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https://www.readbyqxmd.com/read/27901263/negative-effects-of-submandibular-botulinum-neurotoxin-a-injections-on-oral-motor-function-in-children-with-drooling-due-to-central-nervous-system-disorders
#1
Karen van Hulst, Carlyn V Kouwenberg, Pieter H Jongerius, Ton Feuth, Franciscus J A van den Hoogen, Alexander C H Geurts, Corrie E Erasmus
AIM: The aims of this study were: (1) to determine the incidence and nature of adverse effects on oral motor function after first injections of botulinum neurotoxin A (BoNT-A) in submandibular glands for excessive drooling in children with central nervous system disorders; and (2) to identify independent predictors of these adverse effects. METHOD: A cohort study involved 209 children (123 males, 86 females, aged 4-27y, median 8y 4mo), who received submandibular BoNT-A injections for drooling...
November 30, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27879418/histopathologic-effects-of-onabotulinum-toxin-a-treatment-in-pediatric-submandibular-glands
#2
Ashley Mosseri, Isabel Cardona, Miriam Blumenkrantz, Sam J Daniel
Onabotulinum toxin A (OBTXA) is an effective treatment for drooling. Our objective was to determine if there are histologic changes in the submandibular glands (SMGs) after repetitive OBTXA injections. The study included blinded histologic analysis and comparison of SMGs with ≥4 OBTXA injections versus controls who never received OBTXA. The number of acinar cells were counted, and the morphology of the cells was evaluated within each histologic sample of the SMGs. Thirty-one glands were analyzed (14 control, 17 cases)...
November 22, 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27814442/botulinum-toxin-in-the-management-of-sialorrhoea-in-acquired-brain-injury
#3
A Carrol, B McGlone
Sialorrhoea as a consequence of severe acquired brain injury can significantly negatively impact on quality of life. Medications used in its management have many side effects which can cause problems in the severely disabled. Botulinum toxin is an effective treatment of sialorrhoea in a number of neurological conditions but may also have a role to play in the management of sialorrhoea following severe ABI. We report on 4 cases of sialorrhoea following acquired brain injury causing a variety of problems, whose parotid glands were injected with Botulinum toxin type A (Dysport) 50mu each, under ultrasound guidance...
June 10, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27771258/development-and-validation-of-a-sensitive-and-selective-lc-ms-ms-method-for-determination-of-tacrolimus-in-oral-fluids
#4
Mwlod Ghareeb, Fatemeh Akhlaghi
Tacrolimus is a commonly used immunosuppressive agent in organ transplant recipients. Therapeutic drug monitoring (TDM) of tacrolimus is essential to adjust the dose and achieve optimal immunosuppression level. Routine TDM is practiced using whole blood samples obtained through venipuncture. However, tacrolimus concentration that is present in oral fluid (OF) can theoretically represent the free or pharmacologically active form of tacrolimus. In this study, we report the development and validation of a rapid, sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantification of tacrolimus in OF...
October 11, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27761237/the-effectiveness-of-conservative-management-for-retropharyngeal-abscesses-greater-than-2%C3%A2-cm
#5
A Khudan, G Jugmohansingh, S Islam, S Medford, V Naraynsingh
OBJECTIVES: Conservative management for retropharyngeal abscesses <2 cm is now a first line option. It is unclear if conservative management can be used to manage larger abscesses without increased morbidity and mortality. STUDY DESIGN: A prospective case series was performed from 2012 to 2015 by the Otolaryngology department of the San Fernando General Hospital involving pediatric patients who presented with retropharyngeal abscesses. All patients were initially treated with antibiotics alone...
November 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27734116/application-of-local-injection-of-botulinum-toxin-a-in-cosmetic-patients-with-congenital-drooping-mouth-corner
#6
Wei Qian, Yan-Kun Zhang, Wei Lv, Ying Hou, Qian Cao, Ju-Feng Fan
OBJECTIVE: This study aimed to investigate the clinical application and efficacy of local injection of botulinum toxin A (BTX-A) at the depressor anguli oris in patients with congenital drooping mouth corner. METHODS: From September 2013 to March 2015, 36 cosmetic patients received local injections of botulinum toxin A at the depressor anguli oris, with 1-3 injection sites in the moving region of the depressor anguli oris on each side. At each injection site, 2-4 U of BTX-A was injected, and the total dose for any unilateral treatment did not exceed 8 U...
December 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/27729154/enhancing-surgical-outcomes-the-effects-of-speech-therapy-on-a-school-aged-girl-with-moebius-syndrome
#7
Elizabeth Fairgray, Anna Miles
PURPOSE: Moebius Syndrome is a rare congenital neurological condition often characterized by multiple cranial nerve involvement. This case study presents an eight-year old girl with Moebius Syndrome (MC) who received 30 sessions of speech therapy. This occurred after presenting to clinic 11 months after left facial reanimation with gracilis thigh muscle transfer surgery. On examination, only flickers of left facial movement were observed. There was no movement on the right side of the face...
November 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27717835/a-resting-state-fmri-study-on-early-stage-drug-na%C3%A3-ve-parkinson-s-disease-patients-with-drooling
#8
Yanbing Hou, Chunyan Luo, Jing Yang, Wei Song, Ruwei Ou, Wanglin Liu, Qiyong Gong, Huifang Shang
OBJECTIVE: Drooling is a common symptom in Parkinson's disease (PD). This study used resting-state functional MRI (fMRI) to evaluate the brain connectivity of cortico-striatal circuits in PD patients with drooling. METHOD: We enrolled 30 early-stage drug-naïve PD patients and 30 matched normal controls. Among the PD patients, 15 patients were classified as "droolers" with the presence of drooling and 15 patients as "non-droolers" with the absence of drooling. All participants underwent resting-state fMRI scans on a 3-T MR system, focusing on the functional connectivity of striatum subregions...
October 4, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27715406/generalization-and-maintenance-of-a-self-management-program-for-drooling-in-children-with-neurodevelopmental-disabilities-a-second-case-series
#9
Jan J W van der Burg, Jody Sohier, Peter H Jongerius
In this case series (n = 10) with a non-concurrent multiple baseline design, a self-management program was shown to be effective during inpatient training in eight participants with oral-motor problems and normal intelligence or mild intellectual disabilities. They were taught to perform a self-management routine and to remain dry for increasing time intervals. In addition, the program provided differential (self-) reinforcement of swallowing, controlling and wiping behavior, explicit formulation of motivational factors, instruction and feedback for parents and teachers, and continued practice after discharge...
October 7, 2016: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/27712822/facial-nerve-rehabilitation
#10
Lisa E Ishii
Facial nerve paralysis, although uncommon in the pediatric population, occurs from several causes, including congenital deformities, infection, trauma, and neoplasms. Similar to the adult population, management of facial nerve disorders in children includes treatment for eye exposure, nasal obstruction/deviation, smile asymmetry, drooling, lack of labial function, and synkinesis. Free tissue transfer dynamic restoration is the preferred method for smile restoration in this population, with outcomes exceeding those of similar procedures in adults...
November 2016: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/27673226/poster-482-botulinum-toxin-a-injections-for-drooling-management-in-children
#11
Chong Tae Kim
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27626472/the-internet-versus-pediatricians-as-a-source-of-infant-teething-information-for-parents-in-turkey
#12
Eda Haznedaroglu, Ali Mentes
OBJECTIVES: Parents are increasingly searching the Internet to gather information about their children's health care. This study compared infant teething information obtained from publically employed pediatricians in Istanbul with that obtained from different Turkish websites (parenting, health, professional, news and commercial). METHODS: This study had two parts. The first part used a descriptive design, with two checklists to assess the quality and comprehensiveness of the teething-specific content on 62 parenting or health websites...
August 2016: Clinics
https://www.readbyqxmd.com/read/27617821/two-thirds-lip-defects-a-new-combined-reconstructive-technique-for-patients-with-epithelial-cancer
#13
Tiziana Vitagliano, Lucia Stella Curto, Antonio Greto Ciriaco, Pietro Gareri, Diego Ribuffo, Manfredi Greco
BACKGROUND: The lips are a common site prone to squamous cell carcinomas, which arise in the facial region. There are different techniques to reconstruct the excised lip region, according to dimensions, area, and position of the tumor. The authors describe a new technique of lip reconstruction born from a combination between a nasolabial flap and adipose tissue transplant. METHODS: The study was lead in the Plastic and Reconstructive Surgery Department of the University of Catanzaro...
September 9, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27613712/pathophysiology-underlying-drooling-in-parkinson-s-disease-oropharyngeal-bradykinesia
#14
Mehmet Karakoc, Mehmet Ilker Yon, Gul Yalcin Cakmakli, Ersin Kasim Ulusoy, Aydin Gulunay, Nese Oztekin, Fikri Ak
We aimed to investigate the association between drooling and possible etiological factors in Parkinson's disease (PD) and to determine its effect on the quality of life. Demographic data of the 63 patients with idiopathic PD were recorded. Radboud Oral Motor Inventory for Parkinson's disease (ROMP) test was administered to all patients to evaluate speech, swallowing functions, and saliva control. The freezing of gait questionnaire (FOGQ) was used to evaluate gait and freezing of gait. Dynamic Parkinson gait scale (DYPAGS) was administered for the objective quantification of PD gait features...
December 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27567997/percutaneous-ct-guided-cryoablation-of-the-salivary-glands-in-a-porcine-model
#15
Ji Y Buethe, Salim Abboud, Kristie Brock, Greg Nizialek, Rod Rezaee, Jay Wasman, Jonathan Frankel, Dean A Nakamoto
PURPOSE: To evaluate the imaging, histologic changes and safety of computed tomography (CT)-guided cryoablation of the parotid glands in a porcine model. MATERIALS AND METHODS: Unilateral CT-guided parotid gland cryoablation was performed in 5 juvenile miniature pigs. The ablated parotid glands underwent 2 cycles of 10-minute freeze and 5-minute thaw using three 17-g cryoprobes. The animals were monitored daily for complications including pain, frostbite, infection, and sialocele or fistula formation...
December 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27544855/assessing-heat-load-in-drylot-dairy-cattle-refining-on-farm-sampling-methodology
#16
Grazyne Tresoldi, Karin E Schütz, Cassandra B Tucker
Identifying dairy cattle experiencing heat stress and adopting appropriate mitigation strategies can improve welfare and profitability. However, little is known about how cattle use heat abatement resources (shade, sprayed water) on drylot dairies. It is also unclear how often we need to observe animals to measure high heat load, or the relevance of specific aspects of this response, particularly in terms of panting. Our objectives were to describe and determine sampling intervals to measure cattle use of heat abatement resources, respiration rate (RR) and panting characteristics (drooling, open mouth, protruding tongue), and to evaluate the relationship between the latter 2...
August 17, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27537409/salivary-lymphocyte-responses-follwing-acute-anaerobic-exercise-in-a-cool-environment
#17
Lara A Carlson, Michael A Lawrence, Kaylee LeCavalier, Alexander J Koch
The purpose of this study was to examine the impact of anaerobic training on salivary lymphocytes (s-LYMPH), and further determine whether these responses differ between cool vs. thermoneutral environments. Nine lightly clothed (∼0.3 clo) volunteers (7/2 women/men: age 21 ± 1 y; height 168.7 ± 7.3 cm; weight 66.4 ± 8.4 kg; body fat 20.6 ± 7.6%) completed speed, agility, and quickness (SAQ) sessions in both warm (18.9°C, Biddeford, Maine, USA) and cool (10.4°C, Thorsmörk, Iceland) temperatures. SAQ sessions consisted of three trials of 20 m sprints, 40 m sprints, t-tests, and box drills, and two 300-yd shuttle runs in both conditions...
August 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27497408/the-impact-of-submandibular-duct-relocation-on-drooling-and-the-well-being-of-children-with-neurodevelopmental-disabilities
#18
Saskia E Kok, Jan J W van der Burg, Karen van Hulst, Corrie E Erasmus, Frank J A van den Hoogen
OBJECTIVE: The aim of this study was to evaluate the impact of a reduction in drooling after bilateral submandibular duct relocation (SMDR) with sublingual gland excision on daily life and care, as well as social and emotional consequences in children and adolescents with neurodevelopmental disabilities. METHODS: This prospective cohort study included 72 children and adolescents (46 males, 26 females) with moderate to severe drooling, and their caregivers. Mean age at the time of surgery was 15 years 2 months (SD 4y 3mo)...
September 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27497402/botulinum-toxin-injections-for-chronic-sialorrhoea-in-children-are-effective-regardless-of-the-degree-of-neurological-dysfunction-a-single-tertiary-institution-experience
#19
Murali Mahadevan, Maayan Gruber, Darin Bilish, Kathryn Edwards, David Davies-Payne, Graeme van der Meer
OBJECTIVE: To determine the effectiveness of submandibular salivary gland Botulinum Toxin Type-A (BTX-A) injection in the treatment of drooling in children with varying degrees of neurological dysfunction. METHODS: A retrospective review of pre- and post-procedure drooling frequency and severity scores of patients receiving BTX-A between January 2008 and January 2013. Stratification to different subgroups of neurological impairment was performed according to Gross Motor Function Classification System (GMFCS) score...
September 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27497209/anatomy-and-disorders-of-the-oral-cavity-of-chinchillas-and-degus
#20
REVIEW
Christoph Mans, Vladimir Jekl
Dental disease is among the most common causes for chinchillas and degus to present to veterinarians. Most animals with dental disease present with weight loss, reduced food intake/anorexia, and drooling. Degus commonly present with dyspnea. Dental disease has been primarily referred to as elongation and malocclusion of the cheek teeth. Periodontal disease, caries, and tooth resorption are common diseases in chinchillas, but are missed frequently during routine intraoral examination, even performed under general anesthesia...
September 2016: Veterinary Clinics of North America. Exotic Animal Practice
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