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JOURNAL ARTICLE
Thijs van Dalen, Jessica F Kirkham, Aswin Chari, Felice D'Arco, Friederike Moeller, Christin Eltze, J Helen Cross, Martin M Tisdall, Rachel C Thornton
OBJECTIVE: The objective was to analyze seizure semiology in pediatric frontal lobe epilepsy patients, considering age, to localize the seizure onset zone for surgical resection in focal epilepsy. METHODS: Fifty patients were identified retrospectively, who achieved seizure freedom after frontal lobe resective surgery at Great Ormond Street Hospital. Video-electroencephalography recordings of preoperative ictal seizure semiology were analyzed, stratifying the data based on resection region (mesial or lateral frontal lobe) and age at surgery (≤4 vs >4)...
April 16, 2024: Annals of Neurology
#22
JOURNAL ARTICLE
Maurice Pasternak, Saira S Mirza, Nicholas Luciw, Henri J M M Mutsaerts, Jan Petr, David Thomas, David Cash, Martina Bocchetta, Maria Carmela Tartaglia, Sara B Mitchell, Sandra E Black, Morris Freedman, David Tang-Wai, Ekaterina Rogaeva, Lucy L Russell, Arabella Bouzigues, John C van Swieten, Lize C Jiskoot, Harro Seelaar, Robert Laforce, Pietro Tiraboschi, Barbara Borroni, Daniela Galimberti, James B Rowe, Caroline Graff, Elizabeth Finger, Sandro Sorbi, Alexandre de Mendonça, Chris Butler, Alex Gerhard, Raquel Sanchez-Valle, Fermin Moreno, Matthis Synofzik, Rik Vandenberghe, Simon Ducharme, Johannes Levin, Markus Otto, Isabel Santana, Antonio P Strafella, Bradley J MacIntosh, Jonathan D Rohrer, Mario Masellis
INTRODUCTION: Effective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD). We investigate the utility of cerebral perfusion as one such biomarker in presymptomatic FTD mutation carriers. METHODS: We investigated longitudinal profiles of cerebral perfusion using arterial spin labeling magnetic resonance imaging in 42 C9orf72, 70 GRN, and 31 MAPT presymptomatic carriers and 158 non-carrier controls...
April 16, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#23
JOURNAL ARTICLE
Nuria Campora, Juan Pablo Princich, Alejandro Nasimbera, Santiago Cordisco, Manuela Villanueva, Silvia Oddo, Brenda Giagante, Silvia Kochen
The loss of consciousness (LOC) during seizures is one of the most striking features that significantly impact the quality of life, even though the neuronal network involved is not fully comprehended. We analyzed the intracerebral patterns in patients with focal drug-resistant epilepsy, both with and without LOC. We assessed the localization, lateralization, stereo electroencephalography (SEEG) patterns, seizure duration, and the quantification of contacts exhibiting electrical discharge. The degree of LOC was quantified using the Consciousness Seizure Scale...
2024: Neuroscience of Consciousness
#24
Vibha Viswanathan, Kyle M Rupp, Jasmine L Hect, Emily E Harford, Lori L Holt, Taylor J Abel
UNLABELLED: Prior lesion, noninvasive-imaging, and intracranial-electroencephalography (iEEG) studies have documented hierarchical, parallel, and distributed characteristics of human speech processing. Yet, there have not been direct, intracranial observations of the latency with which regions outside the temporal lobe respond to speech, or how these responses are impacted by task demands. We leveraged human intracranial recordings via stereo-EEG to measure responses from diverse forebrain sites during (i) passive listening to /bi/ and /pi/ syllables, and (ii) active listening requiring /bi/-versus-/pi/ categorization...
April 5, 2024: bioRxiv
#25
JOURNAL ARTICLE
Li-Na Wang, Shuo Lin, Lu Tian, Han Wu, Wen-Qing Jin, Wen Wang, Wei-Gang Pan, Chun-Lin Yang, Yan-Ping Ren, Xin Ma, Yi-Lang Tang
BACKGROUND: Previous studies have documented thalamic functional connectivity (FC) abnormalities in schizophrenia, typically examining the thalamus as a whole. The specific link between subregional thalamic FC and cognitive deficits in first-episode schizophrenia (FES) remains unexplored. METHODS: Using data from resting-state functional magnetic resonance imaging, we compared whole-brain FC with thalamic subregions between patients and HCs, and analyzed FC changes in drug-naïve patients separately...
April 2, 2024: Asian Journal of Psychiatry
#26
JOURNAL ARTICLE
Isabelle Anne-Claire Périard, Angelika Margarete Dierolf, Annika Lutz, Claus Vögele, Ulrich Voderholzer, Stefan Koch, Michael Bach, Carina Asenstorfer, Gilles Michaux, Vera-Christina Mertens, André Schulz
Cardinal characteristics of somatoform disorders (SFDs) are worry of illness, and impaired affective processing. We used relative frontal alpha asymmetry (FAA), a method to measure functional lateralization of affective processing, to investigate psychobiological correlates of SFDs. With alpha activity being inversely related to cortical network activity, relative FAA refers to alpha activity on the right frontal lobe minus alpha activity on the left frontal lobe. Less relative left frontal activity, reflected by negative FAA scores, is associated with lower positive and greater negative affectivity, such as observed in depression...
April 11, 2024: International Journal of Psychophysiology
#27
JOURNAL ARTICLE
Fangfang Chen, Yuchuan Fu, Biqiu Tang, Bo Tao, Yu Wang, Yinyin Huang, Tao Chen, Chenyi Yu, Changcan Jiang, Su Lui, Xiaohong Cai, Yi Lu, Zhihan Yan
OBJECTIVES: The study aimed to explore the underlying mechanisms of OSA-related cognitive impairment by investigating the altered topology of brain white matter networks in children with OSA. METHODS: Graph theory was used to examine white matter networks' network topological properties in 46 OSA and 31 non-OSA children. All participants underwent MRI, polysomnography, and cognitive testing. The effects of the obstructive apnea-hypopnea index (OAHI) on topological properties of white matter networks and network properties on cognition were studied using hierarchical linear regression...
April 3, 2024: Sleep Medicine
#28
JOURNAL ARTICLE
Xin He, Sheng Qin, Genfa Yu, Songxing Zhang, Fengping Yi
Dalbergia pinnata (Lour.) Prain ( D. pinnata ) is a valuable medicinal plant, and its volatile parts have a pleasant aroma. In recent years, there have been a large number of studies investigating the effect of aroma on human performance. However, the effect of the aroma of D. pinnata on human psychophysiological activity has not been reported. Few reports have been made about the effects of aroma and sound on human electroencephalographic (EEG) activity. This study aimed to investigate the effects of D. pinnata essential oil in EEG activity response to various auditory stimuli...
April 2, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#29
JOURNAL ARTICLE
Stéphane Dufau, Jeremy Yeaton, Jean-Michel Badier, Sophie Chen, Phillip J Holcomb, Jonathan Grainger
When a sequence of written words is briefly presented and participants are asked to identify just one word at a post-cued location, then word identification accuracy is higher when the word is presented in a grammatically correct sequence compared with an ungrammatical sequence. This sentence superiority effect has been reported in several behavioral studies and two EEG investigations. Taken together, the results of these studies support the hypothesis that the sentence superiority effect is primarily driven by rapid access to a sentence-level representation via partial word identification processes that operate in parallel over several words...
April 9, 2024: Neuropsychologia
#30
JOURNAL ARTICLE
Hou Xueyan, Ai Qi, Song Chunming, Zhi Yu, Weng Wencai
PURPOSE: To explore white matter network topological properties changes in middle-aged and elderly patients with functional constipation (Functional Constipation, FC) by diffusion tensor imaging (DTI), and to evaluate the correlation between the abnormal changes and clinical data. METHODS: 29 FC patients and 31 age- and sex-matched healthy controls (HC) were recruited. Magnetic resonance imaging and clinical data were collected. The white matter network changes in FC patients were analyzed using deterministic fiber tracking methods, graph theory algorithms, and partial correlation analysis with clinical data...
2024: Frontiers in Neurology
#31
JOURNAL ARTICLE
Karin Persson, Maria L Barca, Trine Holt Edwin, Lena Cavallin-Eklund, Gro Gujord Tangen, Hanneke F M Rhodius-Meester, Geir Selbæk, Anne-Brita Knapskog, Knut Engedal
BACKGROUND AND PURPOSE: The aims were to compare the novel regional brain volumetric measures derived by the automatic software NeuroQuant (NQ) with clinically used visual rating scales of medial temporal lobe atrophy (MTA), global cortical atrophy-frontal (GCA-f), and posterior atrophy (PA) brain regions, assessing their diagnostic validity, and to explore if combining automatic and visual methods would increase diagnostic prediction accuracy. METHODS: Brain magnetic resonance imaging (MRI) examinations from 86 patients with subjective and mild cognitive impairment (i...
February 2024: Brain and Behavior
#32
Athena Huynh, Collin Pryma, Heather McPhaden, Karl-Christopher Yared, Yilin Zhang, Katie Beadon, Tony Ng, Luke Y C Chen
A 52-year-old woman with no significant medical history was referred to our hospital for expedited workup of progressive dysarthria and ataxia over the past year. Prior CT angiography of the head and neck showed no relevant neurologic findings but did reveal miliary lesions in the lung apices, which was later confirmed via dedicated CT chest scan (Fig 1). Review of systems was negative for any respiratory, constitutional, or rheumatologic symptoms, except for new xanthelasma-like lesions over her forehead. She previously had smoked with 20 pack-years and had no TB risk factors...
April 2024: Chest
#33
JOURNAL ARTICLE
Tsz-Kit Chow, Kwok-Man Ma
Progressive supranuclear palsy (PSP) is the most prevalent form of degenerative atypical parkinsonism. Clinical manifestations of PSP commonly encompass deficits in vertical gaze, postural stability, akinesia, and cognitive impairment. The characteristic metabolic pattern observed in PSP through FDG PET displays hypometabolism in the midbrain, striatum, thalamus, and frontal lobe. However, visual interpretation of midbrain hypometabolism poses challenges. In this report, we aim to elucidate a novel observation termed the "loss of Mickey Mouse ears' sign," which signifies midbrain hypometabolism as detected through visual assessment of FDG PET images...
April 8, 2024: Clinical Nuclear Medicine
#34
JOURNAL ARTICLE
Alma Ghirelli, Edoardo Gioele Spinelli, Elisa Canu, Silvia Basaia, Veronica Castelnovo, Giordano Cecchetti, Elisa Sibilla, Teuta Domi, Giuseppe Magnani, Francesca Caso, Paola Caroppo, Sara Prioni, Cristina Villa, Giacomina Rossi, Lucio Tremolizzo, Ildebrando Appollonio, Federico Verde, Nicola Ticozzi, Vincenzo Silani, Massimo Filippi, Federica Agosta
BACKGROUND: Semantic behavioral variant frontotemporal dementia (sbvFTD) is a neurodegenerative condition presenting with specific behavioral and semantic derangements and predominant atrophy of the right anterior temporal lobe (ATL). The objective was to evaluate clinical, neuropsychological, neuroimaging, and genetic features of an Italian sbvFTD cohort, defined according to recently proposed guidelines, compared to semantic variant primary progressive aphasia (svPPA) and behavioral variant FTD (bvFTD) patients...
April 10, 2024: Journal of Neurology
#35
JOURNAL ARTICLE
Jinxin Bu, Nanxiao Ren, Yonglu Wang, Ran Wei, Rui Zhang, Haitao Zhu
Epilepsy is a disorder of brain networks, that is usually combined with cognitive and emotional impairment. However, most of the current research on closed-loop pathways in epilepsy is limited to the neuronal level or has focused only on known closed-loop pathways, and studies on abnormalities in closed-loop pathways in epilepsy at the whole-brain network level are lacking. A total of 26 patients with magnetic resonance imaging-negative pharmacoresistant epilepsy (MRIneg-PRE) and 26 healthy controls (HCs) were included in this study...
April 9, 2024: Brain Imaging and Behavior
#36
JOURNAL ARTICLE
Aysha Gomaa, Chemindra Biyanwila, Mansi Jantre
A previously healthy man in his 60s presents with a one-day history of insidious onset headache and 'walking into doors'. He reported transient right arm pain and tingling but no weakness. A CT brain showed a right middle cerebral artery (MCA) infarct as well as a synchronous right frontal lobe convexal subarachnoid haemorrhage (cSAH). An arch to vertex CT angiogram demonstrated right MCA occlusion and complete right internal carotid artery (ICA) occlusion from its origin. Reconstitution of flow was seen within the distal right ICA at the level of the distal foramen lacerum...
April 8, 2024: BMJ Case Reports
#37
JOURNAL ARTICLE
Harsimran Panesar, Mai Hatazaki, Yevgenia Shekhtman
A woman in her late 50s with a left frontal lobe convexity meningioma underwent an elective endovascular embolisation of the left middle meningeal artery and distal branches of the left superficial temporal artery prior to surgical resection of the tumour. On postoperative day 46, she developed scalp necrosis, leading to poor wound healing requiring wound debridement and a complex plastic surgery reconstruction with a rotational flap. Endovascular embolisation of vascular tumours prior to surgical resection does not come without risks...
April 8, 2024: BMJ Case Reports
#38
JOURNAL ARTICLE
Anne-Mari Holte Flusund, Lars Eirik Bø, Ingerid Reinertsen, Ole Solheim, Toril Skandsen, Asta Kristine Håberg, Nada Andelic, Anne Vik, Kent Gøran Moen
Traumatic axonal injury (TAI) is a common finding on MRI in patients with moderate - severe traumatic brain injury (TBI), and the burden of TAI is associated with outcome in this patient group. Lesion mapping offers a way to combine imaging findings from numerous individual patients into common lesion maps where the findings from a whole patient cohort can be assessed. The aim of this study was to evaluate the spatial distribution of traumatic axonal injury (TAI) lesions on different MRI sequences and its associations to outcome with use of lesion mapping...
April 8, 2024: Journal of Neurotrauma
#39
JOURNAL ARTICLE
Junyan Liu, Shigenori Kanno, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Kazuto Katsuse, Shiho Matsubara, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-Ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Shunji Mugikura, Kyoko Suzuki
OBJECTIVE: To investigate the prevalence and intensity of grasp reflexes and to examine changes in these reflexes after shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH). METHODS: We enrolled 147 patients with probable iNPH. A standard procedure was used to determine the presence of grasp reflexes, and the intensity of these reflexes was assessed using a four-category classification. Clinical rating scales and their correlation with grasp reflexes were also evaluated...
April 8, 2024: Journal of Neurology
#40
Keita Tamada, Hiroki Sato, Satoshi Iihoshi, Yukihiro Imaoka, Shinichiro Yoshikawa, Hiroki Kurita, Shinya Kohyama
An 85-year-old female with situs inversus totalis presented with right hemiplegia, right facial nerve palsy, eye deviation to the left, and aphasia. Magnetic resonance imaging revealed acute ischemic lesions in the left insular cortex and the frontal lobe. Magnetic resonance angiography revealed an occlusion of the left internal carotid artery. Reversed-image mechanical thrombectomy achieved complete reperfusion in three passes within 54 minutes. Six months post-intervention, the patient could walk indoors independently...
March 2024: Curēus
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