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https://www.readbyqxmd.com/read/29201866/getting-lost-behavior-in-patients-with-mild-alzheimer-s-disease-a-cognitive-and-anatomical-model
#1
Chathuri Yatawara, Daryl Renick Lee, Levinia Lim, Juan Zhou, Nagaendran Kandiah
Background: Getting lost behavior (GLB) in the elderly is believed to involve poor top-down modulation of visuospatial processing, by impaired executive functions. However, since healthy elderly and elderly with Alzheimer's disease (AD) experience a different pattern of cognitive decline, it remains unclear whether this hypothesis can explain GLB in dementia. Objective: We sought to identify whether poor executive functions and working memory modulate the relationship between visuospatial processing and prevalence of GLB in healthy elderly and patients with AD...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29201555/background-and-distribution-of-lobar-microbleeds-in-cognitive-dysfunction
#2
Hirofumi Matsuyama, Yuichiro Ii, Masayuki Maeda, Maki Umino, Yukito Ueda, Ken-Ichi Tabei, Hirotaka Kida, Masayuki Satoh, Akihiro Shindo, Akira Taniguchi, Ryosuke Takahashi, Hidekazu Tomimoto
Objectives: Cerebral microbleeds (CMBs) are often observed in memory clinic patients. It has been generally accepted that deep CMBs (D-CMBs) result from hypertensive vasculopathy (HV), whereas strictly lobar CMBs (SL-CMBs) result from cerebral amyloid angiopathy (CAA) which frequently coexists with Alzheimer's disease (AD). Mixed CMBs (M-CMBs) have been partially attributed to HV and also partially attributed to CAA. The aim of this study was to elucidate the differences between SL-CMBs and M-CMBs in terms of clinical features and regional distribution...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29200859/abnormal-regional-spontaneous-neural-activity-in-visual-pathway-in-retinal-detachment-patients-a-resting-state-functional-mri-study
#3
Xin Huang, Dan Li, Hai-Jun Li, Yu-Lin Zhong, Shelby Freeberg, Jing Bao, Xian-Jun Zeng, Yi Shao
Objective: The aim of the study was to investigate changes of brain neural homogeneity in retinal detachment (RD) patients using the regional homogeneity (ReHo) method to understand their relationships with clinical features. Materials and methods: A total of 30 patients with RD (16 men and 14 women), and 30 healthy controls (HCs) (16 men and 14 women) closely matched in age and sex were recruited. Resting-state functional magnetic resonance imaging scans were performed for all subjects...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29198072/pres-in-the-course-of-hemato-oncological-treatment-in-children
#4
Katarzyna Musioł, Sylwia Waz, Michał Boroń, Magdalena Kwiatek, Magdalena Machnikowska-Sokołowska, Katarzyna Gruszczyńska, Grażyna Sobol-Milejska
INTRODUCTION: Posterior reversible leukoencephalopathy syndrome (PRES) is a clinical syndrome of varying aetiologies, characterised by acute neurological symptoms of brain dysfunction with MRI abnormalities in posterior cerebral white and grey matter. In most cases, symptoms resolve without neurological consequences. AIM: The aim of this paper is the analysis of predisposing factors, clinical outcomes and radiological features of PRES in eight children with hemato-oncological disease...
December 2, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29170933/impact-of-previous-episodes-of-hepatic-encephalopathy-on-short-term-brain-function-recovery-after-liver-transplantation-a-functional-connectivity-strength-study
#5
Yue Cheng, Gaoyan Zhang, Wen Shen, Li-Xiang Huang, Li Zhang, Shuang-Shuang Xie, Xiao-Dong Zhang, Baolin Liu
Neuropsychological studies have documented an incomplete reversal of pre-existing cognitive dysfunction in cirrhotic patients after liver transplantation (LT) and have found this is more severe in patients with hepatic encephalopathy (HE). In this study, we aimed to investigate the impact of prior HE episodes on post-transplantation brain function recovery. Resting-state functional magnetic resonance imaging data was collected from 30 healthy controls and 33 cirrhotic patients (HE, n = 15 and noHE, n = 18) before and one month after LT...
November 23, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29073774/migraine-with-brainstem-aura-why-not-a-cortical-origin
#6
Geneviève Demarquay, Anne Ducros, Alexandra Montavont, François Mauguiere
Background Migraine with brainstem aura is defined as a migraine with aura including at least two of the following symptoms: dysarthria, vertigo, tinnitus, hypacusis, diplopia, ataxia and/or decreased level of consciousness. Aim The aim of this study is to review data coming from clinical observations and functional mapping that support the role of the cerebral cortex in the initiation of brainstem aura symptoms. Results Vertigo can result from a vestibular cortex dysfunction, while tinnitus and hypacusis can originate within the auditory cortex...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28968233/peripheral-versus-central-index-of%C3%A2-metabolic-dysfunction-and-associations-with-clinical-and-pathological-outcomes-in%C3%A2-alzheimer-s-disease
#7
Kelsey E McLimans, Joseph L Webb, Vellareddy Anantharam, Anumantha Kanthasamy, Auriel A Willette
BACKGROUND/OBJECTIVE: Insulin-like growth factor binding protein 2 (IGFBP-2) regulates blood glucose levels, facilitates hippocampal synaptic plasticity and may have a predictive value for Alzheimer's disease (AD) diagnosis. METHODS: IGFBP-2 levels were studied in plasma in 566 subjects and in cerebrospinal fluid (CSF) in 245 subjects across the AD spectrum from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Variants in the IGFBP-2 gene were examined. Linear mixed modeling in SPSS tested main effects of IGFBP-2 and interactions with APOE4 on neurocognitive indices and biomarkers...
September 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28922736/reduced-white-matter-integrity-in-borderline-personality-disorder-a-diffusion-tensor-imaging-study
#8
Taiga Ninomiya, Harumi Oshita, Yoshihisa Kawano, Chiharu Goto, Mai Matsuhashi, Koji Masuda, Fuku Takita, Toshihiko Izumi, Ayako Inoue, Haruka Higuma, Masayuki Kanehisa, Jotaro Akiyoshi
BACKGROUND: Borderline personality disorder (BPD) has a pervasive pattern of instability in interpersonal relationships, self-image, and emotions. BPD may be linked to an abnormal brain anatomy, but little is known about possible impairments of the white matter microstructure in BPD or their relationship with impulsivity or risky behaviors. The aims of the present study were to explore the relationship between BPD and diffusion tensor imaging (DTI) parameters and psychological tests. METHODS: We evaluated 35 un-medicated BPD patients in a medication-free state and 50 healthy controls (HCs)...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28869474/cortical-metabolic-and-cognitive-correlates-of-disorientation-in-alzheimer-s-disease
#9
Gali H Weissberger, Rebecca J Melrose, Candace M Fanale, Joseph V Veliz, David L Sultzer
Orientation to time, date, and place is commonly utilized in clinical settings to aid in diagnosis, staging, and monitoring of Alzheimer's disease (AD). This study aimed to identify the cerebral metabolic correlates of orientation in patients with AD, and the degree to which regions associated with orientation overlap with memory-related structures. Eighty-five patients with a diagnosis of probable AD underwent fluorodeoxyglucose positron emission tomography (FDG-PET) and neuropsychological testing. Orientation items from the Dementia Rating Scale and recognition performance from the Consortium to Establish a Registry for AD (CERAD) Word List Learning test were correlated with cerebral glucose metabolism...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28861031/visual-dysfunction-in-posterior-cortical-atrophy
#10
REVIEW
Mari N Maia da Silva, Rebecca S Millington, Holly Bridge, Merle James-Galton, Gordon T Plant
Posterior cortical atrophy (PCA) is a syndromic diagnosis. It is characterized by progressive impairment of higher (cortical) visual function with imaging evidence of degeneration affecting the occipital, parietal, and posterior temporal lobes bilaterally. Most cases will prove to have Alzheimer pathology. The aim of this review is to summarize the development of the concept of this disorder since it was first introduced. A critical discussion of the evolving diagnostic criteria is presented and the differential diagnosis with regard to the underlying pathology is reviewed...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28736888/alterations-in-cortical-thickness-in-nonmedicated-premature-ejaculation-patients-a-morphometric-mri-study
#11
Fan Guo, Yi-Bin Xi, Ming Gao, Lin Liu, Ning-Bo Fei, Wei Qin, Chen Li, Long-Biao Cui, Fei Yan, Lei Yu, Jian-Lin Yuan, Hong Yin
PURPOSE: Premature ejaculation (PE) is one of the most common sexual dysfunctions in men. However, there has been little research evaluating alterations in brain structure related to PE. We aimed to investigate the characteristics of nonmedicated PE patients in terms of brain morphometry. MATERIALS AND METHODS: The sample consisted with 32 medication-naïve adult men with clinical diagnosed PE and matched 31 healthy controls. All participants received diagnostic interviews and 3...
July 24, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28693073/-resting-state-fmri-study-of-emotional-network-in-patients-with-postconcussion-syndrome
#12
X Zhang, R B Qian, X M Fu, B Lin, D Zhang, C S Xia, X P Wei, C S Niu, Y H Wang
Objective: To discuss functional connectivity changes in the emotional network of patients with post-concussion syndrome (PCS) and their clinical significance by resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Twenty-seven patients with PCS were recruited from the Department of Neurosurgery of Anhui provincial hospital affiliated to Anhui medical university from October 2015 to April 2016, and 27 healthy subjects were recruited as the controls. The Hamilton Anxiety Scale (HAMA) and The Hamilton Depression Scale (HAMD) were used to evaluate the emotional state of two groups of subjects...
July 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28566609/progressive-b%C3%A3-lint-s-syndrome-in-a-patient-demonstrating-dementia-with-lewy-bodies
#13
Yasuhisa Sakurai, Yoshifumi Nakashima
We herein report a 65-year-old man demonstrating dementia with Lewy bodies who first presented with Bálint's syndrome. Two years later, a mild cognitive impairment was noted. From three years after onset, he developed progressive parkinsonism, visual hallucination, and autonomic dysfunction, in line with the deterioration of the cognitive function. Single photon emission computed tomography with a (99m)Tc-ethylcysteinate dimer performed two years after onset revealed hypoperfusion in the restricted area of the bilateral superior parietal lobule, which extended to the lateral occipital cortices within two years...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28539636/effect-of-kidney-dysfunction-on-cerebral-cortical-thinning-in-elderly-population
#14
Chih-Hao Chen, Ya-Fang Chen, Ming-Jang Chiu, Ta-Fu Chen, Ping-Huan Tsai, Jen-Hau Chen, Chung-Jen Yen, Sung-Chun Tang, Shin-Joe Yeh, Yen-Ching Chen
Chronic kidney disease has been linked to cognitive impairment and morphological brain change. However, less is known about the impact of kidney functions on cerebral cortical thickness. This study investigated the relationship between kidney functions and global or lobar cerebral cortical thickness (CTh) in 259 non-demented elderly persons. Forty-three participants (16.7%) had kidney dysfunction, which was defined as either a glomerular filtration rate (GFR) of <60 ml/min/1.73 m(2) or presence of proteinuria...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28509077/relationships-between-cognitive-impairment-on-adas-cog-and-regional-cerebral-blood-flow-using-spect-in-late-onset-alzheimer-s-disease
#15
Michio Takahashi, Yasunori Oda, Toshiyuki Okubo, Yukihiko Shirayama
The aim of this study was to examine brain hypoperfusion and its relationship with cognitive dysfunction in late-onset Alzheimer's disease (AD). Forty patients with late-onset AD and not receiving acetylcholinesterase inhibitors were recruited from outpatient clinics. We examined cognitive function using the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and brain perfusion using single-photon emission computed tomography, and analyzed classified gyrus level segments with three-dimensional stereotactic surface projection and the stereotactic extraction estimation method level 3...
May 16, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28498826/divergent-influences-of-cardiovascular-disease-risk-factor-domains-on-cognition-and-gray-and-white-matter-morphology
#16
Mitzi M Gonzales, Olusola Ajilore, Rebecca C Charlton, Jamie Cohen, Shaolin Yang, Erica Sieg, Dulal K Bhaumik, Anand Kumar, Melissa Lamar
OBJECTIVE: Hypertension, diabetes, dyslipidemia, and obesity are associated with preclinical alterations in cognition and brain structure; however, this often comes from studies of comprehensive risk scores or single isolated factors. We examined associations of empirically derived cardiovascular disease risk factor domains with cognition and brain structure. METHODS: A total of 124 adults (age, 59.8 [13.1] years; 41% African American; 50% women) underwent neuropsychological and cardiovascular assessments and structural magnetic resonance imaging...
June 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28491196/cerebral-palsy-and-seizures-in-a-child-with-tubulinopathy-pattern-dysgenesis-and-focal-cortical-dysplasia
#17
Kevin M Sweet, Dennis W W Shaw, Teresa Chapman
A 7-year-old boy with a history of spasticity, global developmental delay, and seizures was given the general diagnosis of cerebral palsy at an early age. Chromosomal array analysis performed at an outside center was normal. The patient's family sought neurodevelopmental pediatric care at a new institution following a move out of state. Electroencephalography confirmed abnormal epileptogenic activity. Brain magnetic resonance imaging showed findings consistent with a tubulin gene defect (tubulinopathy) and of focal cortical dysplasia, as well as evidence of a remote occipital lobe injury...
June 2017: Radiology Case Reports
https://www.readbyqxmd.com/read/28481932/unmasking-adrenoleukodystrophy-in-a-cohort-of-cerebellar-ataxia
#18
Ying-Hao Chen, Yi-Chung Lee, Yu-Shuen Tsai, Yuh-Cherng Guo, Cheng-Tsung Hsiao, Pei-Chien Tsai, Jin-An Huang, Yi-Chu Liao, Bing-Wen Soong
Adrenoleukodystrophy (ALD) is a rare and progressive neurogenetic disease that may manifest disparate symptoms. The present study aims at investigating the role of ataxic variant of ALD (AVALD) in patients with adult-onset cerebellar ataxia, as well as characterizing their clinical features that distinguish AVALD from other cerebellar ataxias. Mutations in the ATP binding cassette subfamily D member 1 gene (ABCD1) were ascertained in 516 unrelated patients with ataxia. The patients were categorized into three groups: molecularly unassigned hereditary ataxia (n = 118), sporadic ataxia with autonomic dysfunctions (n = 296), and sporadic ataxia without autonomic dysfunctions (n = 102)...
2017: PloS One
https://www.readbyqxmd.com/read/28424054/an-unusual-delusion-of-duplication-in-a-patient-affected-by-dementia-with-lewy-bodies
#19
Paolo Solla, Gioia Mura, Antonino Cannas, Gianluca Floris, Davide Fonti, Gianni Orofino, Mauro Giovanni Carta, Francesco Marrosu
BACKGROUND: Dementia with Lewy bodies (DLB) is the second most frequent diagnosis of progressive degenerative dementia in older people. Delusions are common features in DLB and, among them, Capgras syndrome represents the most frequent disturbance, characterized by the recurrent and transient belief that a familiar person, often a close family member or caregiver, has been replaced by an identical-looking imposter. However, other delusional conditions near to misidentification syndromes can occur in DLB patients and may represent a major psychiatric disorder, although rarely studied systematically...
April 19, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28289629/neurocognitive-dysfunction-according-to-hypoperfusion-territory-in-patients-with-moyamoya-disease
#20
Chang Gu Kang, Min Ho Chun, Jung-A Kang, Kyung Hee Do, Su Jin Choi
OBJECTIVE: To demonstrate the prevalence of cerebral hypoperfusion without focal cerebral lesions in patients with Moyamoya disease (MMD), and the relationship between areas of hypoperfusion and cognitive impairment. METHODS: Twenty-six MMD patients were included. Patients were categorized according to the presence/absence of hypoperfusion in the frontal, parietal, temporal, and occipital lobes on brain single-photon-emission computed tomography (SPECT) after acetazolamide challenge...
February 2017: Annals of Rehabilitation Medicine
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