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SSA anti bodies

Julia H Goedecke, Asanda Mtintsilana, Siphiwe N Dlamini, Andre Pascal Kengne
Compared to global estimates, Sub-Saharan Africa (SSA) has the highest projected rates of increase in type 2 diabetes (T2D) over the next 25years. This is attributed to the ageing population, increasing urbanisation and the associated lifestyle changes. Although the prevalence does not differ by gender, deaths attributable to T2D in SSA are greater in women, likely due to differences in beliefs and access to care. Women in SSA also have greater risk factor burden for T2D than men, in particular obesity, which is explained in part by sociocultural factors...
January 2017: Diabetes Research and Clinical Practice
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
C Ballester, V Grobost, P Roblot, O Pourrat, F Pierre, H Laurichesse-Delmas, D Gallot, Y Aubard, H Bezanahary, A-L Fauchais
OBJECTIVES: Primary Sjögren's syndrome (pSS) is one of the most common autoimmune diseases, mainly affecting women during the fourth decade of life. During pregnancy, the presence of anti-Ro/SSa and anti-La/SSb antibodies increases the risk of congenital heart block (CHB). Foetal and pregnancy outcomes in pregnant women with pSS compared with the general population are difficult to evaluate because of confounding factors including age and body mass index (BMI). METHOD: The aim of this case-control study was to analyse the impact of pSS in pregnant women on foetal and pregnancy outcomes...
January 2017: Scandinavian Journal of Rheumatology
Xiang Mao, Guozhuan Miao, Xiaogang Tao, Shuyu Hao, Hao Zhang, Huan Li, Zonggang Hou, Runfa Tian, Te Lu, Jun Ma, Xiaodong Zhang, Hongwei Cheng, Baiyun Liu
The inflammatory response plays a significant role in neuronal cell death and functional deficits after Traumatic brain injury (TBI). Importantly, anti-inflammatory agents have neuroprotective effects. To date, however, no studies have investigated the neuroprotective effects of Saikosaponin a (SSa) after TBI. In the present study, rats with controlled cortical impact (CCI) were used to investigate the neuroprotective effects of SSa. The results showed that SSa reduced body weight loss, improved neurological functions andcognition, and reduced brain edema and blood brain barrier permeability after CCI...
2016: American Journal of Translational Research
Bhushan Madke, Uday Khopkar
Lupus erythematosus (LE) with erythema multiforme-like lesions with its characteristic serological picture had been described in 1963. We report a 33-year-old married male who presented with skin lesions of various morphology on different body parts since four months. The skin lesions ranged from lupus-specific tumid LE to Rowell's syndrome and discoid LE. Histopathology of skin biopsy from all representative sites showed different forms of lupus erythematosus. Antinuclear and anti-double-stranded DNA was positive; however, serology for anti-SSA and anti-SSB was negative...
December 2015: Indian Dermatology Online Journal
Gerd Cecilie Dobloug, Torhild Garen, Cathrine Brunborg, Jan Tore Gran, Øyvind Molberg
OBJECTIVE: To utilise an exposed/unexposed cohort strategy for mortality and cancer analyses across unselected and complete cohorts of patients with idiopathic inflammatory myopathy (IIM) resident in south-east Norway (denominator population 2.6 million), between 2003 and 2012. METHOD: IIM cases were identified by comprehensive searches through patient administrative databases followed by manual chart review. Polymyositis (PM) and dermatomyositis (DM) cases were classified by the Peter and Bohan and/or Targoff diagnostic criteria and sporadic inclusion body myositis (sIBM) by the European NeuroMuscular Centre (ENMC) criteria from 1997 and/or 2011...
December 2015: Seminars in Arthritis and Rheumatism
Zavier Zomalheto, Michee Assogba, Anthelme Agbodande, Felix Atadokpede, Marcelle Gounongbe, Martin Avimadje
AIMS: To describe the clinical features, laboratory characteristics and the treatment of systemic lupus erythematosus (SLE) among Benin people and West Africa people. METHODS: This is a part of a retrospective study which initially concerned patients seen in the rheumatology, dermatology and internal medicine departments of National Hospital University of Cotonou during January 2000 to March 2013 (14 years). Patients included in the study were all older than 16 years and fulfilling at least four of ACR criteria 1997 for Systemic lupus erythematosus...
December 2014: La Tunisie Médicale
Salah Fares, Daniel Dilling
Interstitial Lung Disease Cases IISESSION TYPE: Affiliate Case Report SlidePRESENTED ON: Wednesday, October 29, 2014 at 11:00 AM - 12:15 PMINTRODUCTION: The Differential diagnosis of cystic lung lesions is broad, it has been reported that cystic lung disease can a part of the of the spectrum of pulmonary lymphoid lesions, we are presenting a rare case of non-Hodgkin primary pulmonary lymphoma causing cystic lung lesions.CASE PRESENTATION: A 64-year-old woman presented with shortness of breath. Chest CT revealed right lower lobe mass, bilateral pulmonary nodules, and multiple thin-walled cysts with lower lobe predominance...
October 1, 2014: Chest
J Fongue, B Meunier, D Lardet, M-P Dicostanzo, F Rouby, J-P Terrier, J-R Harlé, M-A Richard, L Chiche
BACKGROUND: More than 100 drugs have been registered as inducing subacute cutaneous lupus erythematosus (SCLE). Recently, some types of chemotherapy have also been incriminated. If SCLE develops in a setting of neoplasia, two possibilities should be considered: it is either a paraneoplastic syndrome or it is caused by the chemotherapy, thus calling for important decisions on the benefit/risk of stopping potentially effective medication. We report a case of SCLE induced by Xeloda (capecitabine)...
October 2014: Annales de Dermatologie et de Vénéréologie
M Dey, T Jose, A Shrivastava, R D Wadhwa, R Agarwal, V Nair
Congenital heart block (CHB) is the most severe manifestation of neonatal lupus which can develop into a lethal atrioventricular (AV) block. Complete congenital foetal heart block related to maternal anti-Ro/SSA autoanti-bodies typically develops between 20 and 24 weeks of gestation. CHB with a structurally normal heart is frequently associated with maternal autoantibodies to Ro/SSA and La/SSB. We are presenting a case of foetal complete CHB with high maternal Ro/SSA and La/SSB titre with favourable outcome...
2014: Facts, Views & Vision in ObGyn
Bijayini Behera, Purva Mathur, Nidhi Bhardwaj, Neetu Jain, M C Misra, Arti Kapil, Sarman Singh
BACKGROUND & OBJECTIVES: Group C and group G streptococci (together GCGS) are often regarded as commensal bacteria and their role in streptococcal disease burden is under-recognized. While reports of recovery of GCGS from normally sterile body sites are increasing, their resistance to macrolides, fluoroquinolone further warrants all invasive β haemolytic streptococci to be identified to the species level and accurately tested for antimicrobial susceptibility. This study was aimed to determine the prevalence, clinical profile, antimicrobial susceptibility and streptococcal pyrogenic exotoxin gene profile (speA, speB, speC, speF, smeZ, speI, speM, speG, speH and ssa) of GCGS obtained over a period of two years at a tertiary care centre from north India...
March 2014: Indian Journal of Medical Research
Kavitha Kandiah, Prabhu Muthusamy, Selvam Mohan, Rajendran Venkatachalam
Bone defects and damages are common these days, which increases the usage of biomaterial for humans. To prepare a potential biomaterial, we synthesised a series of titania-graphene nanocomposites (TGS) (2:x (0.25, 0.5, 1.0, 2.0, and 4.0 g)) using in situ sol-gel method. The obtained structural results show that the prepared TGS nanocomposites are an irregular sheet with spherical TiO2 intercalated morphology. The SSA of the nanocomposites ranging from 167.98 to 234.56 m(2) g(-1) with mesoporosity and swelling tendency ranging from 11...
May 1, 2014: Materials Science & Engineering. C, Materials for Biological Applications
Alexander J Lankowski, Mark J Siedner, David R Bangsberg, Alexander C Tsai
Difficulty obtaining reliable transportation to clinic is frequently cited as a barrier to HIV care in sub-Saharan Africa (SSA). Numerous studies have sought to characterize the impact of geographic and transportation-related barriers on HIV outcomes in SSA, but to date there has been no systematic attempt to summarize these findings. In this systematic review, we summarized this body of literature. We searched for studies conducted in SSA examining the following outcomes in the HIV care continuum: (1) voluntary counseling and testing, (2) pre-antiretroviral therapy (ART) linkage to care, (3) loss to follow-up and mortality, and (4) ART adherence and/or viral suppression...
July 2014: AIDS and Behavior
E J ter Borg, J C Kelder
OBJECTIVES: To investigate in primary Sjögren's syndrome, the differences between patients with and without widespread pain (WSP) with respect to the cumulative prevalence of extra-glandular manifestations (EGMs) and systemic auto-antibodies. METHODS: All outpatients diagnosed with primary Sjögren's syndrome (2) were included in a prospective follow-up, with at least one check up each year, from June 1991 until November 2011. Patients who also fulfilled criteria for concomitant connective tissue disorders were excluded...
May 2014: Clinical and Experimental Rheumatology
David G Dillon, Deepti Gurdasani, Johanna Riha, Kenneth Ekoru, Gershim Asiki, Billy N Mayanja, Naomi S Levitt, Nigel J Crowther, Moffat Nyirenda, Marina Njelekela, Kaushik Ramaiya, Ousman Nyan, Olanisun O Adewole, Kathryn Anastos, Livio Azzoni, W Henry Boom, Caterina Compostella, Joel A Dave, Halima Dawood, Christian Erikstrup, Carla M Fourie, Henrik Friis, Annamarie Kruger, John A Idoko, Chris T Longenecker, Suzanne Mbondi, Japheth E Mukaya, Eugene Mutimura, Chiratidzo E Ndhlovu, George Praygod, Eric W Pefura Yone, Mar Pujades-Rodriguez, Nyagosya Range, Mahmoud U Sani, Aletta E Schutte, Karen Sliwa, Phyllis C Tien, Este H Vorster, Corinna Walsh, Rutendo Zinyama, Fredirick Mashili, Eugene Sobngwi, Clement Adebamowo, Anatoli Kamali, Janet Seeley, Elizabeth H Young, Liam Smeeth, Ayesha A Motala, Pontiano Kaleebu, Manjinder S Sandhu
BACKGROUND: Sub-Saharan Africa (SSA) has the highest burden of HIV in the world and a rising prevalence of cardiometabolic disease; however, the interrelationship between HIV, antiretroviral therapy (ART) and cardiometabolic traits is not well described in SSA populations. METHODS: We conducted a systematic review and meta-analysis through MEDLINE and EMBASE (up to January 2012), as well as direct author contact. Eligible studies provided summary or individual-level data on one or more of the following traits in HIV+ and HIV-, or ART+ and ART- subgroups in SSA: body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TGs) and fasting blood glucose (FBG) or glycated hemoglobin (HbA1c)...
December 2013: International Journal of Epidemiology
András Vereckei, Adám Fazakas, Timea Baló, Béla Fekete, Mária Judit Molnár, István Karádi
The authors report a case of rare chloroquine cardiotoxicity mimicking connective tissue disease heart involvement in a 56-year-old woman with mixed connective tissue disease (MCTD) manifested suddenly as third degree A-V block with QT(c) interval prolongation and short torsade de pointes runs ultimately degenerating into ventricular fibrillation. Immunological tests suggested an MCTD flare, implying that cardiac arrest had resulted from myocardial involvement by MCTD. However, QT(c) prolongation is not a characteristic of cardiomyopathy caused by connective tissue disease, unless anti-Ro/SSA positivity is present, but that was not the case...
April 2013: Immunopharmacology and Immunotoxicology
Vishu Vijayant, Manjit Sarma, Hrushikesh Aurangabadkar, Lata Bichile, Sandip Basu
AIM: To evaluate the role of fluorine-18-labeled fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in various rheumatic diseases and its potential in the early assessment of treatment response in a limited number of patients. METHODS: This study involved 28 newly diagnosed patients, of these 17 had rheumatoid arthritis (RA) and 11 had seronegative spondyloarthropathy (SSA). In the SSA group, 7 patients had ankylosing spondylitis, 3 had psoriatic arthritis, and one had non-specific SSA...
December 28, 2012: World Journal of Radiology
Makoto Tanaka, Tetsu Kamitani
The RING-finger protein Ro52/TRIM21 is known to be an autoantigen and is recognized by anti-Ro/SSA antibodies, which are commonly found in patients with Sjögren's syndrome and systemic lupus erythematosus. We recently showed that Ro52 is an E3 ubiquitin ligase and localizes to cytoplasmic bodies that are highly motile along the microtubule network. To expand our knowledge of Ro52, we searched partners co-operating with Ro52. We performed a yeast two-hybrid screening of a human brain cDNA library with Ro52 as bait...
September 2010: Histochemistry and Cell Biology
Angela Ceribelli, Angela Tincani, Ilaria Cavazzana, Franco Franceschini, Roberto Cattaneo, Brad A Pauley, Jason Y F Chan, Edward K L Chan, Minoru Satoh
OBJECTIVES: Primary anti-phospholipid syndrome (PAPS) is an autoimmune condition defined by anti-phospholipid antibodies (aPL) and thrombotic or obstetric events. Some PAPS can evolve into systemic lupus erythematosus (SLE) during follow-up. Few studies systematically examined lupus autoantibodies and their clinical significance in PAPS. The aim of our study is to analyze the clinical and laboratory correlations with lupus-related autoantibodies, detected by immunoprecipitation (IP), a technique not yet systematically applied to investigate autoantibodies in this condition...
March 2011: Autoimmunity
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