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https://www.readbyqxmd.com/read/29325741/functional-engineered-mesenchymal-stem-cells-with-fibronectin-gold-composite-coated-catheters-for-vascular-tissue-regeneration
#1
Yun-Wen Chen, Shu-Chen Hsieh, Yi-Chin Yang, Shan-Hui Hsu, Mei-Lang Kung, Pei-Ying Lin, Hsien-Hsu Hsieh, Ching-Hao Lin, Cheng-Ming Tang, Huey-Shan Hung
Vascularization of engineered tissues remains one of the key problems. Here, we described a novel approach to promote vascularization of engineered tissues using fibronectin (FN) incorporated gold nanoparticles (AuNP) coated onto catheters with mesenchymal stem cells (MSCs) for tissue engineering. We found that the FN-AuNP composite with 43.5 ppm of AuNP exhibited better biomechanical properties and thermal stability than pure FN. FN-AuNP composites promoted MSC proliferation and increased the biocompatibility...
January 8, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29315845/deformable-organic-nanowire-field-effect-transistors
#2
Yeongjun Lee, Jin Young Oh, Taeho Roy Kim, Xiaodan Gu, Yeongin Kim, Ging-Ji Nathan Wang, Hung-Chin Wu, Raphael Pfattner, John W F To, Toru Katsumata, Donghee Son, Jiheong Kang, James R Matthews, Weijun Niu, Mingqian He, Robert Sinclair, Yi Cui, Jeffery B-H Tok, Tae-Woo Lee, Zhenan Bao
Deformable electronic devices that are impervious to mechanical influence when mounted on surfaces of dynamically changing soft matters have great potential for next-generation implantable bioelectronic devices. Here, deformable field-effect transistors (FETs) composed of single organic nanowires (NWs) as the semiconductor are presented. The NWs are composed of fused thiophene diketopyrrolopyrrole based polymer semiconductor and high-molecular-weight polyethylene oxide as both the molecular binder and deformability enhancer...
January 8, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29310817/dental-implant-navigation-system-guide-the-surgery-future
#3
Ting-Mao Sun, Ting-Hsun Lan, Chin-Yun Pan, Huey-Er Lee
No study has investigated the effect of learning curves on the accuracy of dental implant navigation systems. This study evaluated the accuracy of the dental implant navigation system and established the learning curve according to operation site and operating time. Each dental model was used for drilling 3 missing tooth positions, and a patient tracking module was created. The same dentist performed the drilling test for 5 sets of dental models. CT back scanning was performed on the dental models. Customized implants based on the drilled holes were inserted...
January 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306096/embryotoxic-cytokines-potential-roles-in-embryo-loss-and-fetal-programming
#4
REVIEW
Sarah A Robertson, Peck-Yin Chin, Joseph G Femia, Hannah M Brown
Cytokines in the reproductive tract environment at conception mediate a dialogue between the embryo and maternal tissues to profoundly influence embryo development and implantation success. Through effects on gene expression and the cell stress response, cytokines elicit an epigenetic impact with consequences for placental development and fetal growth, which in turn affect metabolic phenotype and long-term health of offspring. There is substantial evidence demonstrating that pro-survival cytokines, such as GM-CSF, CSF1, LIF, HB-EGF and IGFII, support embryos to develop optimally...
December 27, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29306080/hybrid-micro-nanostructural-surface-offering-improved-stress-distribution-and-enhanced-osseointegration-properties-of-the-biomedical-titanium-implant
#5
Ping-Jen Hou, Keng-Liang Ou, Chin-Chieh Wang, Chiung-Fang Huang, Muhammad Ruslin, Erwan Sugiatno, Tzu-Sen Yang, Hsin-Hua Chou
OBJECTIVES: The aim of the present study was to investigate the surface characteristic, biomechanical behavior, hemocompatibility, bone tissue response and osseointegration of the optimal micro-arc oxidation surface-treated titanium (MST-Ti) dental implant. MATERIALS AND METHODS: The surface characteristic, biomechanical behavior and hemocompatibility of the MST-Ti dental implant were performed using scanning electron microscope, finite element method, blood dripping and immersion tests...
November 27, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29261517/treatment-approach-to-severe-microgenia-cases-combined-use-of-osseous-and-implant-genioplasty
#6
Kemal Findikcioglu, Serhat Sibar, Ayse Gulsen
INTRODUCTION: As well as the chin is an important esthetic unit of the facial structure, it is also the region having a key role in the appearance of the face. Correction of cosmetic and functional deformities that may occur in this region because of serious hypoplasia (microgenia) is performed by chin augmentation. Chin augmentation is most frequently performed via implant or osseous genioplasty in the literature. Both 2 techniques have their own advantages and disadvantages. In the literature, various studies comparing these 2 techniques and their long-term results are present, but in some severe microgenia cases, these techniques can be insufficient only for augmentation...
December 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29240567/theoretical-evaluation-and-experimental-validation-of-localized-therapeutic-hypothermia-application-to-preserve-residual-hearing-after-cochlear-implantation
#7
Ilmar Tamames, Curtis King, Chin-Yuh Huang, Fred F Telischi, Michael E Hoffer, Suhrud M Rajguru
OBJECTIVES: Cochlear implantation surgery has been shown to result in trauma to inner ear sensory structures, resulting in loss of residual hearing. Localized therapeutic hypothermia has been shown in clinical care to be a neuroprotective intervention. Previously, we have shown in an experimental model that localized hypothermia protects cochlear hair cells and residual hearing function against surgical and cochlear implantation trauma. Using experimental temperature measurements carried out in human cadaver temporal bones and a finite element model of the inner ear, the present study examined the temperature distribution of a custom-designed hypothermia delivery system in the human inner ear organs...
December 13, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29234013/the-differentiation-stage-of-transplanted-stem-cells-modulates-nerve-regeneration
#8
Ching-Wen Huang, Wen-Chin Huang, Xuefeng Qiu, Flavia Fernandes Ferreira da Silva, Aijun Wang, Shyam Patel, Leon J Nesti, Mu-Ming Poo, Song Li
In regenerative medicine applications, the differentiation stage of implanted stem cells must be optimized to control cell fate and enhance therapeutic efficacy. We investigated the therapeutic potential of human induced pluripotent stem cell (iPSC)-derived cells at two differentiation stages on peripheral nerve regeneration. Neural crest stem cells (NCSCs) and Schwann cells (NCSC-SCs) derived from iPSCs were used to construct a tissue-engineered nerve conduit that was applied to bridge injured nerves in a rat sciatic nerve transection model...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29217082/-prosthetic-genioplasty-versus-osseous-genioplasty-in-aesthetic-chin-augmentation-literature-review-and-knowledge-update
#9
A Baus, K Rem, M Revol, S Cristofari
Chin augmentation is commonly practiced, whether in microgenia treatment, in cases of orthognathic or cosmetic surgery. Located at the crossroads of many specialties, the technique choice still differs according to the surgeon specialiy. A large number of publications on the subject are available. A comparaison between different surgical methods is therefore possible concerning their indications and their complication. The purpose of this study was to carry out a literature review, with updating knowledge, as well as a synthesis indication regarding aesthetic osseous and alloplastic genioplasty...
December 4, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29214634/a-case-of-hypoglossal-nerve-stimulator-resistant-obstructive-sleep-apnea-cured-with-the-addition-of-a-chin-strap
#10
Apoorva T Ramaswamy, Carol Li, Maria V Suurna
A population of appropriately selected patients does not respond, or does not achieve cure, with hypoglossal nerve stimulation (HGNS). We describe the case of nonresponder whose obstructive sleep apnea (OSA) resolved with the addition of chin strap. After initial placement and titration of HGNS implant, follow-up sleep study demonstrated persistent moderate OSA. Drug-induced sleep endoscopy demonstrated supraglottic collapse with activate neurostimulation. With mouth closure and change of stimulation settings to unipolar from bipolar, the airway collapse and desaturations improved...
December 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29211970/facilitating-in-vivo-articular-cartilage-repair-by-tissue-engineered-cartilage-grafts-produced-from-auricular-chondrocytes
#11
Chin-Chean Wong, Chih-Hwa Chen, Li-Hsuan Chiu, Yang-Hwei Tsuang, Meng-Yi Bai, Ren-Jei Chung, Yun-Ho Lin, Fon-Jou Hsieh, You-Tzung Chen, Tsung-Lin Yang
BACKGROUND: Insufficient cell numbers still present a challenge for articular cartilage repair. Converting heterotopic auricular chondrocytes by extracellular matrix may be the solution. HYPOTHESIS: Specific extracellular matrix may convert the phenotype of auricular chondrocytes toward articular cartilage for repair. STUDY DESIGN: Controlled laboratory study. METHODS: For in vitro study, rabbit auricular chondrocytes were cultured in monolayer for several passages until reaching status of dedifferentiation...
December 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29207850/a-novel-technique-of-fabricating-a-modified-removable-provisional-prosthesis-over-an-autologous-bone-grafted-maxillary-anterior-edentulous-segment-prior-to-implant-placement
#12
Leoney Andonissamy, N Sri Vidhya
Implant dentistry has provided a lot of surgical as well as prosthetic techniques for improving the success of the implants. The surgical technique commonly followed now prior to implant placement is bone grafting procedure. One of the commonest techniques is the use of autologous block graft harvested from mandibular chin region. However, interference in healing as well as excessive bone resorption due to the use of removable provisional prosthesis over the bone grafted region has been commonly observed/reported...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205938/peptide-functionalized-polyurethane-coatings-prepared-via-grafting-to-strategy-to-selectively-promote-endothelialization
#13
Xin Ding, Willy Chin, Chuen Neng Lee, James L Hedrick, Yi Yan Yang
Endothelialization, formation of endothelial cells (ECs) layer on cardiovascular implant surface, is considered an ideal approach to prevent restenosis (renarrowing of blood vessel mainly due to the accumulation of proliferated vascular smooth muscle cells, SMCs) and thrombosis. In this study, the possibility of using polyurethane (PU) as a coating platform for functionalization with peptide to enhance endothelialization on implants is explored. PUs are synthesized through metal-free organocatalytic polymerization followed by chemical conjugation with an EC-specific REDV peptide through thiol-ene reaction...
December 4, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29188648/-application-of-bone-grafts-from-chin-of-the-mandible-in-the-reconstruction-of-orbital-fracture
#14
Li Xiaoyu, Wu Jing, Du Xinya, Huang Jian, Wu Bin, Xie Chun
OBJECTIVE: To evaluate the clinical effects of bone graft from the mandible in repairing orbital floor defects. METHODS: Bone grafts from the mandible were used to treat 11 cases of orbital floor defects and followed up for 6-12 months. RESULTS: The surgical incisions healed primarily in all 11 patients. The orbital floor structure was restored. No vision loss, limited eye movement, implant infection, or resorption were observed postoperatively, and no complications occurred in the supply area...
October 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29179885/bilaterality-of-ovarian-endometriomas-does-not-affect-the-outcome-of-in%C3%A2-vitro-fertilization-intracytoplasmic-sperm-injection-in-infertile-women-after-laparoscopic-cystectomy
#15
Hsing-Tse Yu, Hong-Yuan Huang, Hsiao-Jung Tseng, Chin-Jung Wang, Chyi-Long Lee, Yung-Kuei Soong
BACKGROUND: To assess whether the unilateral or bilateral lesions can affect ovarian reserve and pregnancy outcome in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in infertility patients underwent laparoscopic cystectomy. METHODS: A total of 148 IVF/ICSI cycle in patients who had undergone laparoscopic cystectomy for unilateral or bilateral endometriomas were reviewed retrospectively. There were 103 cycles where laparoscopic cystectomy had been carried out for unilateral endometriomas and 45 cycles after bilateral-side surgery...
October 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29179457/traditional-chinese-medicine-danggui-buxue-tang-inhibits-colorectal-cancer-growth-through-induction-of-autophagic-cell-death
#16
Shun-Ting Chen, Tzung-Yan Lee, Tung-Hu Tsai, Yu-Chuen Huang, Yin-Cheng Lin, Chin-Ping Lin, Hui-Ru Shieh, Ming-Ling Hsu, Chih-Wen Chi, Ming-Cheng Lee, Hen-Hong Chang, Yu-Jen Chen
Purpose: The induction of autophagic cell death is an important process in the development of anticancer therapeutics. We aimed to evaluate the activity of the ancient Chinese decoction Danggui Buxue Tang (DBT) against colorectal cancer (CRC) and the associated autophagy-related mechanism. Materials and methods: CT26 CRC cells were implanted into syngeneic BALB/c mice for the tumor growth assay. DBT extracts and DBT-PD (polysaccharide-depleted) fractions were orally administered...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29173414/neuromuscular-disease-cardiac-manifestations-and-sudden-death-risk
#17
REVIEW
Worawan Limipitikul, Chin Siang Ong, Gordon F Tomaselli
Cardiovascular complications of neuromuscular diseases disproportionately affect the cardiac conduction system. Cardiomyopathy and cardiac arrhythmias produce significant morbidity and mortality. Patients with neuromuscular diseases should be carefully and frequently evaluated for the presence of bradycardia, heart block, and tachyarrhythmias. Preemptive treatment with permanent pacemakers or implanted defibrillators is appropriate in patients with conduction system disease or who are at risk for ventricular arrhythmias...
December 2017: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/29150533/disparity-between-indications-for-and-utilization-of-implantable-cardioverter-defibrillators-in-asian-patients-with-heart-failure
#18
Yvonne May Fen Chia, Tiew-Hwa Katherine Teng, Eugene S J Tan, Wan Ting Tay, A Mark Richards, Calvin Woon Loong Chin, Wataru Shimizu, Sang Weon Park, Chung-Lieh Hung, Lieng H Ling, Tachapong Ngarmukos, Razali Omar, Bambang B Siswanto, Calambur Narasimhan, Eugene B Reyes, Cheuk-Man Yu, Inder Anand, Michael R MacDonald, Jonathan Yap, Shu Zhang, Eric A Finkelstein, Carolyn S P Lam
BACKGROUND: Implantable cardioverter defibrillators (ICDs) are lifesaving devices for patients with heart failure (HF) and reduced ejection fraction. However, utilization and determinants of ICD insertion in Asia are poorly defined. We determined the utilization, associations of ICD uptake, patient-perceived barriers to device therapy and, impact of ICDs on mortality in Asian patients with HF. METHODS AND RESULTS: Using the prospective ASIAN-HF (Asian Sudden Cardiac Death in Heart Failure) registry, 5276 patients with symptomatic HF and reduced ejection fraction (HFrEF) from 11 Asian regions and across 3 income regions (high: Hong Kong, Japan, Korea, Singapore, and Taiwan; middle: China, Malaysia, and Thailand; and low: India, Indonesia, and Philippines) were studied...
November 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29146734/humanized-mice-in-studying-efficacy-and-mechanisms-of-pd-1-targeted-cancer-immunotherapy
#19
Minan Wang, Li-Chin Yao, Mingshan Cheng, Danying Cai, Jan Martinek, Chong-Xian Pan, Wei Shi, Ai-Hong Ma, Ralph W De Vere White, Susan Airhart, Edison T Liu, Jacques Banchereau, Michael A Brehm, Dale L Greiner, Leonard D Shultz, Karolina Palucka, James G Keck
Establishment of an in vivo small animal model of human tumor and human immune system interaction would enable preclinical investigations into the mechanisms underlying cancer immunotherapy. To this end, non-obese diabetic (NOD).Cg-Prkdc(scid)IL2rg(tm1Wjl) /Sz (null; NSG) mice were transplanted with human (h)CD34(+) hematopoietic progenitor and stem cells, which leads to the development of human hematopoietic and immune systems [humanized NSG (HuNSG)]. HuNSG mice received human leukocyte antigen partially matched tumor implants from patient-derived xenografts [PDX; nonsmall cell lung cancer (NSCLC), sarcoma, bladder cancer, and triple-negative breast cancer (TNBC)] or from a TNBC cell line-derived xenograft (CDX)...
November 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29141386/-clinical-characteristics-and-surgical-effect-observation-of-congenital-aniridia-combined-with-cataract
#20
X H Wu, Q Z Cao, Y X Hu, J N Lin, H T Lin, W R Chen, Y Z Liu
Objective: To analyze the clinical manifestations, surgical approaches and postoperative prognosis for the cases of congenital aniridia combined with cataract. Methods: In this retrospective case series, 26 patients diagnosed with congenital aniridia combined with cataract were collected from Zhongshan Ophthalmic Center from February 2002 to August 2016. The Clinical data were collected to analyze the clinical features, surgical approaches and postoperative prognosis. T-test was used for statistical analysis...
November 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
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