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https://www.readbyqxmd.com/read/29330784/tacrolimus-concentration-in-saliva-of-kidney-transplant-recipients-factors-influencing-the-relationship-with-whole-blood-concentrations
#1
Mwlod Ghareeb, Reginald Y Gohh, Fatemeh Akhlaghi
OBJECTIVE: The objective of this study was to examine the association between tacrolimus concentration in oral fluids and in whole blood and to investigate the various factors that influence this relationship. PATIENTS AND METHODS: Forty-six adult kidney transplant recipients were included in the study. Study A (ten patients) included the collection of several paired oral fluid samples by passive drool over a 12-h post-dose period. Study B (36 patients) included the collection of oral fluids pre-dose and at 2 h after the tacrolimus dose under three conditions: un-stimulated, after stimulation with a tart candy, and after mouth rinsing...
January 12, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29315470/motor-subtypes-and-other-risk-factors-associated-with-drooling-in-parkinson-s-disease-patients
#2
C J Mao, Y T Xiong, F Wang, Y P Yang, W Yuan, C Zhu, J Chen, C F Liu
OBJECTIVE: To explore the relationship between motor subtypes and drooling, and other risk factors associated with drooling in a large cohort of Chinese patients with Parkinson's disease (PD). METHODS: A total of 586 PD patients were enrolled in this study. Unified Parkinson's disease rating scale (UPDRS) and Hoehn & Yahr stage (H & Y stage) scale, Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Hamilton Rating Scale for Depression-24 item (HRSD), and Mini-Mental State Examination (MMSE) were applied to all subjects...
January 9, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29285473/mother-s-work-status-on-children-s-bruxism-in-a-subset-of-saudi-population
#3
Rana Alouda, Maram Alshehri, Shoog Alnaghmoosh, Maryam Shafique, May Wathiq Al-Khudhairy
Aims and Objectives: The aims and objectives of this study were to determine if an association exists between mothers work status and her children's incidence of bruxism and habits related to bruxism. Materials and Methods: A cross-sectional study was conducted through data collection of a questionnaire answered by 561 mothers' about their working status and their child's habits and behaviors. The survey consisted of 5 parts with a total of 34 questions: mother's information, child's behavior, child's sleeping pattern, mother's knowledge about bruxism, and child's medical history...
November 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29285470/oral-health-status-among-children-with-cerebral-palsy-in-dubai-united-arab-emirates
#4
Haifa Al Hashmi, Mawlood Kowash, Amar Hassan, Manal Al Halabi
Objectives: The purpose of this study was to assess the oral health status of children with cerebral palsy (CP) in Dubai, United Arab Emirates (UAE). Materials and Methods: Eighty-four CP and 125 healthy children were recruited from special needs centers and private/public schools in Dubai. A dental examination for decayed-missing-filled teeth in primary dentition (dmft)/Decayed-Missing-Filled teeth in permanent dentition (DMFT) indices, simplified oral hygiene index, calculus index (CI), and oral debris index was conducted...
November 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29224753/castillo-morales-appliance-therapy-in-the-treatment-of-drooling-children
#5
Silvia Marinone, Wanda Gaynor, James Johnston, Murali Mahadevan
OBJECTIVE: To evaluate the efficacy of Castillo Morales Appliance Therapy (CMAT) in reducing the severity and frequency of problematic drooling in children. METHODS: A de-identified extraction of all hospital morbidity records belonging to patients with drooling who underwent treatment with CMAT was performed between June 22, 2000 and April 12, 2016. Data were obtained from Starship Children's Hospital clinical records department. Demographic, diagnostic, and procedural data were included...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29205472/progressive-deafness-dystonia-due-to-serac1-mutations-a-study-of-67-cases
#6
Saskia B Wortmann, Katarzyna Iwanicka-Pronicka, Sema Kalkan Ucar, Bader Alhaddad, Moeenaldeen AlSayed, Mohammed A Al-Owain, Hamad I Al-Zaidan, Shanti Balasubramaniam, Ivo Barić, Dalal Bubshait, Alberto Burlina, John Christodoulou, Wendy K Chung, Roberto Colombo, Niklas Darin, Peter Freisinger, Maria Teresa Garcia Silva, Stephanie Grunewald, Tobias B Haack, Peter M van Hasselt, Omar Hikmat, Friederike Hörster, Pirjo Isohanni, Khushnooda Ramzan, Reka Kovacs-Nagy, Zita Krumina, Elena Martin-Hernandez, Johannes A Mayr, Patricia McClean, Linda De Meirleir, Karin Naess, Lock H Ngu, Magdalena Pajdowska, Shamima Rahman, Gillian Riordan, Lisa Riley, Benjamin Roeben, Frank Rutsch, Rene Santer, Manuel Schiff, Martine Seders, Silvia Sequeira, Wolfgang Sperl, Christian Staufner, Matthis Synofzik, Robert W Taylor, Joanna Trubicka, Konstantinos Tsiakas, Ozlem Unal, Evangeline Wassmer, Yehani Wedatilake, Toni Wolff, Holger Prokisch, Eva Morava, Ewa Pronicka, Ron A Wevers, Arjan P de Brouwer, Roeltje R Maas
OBJECTIVE: 3-MEthylGlutaconic aciduria, Dystonia-Deafness, Hepatopathy, Encephalopathy, Leigh-like syndrome (MEGDHEL) syndrome is caused by biallelic variants in SERAC1. METHODS: Multi centre study concerning the course of disease for each organ system, together with metabolic, neuroradiological and genetic findings. RESULTS: 67 individuals (39 previously unreported) from 59 families were included (age range 5 days - 33.4 years, median age 9 years)...
December 2, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29192000/drooling-reduction-intervention-randomised-trial-dri-comparing-the-efficacy-and-acceptability-of-hyoscine-patches-and-glycopyrronium-liquid-on-drooling-in-children-with-neurodisability
#7
Jeremy R Parr, Emma Todhunter, Lindsay Pennington, Deborah Stocken, Jill Cadwgan, Anne E O'Hare, Catherine Tuffrey, Jane Williams, Mike Cole, Allan F Colver
OBJECTIVE: Investigate whether hyoscine patch or glycopyrronium liquid is more effective and acceptable to treat drooling in children with neurodisability. DESIGN: Multicentre, single-blind, randomised controlled trial. SETTING: Recruitment through neurodisability teams; treatment by parents. PARTICIPANTS: Ninety children with neurodisability who had never received medication for drooling (55 boys, 35 girls; median age 4 years)...
November 30, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29179990/snakebite-by-micrurus-averyi-schmidt-1939-in-the-brazilian-amazon-basin-case-report-coral-snakebite-by-micrurus-averyi
#8
REVIEW
Iran Mendonça da Silva, Jorge Contreras Bernal, Pedro Ferreira Gonçalves Bisneto, Antônio Magela Tavares, Valéria Mourão de Moura, Claudio S Monteiro-Junior, Rima Raad, Paulo Sergio Bernarde, Jacqueline de Almeida Gonçalves Sachett, Wuelton Marcelo Monteiro
Micrurus snakes, commonly known as coral snakes, are responsible for 0.4% of the snakebites envenomings in Brazil. In this report, we describe a case of envenoming by Micrurus averyi, the black-headed coral snake, recorded in the western Brazilian Amazon. To the best of our knowledge, this is the first published case perpetrated by this species. The major complaint of the patient was an intense local pain and paresthesia. Examination of the bite site revealed edema extending from the left foot up the left leg that was accompanied by erythema involving the foot and distal third of the leg...
November 24, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29178420/drooling-is-no-early-sign-of-dysphagia-in-parkinson-s-disease
#9
J C Nienstedt, C Buhmann, M Bihler, A Niessen, R Plaetke, C Gerloff, C Pflug
BACKGROUND: Dysphagia is frequent and clinically highly relevant in Parkinson's disease (PD). For a rational dysphagia screening predictors are required. Previous investigations suggested that drooling correlates with dysphagia and may serve as its early sign. The aim of this study was to clarify the interrelationship of drooling and dysphagia. METHODS: In a controlled, cross-sectional, observational study, a total of 119 Parkinson outpatients and 32 controls were examined clinically and by flexible-endoscopic evaluation of swallowing (FEES)...
November 27, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29084070/utility-of-soft-tissue-lateral-neck-radiographs-in-the-emergency-department-the-5-year-experience-of-a-large-tertiary-care-pediatric-hospital
#10
Tais Sao Pedro, Dennis Scolnik, Jeffrey Traubici, Derek Stephens
INTRODUCTION: Although retropharyngeal infection (RPI) may present with voice change, drooling, fever, and a toxic appearance, diagnosis based on symptoms alone is unreliable. As incidence is increasing in children and drug-resistant bacterial strains such as methicillin-resistant Staphylococcus aureus are becoming more common, we decided to assess the clinical utility of lateral neck radiography. OBJECTIVE: The aim of this study was to review the experience of a large tertiary care pediatric emergency department (ED) in using lateral soft tissue neck radiographs in the diagnosis of suspected RPI...
October 27, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29062669/reconstruction-of-near-total-loss-of-the-upper-and-lower-lips-due-to-purpura-fulminans-with-local-tissue-and-a-dual-skin-paddled-anterolateral-thigh-flap
#11
Masamitsu Kuwahara, Satoshi Yurugi, Yuji Yamanaka, Chikako Sasaki, Takashi Nakanishi
It is difficult to totally reconstruct the lip, achieving good functional and aesthetic results. There have been few reports of reconstructing complete lip defects. Moreover, upper and lower lip necrosis by purpura fulminans has not been reported. We present a case of a 60-year-old male purpura fulminans patient with upper and lower lip necrosis. Fortunately, our patient had retained his oral commissure function. We reconstructed this defect with an orbicularis oris muscle-skin-mucosal pedicled flap derived from the region between the nasolabial folds for upper lip; a similar bipedicled flap for the lower lip and the donor site was closed with a dual-skin paddled anterolateral thigh flap...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29033523/mothers-teething-beliefs-and-treatment-practices-in-mansoura-egypt
#12
Abdel-Hady El-Gilany, Fawzia El Sayed Abusaad
OBJECTIVES: To reveal mothers' beliefs about signs and symptoms associated with teething and their treatment practices. POPULATION AND METHODS: A cross-sectional study done in Mansoura District on 457 mothers and their children with one or more erupted teeth. Mothers were interviewed during vaccination session at 25 chosen health facilities. Mothers were asked whether they agree or disagree about 24 signs and symptoms claimed to be associated with teething. RESULTS: Only 1...
October 2017: Saudi Dental Journal
https://www.readbyqxmd.com/read/28977311/toxic-exposures-in-children-involving-legally-and-illegally-commercialized-household-sanitizers
#13
Alessandra Marcuz de Souza Campos, Fábio Bucaretchi, Luciane Cristina Rodrigues Fernandes, Carla Borrasca Fernandes, Eduardo Mello de Capitani, Ana Raquel Medeiros Beck
OBJECTIVES: To analyze and to compare clinical repercussions of accidents involving legally and illegally commercialized household sanitizers in children under 7 years of age. METHODS: A descriptive cross-sectional design was used to collect data from electronic database of a regional Poison Control Center during one year. Data were analyzed by means of descriptive non-parametric statistics and association tests. Results: The sample had 737 reported cases. Most of the accidents occurred with children under 3 years of age (median: 1 year of age; interquartile interval: 1-3 years of age), at home (92...
January 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/28974882/kluth-type-iv3-membranous-esophageal-atresia-at-middle-one-third-of-esophagus-an-extremely-rare-entity
#14
Rahul Gupta, Pramila Sharma, Arvind Kumar Shukla, Sunil Mehra
We herein present an extremely rare case of an isolated membranous atresia causing near-complete obstruction of the esophagus. The neonate presented with drooling of saliva and frothing from the mouth. A red rubber catheter met with an obstruction at 12 cm from the gum margins. Radiograph showed paucity of gas in the abdomen. Thoracotomy revealed external continuity of esophagus; dilated and elongated proximal segment constituting upper half of esophagus, and a membrane with tiny opening in the center, at its junction with narrow distal segment...
October 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28964285/pediatric-leukodystrophies-the-role-of-the-otolaryngologist
#15
Emily Kay-Rivest, Léticia Khendek, Geneviève Bernard, Sam J Daniel
BACKGROUND: Leukodystrophies consist of degenerative neurogenetic diseases often associated with comorbidities that extend beyond the neurological system. Despite their impacts on patients' quality of life and risks of complications, head and neck symptomology is poorly reported in the literature. The objective of this study was to identify and quantify the main head and neck complaints among a cohort of patients diagnosed with leukodystrophies and define the role of the otolaryngologist as part of a multidisciplinary team for treating these patients...
October 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28943744/outpatient-treatment-based-on-self-management-strategies-for-chronic-drooling-in-two-children
#16
Tessa W P de Bruijn, Jody Sohier, Jan J W van der Burg
Drooling is a distressing condition, which is often caused by reduced oral motor control associated with a neurological disorder. It has significant medical, practical and psychosocial impact on children or youth and their families. Therefore, treatment is necessary. Although behavioural therapy for drooling shows promising results, it is generally time- and cost-intensive. For this reason, alternative ways to provide behavioural treatment for chronic drooling need to be explored. In a pair of case studies, the feasibility and potential of an outpatient variant of a behavioural treatment programme for drooling based on self-management strategies was researched with two children with oral motor difficulties...
2017: Journal of Developmental and Physical Disabilities
https://www.readbyqxmd.com/read/28933983/addition-of-kinesio-taping-of-the-orbicularis-oris-muscles-to-speech-therapy-rapidly-improves-drooling-in-children-with-neurological-disorders
#17
Denise Lica Yoshimura Mikami, Cristina Lemos Barbosa Furia, Alexis Fonseca Welker
OBJECTIVE: To evaluate the effects of Kinesio Taping (KT) of the orbicularis oris muscles as an adjunct to standard therapy for drooling. METHODS: Fifteen children with neurological disorders and drooling received speech therapy and twice-weekly KT of the orbicularis muscles over a 30-day period. Drooling was assessed by six parameters: impact on the life of the child and caregiver; severity of drooling; frequency of drooling; drooling volume (estimated by number of bibs used); salivary leak; and interlabial gap...
September 21, 2017: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/28932152/human-salivary-protein-extraction-from-rnapro%C3%A2-sal%C3%A2-pure%C3%A2-sal%C3%A2-and-passive-drooling-method
#18
Zohaib Khurshid, Syed Faraz Moin, Rabia Sannam Khan, Muhammad Atif Saleem Agwan, Abdullah Hamed Alwadaani, Muhammad Sohail Zafar
OBJECTIVE: The aim of the current study was to carry out a preliminary validation of devices for standardized collection of whole mouth fluid (WMF) in comparison to the passive drooling method for protein analysis in healthy subjects. MATERIALS AND METHODS: A carefully designed sample collection/pretreatment protocol is crucial to the success of any saliva proteomics project. In this study, WMF was collected from healthy volunteers (n = 10, ages: 18-26 years). Individuals with any oral disease were excluded from the study group...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28903752/measurement-of-cortisol-in-saliva-a-comparison-of-measurement-error-within-and-between-international-academic-research-laboratories
#19
Jessica L Calvi, Frances R Chen, Victoria Brann Benson, Eleanor Brindle, Matt Bristow, Alpana De, Sonja Entringer, Helen Findlay, Christine Heim, Eric A Hodges, Heiko Klawitter, Sonia Lupien, Holly M Rus, Jitske Tiemensma, Silvanna Verlezza, Claire-Dominique Walker, Douglas A Granger
OBJECTIVE: Hundreds of scientific publications are produced annually that involve the measurement of cortisol in saliva. Intra- and inter-laboratory variation in salivary cortisol results has the potential to contribute to cross-study inconsistencies in findings, and the perception that salivary cortisol results are unreliable. This study rigorously estimates sources of measurement variability in the assay of salivary cortisol within and between established international academic-based laboratories that specialize in saliva analyses...
September 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28865210/clinical-efficacy-of-nutraceutical-diet-for-cats-with-clinical-signs-of-cutaneus-adverse-food-reaction-cafr
#20
RANDOMIZED CONTROLLED TRIAL
F Mazzeranghi, C Zanotti, A Di Cerbo, J P Verstegen, R Cocco, G Guidetti, S Canello
Food allergies and food intolerances are clinically difficult to discriminate. Most often, along with cutaneous adverse food reactions or CAFR, they are classified as adverse food reactions, whose causes are numerous, including toxic compounds. Eighteen indoor-housed domestic cats with evident clinical symptoms related to CAFR (drooling, back and neck intense itching, neck eczema, chronic conjunctivitis and stomatitis) involving skin lesions were studied. Cytological evaluations of ear, skin and gingival swabs revealed an increased turnover of keratinocytes while the oxytetracycline ELISA determination showed an unexpected high amount of oxytetracycline in all cats at the first visit...
March 1, 2017: Polish Journal of Veterinary Sciences
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