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https://www.readbyqxmd.com/read/28813078/quality-of-life-in-parkinson-s-disease-patients-progression-markers-of-mild-to-moderate-stages
#1
Raissa Carla Moreira, Marise Bueno Zonta, Ana Paula Serra de Araújo, Vera Lúcia Israel, Hélio A G Teive
Objective: To investigate which factors are associated with the quality of life decline in Parkinson's disease patients from mild to moderate stages. Methods: The Unified Parkinson's Disease Rating Scale and Parkinson's Disease Questionnaire-39 were used to evaluate clinical/functional data and the quality of life. Results: The markers of clinical/functional worsening were drooling (p < 0.004), need for assistance with hygiene (p = 0.02), greater freezing frequency (p = 0...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28811748/salivary-diagnostic-markers-in-males-and-females-during-rest-and-exercise
#2
Kay Rutherfurd-Markwick, Carlene Starck, Deborah K Dulson, Ajmol Ali
BACKGROUND: Saliva is a useful diagnostic tool for analysis in sports, exercise and nutrition research, as collection is easy and non-invasive and it contains a large number of analytes affected by a range of physiological and pathological stressors and conditions. This study examined key salivary electrolytes and stress and immune markers in males and females at rest and during exercise. METHODS: Unstimulated whole saliva from 20 healthy, recreationally active participants (8 males and 12 females) was analysed for flow rate, osmolality, sodium (Na(+)), potassium (K(+)), chloride (Cl(-)), secretory immunoglobulin A (SIgA), α-amylase activity and cortisol during both rest and moderate intensity (70% peak power) cycling exercise in a randomised crossover design...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28808084/glycopyrronium-for-severe-drooling-in-children
#3
(no author information available yet)
Drooling of saliva is common in children with physical, intellectual and learning disability, and with poor neuromuscular coordination and oral control.(1) It can cause skin breakdown, damage to clothes and equipment and psychosocial problems for the child and family. For many years, glycopyrronium has been prescribed off-label using the injection solution given orally or tablets crushed and suspended in water, or as unlicensed products that were imported or manufactured as pharmaceutical specials.(2,3) In January 2017, a glycopyrronium oral solution (Sialanar-Proveca Limited) became available in the UK as the first licensed product for the treatment of severe drooling (sialorrhoea) in children and adolescents aged 3 years and older with chronic neurological disorders...
August 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28805566/botulinum-toxin-therapy-for-nonmotor-aspects-of-parkinson-s-disease
#4
Jarosław Sławek, Mariusz Madaliński
The medical treatment of Parkinson's disease (PD) is symptomatic both in terms of motor and nonmotor aspects. The nonmotor symptoms therapy should be taken into account as many of them negatively influence the quality of life and are treatable. Botulinum neurotoxin (BoNT) offers effective treatment for drooling and bladder dysfunctions and alternative treatment for constipation and pain related to parkinsonism. BoNT for drooling is probably the best-documented therapy for nonmotor symptoms by clinical trials...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28803510/epizootic-hemorrhagic-disease-virus-serotype-6-outbreak-in-israeli-cattle-in-2015
#5
Natalia Golender, Yevgeny Khinich, Anna Gorohov, Itzik Abramovitz, Velizar Bumbarov
In September 2015, a large outbreak caused by epizootic hemorrhagic disease virus (EHDV) was identified in Israeli dairy and beef farms. The main clinical signs were reduced milk production, weakness, drooling, lameness and recumbency, fever, slight erythema of nasal and oral mucosae, weight loss, and abortion. Dyspnea, cachexia, and death were observed less frequently. The clinical diagnosis was confirmed by ELISAs and EHDV-specific real-time reverse transcription PCR (RT-rtPCR), followed by conventional RT-PCR of the VP2 gene and sequence analysis...
August 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28798882/evolution-of-orofacial-symptoms-and-disease-progression-in-idiopathic-parkinson-s-disease-longitudinal-data-from-the-j%C3%A3-nk%C3%A3-ping-parkinson-registry
#6
Seyed-Mohammad Fereshtehnejad, Örjan Skogar, Johan Lökk
BACKGROUND: Orofacial symptoms are common in Parkinson's disease (PD) both as initial manifestations and late markers of disease complications. We aimed to investigate the evolution of orofacial manifestations and their prognostic value throughout PD progression. METHODS: Data was obtained from "Jönköping Parkinson Registry" database on routine care visits of 314 people with idiopathic PD in southern Sweden. Information on baseline symptomatology, orofacial features, UPDRS, and medications was recorded at baseline and during each follow-up visit within an average of 4...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28796029/reconstruction-of-full-thickness-buccal-defects-with-folded-radial-forearm-flaps-a-retrospective-clinical-study
#7
Fei Liu, Lei Wang, Shuang Pang, Quancheng Kan
Our goal was to describe our experience of the folded radial forearm flap (RFF) flap in through-and-through buccal defect reconstructions.Patients who had received a folded RFF flap for full-thickness cheek defect reconstruction were included. The flap success rate and functional results were evaluated.Six patients were enrolled. All flaps survived totally without any complication; the mean flap size was 75.5 (range 32-135) cm. The mean mouth-open width was 4.2 (range 3.5-4.7) cm at 6 months after operation...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28748430/inicu-integrated-neonatal-care-unit-capturing-neonatal-journey-in-an-intelligent-data-way
#8
Harpreet Singh, Gautam Yadav, Raghuram Mallaiah, Preetha Joshi, Vinay Joshi, Ravneet Kaur, Suneyna Bansal, Samir K Brahmachari
Neonatal period represents first 28 days of life, which is the most vulnerable time for a child's survival especially for the preterm babies. High neonatal mortality is a prominent and persistent problem across the globe. Non-availability of trained staff and infrastructure are the major recognized hurdles in the quality care of these neonates. Hourly progress growth charts and reports are still maintained manually by nurses along with continuous calculation of drug dosage and nutrition as per the changing weight of the baby...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28729791/correlation-between-salivary-cortisol-levels-and-dental-anxiety-in-children-of-smokers-and-nonsmokers
#9
S Pavani Reddy, M Ghanashyam Prasad, A Naga RadhaKrishna, Kaniti Saujanya, N V K Raviteja, B Deepthi
OBJECTIVES: The present study was undertaken to evaluate salivary cortisol levels in children of smokers and nonsmokers and thereby establishing the relationship between cortisol levels in response to anxiety in children based on their father's habit of smoking. MATERIALS AND METHODS: The study population aged between 8 and 10 years includes two groups. Group 1 is comprised 20 children of cigarette smokers and Group 2 is comprised 20 children of nonsmokers. The passive drooling technique was used to collect unstimulated saliva from the children using a sterile container...
April 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28728161/quality-of-life-and-caregivers-burden-of-parkinson-s-disease
#10
Kingston Rajiah, Mari Kannan Maharajan, Si Jen Yeen, Sara Lew
AIM: This study focused on the impact of the clinical features on the quality of life (QoL) of Parkinson's disease (PD) patients and of their caregivers. METHODS: This study included PD patients along with their caregivers and was undertaken at the Malaysian Parkinson's Disease Association from June 2016 to November 2016. Clinical features of PD patients were assessed using the Movement Disorder Society revised Unified Parkinson Disease Rating Scale; the Hoehn and Yahr stage and the Schwab and England Activities of Daily Living Scale were used to assess the severity and the ability of PD patients respectively...
July 21, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28710905/administration-of-fortifier-by-finger-feeder-during-breastfeeding-in-preterm-infants
#11
Margarita Thanhaeuser, Alexandra Kreissl, Claudia Lindtner, Sophia Brandstetter, Angelika Berger, Nadja Haiden
OBJECTIVE: To evaluate the acceptance, adherence, and feasibility of fortifier administration by finger feeder during breastfeeding and to determine weight, length, and head circumference gains after discharge for preterm infants. DESIGN: Observational pilot study. SETTING: A Level III NICU and its outpatient clinic in Vienna, Austria. PARTICIPANTS: Infants born at younger than 34 weeks gestation were included. METHODS: Mothers were screened in a tertiary NICU and trained by certified lactation consultants to administer fortifier with a finger feeder during breastfeeding...
July 12, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28706566/motor-vehicle-collisions-caused-by-the-super-strength-synthetic-cannabinoids-mam-2201-5f-pb-22-5f-ab-pinaca-5f-amb-and-5f-adb-in-japan-experienced-from-2012-to-2014
#12
REVIEW
Shuji Kaneko
From 2012 to 2014 in Japan, 214 cases of motor vehicle collisions were attributed to the use of illegal drugs. In 93 out of 96 investigated cases, the causative agents were a variety of synthetic cannabinoids (SCs). These SCs can be classified into three groups according to the lineage of the chemical structures: (1) naphthoyl indoles, such as MAM-2201, (2) quinolinyl ester indoles, such as 5F-PB-22, and (3) indazole carboxamides, such as 5F-AB-PINACA, 5F-AMB, and 5F-ADB. These SCs became available sequentially with increasing cannabinoid CB1 agonist potencies and reached a nationwide outbreak in the summer of 2014...
2017: Forensic Toxicology
https://www.readbyqxmd.com/read/28681387/effect-of-functional-chewing-training-on-tongue-thrust-and-drooling-in-children-with-cerebral-palsy-a-randomised-controlled-trial
#13
Ö Inal, S Serel Arslan, N Demir, Ö Tunca Yilmaz, A A Karaduman
Tongue thrust, which is an oral reflex associated with sucking behaviour, may cause problems in swallowing, speech, oro-facial development and also drooling. We aimed to examine the effect of Functional Chewing Training (FuCT) on tongue thrust and drooling in children with cerebral palsy. The study included 32 children with a mean age of 58·25 ± 9·58 months who had tongue thrust. Children were divided into two groups: the FuCT group and control group receiving classical oral motor exercises. Each group received training for 12 weeks...
July 6, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28661987/upper-gastrointestinal-endoscopic-evaluation-following-household-sodium-hypochlorite-ingestion
#14
Shahriar Nikpour, Elnaz Masoumi-Moghaddam, Soha Pazoki, Hossein Hassanian-Moghaddam, Nasim Zamani
Endoscopy is generally speculated to be unnecessary in sodium hypochlorite (NaClO) ingestions; however, a significant number of endoscopic evaluations are still being performed when this chemical is ingested. Therefore, the aim of the current study was to compare the outcome and endoscopic findings between patients who had ingested household NaClO and those who had ingested other types of corrosives. This retrospective cohort study enrolled 137 patients with a history of corrosive substance ingestion admitted to a tertiary hospital...
June 28, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28653927/detection-of-interleukins-6-and-8-in-saliva-as-potential-biomarkers-of-oral-pre-malignant-lesion-and-oral-carcinoma-a-breakthrough-in-salivary-diagnostics-in-pakistan
#15
Iqbal A Muhammad Khyani, Masood A Qureshi, Talat Mirza, M Umar Farooq
Oral cancer is at rise in our population due to increasing use of areca nut (Betel nut) with or without tobacco. It is the second frequent malignant tumour for both the gender in Pakistan. This non-interventional case control study was carried out with the aim to explore saliva as diagnostic medium for detecting interleukins (IL) 6 and 8 as biomarkers of pre-malignant lesions (PML) and oral carcinoma. Total 105 subjects were recruited and were divided into three groups "A", "B" and "C" each comprising of 35 subjects...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28632108/swallowing-in-parkinson-s-disease-clinical-issues-and-management
#16
Nick Miller
Changes to swallowing affect most people with Parkinson's disease (PD). Changes may not initially exercise a decisive impact, but can later pose significant threats to nutritional, hydration and respiratory health and psychosocial quality of life. This review, from a largely clinical viewpoint, outlines the nature of changes in PD and considers the issue of how many people are affected and in what ways. It outlines main approaches to assessment and management, with an emphasis on aspects relevant to PD. Dysphagia contributes to drooling in PD...
June 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28609669/sex-differences-in-associations-between-white-matter-microstructure-and-gonadal-hormones-in-children-and-adolescents-with-prenatal-alcohol-exposure
#17
K A Uban, M M Herting, J R Wozniak, E R Sowell
Despite accumulating evidence from animal models demonstrating that prenatal alcohol exposure (PAE) results in life-long neuroendocrine dysregulation, very little is known on this topic among humans with fetal alcohol spectrum disorders (FASD). We expected that alterations in gonadal hormones might interfere with the typical development of white matter (WM) myelination, and in a sex-dependent manner, in human adolescents with FASD. In order to investigate this hypothesis, we used diffusion tensor imaging (DTI) to assess: 1) whether or not sex moderates the impact of PAE on WM microstructure; and 2) how gonadal hormones relate to alterations in WM microstructure in children and adolescents affected by PAE...
May 26, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28591387/treatment-of-drooling-with-sublingual-atropine-sulfate-in-children-and-adolescents-with-cerebral-palsy
#18
RANDOMIZED CONTROLLED TRIAL
Bruno L Scofano Dias, Alexandre R Fernandes, Heber de S Maia
Objective: To report the effect of sublingual atropine sulfate to treat drooling in children with cerebral palsy by comparing the results of the Drooling Impact Scale in a non-controlled open clinical trial. Results: Twenty-five children were assessed. The difference in the mean scores of the pre- and post-treatment scales reached statistical significance. There was a low frequency of side effects compared to studies with other anticholinergics. Conclusion: The use of sublingual atropine sulfate seems to be safe and there is a reduction in the Drooling Impact Scale score, which suggests efficacy in the treatment of drooling in children and adolescents with cerebral palsy...
May 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28581652/adolescent-personality-as-risk-and-resiliency-in-the-testosterone-externalizing-association
#19
Kathleen W Reardon, Kathrin Herzhoff, Jennifer L Tackett
Previous investigations of testosterone and externalizing behavior have provided mixed findings. We tested the hypothesis that self-regulatory personality moderates the testosterone-externalizing behavior association in adolescence. Parents reported on their 13- to 18-year-old (N = 106, Mage = 16.01, SD = 1.29) children's personalities and psychopathology. Testosterone was measured via drool samples. As hypothesized, personality moderated the testosterone-externalizing behavior association. High testosterone predicted higher levels of externalizing behaviors, but only for adolescents low in Agreeableness and Conscientiousness...
September 2016: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/28571283/estimation-of-dmft-salivary-streptococcus-mutans-count-flow-rate-ph-and-salivary-total-calcium-content-in-pregnant-and-non-pregnant-women-a-prospective-study
#20
Wasim Ismail Kamate, Nupura Aniket Vibhute, Rajendra Krishna Baad
INTRODUCTION: Pregnancy, a period from conception till birth, causes changes in the functioning of the human body as a whole and specifically in the oral cavity that may favour the emergence of dental caries. Many studies have shown pregnant women at increased risk for dental caries, however, specific salivary caries risk factors and the particular period of pregnancy at heightened risk for dental caries are yet to be explored and give a scope of further research in this area. AIM: The aim of the present study was to assess the severity of dental caries in pregnant women compared to non-pregnant women by evaluating parameters like Decayed, Missing, Filled Teeth (DMFT) index, salivary Streptococcus mutans count, flow rate, pH and total calcium content...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
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