Eléonore Bettacchioli, Alain Saraux, Alice Tison, Divi Cornec, Maryvonne Dueymes, Nathan Foulquier, Sophie Hillion, Anne-Marie Roguedas-Contios, Anas-Alexis Benyoussef, Marta E Alarcon-Riquelme, Jacques-Olivier Pers, Valérie Devauchelle-Pensec
OBJECTIVE: The biologic diagnosis of primary Sjögren disease (SjD) mainly relies on anti-Ro60/SSA antibodies, whereas the significance of anti-Ro52/TRIM21 antibodies currently remains unclear. The aim of this study was to characterize the clinical, serological, biologic, transcriptomic, and interferon profiles of patients with SjD according to their anti-Ro52/TRIM21 antibody status. METHODS: Patients with SjD from the European PRECISESADS (n = 376) and the Brittany Diagnostic Suspicion of primitive Sjögren's Syndrome (DIApSS); (n = 146) cohorts were divided into four groups: double negative (Ro52- /Ro60- ), isolated anti-Ro52/TRIM21 positive (Ro52+ ), isolated anti-Ro60/SSA positive (Ro60+ ), and double-positive (Ro52+ /Ro60+ ) patients...
December 21, 2023: Arthritis & Rheumatology