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https://www.readbyqxmd.com/read/29752072/tar-dna-binding-protein-43-and-disrupted-in-schizophrenia-1-coaggregation-disrupts-dendritic-local-translation-and-mental-function-in-frontotemporal-lobar-degeneration
#1
Ryo Endo, Noriko Takashima, Yoko Nekooki-Machida, Yusuke Komi, Kelvin Kai-Wan Hui, Masaki Takao, Hiroyasu Akatsu, Shigeo Murayama, Akira Sawa, Motomasa Tanaka
BACKGROUND: Neurodegenerative diseases involving protein aggregation often accompany psychiatric symptoms. Frontotemporal lobar degeneration (FTLD) associated with TAR DNA-binding protein 43 (TDP-43) aggregation is characterized by progressive neuronal atrophy in frontal and temporal lobes of cerebral cortex. Furthermore, patients with FTLD display mental dysfunction in multiple behavioral dimensions. Nevertheless, their molecular origin for psychiatric symptoms remains unclear. METHODS: In FTLD neurons and mouse models with TDP-43 aggregates, we examined coaggregation between TDP-43 and disrupted in schizophrenia 1 (DISC1), a key player in the pathology of mental conditions and its effects on local translation in dendrites and psychiatric behaviors...
March 29, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29748771/inhibition-impairment-in-frontotemporal-dementia-amyotrophic-lateral-sclerosis-and-alzheimer-s-disease-clinical-assessment-and-metabolic-correlates
#2
Jordi A Matías-Guiu, María Nieves Cabrera-Martín, María Valles-Salgado, Teresa Rognoni, Lucía Galán, Teresa Moreno-Ramos, José Luis Carreras, Jorge Matías-Guiu
The ability to reject an automatic tendency, i.e. inhibition, has been linked to the prefrontal cortex, but its neural underpinnings are still controversial. Neurodegenerative diseases represent an interesting model to explore this issue, given its frequent impairment in these disorders. We investigated the inhibitory impairment and its neural basis using four different tests, which evaluate the presence of inhibitory dysfunction (Stroop test, Hayling test, and two graphical perseveration tests), and assessed their correlation with brain metabolism using 18 F-fluorodeoxyglucose positron emission tomography in a group of 76 participants with behavioral variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and healthy controls (HC)...
May 10, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29722319/dry-needling-at-myofascial-trigger-points-mitigates-chronic-post-stroke-shoulder-spasticity
#3
Li Tang, Yan Li, Qiang-Min Huang, Yang Yang
Post-stroke spasticity is associated with restriction in the range of motion of the shoulder. Reducing muscular dystrophy may help relieve muscular dysfunction in patients with post-stroke shoulder spasticity. Dry needle therapy is a method of needling the trigger points using a syringe needle without the use of a drug. Dry needle therapy is commonly used for pain at the shoulder, neck, waist, and back. In this case study, a 62-year-old male patient affected with cerebral hemorrhage of the right frontal lobe had received rehabilitative treatment for 12 years...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29706885/brain-transcriptomic-analysis-of-hereditary-cerebral-hemorrhage-with-amyloidosis-dutch-type
#4
Laure Grand Moursel, Willeke M C van Roon-Mom, Szymon M Kiełbasa, Hailiang Mei, Henk P J Buermans, Linda M van der Graaf, Kristina M Hettne, Emile J de Meijer, Sjoerd G van Duinen, Jeroen F J Laros, Mark A van Buchem, Peter A C 't Hoen, Silvère M van der Maarel, Louise van der Weerd
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) caused by a point mutation resulting in an amino acid change (NP_000475.1:p.Glu693Gln) in the amyloid precursor protein (APP). Post-mortem frontal and occipital cortical brain tissue from nine patients and nine age-related controls was used for RNA sequencing to identify biological pathways affected in HCHWA-D. Although previous studies indicated that pathology is more severe in the occipital lobe in HCHWA-D compared to the frontal lobe, the current study showed similar changes in gene expression in frontal and occipital cortex and the two brain regions were pooled for further analysis...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29685540/resting-state-functional-connectivity-mri-analysis-in-human-immunodeficiency-virus-and-hepatitis-c-virus-co-infected-subjects-a-pilot-study
#5
Simone Corgiolu, Luigi Barberini, Jasjit S Suri, Antonella Mandas, Diego Costaggiu, Paola Piano, Fulvio Zaccagna, Pierleone Lucatelli, Antonella Balestrieri, Luca Saba
BACKGROUND AND PURPOSE: Hepatitis C virus (HCV) co-infection's role on cognitive impairment of human immunodeficiency virus (HIV) positive patients is still debated and functional neuroimaging evaluation on this matter is lacking. To provide further insight about HCV's neuro-effects on HIV associated neurocognitive disorder (HAND), we performed a pilot resting state (RS) functional connectivity magnetic resonance imaging (fcMRI) study to find eventual functional connectivity alteration that could reflect HCV related cognitive performance degradation...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29644521/functional-connectivity-change-between-posterior-cingulate-cortex-and-ventral-attention-network-relates-to-the-impairment-of-orientation-for-time-in-alzheimer-s-disease-patients
#6
Ken-Ichiro Yamashita, Taira Uehara, Pukovisa Prawiroharjo, Koji Yamashita, Osamu Togao, Akio Hiwatashi, Yoshihide Taniwaki, Hidetsuna Utsunomiya, Takuya Matsushita, Ryo Yamasaki, Jun-Ichi Kira
Alzheimer's disease (AD) patients exhibit various cognitive dysfunctions, including impairment of orientation for time (OT). The brain regions underlying OT impairment remain to be elucidated. A previous single-photon emission computed tomography study has indicated hypoperfusion of the posterior cingulate cortex (PCC) in relation to deterioration of OT. In this study, we investigated whole brain functional connectivity changes of PCC using resting-state functional magnetic resonance imaging. Voxel-based functional connectivity with PCC was analyzed in OT-poor or OT-good AD patients, classified according to the mean OT scores of the Mini-Mental State Examination subscale...
April 12, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29616521/the-relationship-between-cerebral-oxygen-saturation-and-quantitative-metrics-of-neurological-function-after-coronary-bypass-surgery-a-feasibility-study
#7
Joanna S Semrau, Stephen H Scott, Andrew G Hamilton, Dimitri Petsikas, Darrin M Payne, Gianluigi Bisleri, Tarit Saha, J Gordon Boyd
BACKGROUND: It is well-known that patients undergoing coronary artery bypass grafting (CABG) surgery may experience neurological dysfunction following their operation. However, the nature of this dysfunction has not been properly quantified. Furthermore, the relationship between post-operative impairment and cerebral oxygen saturation during surgery has remained unclear. This study aims to define the feasibility of using robotic technology to quantify post- CABG neurocognitive function, and to correlate these objective metrics with intraoperative brain tissue oxygen...
April 3, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29554279/disrupted-dynamic-network-reconfiguration-of-the-language-system-in-temporal-lobe-epilepsy
#8
Xiaosong He, Danielle S Bassett, Ganne Chaitanya, Michael R Sperling, Lauren Kozlowski, Joseph I Tracy
Temporal lobe epilepsy tends to reshape the language system causing maladaptive reorganization that can be characterized by task-based functional MRI, and eventually can contribute to surgical decision making processes. However, the dynamic interacting nature of the brain as a complex system is often neglected, with many studies treating the language system as a static monolithic structure. Here, we demonstrate that as a specialized and integrated system, the language network is inherently dynamic, characterized by rich patterns of regional interactions, whose transient dynamics are disrupted in patients with temporal lobe epilepsy...
March 15, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29548954/effects-of-subthalamic-stimulation-on-olfactory-function-in-parkinson-s-disease
#9
Rubens Gisbert Cury, Margarete de Jesus Carvalho, Fernando Jeyson Lopez Lasteros, Alice Estevo Dias, Maria Gabriela Dos Santos Ghilardi, Anderson Rodrigues Brandão Paiva, Artur Martins Coutinho, Carlos Alberto Buchpiguel, Manoel J Teixeira, Egberto Reis Barbosa, Erich Talamoni Fonoff
BACKGROUND: Olfactory dysfunction is a non-motor symptom of Parkinson's disease (PD) associated with reduction in quality of life. There is no evidence on whether improvements in olfaction after subthalamic deep brain stimulation (STN-DBS) may be directly attributable to motor improvement or whether this reflect a direct effect of DBS on olfactory brain areas. The aim of this study was to evaluate the effect of DBS on olfactory function (OF) in PD as well as to explore the correlation between these changes and changes in motor symptoms and brain metabolism...
March 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29527497/dysfunctional-frontal-lobe-activity-during-inhibitory-tasks-in-individuals-with-childhood-trauma-an-event-related-potential-study
#10
Sungkean Kim, Ji Sun Kim, Min Jin Jin, Chang-Hwan Im, Seung-Hwan Lee
Background: Individuals who experience childhood trauma are vulnerable to various psychological and behavioral problems throughout their lifetime. This study aimed to investigate whether individuals with childhood trauma show altered frontal lobe activity during response inhibition tasks. Methods: In total, 157 healthy individuals were recruited and instructed to perform a Go/Nogo task during electroencephalography recording. Source activities of N2 and P3 of Nogo event-related potentials (ERP) were analyzed...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29515418/a-case-of-traumatic-brain-injury-presenting-with-musical-hallucinations
#11
Yasutaka Kobayashi
A 67-year-old woman was hospitalized for rehabilitation from the after effects of a traumatic brain injury. In addition to memory impairment, attention disorder, and executive dysfunction, she experienced musical hallucinations. Brain magnetic resonance imaging revealed cerebral contusion in the bilateral temporal lobes and the left frontal lobe. Case reports of musical hallucinations caused by traumatic brain injury are extremely rare.
January 2018: Case Reports in Neurology
https://www.readbyqxmd.com/read/29510290/impact-of-laterality-on-surgical-outcome-of-glioblastoma-patients-a-retrospective-single-center-study
#12
Daniel Coluccia, Tabitha Roth, Serge Marbacher, Javier Fandino
BACKGROUND: Resection of left hemisphere (LH) tumors is often complicated by the risks of causing language dysfunction. Although neurosurgeons' concerns when operating on the presumed dominant hemisphere are well known, literature evaluating laterality as a predictive surgical parameter in glioblastoma (GB) patients is sparse. We evaluated whether tumor laterality correlated with surgical performance, functional outcome, and survival. METHODS: All patients with GB treated at our institution between 2006 and 2016 were reviewed...
March 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29502113/default-mode-network-disruption-in-stroke-free-patients-with-atrial-fibrillation
#13
Danilo S Silva, Wagner M Avelar, Brunno M de Campos, Ana Paula B L Lino, Márcio L F Balthazar, Marcio J O Figueiredo, Fernando Cendes, Ana Carolina Coan
BACKGROUND: Atrial fibrillation (AF) is a widely accepted risk for causing stroke. However, recent studies show AF as a risk factor for dementia, even without causing stroke. The mechanisms by which dementia develops in stroke-free patients with AF are still poorly understood and the association of AF with abnormal function of brain networks activities, such as the default mode network (DMN), has not been previously studied. We aimed to determine whether, in the absence of stroke and dementia, patients with AF have abnormal resting-state brain networks compared to controls without AF...
2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29475078/damage-of-the-temporal-lobe-and-apoe-status-determine-neural-compensation-in-mild-cognitive-impairment
#14
Laura Prieto Del Val, Jose L Cantero, Daniel Baena, Mercedes Atienza
In mild cognitive impairment (MCI), the APOE4 genotype is associated with accelerated memory decline, likely due to the impact of neuropathology on main cerebral networks required for successful memory retrieval and/or to decreased capacity for recruiting secondary networks that might compensate for that brain damage. Here, we tested this hypothesis in twenty-six healthy older adults and thirty-four MCI patients, of which sixteen were APOE4 carriers. Compared to controls, MCI showed hippocampal volume reduction, cortical thinning in frontal, temporal and parietal regions, and dysfunctional EEG oscillations across fronto-temporal networks...
April 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29451027/a-case-of-late-onset-ocd-developing-pls-and-ftd
#15
Enrica Bersano, Maria Francesca Sarnelli, Valentina Solara, Fabiola De Marchi, Gian Mauro Sacchetti, Alessandro Stecco, Lucia Corrado, Sandra D'alfonso, Roberto Cantello, Letizia Mazzini
We describe a 64-year-old woman, suffering from late-onset obsessive-compulsive disorder (OCD) from the age of 57, who developed dysarthria and dysphagia, spastic diplegic, and proximal muscles weakness. Needle electromyography showed no active denervation. Neuropsychological evaluation showed intact cognitive functioning. We diagnosed upper motor neuron disease (MND), with no known genetic correlates. Brain magnetic resonance (MRI) detected bilateral hippocampal atrophy with sclerosis of right hippocampus...
February 16, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29429985/posterior-associative-and-cingulate-cortex-involvement-of-brain-single-photon-emission-computed-tomography-spect-imaging-in-semantic-dementia-with-probable-alzheimer-disease-pathology-a-case-report
#16
Yumi Takano, Keiko Kunitoki, Yasuko Tatewaki, Tatsushi Mutoh, Tomoko Totsune, Hideo Shimomura, Manabu Nakagawa, Hiroyuki Arai, Yasuyuki Taki
BACKGROUND Semantic dementia (SD) is a type of primary progressive aphasia with prominent language dysfunction, mostly within the spectrum of frontotemporal lobar degeneration (FTLD). Although there is an overlap in clinical manifestations of SD attributable to FTLD and neuropathologically proven Alzheimer disease (AD), clinical diagnostic clues are not readily available. We present a characteristic finding based on a single-photon emission computed tomography (SPECT)-based regional cerebral blood flow study and its statistical imaging analysis for a rare case of SD with AD-like pathology...
February 12, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29424837/erratum-to-frontal-lobe-dysfunction-in-a-depressed-patient-who-survived-a-suicide-attempt-by-jumping-from-the-bridge-on-the-han-river
#17
Kiwon Kim, Hong Jin Jeon
[This corrects the article on p. 904 in vol. 14.].
January 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29414553/cognitive-and-motor-outcomes-in-children-with-unilateral-sturge-weber-syndrome-effect-of-age-at-seizure-onset-and-side-of-brain-involvement
#18
Aimee F Luat, Michael E Behen, Harry T Chugani, Csaba Juhász
PURPOSE: Most children with Sturge-Weber syndrome (SWS) develop seizures that may contribute to neurocognitive status. In this study, we tested the hypothesis that very early seizure onset has a particularly detrimental effect on the cognitive and/or motor outcomes of children with unilateral SWS. We also tested whether side of SWS brain involvement modulates the effect of seizure variables on the pattern of cognitive abnormalities. METHODS: Thirty-four children (22 girls; mean age 6...
March 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29414546/unique-and-shared-areas-of-cognitive-function-in-children-with-intractable-frontal-or-temporal-lobe-epilepsy
#19
Nicole Law, Elysa Widjaja, Mary Lou Smith
OBJECTIVE: Previous findings have been mixed in terms of identifying a distinct pattern of neuropsychological deficits in children with frontal lobe epilepsy (FLE) and in those with temporal lobe epilepsy (TLE). The current study investigated the neuropsychological similarities and differences across these two pediatric medically intractable localization-related epilepsies. METHOD: Thirty-eight children with FLE, 20 children with TLE, and 40 healthy children (HC) participated in this study...
March 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29410512/clinical-and-molecular-characteristics-of-newly-reported-mitochondrial-disease-entity-caused-by-biallelic-pars2-mutations
#20
Elżbieta Ciara, Dariusz Rokicki, Michal Lazniewski, Hanna Mierzewska, Elżbieta Jurkiewicz, Monika Bekiesińska-Figatowska, Dorota Piekutowska-Abramczuk, Katarzyna Iwanicka-Pronicka, Edyta Szymańska, Piotr Stawiński, Joanna Kosińska, Agnieszka Pollak, Maciej Pronicki, Dariusz Plewczyński, Rafał Płoski, Ewa Pronicka
Most of the 19 mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs) involved in mitochondrial protein synthesis are already linked to specific entities, one of the exceptions being PARS2 mutations for which pathogenic significance is not finally validated. The aim of the study was to characterize the PARS2- related phenotype.Three siblings with biallelic PARS2 mutations presented from birth with infantile spasms, secondary microcephaly, and similar facial dysmorphy. Mental development was deeply impaired with speech absence and no eye contact...
April 2018: Journal of Human Genetics
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