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https://www.readbyqxmd.com/read/28188210/management-of-oral-secretions-in-neurological-disease
#1
REVIEW
Alexander J McGeachan, Christopher J Mcdermott
Sialorrhoea is a common and problematic symptom that arises from a range of neurological conditions associated with bulbar or facial muscle dysfunction. Drooling can significantly affect quality of life due to both physical complications such as oral chapping, and psychological complications such as embarrassment and social isolation. Thicker, tenacious oral and pharyngeal secretions may result from the drying management approach to sialorrhoea. The management of sialorrhoea in neurological diseases depends on the underlying pathology and severity of symptoms...
February 10, 2017: Practical Neurology
https://www.readbyqxmd.com/read/28168747/double-paddle-peroneal-flap-for-extensive-lip-defect-reconstruction
#2
Ying-Sheng Lin, Wen-Chung Liu, Yaoh-Shiang Lin, Lee-Wei Chen, Jung-Hua Hsueh, Kuo-Chung Yang
INTRODUCTION: Today, reconstructive surgeons offer an array of options to reconstruct the lip defects. Herein we present our experience of using free double-paddle peroneal flaps for extensive lip defect reconstruction. PATIENTS AND METHODS: From 1996 to 2014, 16 patients with extensive lip defects after tumor ablation were included. Free double-paddle peroneal flaps were used for reconstructions. In terms of flap design, one skin paddle superiorly placed on the lateral lower leg was used to reconstruct intraoral defects, whereas the other was inferiorly located and was used to reconstruct extraoral defects...
February 7, 2017: Microsurgery
https://www.readbyqxmd.com/read/28166999/unresolved-drooling-in-a-previously-healthy-child-caused-by-a-brainstem-malignancy
#3
Fenella Shelton, Eleanor Sproson, Jana Van der Veen, Hazel Evans, Andrea Burgess, Hasnaa Ismail-Koch
Drooling occurs commonly in children below the age of two. In a small group of children this persists and an otorhinolaryngology consultation is sought. In children with no neurological abnormality or comorbidity, reassurance and behavioural management is often suggested. We present a case where drooling was the presenting feature of brain stem malignancy. Diagnosis was suggested following a sleep study demonstrating central apnoeas. Magnetic resonance imaging (MRI) showed an intra-axial brainstem tumour. This case highlights the importance of multidisciplinary team (MDT) management of children with persistent drooling of unknown cause...
March 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28151491/clinical-and-molecular-consequences-of-disease-associated-de-novo-mutations-in-satb2
#4
Hemant Bengani, Mark Handley, Mohsan Alvi, Rita Ibitoye, Melissa Lees, Sally Ann Lynch, Wayne Lam, Madeleine Fannemel, Ann Nordgren, H Malmgren, M Kvarnung, Sarju Mehta, Shane McKee, Margo Whiteford, Fiona Stewart, Fiona Connell, Jill Clayton-Smith, Sahar Mansour, Shehla Mohammed, Alan Fryer, Jenny Morton, Detelina Grozeva, Tara Asam, David Moore, Alejandro Sifrim, Jeremy McRae, Matthew E Hurles, Helen V Firth, F Lucy Raymond, Usha Kini, Christoffer Nellåker, Ddd Study, David R FitzPatrick
PURPOSE: To characterize features associated with de novo mutations affecting SATB2 function in individuals ascertained on the basis of intellectual disability. METHODS: Twenty previously unreported individuals with 19 different SATB2 mutations (11 loss-of-function and 8 missense variants) were studied. Fibroblasts were used to measure mutant protein production. Subcellular localization and mobility of wild-type and mutant SATB2 were assessed using fluorescently tagged protein...
February 2, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28145196/recognition-and-management-of-foreign-body-ingestion-and-aspiration
#5
Oliver William McKinney, Paul Anthony Heaton, Jane Gamble, Siba Prosad Paul
Foreign body ingestion and foreign body aspiration commonly affect children. The most vulnerable age is between six months and four years, when children tend to explore new objects with their mouths. Many of these events remain asymptomatic, with the swallowed object passing through the gastrointestinal tract without causing harm. However, the frequency of serious complications as a result of the ingestion of hazardous objects has increased in recent years, in particular button batteries and magnets. To increase the likelihood of identifying foreign body ingestion and aspiration, healthcare professionals should maintain a high index of suspicion, be aware of the variation in presentations and include it as a differential diagnosis in children presenting with non-specific symptoms, such as fever, cough, drooling, dysphagia and abdominal pain...
February 1, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28141712/significant-sleep-dysregulation-in-a-toddler-with-developmental-delay
#6
Martin T Stein, Judith Owens, Myles Abbott
Derrick's parents made an appointment with a new pediatrician for a second opinion about disordered sleep. Now 22-months old, he was evaluated at 18 months of age for developmental delay when he was found to have "a regulatory disorder associated with delays in language and motor development, hypotonia and significant sleep problems." The parents are now most concerned about his sleeping pattern. Prolonged sleep onset and frequent night awaking occur each night since 6-months of age. These problems are more severe in the past few months when he awakes screaming and cannot be settled...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28120594/a-15-month-old-boy-with-respiratory-distress-and-parapharyngeal-abscess-a-case-report
#7
Behdad Gharib, Masoud Mohammadpour, Meisam Sharifzadeh, Fatemeh Mirashrafi, Bahareh Yaghmaie, Neda Pak, Mehrzad Mehdizadeh, Hamid Eshaghi, Mojtaba Gorji, Sara Memarian
Parapharyngeal abscess is a life-threatening disease. Upper respiratory tract infection is the main cause in children. We present a 15-month-old boy admitted to the emergency ward with the chief complaint of difficulty in breathing caused by parapharyngealabscess. His condition deteriorated gradually, and he transferred to the operation theater quickly for abscess drainage and because of the difficulty in orotracheal intubation; a tracheostomy was performed. His respiratory condition deteriorated 2 days after PICU admission, and the medical team noticed an unexplainable respiratory distress...
December 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/28099276/factors-in-the-efficacy-safety-and-impact-on-quality-of-life-for-treatment-of-drooling-with-botulinum-toxin-type-a-in-patients-with-cerebral-palsy
#8
Maria D Gonzalez-L, Carmen Martinez, Inma Bori Y Fortuny, Santiago Suso-Vergara
OBJECTIVE: To assess the efficacy and safety of botulinum toxin A (BoNT-A) injected in both submandibular and parotid versus only in parotid glands as a treatment for drooling in patients with spastic and dyskinetic cerebral palsy (CP), including an assessment of impact on quality of life (QoL) based on items from the International Classification of Functioning, Disability, and Health (ICF) core set. DESIGN: Forty patients with CP 18 years or older (mean, 21.8 years) participated in a prospective, single-center, randomized controlled interventional study...
February 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28081026/the-effect-of-nebulized-glycopyrrolate-on-posterior-drooling-in-patients-with-brain-injury-two-cases-of-different-brain-lesions
#9
Zee-Ihn Lee, Kwang Jae Yu, Dae Hee Lee, Seong Kyung Hong, Seung Beom Woo, Jong Min Kim, Donghwi Park
Posterior drooling, which can lead to substantial respiratory morbidity, including unexplained lung diseases and recurrent pneumonia, is an important issue in the rehabilitation unit. There are various treatment options for posterior drooling, including pharmacologic therapy, oral motor or behavioral therapy, biofeedback, local glandular injection of botulinum toxin, irradiation, and surgery. Among them, nebulized glycopyrrolate has the following advantages: It is noninvasive and is relatively free of central adverse effects because it does not cross the blood-brain barrier unlike other anticholinergics...
January 9, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28059928/clozapine-usage-increases-the-incidence-of-pneumonia-compared-with-risperidone-and-the-general-population-a-retrospective-comparison-of-clozapine-risperidone-and-the-general-population-in-a-single-hospital-over-25-months
#10
Zachary R Stoecker, Wales T George, Jeffrey B O'Brien, Jon Jancik, Eduardo Colon, Joseph J Rasimas
The aim of this study was to determine whether the incidence of pneumonia in patients taking clozapine was more frequent compared with those taking risperidone or no atypical antipsychotics at all before admission to a tertiary care medical center. This was a retrospective, case-matched study of 465 general medicine patients over a 25 month period from 1 July 2010 to 31 July 2012. Detailed electronic medical records were analyzed to explore the association between the use of two atypical antipsychotics and incidence of pneumonia...
January 4, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28009048/management-of-drooling-in-neurological-disabilities-more-evidence-is-needed
#11
Dinah Reddihough
No abstract text is available yet for this article.
December 23, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28008396/esophageal-foreign-body-a-case-report-of-a-refractory-croup-in-a-20-month-old-boy
#12
Sevil Nasirmohtaram, Nooshin Shabani
INTRODUCTION: Foreign body ingestion is common among children and more common in boys and in children under the age of 3. It can present with a wide variety of symptoms like dysphagia and drooling or symptoms related to the upper aerodigestive tract. CASE REPORT: A 20-month-old male presented with refractory croup and poor feeding since 2 weeks. Bronchoscopy and esophagoscopy was performed due to suspicious history of eating loquat. The core of the fruit was found in the esophagus...
November 2016: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28005741/two-thirds-lip-defects-a-new-combined-reconstructive-technique-for-patients-with-epithelial-cancer
#13
Tiziana Vitagliano, Lucia Stella Curto, Antonio Greto Ciriaco, Pietro Gareri, Diego Ribuffo, Manfredi Greco
BACKGROUND: The lips are a common site prone to squamous cell carcinomas, which arise in the facial region. There are different techniques to reconstruct the excised lip region, according to dimensions, area, and position of the tumor. The authors describe a new technique of lip reconstruction born from a combination between a nasolabial flap and adipose tissue transplant. METHODS: The study was lead in the Plastic and Reconstructive Surgery Department of the University of Catanzaro...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27997348/relationship-between-plasma-and-salivary-melatonin-and-cortisol-investigated-by-lc-ms-ms
#14
Martijn van Faassen, Rainer Bischoff, Ido P Kema
BACKGROUND: Disturbance of the circadian rhythm has been associated with disease states, such as metabolic disorders, depression and cancer. Quantification of the circadian markers such as melatonin and cortisol critically depend on reliable and reproducible analytical methods. Previously, melatonin and cortisol were primarily analyzed separately, mainly using immunoassays. METHODS: Here we describe the validation and application of a high-throughput liquid chromatography in combination with mass spectrometry (LC-MS/MS) method for the combined analysis of melatonin and cortisol in plasma and saliva...
December 20, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27993522/non-motor-symptoms-and-the-quality-of-life-in-multiple-system-atrophy-with-different-subtypes
#15
LingYu Zhang, Bei Cao, RuWei Ou, Qian-Qian Wei, Bi Zhao, Jing Yang, Ying Wu, HuiFang Shang
BACKGROUND: The differences in non-motor symptoms (NMS) and quality of life (QOL) between MSA patients with different subtypes remain unknown, so do the determinants of poor QOL in both subtypes. METHODS: A total of 172 MSA patients were enrolled in the study. NMS of patients with MSA were assessed using the non-motor symptoms scale (NMSS) and Parkinson's Disease Questionnaire-39 item version (PDQ-39) was used to evaluate the QOL of patients with MSA. RESULTS: The most prevalent NMS domain was urinary (91...
December 13, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27973693/reliability-and-validity-of-a-tool-to-measure-the-severity-of-tongue-thrust-in-children-the-tongue-thrust-rating-scale
#16
Selen Serel Arslan, Numan Demir, Aynur Ayşe Karaduman
OBJECTIVE(S): This study aimed to develop a scale called Tongue Thrust Rating Scale (TTRS), which categorized tongue thrust in children in terms of its severity during swallowing, and to investigate its validity and reliability. METHODS: The study describes the developmental phase of the TTRS and presented its content and criterion-based validity and inter-observer and intra-observer reliability. For content validation, seven experts assessed the steps in the scale over two Delphi rounds...
December 14, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27901263/negative-effects-of-submandibular-botulinum-neurotoxin-a-injections-on-oral-motor-function-in-children-with-drooling-due-to-central-nervous-system-disorders
#17
Karen van Hulst, Carlyn V Kouwenberg, Pieter H Jongerius, Ton Feuth, Franciscus J A van den Hoogen, Alexander C H Geurts, Corrie E Erasmus
AIM: The aims of this study were: (1) to determine the incidence and nature of adverse effects on oral motor function after first injections of botulinum neurotoxin A (BoNT-A) in submandibular glands for excessive drooling in children with central nervous system disorders; and (2) to identify independent predictors of these adverse effects. METHOD: A cohort study involved 209 children (123 males, 86 females, aged 4-27y, median 8y 4mo), who received submandibular BoNT-A injections for drooling...
November 30, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27879418/histopathologic-effects-of-onabotulinum-toxin-a-treatment-in-pediatric-submandibular-glands
#18
Ashley Mosseri, Isabel Cardona, Miriam Blumenkrantz, Sam J Daniel
Onabotulinum toxin A (OBTXA) is an effective treatment for drooling. Our objective was to determine if there are histologic changes in the submandibular glands (SMGs) after repetitive OBTXA injections. The study included blinded histologic analysis and comparison of SMGs with ≥4 OBTXA injections versus controls who never received OBTXA. The number of acinar cells were counted, and the morphology of the cells was evaluated within each histologic sample of the SMGs. Thirty-one glands were analyzed (14 control, 17 cases)...
February 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27814442/botulinum-toxin-in-the-management-of-sialorrhoea-in-acquired-brain-injury
#19
A Carrol, B McGlone
Sialorrhoea as a consequence of severe acquired brain injury can significantly negatively impact on quality of life. Medications used in its management have many side effects which can cause problems in the severely disabled. Botulinum toxin is an effective treatment of sialorrhoea in a number of neurological conditions but may also have a role to play in the management of sialorrhoea following severe ABI. We report on 4 cases of sialorrhoea following acquired brain injury causing a variety of problems, whose parotid glands were injected with Botulinum toxin type A (Dysport) 50mu each, under ultrasound guidance...
June 10, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27771258/development-and-validation-of-a-sensitive-and-selective-lc-ms-ms-method-for-determination-of-tacrolimus-in-oral-fluids
#20
Mwlod Ghareeb, Fatemeh Akhlaghi
Tacrolimus is a commonly used immunosuppressive agent in organ transplant recipients. Therapeutic drug monitoring (TDM) of tacrolimus is essential to adjust the dose and achieve optimal immunosuppression level. Routine TDM is practiced using whole blood samples obtained through venipuncture. However, tacrolimus concentration that is present in oral fluid (OF) can theoretically represent the free or pharmacologically active form of tacrolimus. In this study, we report the development and validation of a rapid, sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantification of tacrolimus in OF...
December 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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