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https://www.readbyqxmd.com/read/28741438/bilateral-arteriovenous-shunts-as-a-method-for-evaluating-tissue-engineered-vascular-grafts-in-large-animal-models
#1
Chin Siang Ong, Takuma Fukunishi, Rui Han Liu, Kevin Nelson, Huaitao Zhang, Elizabeth Wieczorek, McKenna Palmieri, Yukie Ueyama, Erin Ferris, Gail E Geist, Bradley L Youngblood, Jed Johnson, Narutoshi Hibino
There remains a need for large animal models to evaluate tissue engineered vascular grafts (TEVGs) under arterial pressure to provide preclinical data for future potential human clinical trials. We present a comprehensive method for the interrogation of TEVGs, using an ovine bilateral arteriovenous shunt implantation model. Our results demonstrate that this method can be performed safely without complications, specifically acute heart failure, steal syndrome, and hypoxic brain injury and is a viable experimental paradigm...
July 25, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28733044/management-of-displaced-inferior-patellar-pole-fractures-with-modified-tension-band-technique-combined-with-cable-cerclage-using-cable-grip-system
#2
Xu Yang, Qinfen Wu, Chin-Hui Lai, Xin Wang
INTRODUCTION: We present a modified tension band technique combined with cable cerclage using Cable Grip System for the treatment of displaced inferior patellar pole fractures and report the knee functional outcome. PATIENTS AND METHODS: The patients who had had operative treatment of a displaced inferior patellar pole fracture (AO/OTA 34-A1) between December 2013 and December 2015 were studied retrospectively. Eleven consecutive patients had had open reduction and internal fixation with the modified technique using Cable Grip System, of whom, five males and six females with an average age of 60...
July 13, 2017: Injury
https://www.readbyqxmd.com/read/28728285/-prevalence-and-surgery-status-of-cataract-among-adults-aged-60-years-or-above-in-two-villages-of-nantong
#3
J Zhou, Y Yuan, X Zhang, M Yang, H J Guan
Objective: To assess the prevalence, surgical coverage rate and social burden rate of cataract blindness among adults aged ≥60 years in the suburban population of Nantong, Jiangsu, China. Methods: It was a population-based cross-section study. A census with individuals aged ≥60 years was conducted in two villages of the suburb area in Nantong from June to August, 2008. A total of 1 305 individuals received visual acuity and eye examinations. Lens and cataract operative status were evaluated by slit-lamp biomicroscopy...
July 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28713743/bone-ring-augmentation-around-immediate-implants-a-clinical-and-radiographic-study
#4
Girish B Giraddi, Aamir Malick Saifi
PURPOSE: The purpose of this study was to evaluate the efficacy of bone ring augmentation technique for three-dimensional augmentation of severely defective sockets along with placement of immediate dental implants. MATERIALS AND METHODS: A clinical study was conducted on 14 patients with 15 defective sockets requiring extractions and immediate implant placement. Following extraction, bone ring with an implant osteotomy, harvested from chin, was sculptured and fitted into the extraction socket...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28676704/biomaterial-free-three-dimensional-bioprinting-of-cardiac-tissue-using-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#5
Chin Siang Ong, Takuma Fukunishi, Huaitao Zhang, Chen Yu Huang, Andrew Nashed, Adriana Blazeski, Deborah DiSilvestre, Luca Vricella, John Conte, Leslie Tung, Gordon F Tomaselli, Narutoshi Hibino
We have developed a novel method to deliver stem cells using 3D bioprinted cardiac patches, free of biomaterials. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), fibroblasts (FB) and endothelial cells (EC) were aggregated to create mixed cell spheroids. Cardiac patches were created from spheroids (CM:FB:EC = 70:15:15, 70:0:30, 45:40:15) using a 3D bioprinter. Cardiac patches were analyzed with light and video microscopy, immunohistochemistry, immunofluorescence, cell viability assays and optical electrical mapping...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28674083/combining-local-immunotoxins-targeting-mesothelin-with-ctla-4-blockade-synergistically-eradicates-murine-cancer-by-promoting-anti-cancer-immunity
#6
Yasmin Leshem, James O'Brien, Xiufen Liu, Tapan K Bera, Masaki Terabe, Jay A Berzofsky, Birgit Bossenmaier, Gerhard Niederfellner, Chin-Hsien Tai, Yoram Reiter, Ira Pastan
Immune checkpoint blockade using antibodies to cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) benefits a limited number of cancer patients. SS1P and LMB-100 are immunotoxins that target mesothelin. We observed delayed responses to SS1P in patients with mesothelioma suggesting that anti-tumor immunity was induced. Our goal was to stimulate anti-tumor immunity by combining SS1P or LMB-100 with anti-CTLA-4. We constructed a BALB/c breast cancer cell line expressing human mesothelin (66C14-M) which was implanted in one or two locations...
July 3, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28668212/fretting-and-corrosion-damage-in-taper-adapter-sleeves-for-ceramic-heads-a-retrieval-study
#7
Daniel W MacDonald, Antonia F Chen, Gwo-Chin Lee, Gregg R Klein, Michael A Mont, Steven M Kurtz, Harold E Cates, Matthew J Kraay, Clare M Rimnac
BACKGROUND: During revision surgery with a well-fixed stem, a titanium sleeve can be used in conjunction with a ceramic head to achieve better stress distribution across the taper surface. In vitro testing suggests that corrosion is not a concern in sleeved ceramic heads; however, little is known about the in vivo fretting corrosion of the sleeves. The purpose of this study was to investigate fretting corrosion in sleeved ceramic heads in retrieved total hip arthroplasties. METHODS: Thirty-seven sleeved ceramic heads were collected during revision...
April 26, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28666885/sandwich-type-plla-nanosheets-loaded-with-bmp-2-induce-bone-regeneration-in-critical-sized-mouse-calvarial-defects
#8
Kuo-Chin Huang, Fumiko Yano, Yasutaka Murahashi, Shuta Takano, Yoshiaki Kitaura, Song Ho Chang, Kazuhito Soma, Steve W N Ueng, Sakae Tanaka, Kazuhiko Ishihara, Yosuke Okamura, Toru Moro, Taku Saito
To overcome serious clinical problems caused by large bone defects, various approaches to bone regeneration have been researched, including tissue engineering, biomaterials, stem cells and drug screening. Previously, we developed a free-standing biodegradable polymer nanosheet composed of poly(L-lactic acid) (PLLA) using a simple fabrication process consisting of spin-coating and peeling techniques. Here, we loaded recombinant human bone morphogenetic protein-2 (rhBMP-2) between two 60-nm-thick PLLA nanosheets, and investigated these sandwich-type nanosheets in bone regeneration applications...
June 27, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28663148/oral-reproductive-and-developmental-toxicity-of-lignosus-rhinocerotis-mycelium-in-rat
#9
Bo-Yi Jhou, Hsiao-Hui Liu, Shu-Hsing Yeh, Chin-Chu Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Lignosus rhinocerotis (L. rhinocerotis), also known as the tiger milk mushroom, is widely used as traditional medicine and as soup ingredient in Malaysia and Hong Kong. It is edible and is used traditionally for the treatment of fever, cough, asthma, wounds, chronic hepatitis, gastric ulcers and cancers. In view of its safety profile, little information is found in scientific literature. The objective of this study is to investigate developmental toxicity of L...
June 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28660005/histological-findings-in-the-trabecular-meshwork-of-a-patient-with-atopic-glaucoma
#10
Satoru Kase, Shiki Chin, Teruhiko Hamanaka, Yasuhiro Shinmei, Takeshi Ohguchi, Riki Kijima, Akira Matsuda, Susumu Ishida
PURPOSE: The aim of this study was to report a case of atopic dermatitis showing elevated intraocular pressure (IOP) beyond the baseline levels followed by a modified 360-degree suture trabeculotomy, and to analyze the histological findings in the trabecular meshwork. METHODS: A 40-year-old male suffered from blurred vision in the right eye (OD). He had a medical history of severe atopic dermatitis and intraocular lens implantation OU due to atopic cataract. At the initial presentation, the visual acuity was 0...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28655891/a-gelatin-sulfonated-silk-composite-scaffold-based-on-3d-printing-technology-enhances-skin-regeneration-by-stimulating-epidermal-growth-and-dermal-neovascularization
#11
Si Xiong, Xianzhu Zhang, Ping Lu, Yan Wu, Quan Wang, Heng Sun, Boon Chin Heng, Varitsara Bunpetch, Shufang Zhang, Hongwei Ouyang
One of the key problems hindering skin repair is the deficiency of dermal vascularization and difficulty of epidermis regeneration, which makes it challenging to fabricate scaffolds that can biologically fulfill the requirements for skin regeneration. To overcome this problem, three-dimensional printing was used to fabricate a gelatin-sulfonated silk composite scaffold that was incorporated with basic fibroblast growth factor 2 (FGF-2) through binding with a sulfonic acid group (SO3) (3DG-SF-SO3-FGF). The efficacy and mechanism by which the 3DG-SF-SO3-FGF scaffolds promote skin regeneration were investigated both within in vitro cell culture and in vivo with a full-thickness skin defect model...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646935/five-year-results-of-the-prospective-randomized-controlled-prostatic-urethral-l-i-f-t-study
#12
Claus G Roehrborn, Jack Barkin, Steven N Gange, Neal D Shore, Jonathan L Giddens, Damien M Bolton, Barrett E Cowan, Anthony L Cantwell, Kevin T McVary, Alexis E Te, Shahram S Gholami, William G Moseley, Peter T Chin, William T Dowling, Sheldon J Freedman, Peter F Incze, K Scott Coffield, Sean Herron, Prem Rashid, Daniel B Rukstalis
INTRODUCTION: To report the five year results of a prospective, multi-center, randomized, blinded sham control trial of the Prostatic Urethral Lift (PUL) in men with bothersome lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: At 19 centers in North America and Australia, 206 subjects ≥ 50 years old with International Prostate Symptom Score (IPSS ) > 12, peak flow rate (Qmax) ≤ 12 mL/s, and prostate volume 30 cc-80 cc were randomized 2:1 to the PUL procedure or blinded sham control...
June 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28623847/toxicity-after-post-prostatectomy-image-guided-intensity-modulated-radiotherapy-using-australian-guidelines
#13
Stephen Chin, Noel J Aherne, Andrew Last, Hassan Assareh, Thomas P Shakespeare
INTRODUCTION: We evaluated single institution toxicity outcomes after post-prostatectomy radiotherapy (PPRT) via image-guided intensity-modulated radiation therapy (IG-IMRT) with implanted fiducial markers following national eviQ guidelines, for which late toxicity outcomes have not been published. METHODS: Prospectively collected toxicity data were retrospectively reviewed for 293 men who underwent 64-66 Gy IG-IMRT to the prostate bed between 2007 and 2015. RESULTS: Median follow-up after PPRT was 39 months...
June 17, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28619483/characterizing-infections-in-prosthetic-breast-reconstruction-a-validity-assessment-of-national-health-databases
#14
Merisa L Piper, Lauren O Roussel, Peter F Koltz, Frederick Wang, Kyra Singh, Robin Chin, Hani Sbitany, Howard N Langstein
INTRODUCTION: Current guidelines in the United States require reporting only the 30-day postoperative outcomes to standardized databases, including the National Surgical Quality Improvement Program (NSQIP). Thus, many breast implant-related complications go unreported in standard databases. We sought to characterize late periprosthetic infections following implant-based breast reconstruction. METHODS: We conducted a retrospective analysis of all women who underwent expander/implant reconstruction from 2005 to 2014 at two institutions...
May 18, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28606268/-clinical-observation-on-monovision-of-cataract-surgery-with-different-near-addition
#15
J Mu, Y Z Li, Q Wu, L Yan, H Chen
Objective: To observe the influence on spectacle independence, satisfaction and visual function after cataract surgery monovision with different ADD. Methods: Prospective clinical study. All patients were collected from the department of ophthalmology, Shanghai JiaoTong University Affiliated Sixth People's Hospital who were diagnosed as bilateral cataract from Oct. 2013 to Mar. 2015. This study comprised 64 cases (128 eyes). All consecutive patients scheduled to undergo bilateral cataract phacoemulsification and implantation of a monofocal AcrySof IQ IOL...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28571065/cheek-and-chin-implants-to-enhance-facelift-results
#16
Russell W H Kridel, Sagar Patel
The traditional rhytidectomy addresses facial and neck aging as it relates to soft tissue laxity. The modern volumetric facelift provides optimal results by addressing not only skin laxity but also the loss of volume secondary to tissue atrophy and bony resorption. While multiple techniques including fat grafting, dermal fillers, and tissue resuspension are used to correct the tissue loss, alloplastic midface augmentation remains the most permanent method. In our practice we often address midface cheek hollowness or atrophy with the placement of submalar implants at the time of rhytidectomy...
June 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28570409/microsurgical-decompression-of-inferior-alveolar-nerve-after-endodontic-treatment-complications
#17
Bernardo Bianchi, Andrea Ferri, Andrea Varazzani, Michela Bergonzani, Enrico Sesenna
Iatrogenic injury in oral surgery is the most frequent cause of sensory disturbance in the distribution of the inferior alveolar nerve (IAN) and mental nerve.Inferior alveolar nerve damage can occur during third molar extraction, implant location, orthognathic surgery, preprosthetic surgery, salivary gland surgery, local anesthetic injections or during the resection of benign or malignant tumors.Injuries to the IAN can be caused also by endodontic treatment of mandibular molars and premolars when filling material is forced into the tooth and mandibular canal...
May 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28556476/neurophysiological-changes-associated-with-implant-associated-augmentation-procedures-in-the-lower-jaw
#18
Amely Hartmann, Claudia Welte-Jzyk, Marcus Seiler, Monika Daubländer
BACKGROUND: Neurophysiological changes after oral and maxillofacial surgery remain one of the topics of current research. PURPOSE: This study evaluated if implant placement associated with augmentation procedures increases the possibility of sensory disturbances or result in impaired quality of life during the healing period. MATERIAL AND METHODS: Patients who had obtained an implant placement in the lower jaw in combination with augmentation procedures were examined by implementing a comprehensive Quantitative Sensory Testing (QST) protocol for extra- and intraoral use...
May 29, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28552201/increasing-the-accuracy-of-mandibular-reconstruction-with-free-fibula-flaps-using-functionalized-selective-laser-melted-patient-specific-implants-a-retrospective-multicenter-analysis
#19
Majeed Rana, Shih-Jan Chin, Thomas Muecke, Marco Kesting, Alexander Groebe, Bjoern Riecke, Max Heiland, Nils-Claudius Gellrich
In this study, selective laser melted patient specific functional implants (PSFI) were utilised in combination with a fibula free flap, for mandible reconstruction. The shape and length of the PSFI, the shaping of fibula graft, its angulation and the length of the screws, were virtually planned before the surgery. Information, such as resection margin and screw lengths, were coded on the implant. 22 patients were reconstructed with PSFI and fibula transplantation. Data collected related to the size of the defect, pre- and postoperative intercondylar distance, ischemia time, time consumed to shape the fibula graft and complications...
April 19, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28548306/zanthoxylum-avicennae-extract-enhances-gsk-3%C3%AE-to-attenuate-%C3%AE-catenin-via-phosphatase-2a-to-block-metastatic-effects-of-ha22t-cells-and-hepatocellular-carcinoma-xenografted-nude-mice
#20
Hsi-Chin Wu, Ing-Shiow Lay, Marthandam Asokan Shibu, Tsung-Jung Ho, Shiu-Min Cheng, Chih-Hao Lin, Tran Duc Dung, Long-Bin Jeng, Vijaya Padma Viswanadha, Chih-Yang Huang
Hepatocellular carcinoma (HCC) metastasis is often associated with the activation of Wnt/β-catenin signaling pathway. Zanthoxylum avicennae (Ying Bu Bo, YBB), a traditional herb with hepatoprotective effect, has been proven to inhibit human HCC in in vivo models however, the in vitro and in vivo effect of YBB on tumor metastasis is not clear yet. To determine whether YBB could inhibit HA22T human HCC cell by acting on β-catenin metastatic signaling in vitro and in vivo, HA22T cells were treated with different concentrations of YBB extracts (YBBE) and analyzed by Immunofluorescence staining assay, western blot analysis, siRNA mediated gene knock-down assays and co-immunoprecipitation assay...
May 26, 2017: Environmental Toxicology
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