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https://www.readbyqxmd.com/read/28928978/implantation-of-the-micra-leadless-pacemaker-in-a-patient-with-a-low-body-mass-index-of-16
#1
Gary Tse, Tong Liu, Guangping Li, Wing Tak Wong, Gary Chin Pang Chan, Yat Sun Chan, Bryan Yan
A 71-year-old female patient has a history of complete heart block and recurrent pacemaker site infection requiring multiple pacemaker explanations. A leadless pacemaker using passive fixation was inserted into the right ventricular apex via transvenous approach without complications. This case illustrates the feasibility of implanting a leadless pacemaker system in a small-sized adult with a low body mass index of 16 (weight: 33.7 kg, height: 145 cm) which may have potential application in elderly Asian subjects...
September 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28894408/deep-brain-stimulation-dbs-for-movement-disorders-an-experience-in-hospital-universiti-sains-malaysia-husm-involving-12-patients
#2
Lim Liang Hooi, Diana Noma Fitzrol, Senthil Kumar Rajapathy, Tan Yew Chin, Sanihah Abdul Halim, Regunath Kandasamy, Wan Mohd Nazaruddin Wan Hassan, Badrisyah Idris, Abdul Rahman Izaini Ghani, Zamzuri Idris, John Tharakan, Sarun Nunta-Aree, Jafri Malin Abdullah
Deep brain stimulation (DBS) was first introduced in 1987 to the developed world. As a developing country Malaysia begun its movement disorder program by doing ablation therapy using the Radionics system. Hospital Universiti Sains Malaysia a rural based teaching hospital had to take into consideration both health economics and outcomes in the area that it was providing neurosurgical care for when it initiated its Deep Brain Stimulation program. Most of the patients were from the low to medium social economic groups and could not afford payment for a DBS implant...
March 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28888353/preimplantation-genetic-diagnosis-and-screening-current-status-and-future-challenges
#3
REVIEW
Hsin-Fu Chen, Shee-Uan Chen, Gwo-Chin Ma, Sung-Tsang Hsieh, Horng-Der Tsai, Yu-Shih Yang, Ming Chen
Preimplantation genetic diagnosis (PGD) is a clinically feasible technology to prevent the transmission of monogenic inherited disorders in families afflicted the diseases to the future offsprings. The major technical hurdle is it does not have a general formula for all mutations, thus different gene locus needs individualized, customized design to make the diagnosis accurate enough to be applied on PGD, in which the quantity of DNA is scarce, whereas timely result is sometimes requested if fresh embryo transfer is desired...
September 6, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28868207/host-non-inflammatory-neutrophils-mediate-the-engraftment-of-bioengineered-vascular-networks
#4
Ruei-Zeng Lin, Chin Nien Lee, Rafael Moreno-Luna, Joseph Neumeyer, Breanna Piekarski, Pingzhu Zhou, Marsha A Moses, Monisha Sachdev, William T Pu, Sitaram Emani, Juan M Melero-Martin
Notwithstanding remarkable progress in vascular network engineering, implanted bioengineered microvessels largely fail to form anastomoses with the host vasculature. Here, we demonstrate that implants containing assembled human vascular networks (A-Grafts) fail to engraft due to their inability to engage non-inflammatory host neutrophils upon implantation into mice. In contrast, unassembled vascular cells (U-Grafts) readily engage alternatively polarized neutrophils, which in turn serve as indispensable mediators of vascular assembly and anastomosis...
2017: Nature biomedical engineering
https://www.readbyqxmd.com/read/28864134/rationale-and-design-of-a-prospective-study-to-assess-the-effect-of-left-cardiac-sympathetic-denervation-in-chronic-heart-failure
#5
Ashley Chin, Mpiko Ntsekhe, Charle Viljoen, Johan Rossouw, Tim Pennel, Peter J Schwartz
BACKGROUND: The main causes of mortality in patients with chronic heart failure include sudden cardiac death (SCD) and progressive heart failure. Autonomic dysfunction plays a detrimental role in the progression of chronic heart failure. Left cardiac sympathetic denervation (LCSD) is an inexpensive and safe procedure which modifies autonomic innervation of the heart and is associated with a significant antifibrillatory effect. Whether LCSD reduces the risk of SCD, delays progression of heart failure and improves quality of life in patients with heart failure with reduced ejection fraction (HFrEF) is not known...
August 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28826954/tubo-omental-ectopic-pregnancy
#6
Yi-Ting Huang, I-Ting Liang, Chin-Jung Wang
A 26-year-old woman presented with lower abdominal pain for days. Human chorionic gonadotropin measured 2096 mIU/mL. Transvaginal ultrasound revealed no intrauterine pregnancy, but a heterogeneous 2.5cm x 2.1cm mass was adjacent to the right ovary, suggesting ectopic pregnancy. After medical therapy methotrexate 50mg/m(2) intramuscularly failed, laparoscopy found an omental mass with right tubal fimbriae attached. The left Fallopian tube and both ovaries appeared normal. Histopathology diagnosed omental pregnancy...
August 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28815251/-morphometric-analysis-of-maxillofacial-bone-in-48-patients-with-ectodermal-dysplasia
#7
Hao-Wei Wang, Feng Wang, Wei Huang, Wen-Jie Zhou, Yue-Ping Wang, Yi-Qun Wu
PURPOSE: The study was performed to analyze the maxillofacial morphology of 48 patients with ectodermal dysplasia (ED) and to provide some reference for implant treatment of ED patients. METHODS: The study collected the clinical data and lateral cephalometric radiographs of 48 patients with ED treated between June 2013 and October 2016. The patients were grouped as follows: group 1, 23 patients, at least with two kinds of ectodermal disorder, besides hypodontia; group 2, 25 patients, only with one kind of ectodermal disorder, besides hypodontia...
April 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28812014/surgical-approach-may-influence-survival-of-large-diameter-head-metal-on-metal-total-hip-arthroplasty-a-6-to-10-year-follow-up-study
#8
Chih-Chien Hu, Tsan-Wen Huang, Shih-Jie Lin, Po-Chun Lin, Feng-Chih Kuo, Kuo-Ti Peng, Kuo-Chin Huang, Hsin-Nung Shih, Mel S Lee
Large-diameter head (LDH) metal-on-metal (MoM) total hip arthroplasty (THA) has lost popularity because of metal allergy or ALTRs (adverse local tissue reactions) in the past decade. Whether the surgical approach may influence the survival of LDH-MoM-THA has not been reported. From 2006 to 2009, we performed 96 LDH-MoM-THAs on 80 patients using an in situ head-neck assembly technique through a modified Watson-Jones approach. With a mean follow-up of 8.4 years (range, 6.3-10.1 years), the implant survival rate was 100%...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28806177/laryngeal-mask-airway-embedded-with-pharyngeal-suction-catheters-for-rhinoplasty-a-case-report
#9
Gary X Zhou
A flexible laryngeal mask airway device (LMAD) embedded with 2 pharyngeal suction catheters was used for a young female patient who underwent a revision rhinoplasty, septoplasty, and chin implant. The modified LMAD was constructed by attaching 2 suction catheters onto the back of the mask; it functioned well without signs of malfunction or complications, with a total of 71 mL of blood evacuated from the pharyngeal area during the five and a half hour surgery. The patient emerged from anesthesia without coughing or straining, and reported no sore throat or nausea/vomiting in the recovery room...
August 10, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28757192/delivery-of-epidermalgrowthfactor-receptor-inhibitor-via-a-customized-collagen-scaffold-promotes-meniscal-defect-regeneration-in-a-rabbit-model
#10
Zongyou Pan, Yan Wu, Xiaolei Zhang, Qianbao Fu, Jun Li, Yang Yang, Dongsheng Yu, Yuzi Xu, Xiaolang Lu, Heng Sun, Xianzhu Zhang, Boon Chin Heng, Varitsara Bunpetch, Shufang Zhang, Hongwei Ouyang
Meniscal injury is one of the most common knee joint injuries, which remains an intractable challenge in clinical practice to date. Aberrant epidermalgrowthfactor receptor (EGFR) activation levels in both human and mice menisci following injury, prompted us to investigate the functional role of EGFR by utilizing an inducible cartilage-specific EGFR-deficient mouse model. We demonstrated that conditional EGFR deletion in mice resulted in increased partial meniscectomy-induced ECM production within the meniscus, which is comparable to utilization of the small molecule EGFR inhibitor, gefitinib, to block EGFR activity...
July 27, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28750118/modification-of-chin-projection-and-aesthetics-with-onabotulinumtoxina-injection
#11
Amy K Hsu, Andrew S Frankel
Importance: Because of the soft-tissue envelope and the dimensional complexity of the muscular contraction of the mentalis muscle, the projection and shape of the chin is not determined by only the bony projection. In a subset of patients with a seemingly underprojected chin, a hyperactive, high-riding mentalis muscle contributes to a blunted chin contour. Objective: To evaluate the use of onabotulinumtoxinA (botulinum toxin A) for improving chin aesthetics in patients with an underprojected bony chin and a high-riding hyperactive mentalis muscle...
July 27, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28741438/bilateral-arteriovenous-shunts-as-a-method-for-evaluating-tissue-engineered-vascular-grafts-in-large-animal-models
#12
Chin Siang Ong, Takuma Fukunishi, Rui Han Liu, Kevin Nelson, Huaitao Zhang, Elizabeth Wieczorek, McKenna Palmieri, Yukie Ueyama, Erin Ferris, Gail E Geist, Bradley L Youngblood, Jed Johnson, Narutoshi Hibino
There remains a need for large animal models to evaluate tissue engineered vascular grafts (TEVGs) under arterial pressure to provide preclinical data for future potential human clinical trials. We present a comprehensive method for the interrogation of TEVGs, using an ovine bilateral arteriovenous shunt implantation model. Our results demonstrate that this method can be performed safely without complications, specifically acute heart failure, steal syndrome, and hypoxic brain injury and is a viable experimental paradigm...
July 25, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28733044/management-of-displaced-inferior-patellar-pole-fractures-with-modified-tension-band-technique-combined-with-cable-cerclage-using-cable-grip-system
#13
Xu Yang, Qinfen Wu, Chin-Hui Lai, Xin Wang
INTRODUCTION: We present a modified tension band technique combined with cable cerclage using Cable Grip System for the treatment of displaced inferior patellar pole fractures and report the knee functional outcome. PATIENTS AND METHODS: The patients who had had operative treatment of a displaced inferior patellar pole fracture (AO/OTA 34-A1) between December 2013 and December 2015 were studied retrospectively. Eleven consecutive patients had had open reduction and internal fixation with the modified technique using Cable Grip System, of whom, five males and six females with an average age of 60...
July 13, 2017: Injury
https://www.readbyqxmd.com/read/28728285/-prevalence-and-surgery-status-of-cataract-among-adults-aged-60-years-or-above-in-two-villages-of-nantong
#14
J Zhou, Y Yuan, X Zhang, M Yang, H J Guan
Objective: To assess the prevalence, surgical coverage rate and social burden rate of cataract blindness among adults aged ≥60 years in the suburban population of Nantong, Jiangsu, China. Methods: It was a population-based cross-section study. A census with individuals aged ≥60 years was conducted in two villages of the suburb area in Nantong from June to August, 2008. A total of 1 305 individuals received visual acuity and eye examinations. Lens and cataract operative status were evaluated by slit-lamp biomicroscopy...
July 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28713743/bone-ring-augmentation-around-immediate-implants-a-clinical-and-radiographic-study
#15
Girish B Giraddi, Aamir Malick Saifi
PURPOSE: The purpose of this study was to evaluate the efficacy of bone ring augmentation technique for three-dimensional augmentation of severely defective sockets along with placement of immediate dental implants. MATERIALS AND METHODS: A clinical study was conducted on 14 patients with 15 defective sockets requiring extractions and immediate implant placement. Following extraction, bone ring with an implant osteotomy, harvested from chin, was sculptured and fitted into the extraction socket...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28676704/biomaterial-free-three-dimensional-bioprinting-of-cardiac-tissue-using-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#16
Chin Siang Ong, Takuma Fukunishi, Huaitao Zhang, Chen Yu Huang, Andrew Nashed, Adriana Blazeski, Deborah DiSilvestre, Luca Vricella, John Conte, Leslie Tung, Gordon F Tomaselli, Narutoshi Hibino
We have developed a novel method to deliver stem cells using 3D bioprinted cardiac patches, free of biomaterials. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), fibroblasts (FB) and endothelial cells (EC) were aggregated to create mixed cell spheroids. Cardiac patches were created from spheroids (CM:FB:EC = 70:15:15, 70:0:30, 45:40:15) using a 3D bioprinter. Cardiac patches were analyzed with light and video microscopy, immunohistochemistry, immunofluorescence, cell viability assays and optical electrical mapping...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28674083/combining-local-immunotoxins-targeting-mesothelin-with-ctla-4-blockade-synergistically-eradicates-murine-cancer-by-promoting-anticancer-immunity
#17
Yasmin Leshem, James O'Brien, Xiufen Liu, Tapan K Bera, Masaki Terabe, Jay A Berzofsky, Birgit Bossenmaier, Gerhard Niederfellner, Chin-Hsien Tai, Yoram Reiter, Ira Pastan
Immune checkpoint blockade using antibodies to cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) benefits a limited number of cancer patients. SS1P and LMB-100 are immunotoxins that target mesothelin. We observed delayed responses to SS1P in patients with mesothelioma suggesting that antitumor immunity was induced. Our goal was to stimulate antitumor immunity by combining SS1P or LMB-100 with anti-CTLA-4. We constructed a BALB/c breast cancer cell line expressing human mesothelin (66C14-M), which was implanted in one or two locations...
August 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28668212/fretting-and-corrosion-damage-in-taper-adapter-sleeves-for-ceramic-heads-a-retrieval-study
#18
Daniel W MacDonald, Antonia F Chen, Gwo-Chin Lee, Gregg R Klein, Michael A Mont, Steven M Kurtz, Harold E Cates, Matthew J Kraay, Clare M Rimnac
BACKGROUND: During revision surgery with a well-fixed stem, a titanium sleeve can be used in conjunction with a ceramic head to achieve better stress distribution across the taper surface. In vitro testing suggests that corrosion is not a concern in sleeved ceramic heads; however, little is known about the in vivo fretting corrosion of the sleeves. The purpose of this study was to investigate fretting corrosion in sleeved ceramic heads in retrieved total hip arthroplasties. METHODS: Thirty-seven sleeved ceramic heads were collected during revision...
April 26, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28666885/sandwich-type-plla-nanosheets-loaded-with-bmp-2-induce-bone-regeneration-in-critical-sized-mouse-calvarial-defects
#19
Kuo-Chin Huang, Fumiko Yano, Yasutaka Murahashi, Shuta Takano, Yoshiaki Kitaura, Song Ho Chang, Kazuhito Soma, Steve W N Ueng, Sakae Tanaka, Kazuhiko Ishihara, Yosuke Okamura, Toru Moro, Taku Saito
To overcome serious clinical problems caused by large bone defects, various approaches to bone regeneration have been researched, including tissue engineering, biomaterials, stem cells and drug screening. Previously, we developed a free-standing biodegradable polymer nanosheet composed of poly(L-lactic acid) (PLLA) using a simple fabrication process consisting of spin-coating and peeling techniques. Here, we loaded recombinant human bone morphogenetic protein-2 (rhBMP-2) between two 60-nm-thick PLLA nanosheets, and investigated these sandwich-type nanosheets in bone regeneration applications...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28663148/oral-reproductive-and-developmental-toxicity-of-lignosus-rhinocerotis-mycelium-in-rat
#20
Bo-Yi Jhou, Hsiao-Hui Liu, Shu-Hsing Yeh, Chin-Chu Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Lignosus rhinocerotis (L. rhinocerotis), also known as the tiger milk mushroom, is widely used as traditional medicine and as soup ingredient in Malaysia and Hong Kong. It is edible and is used traditionally for the treatment of fever, cough, asthma, wounds, chronic hepatitis, gastric ulcers and cancers. In view of its safety profile, little information is found in scientific literature. The objective of this study is to investigate developmental toxicity of L...
June 27, 2017: Journal of Ethnopharmacology
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