select the best condition to produce high qualities of dried T. laurifolia leaves. RESULTS: The 1(st) stage of maturity was selected and steam-microwave blanching (SMB) for 4 min was adequate for blanching leading to the maximum recovery of bioactive compounds...
December 7, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27925005/seed-desiccation-tolerance-and-cryopreservation-of-philippine-calamansi-x-citrofortunella-microcarpa-bunge-wijnands
#8
O L Damasco, L C Refuerzo
BACKGROUND: The traditional on farm conservation of Calamansi [x Citrofortunella microcarpa (Bunge) Wijnands], an important indigenous Citrus species in the Philippines, is now being threatened by shifting agricultural crop production, climate change, and increasing biotic and abiotic stresses. OBJECTIVE: The study aimed to characterize the desiccation and cryopreservation tolerance of seeds as the basis for complementary long term ex situ conservation. MATERIALS AND METHODS: Intact seeds were desiccated in an airtight container filled with activated silica gel for 0-96 h...
July 2016: Cryo Letters
https://www.readbyqxmd.com/read/27924751/neurological-sequelae-of-cancer-immunotherapies-and-targeted-therapies
#9
REVIEW
Wolfgang Wick, Anne Hertenstein, Michael Platten
Neurological complications of cancer and of anticancer treatments can be substantially disabling to patients, especially with classic chemotherapies. As a rare but important complication, targeted therapies might also result in similar unwanted effects, partly because inhibition of VEGF is a common downstream effect. Therapeutic antibodies, such as the CD20-depleting antibody rituximab, and underlying haematological malignancies, can induce long-lasting cellular immunosuppression, predisposing patients to opportunistic CNS infections, such as progressive multifocal leukoencephalopathy, where treatment-induced recovery can result in severe reconstitution of immune inflammatory syndromes of the central nervous system...
December 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27924461/life-satisfaction-and-hemodynamic-reactivity-to-mental-stress
#10
Andreas Schwerdtfeger, Kerstin Gaisbachgrabner, Claudia Traunmüller
BACKGROUND: Satisfaction with life has been considered a health-protective variable, which could impact cardiovascular morbidity and mortality. However, few studies have examined the physiological pathways involved in the potentially salutary effect of life satisfaction. It was hypothesized that life satisfaction should be associated with a cardiovascular response profile that signals challenge (i.e., higher cardiac output, lower peripheral resistance), rather than threat during a mental stress task...
December 6, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/27923406/ameliorative-effects-of-rutin-against-metabolic-biochemical-and-hormonal-disturbances-in-polycystic-ovary-syndrome-in-rats
#11
Sarwat Jahan, Faryal Munir, Suhail Razak, Anam Mehboob, Qurat Ul Ain, Hizb Ullah, Tayyaba Afsar, Ghazala Shaheen, Ali Almajwal
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age. The study was commenced to assess the favorable effects of Rutin against metabolic, biochemical, histological, and androgenic aspects of polycystic ovary syndrome in rats. METHODS: Female Sprague-Dawley rats were administered letrozole (1 mg/kg) per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of rutin (100 mg/kg and 150 mg/kg, p...
December 7, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27923070/macrophage-colony-stimulating-factor-derived-from-cd4-t-cells-contributes-to-control-of-a-blood-borne-infection
#12
Mary F Fontana, Gabrielly L de Melo, Chioma Anidi, Rebecca Hamburger, Chris Y Kim, So Youn Lee, Jennifer Pham, Charles C Kim
Dynamic regulation of leukocyte population size and activation state is crucial for an effective immune response. In malaria, Plasmodium parasites elicit robust host expansion of macrophages and monocytes, but the underlying mechanisms remain unclear. Here we show that myeloid expansion during P. chabaudi infection is dependent upon both CD4+ T cells and the cytokine Macrophage Colony Stimulating Factor (MCSF). Single-cell RNA-Seq analysis on antigen-experienced T cells revealed robust expression of Csf1, the gene encoding MCSF, in a sub-population of CD4+ T cells with distinct transcriptional and surface phenotypes...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27922695/effects-of-five-candidate-laxatives-derived-from-liriope-platyphylla-on-the-5-ht-receptor-signaling-pathway-in-three-cell-types-present-in-the-transverse-colon
#13
Ji Eun Kim, Eun Kyoung Koh, Sung Hwa Song, Ji Eun Sung, Hyun Ah Lee, Hong Gu Lee, Young Whan Choi, Dae Youn Hwang
The laxative effects of aqueous extract of Liriope platyphylla (AEtLP) on loperamide (Lop)‑induced constipation have been reported; however, the key compounds and the mechanism underlying these effects remain unclear. Therefore, the laxative effects of five candidates derived from L. platyphylla: Diosgenin (DG), 5-hydroxymethylfurfural (5-HMF), adenosine (AD), hydroxypropyl cellulose (HPC) and uridine (UD) were investigated by examining the alteration of G protein α (Gα) expression, protein kinase C (PKC) phosphorylation and inositol triphosphate (IP3) concentration levels in the 5-hydroxytryptamine (5‑HT; serotonin) receptor signaling pathway...
December 5, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27922694/cpkc%C3%AE-membrane-translocation-is-involved-in-herkinorin%C3%A2-induced-neuroprotection-against-cerebral-ischemia-reperfusion-injury-in-mice
#14
Xiaochen Gui, Xu Cui, Haiping Wei, Guang Feng, Xuezheng Zhang, Yongjin He, Junfa Li, Tianzuo Li
Herkinorin is an opiate analgesic with limited adverse effects, functioning as a primary selective atypical opioid µ agonist. The present study aimed to identify whether herkinorin has a positive effect on ischemic/reperfusion (I/R) injury. Adult male C57BL/6 mice were randomly divided into five groups: i) Naïve, ii) sham, iii) I/R, iv) I/R with dimethyl sulfoxide (I/R+D) and v) I/R with herkinorin (I/R+H). The I/R injury model was induced by occluding the middle cerebral artery for 1 h followed by 24 h or 7 days of reperfusion...
December 6, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27920978/network-interactions-underlying-mirror-feedback-in-stroke-a-dynamic-causal-modeling-study
#15
Soha Saleh, Mathew Yarossi, Thushini Manuweera, Sergei Adamovich, Eugene Tunik
Mirror visual feedback (MVF) is potentially a powerful tool to facilitate recovery of disordered movement and stimulate activation of under-active brain areas due to stroke. The neural mechanisms underlying MVF have therefore been a focus of recent inquiry. Although it is known that sensorimotor areas can be activated via mirror feedback, the network interactions driving this effect remain unknown. The aim of the current study was to fill this gap by using dynamic causal modeling to test the interactions between regions in the frontal and parietal lobes that may be important for modulating the activation of the ipsilesional motor cortex during mirror visual feedback of unaffected hand movement in stroke patients...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27920299/the-type-iii-secretion-system-effector-sptp-of-salmonella-enterica-serovar-typhi
#16
Rebecca Johnson, Alexander Byrne, Cedric N Berger, Elizabeth Klemm, Valerie F Crepin, Gordon Dougan, Gad Frankel
: Salmonella enterica serovars causes gastroenteritis or typhoid fever in humans, with virulence depending on the action of two type III secretion systems (SPI-1 and SPI-2). SptP is a Salmonella SPI-1 effector, involved in mediating recovery of the host cytoskeleton post-infection. SptP requires a chaperone, SicP, for stability and secretion. SptP has 94% identity between S Typhimurium and S Typhi; direct comparison of the protein sequences revealed that S Typhi SptP has numerous amino acid changes within its chaperone-binding domain...
December 5, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27919986/videoscopic-inguinal-iliac-obturator-lymph-node-dissection-new-videoscopic-technique-for-regional-lymphadenectomy-in-patients-with-melanoma
#17
Nicola Solari, Marco Gipponi, DI Somma Carmine Franco, Francesca Rè, Olcese Sonia, Sergio Bertoglio, Ferdinando Cafiero
AIM: The feasibility of videoscopic inguinal-iliac-obturator lymphadenectomy (VIIOL) was assessed in 20 patients with melanoma and compared with a retrospective sample of 24 patients undergoing standard 'open' technique (IIOL). RESULTS: No postoperative death occurred; the mean operative time was lower in the IIOL series (190 min vs. 302 min) but the quality of life was greatly improved in the VIIOL group thanks to earlier bladder catheter removal, no nasogastric suction, less pain, earlier mobilization, lower in-hospital stay, and earlier resumption of daily activities (27...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919810/immobilization-of-indigenous-holocellulase-on-iron-oxide-fe2o3-nanoparticles-enhanced-hydrolysis-of-alkali-pretreated-paddy-straw
#18
Ajay Kumar, Surender Singh, Rameshwar Tiwari, Renu Goel, Lata Nain
The holocellulase from Aspergillus niger SH3 was characterized and found to contain 125 proteins including cellulases (26), hemicellulases (21), chitinases (10), esterases (6), amylases (4) and hypothetical protein (32). The crude enzyme was immobilized on five different nanoparticles (NPs) via physical adsorption and covalent coupling methods. The enzyme-nanoparticle complexes (ENC) were screened for protein binding, enzymatic activities and immobilization efficiency. Magnetic enzyme-nanoparticle complexes (MENC) formulation showed higher immobilization efficiency (60- 80%) for most of the enzymes...
December 2, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27919757/dietary-administration-of-bacillus-subtilis-hainup40-enhances-growth-digestive-enzyme-activities-innate-immune-responses-and-disease-resistance-of-tilapia-oreochromis-niloticus
#19
Haitian Liu, Shifeng Wang, Yan Cai, Xiaohui Guo, Zhenjie Cao, Yongzheng Zhang, Shubin Liu, Wei Yuan, Weiwei Zhu, Yu Zheng, Zhenyu Xie, Weiliang Guo, Yongcan Zhou
The probiotic properties of Bacillus subtilis HAINUP40 isolated from the aquatic environment, and the effects of dietary administration of B. subtilis HAINUP40 on the growth performance, intestinal probiotic recovery, digestive enzyme activities, innate immunity and disease resistance of tilapia (Oreochromis niloticus) were evaluated. The probiotic properties investigated include tolerance to simulated gastrointestinal stress, auto-aggregation, cell surface hydrophobicity and extracellular enzyme production...
December 2, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27919694/neuron-specific-sumo-knockdown-suppresses-global-gene-expression-response-and-worsens-functional-outcome-after-transient-forebrain-ischemia-in-mice
#20
Lin Zhang, Xiaozhi Liu, Huaxin Sheng, Shuai Liu, Ying Li, Julia Q Zhao, David S Warner, Wulf Paschen, Wei Yang
Small ubiquitin-like modifier (SUMO) conjugation (SUMOylation) plays key roles in neurologic function in health and disease. Neuronal SUMOylation is essential for emotionality and cognition, and this pathway is dramatically activated in post-ischemic neurons, a neuroprotective response to ischemia. It is also known from cell culture studies that SUMOylation modulates gene expression. However, it remains unknown how SUMOylation regulates neuronal gene expression in vivo, in the physiologic state and after ischemia, and modulates post-ischemic recovery of neurologic function...
December 2, 2016: Neuroscience
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