keyword
https://read.qxmd.com/read/37518937/bringing-researchers-to-the-consumer-table-the-process-and-outcomes-of-a-consumer-roundtable-on-telehealth
#21
JOURNAL ARTICLE
Bec Jenkinson, Jo Maxwell, Alison Bell, Adrienne Young, Anthony C Smith, Anja Christoffersen, Dale Trevor, Leonie Young, Trevor Russell
INTRODUCTION: Despite the significant expansion and rapid uptake of telehealth services as a COVID-19 response, the pandemic restricted opportunities to involve health consumers in telehealth research. Authentic consumer and community involvement in research begins with engagement in priority-setting. We report here on the process and outcomes of a consumer-led event intended to support involvement of consumers, from early in the research process. METHODS: In 2022, The University of Queensland's Consumer and Community Network hosted a Consumer Roundtable to 'bring researchers to the consumer table' and explore emerging issues and priorities for future research...
July 30, 2023: Journal of Telemedicine and Telecare
https://read.qxmd.com/read/37491723/diminishing-psychological-reactance-through-self-transcendent-media-experiences-a-self-report-and-psychophysiological-investigation
#22
JOURNAL ARTICLE
Russell B Clayton, Jessica G Myrick, Katherine R Dale, Junho Park, Emily Sarra, Ella Hechlik
Health communication scholars have provided ample evidence demonstrating the ways in which freedom-threatening language used in persuasive health messages evokes freedom-threat perceptions, state psychological reactance, and intentions to engage in behaviors opposite of those recommended by the health message. This study examined a novel mitigation strategy for diminishing these outcomes. We examined whether prior exposure to entertainment portrayals of moral virtue (versus a neutral video) can dampen audiences' psychological reactance, intentions to consume alcohol, and defensive message processing via their psychophysiological responses to a subsequent, freedom-threatening excessive alcohol consumption public service announcement (PSA)...
July 25, 2023: Health Communication
https://read.qxmd.com/read/37486670/association-between-thrombectomy-and-functional-outcomes-in-pediatric-patients-with-acute-ischemic-stroke-from-large-vessel-occlusion
#23
JOURNAL ARTICLE
Kartik D Bhatia, Samyami Chowdhury, Ian Andrews, Robert Goetti, Richard Webster, Christopher Troedson, Russell C Dale, Prakash Muthusami, Carmen Parra Farinas, Nomazulu Dlamini, Mahendra Moharir, Christina Miteff, Ferdinand Miteff, John Worthington, Kylie Tastula, Timothy Ang, Romain Briest, Elizabeth Pulcine
IMPORTANCE: Pediatric large vessel occlusion (LVO) stroke has a poor natural history. However, uptake of mechanical thrombectomy is hindered by a lack of clinical trial data in children. A randomized clinical trial is not feasible due to small sample sizes and absence of equipoise. OBJECTIVE: To evaluate whether pediatric patients with acute LVO stroke who undergo thrombectomy have better clinical outcomes than matched patients managed conservatively. DESIGN, SETTING, AND PARTICIPANTS: This matched case-control study used pooled stroke registry data from 5 tertiary referral hospitals in Australia and Canada from January 2011 to April 2022...
July 24, 2023: JAMA Neurology
https://read.qxmd.com/read/37449585/prehospital-activation-of-the-cardiac-catheterization-laboratory-in-st-segment-elevation-myocardial-infarction-for-primary-percutaneous-coronary-intervention
#24
JOURNAL ARTICLE
Michael L Savage, Karen Hay, William Vollbon, Tan Doan, Dale J Murdoch, Christopher Hammett, Rohan Poulter, Darren L Walters, Russell Denman, Isuru Ranasinghe, Owen Christopher Raffel
Background Prehospital activation of the cardiac catheter laboratory is associated with significant improvements in ST-segment-elevation myocardial infarction (STEMI) performance measures. However, there are equivocal data, particularly within Australia, regarding its influence on mortality. We assessed the association of prehospital activation on performance measures and mortality in patients with STEMI treated with primary percutaneous coronary intervention from the Queensland Cardiac Outcomes Registry (QCOR)...
July 14, 2023: Journal of the American Heart Association
https://read.qxmd.com/read/37340737/csf-neopterin-and-quinolinic-acid-are-biomarkers-of-neuroinflammation-and-neurotoxicity-in-fires-and-other-infection-triggered-encephalopathy-syndromes
#25
JOURNAL ARTICLE
Russell C Dale, Terrence Thomas, Shrujna Patel, Velda X Han, Kavitha Kothur, Christopher Troedson, Sachin Gupta, Deepak Gill, Stephen Malone, Michaela Waak, Sophie Calvert, Gopinath Subramanian, P Ian Andrews, Tejaswi Kandula, Manoj P Menezes, Simone Ardern-Holmes, Shekeeb Mohammad, Sushil Bandodkar, Jingya Yan
OBJECTIVE: Infection-triggered encephalopathy syndromes (ITES) are potentially devastating neuroinflammatory conditions. Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disease. Early detection to enable immune modulatory treatments could improve outcomes. METHODS: We measured CSF neopterin, quinolinic acid, kynurenine and kynurenine/tryptophan ratio using a liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) system...
June 20, 2023: Annals of Clinical and Translational Neurology
https://read.qxmd.com/read/37205244/transitional-care-for-young-people-with-movement-disorders-consensus-based-recommendations-from-the-mds-task-force-on-pediatrics
#26
REVIEW
Tamara Pringsheim, Amit Batla, Ali Shalash, Jitendra Kumar Sahu, Carlos Cosentino, Darius Ebrahimi-Fakhari, Jennifer Friedman, Jean-Pierre Lin, Jonathan Mink, Alexander Munchau, Daniela Munoz, Nardo Nardocci, Belen Perez-Dueñas, Zomer Sardar, Chahnez Triki, Hilla Ben-Pazi, Laura Silveira-Moriyama, Monica Troncoso-Schifferli, Kyoko Hoshino, Russell C Dale, Victor S C Fung, Manju A Kurian, Emmanuel Roze
BACKGROUND: The International Parkinson and Movement Disorders Society (MDS) set up a working group on pediatric movement disorders (MDS Task Force on Pediatrics) to generate recommendations to guide the transition process from pediatrics to adult health care systems in patients with childhood-onset movement disorders. METHODS: To develop recommendations for transitional care for childhood onset movement disorders, we used a formal consensus development process, using a multi-round, web-based Delphi survey...
May 2023: Movement Disorders Clinical Practice
https://read.qxmd.com/read/37181016/biological-and-structural-phenotypes-associated-with-neurodevelopmental-outcomes-in-congenital-heart-disease
#27
REVIEW
Charlotte E Verrall, Shrujna Patel, Leksi Travitz, Jason Tchieu, Russel C Dale, Nadine A Kasparian, David S Winlaw, Gillian M Blue
Neurodevelopmental disability (NDD) is recognised as one of the most common comorbidities in children with congenital heart disease (CHD) and is associated with altered brain structure and growth throughout the life course. Causes and contributors underpinning the CHD and NDD paradigm are not fully understood, and likely include innate patient factors, such as genetic and epigenetic factors, prenatal haemodynamic consequences as a result of the heart defect, and factors affecting the fetal-placental-maternal environment, such as placental pathology, maternal diet, psychological stress and autoimmune disease...
April 29, 2023: Translational Pediatrics
https://read.qxmd.com/read/37179527/social-determinants-of-health-for-children-with-cerebral-palsy-and-their-families
#28
REVIEW
Katarina Ostojic, Isra Karem, Simon P Paget, Alison Berg, Betty-Jean Dee-Price, Raghu Lingam, Russell C Dale, Valsamma Eapen, Sue Woolfenden
Social determinants of health (SDH) influence health and social outcomes in positive and negative ways. Understanding the impact of SDH on children with cerebral palsy (CP) is essential to improve health equity, optimize health outcomes, and support children with CP and their families to thrive in society. In this narrative review, we summarize the landscape of SDH impacting children with CP and their families worldwide. In high-income countries, children from poorer neighbourhoods are more likely to have severe comorbidities, present with spastic bilateral CP, and report lower frequency of participation in community activities...
May 14, 2023: Developmental Medicine and Child Neurology
https://read.qxmd.com/read/37119734/csf-neopterin-quinolinic-acid-and-kynurenine-tryptophan-ratio-are-biomarkers-of-active-neuroinflammation
#29
JOURNAL ARTICLE
Jingya Yan, Kavitha Kothur, Shekeeb Mohammad, Jason Chung, Shrujna Patel, Hannah F Jones, Brooke A Keating, Velda X Han, Richard Webster, Simone Ardern-Holmes, Jayne Antony, Manoj P Menezes, Esther Tantsis, Deepak Gill, Sachin Gupta, Tejaswi Kandula, Hugo Sampaio, Michelle A Farrar, Christopher Troedson, P Ian Andrews, Sekhar C Pillai, Benjamin Heng, Gilles J Guillemin, Anna Guller, Sushil Bandodkar, Russell C Dale
BACKGROUND: Defining the presence of acute and chronic brain inflammation remains a challenge to clinicians due to the heterogeneity of clinical presentations and aetiologies. However, defining the presence of neuroinflammation, and monitoring the effects of therapy is important given its reversible and potentially damaging nature. We investigated the utility of CSF metabolites in the diagnosis of primary neuroinflammatory disorders such as encephalitis and explored the potential pathogenic role of inflammation in epilepsy...
April 27, 2023: EBioMedicine
https://read.qxmd.com/read/37032222/a-national-pilot-of-donation-after-circulatory-death-dcd-heart-transplantation-within-the-united-kingdom
#30
JOURNAL ARTICLE
Simon Messer, Sally Rushton, Lewis Simmonds, Debbie Macklam, Mubbasher Husain, Anand Jothidasan, Stephen Large, Steven Tsui, Pradeep Kaul, Jennifer Baxter, Mohamed Osman, Vipin Mehta, Derval Russell, Uli Stock, John Dunning, Diana Garcia Saez, Rajamiyer Venkateswaran, Philip Curry, Lynne Ayton, Majid Mukadam, Jorge Mascaro, Jacob Simmonds, Guy Macgowan, Stephen Clark, Jerome Jungschleger, Zdenka Reinhardt, Richard Quigley, Jane Speed, Jayan Parameshwar, David Jenkins, Sarah Watson, Fiona Marley, Ayesha Ali, Dale Gardiner, Antonio Rubino, Julie Whitney, Catherine Slater, Ian Currie, Liz Armstrong, Jeanette Foley, Marian Ryan, Sharon Gibson, Karen Quinn, Anna-Maria Macleod, Susan Spence, Christopher J E Watson, Pedro Catarino, Anthony Clarkson, John Forsythe, Derek Manas, Marius Berman
BACKGROUND: The United Kingdom (UK) was one of the first countries to pioneer heart transplantation from donation after circulatory death (DCD) donors. To facilitate equity of access to DCD hearts by all UK heart transplant centers and expand the retrieval zone nationwide, a Joint Innovation Fund (JIF) pilot was provided by NHS Blood and Transplant (NHSBT) and NHS England (NHSE). The activity and outcomes of this national DCD heart pilot program are reported. METHODS: This is a national multi-center, retrospective cohort study examining early outcomes of DCD heart transplants performed across 7 heart transplant centers, adult and pediatric, throughout the UK...
March 13, 2023: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/37029483/could-theropod-dinosaurs-have-evolved-to-a-human-level-of-intelligence
#31
REVIEW
Anton Reiner
Noting that some theropod dinosaurs had large brains, large grasping hands, and likely binocular vision, paleontologist Dale Russell suggested that a branch of these dinosaurs might have evolved to a human intelligence level, had dinosaurs not become extinct. I offer reasons why the likely pallial organization in dinosaurs would have made this improbable, based on four assumptions. First, it is assumed that achieving human intelligence requires evolving an equivalent of the about 200 functionally specialized cortical areas characteristic of humans...
April 7, 2023: Journal of Comparative Neurology
https://read.qxmd.com/read/37029407/prevalence-and-correlates-of-destructive-behaviors-in-the-us-naval-surface-forces-from-2010-2020
#32
JOURNAL ARTICLE
Kevin Lai, Jason T Jameson, Dale W Russell
PURPOSE: To estimate the prevalence of domestic violence, sexual assault, and suicide for United States Navy (USN) personnel between 2010 and 2020 and identify potential associated factors. METHODS: Official report data were used to calculate prevalence rates and odds ratios, accounting for sample and general USN population demographic data to assess differences in over- or underrepresentation of destructive behaviors. RESULTS: Domestic violence and sexual assault offenders tended to be younger lower-ranked males...
April 7, 2023: BMC Psychology
https://read.qxmd.com/read/37024248/codesigning-a-social-prescribing-pathway-to-address-the-social-determinant-of-health-concerns-of-children-with-cerebral-palsy-and-their-families-in-australia-a-protocol-for-a-mixed-methods-formative-research-study
#33
JOURNAL ARTICLE
Katarina Ostojic, Simon Paget, Tanya Martin, Betty-Jean Dee-Price, Sarah McIntyre, Hayley Smithers Sheedy, Laurel Mimmo, Heather Burnett, Timothy Scott, Alison Berg, Anne Masi, Michele Scarcella, Jack Calderan, Sheikh Azmatullah, Masyitah Mohamed, Mackenzie Woodbury, Alunya Wilkinson, Karen Zwi, Russell Dale, Valsamma Eapen, Raghu Lingam, Iva Strnadová, Susan Woolfenden
INTRODUCTION: Social determinants of health (SDH) are contributors to health inequities experienced by some children with cerebral palsy and pose barriers to families engaging with complex and fragmented healthcare systems. There is emerging evidence to support 'social prescribing' interventions that systematically identify SDH concerns and refer patients to non-medical social care support and services to address their needs. To date, social prescribing has not been trialled specifically for children with neurodevelopmental disabilities, including cerebral palsy, in Australia...
April 6, 2023: BMJ Open
https://read.qxmd.com/read/36934086/integrative-omics-identifies-conserved-and-pathogen-specific-responses-of-sepsis-causing-bacteria
#34
JOURNAL ARTICLE
Andre Mu, William P Klare, Sarah L Baines, C N Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D Shah, Nitika Neha, Snehal Jadhav, Sally R Partridge, Amanda J Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J Hancock, Laura Álvarez-Fraga, David M P De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R Stephen, Marie Everest, Matt I Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N Cole, Victor Nizet, Tania C Sorrell, Anton Y Peleg, David L Paterson, Scott A Beatson, Jemma Wu, Mark P Molloy, Anna E Syme, Robert J A Goode, Adam A Hunter, Grahame Bowland, Nicholas P West, Marc R Wilkins, Steven P Djordjevic, Mark R Davies, Torsten Seemann, Benjamin P Howden, Dana Pascovici, Sonika Tyagi, Ralf B Schittenhelm, David P De Souza, Malcolm J McConville, Jonathan R Iredell, Stuart J Cordwell, Richard A Strugnell, Timothy P Stinear, Mark A Schembri, Mark J Walker
Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enabling the identification of common bacterial targets for therapeutic intervention, we applied a standardized genomic, transcriptomic, proteomic and metabolomic technological framework to multiple clinical isolates of four sepsis-causing pathogens: Escherichia coli, Klebsiella pneumoniae species complex, Staphylococcus aureus and Streptococcus pyogenes...
March 18, 2023: Nature Communications
https://read.qxmd.com/read/36908609/the-acute-optic-neuritis-network-acon-study-protocol-of-a-non-interventional-prospective-multicenter-study-on-diagnosis-and-treatment-of-acute-optic-neuritis
#35
JOURNAL ARTICLE
Susanna Asseyer, Nasrin Asgari, Jeffrey Bennett, Omer Bialer, Yolanda Blanco, Francesca Bosello, Anna Camos-Carreras, Edgar Carnero Contentti, Sara Carta, John Chen, Claudia Chien, Mashina Chomba, Russell C Dale, Josep Dalmau, Kristina Feldmann, Eoin P Flanagan, Caroline Froment Tilikete, Carolina Garcia-Alfonso, Joachim Havla, Mark Hellmann, Ho Jin Kim, Philipp Klyscz, Frank Konietschke, Chiara La Morgia, Marco Lana-Peixoto, Maria Isabel Leite, Netta Levin, Michael Levy, Sara Llufriu, Pablo Lopez, Itay Lotan, Alessandra Lugaresi, Romain Marignier, Sara Mariotto, Susan P Mollan, Cassandra Ocampo, Frederike Cosima Oertel, Maja Olszewska, Jacqueline Palace, Lekha Pandit, José Luis Peralta Uribe, Sean Pittock, Sudarshini Ramanathan, Natthapon Rattanathamsakul, Albert Saiz, Sara Samadzadeh, Bernardo Sanchez-Dalmau, Deanna Saylor, Michael Scheel, Tanja Schmitz-Hübsch, Jemal Shifa, Sasitorn Siritho, Pia S Sperber, Prem S Subramanian, Alon Tiosano, Adi Vaknin-Dembinsky, Alvaro Jose Mejia Vergara, Adi Wilf-Yarkoni, Luis Alfonso Zarco, Hanna G Zimmermann, Friedemann Paul, Hadas Stiebel-Kalish
UNLABELLED: Optic neuritis (ON) often occurs at the presentation of multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD). The recommended treatment of high-dose corticosteroids for ON is based on a North American study population, which did not address treatment timing or antibody serostatus. The Acute Optic Neuritis Network (ACON) presents a global, prospective, observational study protocol primarily designed to investigate the effect of time to high-dose corticosteroid treatment on 6-month visual outcomes in ON...
2023: Frontiers in Neurology
https://read.qxmd.com/read/36898755/harnessing-neuroplasticity-to-improve-motor-performance-in-infants-with-cerebral-palsy-a-study-protocol-for-the-game-randomised-controlled-trial
#36
JOURNAL ARTICLE
Catherine Morgan, Nadia Badawi, Roslyn N Boyd, Alicia J Spittle, Russell C Dale, Adrienne Kirby, Rod W Hunt, Koa Whittingham, Kerstin Pannek, Rachael L Morton, William Tarnow-Mordi, Michael C Fahey, Karen Walker, Kristina Prelog, Catherine Elliott, Jane Valentine, Andrea Guzzetta, Shannon Olivey, Iona Novak
INTRODUCTION: Cerebral palsy (CP) is the most common physical disability of childhood worldwide. Historically the diagnosis was made between 12 and 24 months, meaning data about effective early interventions to improve motor outcomes are scant. In high-income countries, two in three children will walk. This evaluator-blinded randomised controlled trial will investigate the efficacy of an early and sustained Goals-Activity-Motor Enrichment approach to improve motor and cognitive skills in infants with suspected or confirmed CP...
March 10, 2023: BMJ Open
https://read.qxmd.com/read/36788293/origins-and-immunopathogenesis-of-autoimmune-central-nervous-system-disorders
#37
REVIEW
Sudarshini Ramanathan, Fabienne Brilot, Sarosh R Irani, Russell C Dale
The field of autoimmune neurology is rapidly evolving, and recent discoveries have advanced our understanding of disease aetiologies. In this article, we review the key pathogenic mechanisms underlying the development of CNS autoimmunity. First, we review non-modifiable risk factors, such as age, sex and ethnicity, as well as genetic factors such as monogenic variants, common variants in vulnerability genes and emerging HLA associations. Second, we highlight how interactions between environmental factors and epigenetics can modify disease onset and severity...
March 2023: Nature Reviews. Neurology
https://read.qxmd.com/read/36701153/association-of-potentially-damaging-de-novo-gene-variants-with-neurologic-outcomes-in-congenital-heart-disease
#38
JOURNAL ARTICLE
Sarah U Morton, Ami Norris-Brilliant, Sean Cunningham, Eileen King, Elizabeth Goldmuntz, Martina Brueckner, Thomas A Miller, Nina H Thomas, Chunyan Liu, Heather R Adams, David C Bellinger, John Cleveland, James F Cnota, Anders M Dale, Michele Frommelt, Bruce D Gelb, P Ellen Grant, Caren S Goldberg, Hao Huang, Joshua M Kuperman, Jennifer S Li, Patrick S McQuillen, Ashok Panigrahy, George A Porter, Amy E Roberts, Mark W Russell, Christine E Seidman, Madalina E Tivarus, Evdokia Anagnoustou, Donald J Hagler, Wendy K Chung, Jane W Newburger
IMPORTANCE: Neurodevelopmental disabilities are commonly associated with congenital heart disease (CHD), but medical and sociodemographic factors explain only one-third of the variance in outcomes. OBJECTIVE: To examine whether potentially damaging de novo variants (dDNVs) in genes not previously linked to neurodevelopmental disability are associated with neurologic outcomes in CHD and, post hoc, whether some dDNVs or rare putative loss-of-function variants (pLOFs) in specific gene categories are associated with outcomes...
January 3, 2023: JAMA Network Open
https://read.qxmd.com/read/36669487/humoral-signatures-of-mog-antibody-associated-disease-track-with-age-and-disease-activity
#39
JOURNAL ARTICLE
Marianna Spatola, Omar Chuquisana, Wonyeong Jung, Joseph A Lopez, Eva-Maria Wendel, Sudarshini Ramanathan, Christian W Keller, Tim Hahn, Edgar Meinl, Markus Reindl, Russell C Dale, Heinz Wiendl, Douglas A Lauffenburger, Kevin Rostásy, Fabienne Brilot, Galit Alter, Jan D Lünemann
Myelin oligodendrocyte glycoprotein (MOG)-antibody (Ab)-associated disease (MOGAD) is an inflammatory demyelinating disease of the CNS. Although MOG is encephalitogenic in different mammalian species, the mechanisms by which human MOG-specific Abs contribute to MOGAD are poorly understood. Here, we use a systems-level approach combined with high-dimensional characterization of Ab-associated immune features to deeply profile humoral immune responses in 123 patients with MOGAD. We show that age is a major determinant for MOG-antibody-related immune signatures...
January 10, 2023: Cell reports medicine
https://read.qxmd.com/read/36658389/whole-genome-sequencing-provides-comprehensive-genetic-testing-in-childhood-b-cell-acute-lymphoblastic-leukaemia
#40
JOURNAL ARTICLE
Sarra L Ryan, John F Peden, Zoya Kingsbury, Claire J Schwab, Terena James, Petri Polonen, Martina Mijuskovic, Jenn Becq, Richard Yim, Ruth E Cranston, Dale J Hedges, Kathryn G Roberts, Charles G Mullighan, Ajay Vora, Lisa J Russell, Robert Bain, Anthony V Moorman, David R Bentley, Christine J Harrison, Mark T Ross
Childhood B-cell acute lymphoblastic leukaemia (B-ALL) is characterised by recurrent genetic abnormalities that drive risk-directed treatment strategies. Using current techniques, accurate detection of such aberrations can be challenging, due to the rapidly expanding list of key genetic abnormalities. Whole genome sequencing (WGS) has the potential to improve genetic testing, but requires comprehensive validation. We performed WGS on 210 childhood B-ALL samples annotated with clinical and genetic data. We devised a molecular classification system to subtype these patients based on identification of key genetic changes in tumour-normal and tumour-only analyses...
January 19, 2023: Leukemia
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