Xiang Mao, Guozhuan Miao, Xiaogang Tao, Shuyu Hao, Hao Zhang, Huan Li, Zonggang Hou, Runfa Tian, Te Lu, Jun Ma, Xiaodong Zhang, Hongwei Cheng, Baiyun Liu
The inflammatory response plays a significant role in neuronal cell death and functional deficits after Traumatic brain injury (TBI). Importantly, anti-inflammatory agents have neuroprotective effects. To date, however, no studies have investigated the neuroprotective effects of Saikosaponin a (SSa) after TBI. In the present study, rats with controlled cortical impact (CCI) were used to investigate the neuroprotective effects of SSa. The results showed that SSa reduced body weight loss, improved neurological functions andcognition, and reduced brain edema and blood brain barrier permeability after CCI...
2016: American Journal of Translational Research