keyword
MENU ▼
Read by QxMD icon Read
search

parietal lobe dysfunction

keyword
https://www.readbyqxmd.com/read/27846290/altered-effective-connectivity-of-the-primary-motor-cortex-in-stroke-a-resting-state-fmri-study-with-granger-causality-analysis
#1
Zhiyong Zhao, Xiangmin Wang, Mingxia Fan, Dazhi Yin, Limin Sun, Jie Jia, Chaozheng Tang, Xiaohui Zheng, Yuwei Jiang, Jie Wu, Jiayu Gong
The primary motor cortex (M1) is often abnormally recruited in stroke patients with motor disabilities. However, little is known about the alterations in the causal connectivity of M1 following stroke. The purpose of the present study was to investigate whether the effective connectivity of the ipsilesional M1 is disturbed in stroke patients who show different outcomes in hand motor function. 23 patients with left-hemisphere subcortical stroke were selected and divided into two subgroups: partially paralyzed hands (PPH) and completely paralyzed hands (CPH)...
2016: PloS One
https://www.readbyqxmd.com/read/27833548/dysfunction-of-the-default-mode-network-in-drug-na%C3%A3-ve-parkinson-s-disease-with-mild-cognitive-impairments-a-resting-state-fmri-study
#2
Yanbing Hou, Jing Yang, Chunyan Luo, Wei Song, Ruwei Ou, Wanglin Liu, Qiyong Gong, Huifang Shang
Objective: Cognitive impairments are common in Parkinson's disease (PD) and can even occur in the early stages. The default mode network (DMN) is highly relevant for cognitive processes; however, it remains largely unknown if changes in the DMN connectivity are related to the cognitive decline in drug-naïve early stage PD patients with a mild cognitive impairment (MCI). This study used resting-state functional MRI (fMRI) to explore the brain connectivity of the DMN in early stage drug-naïve PD patients with MCI...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27752513/longitudinal-profile-of-iron-accumulation-in-good-grade-subarachnoid-hemorrhage
#3
Christoph Scherfler, Alois Josef Schiefecker, Margarete Delazer, Ronny Beer, Thomas Bodner, Georg Spinka, Mario Kofler, Bettina Pfausler, Christian Kremser, Michael Schocke, Thomas Benke, Elke R Gizewski, Erich Schmutzhard, Raimund Helbok
OBJECTIVE: MRI parameters of iron concentration (R2*, transverse relaxation rate), microstructural integrity (mean diffusivity and fractional anisotropy), as well as gray and white matter volumes were analyzed in patients with subarachnoid hemorrhage (SAH) and uncomplicated clinical course to detect the evolution of brain tissue changes 3 weeks and 12 months after ictus. METHODS: MRI scans of 14 SAH patients (aneurysm of the anterior communicating artery, n = 5; no aneurysm n = 9) were compared with 14 age-matched healthy control subjects...
October 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/27729856/aberrant-brain-regional-homogeneity-and-functional-connectivity-in-middle-aged-t2dm-patients-a-resting-state-functional-mri-study
#4
Daihong Liu, Shanshan Duan, Jiuquan Zhang, Chaoyang Zhou, Minglong Liang, Xuntao Yin, Ping Wei, Jian Wang
Type 2 diabetes mellitus (T2DM) has been associated with cognitive impairment. However, its neurological mechanism remains elusive. Combining regional homogeneity (ReHo) and functional connectivity (FC) analyses, the present study aimed to investigate brain functional alterations in middle-aged T2DM patients, which could provide complementary information for the neural substrates underlying T2DM-associated brain dysfunction. Twenty-five T2DM patients and 25 healthy controls were involved in neuropsychological testing and structural and resting-state functional magnetic resonance imaging (rs-fMRI) data acquisition...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27723821/abnormal-intrinsic-functional-hubs-in-severe-male-obstructive-sleep-apnea-evidence-from-a-voxel-wise-degree-centrality-analysis
#5
Haijun Li, Lan Li, Yi Shao, Honghan Gong, Wei Zhang, Xianjun Zeng, Chenglong Ye, Si Nie, Liting Chen, Dechang Peng
PURPOSE: Obstructive sleep apnea (OSA) has been associated with changes in brain structure and regional function in certain brain areas. However, the functional features of network organization in the whole brain remain largely uncertain. The purpose of this study was to identify the OSA-related spatial centrality distribution of the whole brain functional network and to investigate the potential altered intrinsic functional hubs. METHODS: Forty male patients with newly confirmed severe OSA on polysomnography, and well-matched good sleepers, participated in this study...
2016: PloS One
https://www.readbyqxmd.com/read/27623495/impaired-picture-arrangement-subscores-wais-iii-associated-with-decreased-place-orientation-and-frontal-occipital-blood-flow-in-alzheimer-s-disease-implications-for-social-judgment-dysfunction-the-osaki-tajiri-project
#6
Yuka Kato, Kenichi Meguro, Masahiro Nakatsuka, Kei Nakamura, Masahiro Tsuboi, Satoshi Yamaguchi
Alzheimer's disease (AD) patients manifest not only memory impairment but also deficit of social judgment. However, contrary to frequently recognized deficit, only two neuropsychological tests have been established for assessing "judgment" : the Cognitive Abilities Screening Instrument domain Abstraction & judgment and the Picture Arrangement subscale of WAIS-III. For the former, we previously reported an association with decreased regional cerebral blood flow (rCBF) in the left parietal lobe. Herein, we analyzed the scores of the Picture Arrangement test...
October 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27567291/postmortem-structural-studies-of-the-thalamus-in-schizophrenia
#7
Karl-Anton Dorph-Petersen, David A Lewis
In this review, we seek to answer the following question: Do findings in the current literature support the idea that thalamo-cortical dysfunction in schizophrenia is due to structural abnormalities in the thalamus? We base our review on the existing literature of design-unbiased stereological studies of the postmortem thalamus from subjects with schizophrenia. Thus, all reported results are based upon the use of unbiased principles of sampling to determine volume and/or total cell numbers of thalamus or its constituent nuclei...
August 23, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27536237/the-alterations-of-cortical-volume-thickness-surface-and-density-in-the-intermediate-sporadic-parkinson-s-disease-from-the-han-population-of-mainland-china
#8
Xia Deng, Meihong Zhou, Chunyan Tang, Jie Zhang, Lei Zhu, Zunchun Xie, Honghan Gong, Xiangzuo Xiao, Renshi Xu
Many symptoms of sporadic Parkinson's disease (sPD) can't be completely explained by the lesion of simple typical extrapyramidal circuit between striatum and substantia nigra. Therefore, we investigated the alteration of cortical volume, thickness, surface, and density in the intermediate sPD from the Han population of Mainland China in order to find the new pathological brain regions associated with the complex clinical manifestations of sPD. The cortical volume, thickness, surface and density were examined using the voxel-based cortical morphometry and corticometry on magnetic resonance image (MRI) in 67 intermediate sPD and 35 controls, the multiple adjusted comparisons analysis of all MRI data were employed to assess the relationships between the cortical morphometric alteration in the specific brain regions and sPD...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27530801/-research-advances-of-posterior-reversible-encephalopathy-syndrome-in-children
#9
Jing Liu, Jiong Qin
Posterior reversible encephalopathy syndrome (PRES) is a clinico-neuroradiological entity affecting the posterior brain, i.e. occipital and parietal lobes. The syndrome are characterized by headaches, altered mental status, seizures, and visual disturbances. Although the pathogenesis remains unclear, endothelial dysfunction may be a key factor. The basic disease may play a crucial role in the incidence of PRES. In most cases, PRES resolves spontaneously and patients show both clinical and radiological improvements...
August 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27432102/inflammatory-pseudotumor-of-the-brain-parenchyma-with-igg4-hypergammaglobulinemia
#10
Haruko Tanji, Hiroaki Okada, Ryosuke Igari, Yoshitaka Yamaguchi, Hiroyasu Sato, Yoshimi Takahashi, Shingo Koyama, Shigeki Arawaka, Manabu Wada, Toru Kawanami, Koichi Wakabayashi, Takeo Kato
A 58-year-old woman with a 1-month history of right hand clumsiness and speaking difficulty was admitted to our hospital. A neurological examination revealed sensory aphasia and right hemiparesis. Her laboratory tests showed elevated serum levels of IgG and IgG4, pancytopenia, and liver dysfunction. The results of the imaging studies of her abdomen were compatible with sclerosing cholangitis. Brain MRI showed extensive signal abnormalities in the left hemisphere on T2-weighted and fluid-attenuated inversion recovery (FLAIR) images, extending from left internal capsule to the cerebral peduncle with an irregularly enhancing lesion in the left parietal lobe...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27356810/similarity-of-symptoms-between-transient-epileptic-amnesia-and-lewy-body-disease
#11
Katsuyuki Ukai, Hiroshige Fujishiro, Masako Watanabe, Kenji Kosaka, Norio Ozaki
Epilepsy with the main symptom of amnesia is known as transient epileptic amnesia (TEA). Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia. The concept that Lewy body disease includes Parkinson's disease with dementia and dementia with Lewy bodies was proposed in the 2005 revision of the Clinical Diagnostic Criteria. Here, we describe a woman with cognitive impairment, olfactory dysfunction, and reduced (123) I-meta-iodobenzylguanidine uptake on myocardial scintigraphy...
June 30, 2016: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/27354020/working-memory-network-dysfunction-in-relapse-onset-multiple-sclerosis-phenotypes-a-clinical-imaging-evaluation
#12
Laura Vacchi, Maria A Rocca, Alessandro Meani, Mariaemma Rodegher, Vittorio Martinelli, Giancarlo Comi, Andrea Falini, Massimo Filippi
OBJECTIVES: We investigated clinical, behavioural and functional magnetic resonance imaging (fMRI) correlates of working memory load in relapse-onset multiple sclerosis (MS) patients. METHODS: In total, 12 clinically isolated syndromes (CIS) patients at risk of MS, 38 relapsing-remitting multiple sclerosis (RRMS), 22 secondary progressive multiple sclerosis (SPMS) and 24 healthy controls (HC) performed an N-back fMRI task. Correlations between fMRI abnormalities and clinico-behavioural and structural magnetic resonance imaging (MRI) measures were assessed...
June 28, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27349503/insights-into-intrinsic-brain-networks-based-on-graph-theory-and-pet-in-right-compared-to-left-sided-temporal-lobe-epilepsy
#13
Thomas Vanicek, Andreas Hahn, Tatjana Traub-Weidinger, Eva Hilger, Marie Spies, Wolfgang Wadsak, Rupert Lanzenberger, Ekaterina Pataraia, Susanne Asenbaum-Nan
The human brain exhibits marked hemispheric differences, though it is not fully understood to what extent lateralization of the epileptic focus is relevant. Preoperative [(18)F]FDG-PET depicts lateralization of seizure focus in patients with temporal lobe epilepsy and reveals dysfunctional metabolic brain connectivity. The aim of the present study was to compare metabolic connectivity, inferred from inter-regional [(18)F]FDG PET uptake correlations, in right-sided (RTLE; n = 30) and left-sided TLE (LTLE; n = 32) with healthy controls (HC; n = 31) using graph theory based network analysis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27345010/effects-of-hypotension-and-or-hypocapnia-during-sevoflurane-anesthesia-on-perfusion-and-metabolites-in-the-developing-brain-of-piglets-a-blinded-randomized-study
#14
Simone K Ringer, Stefanie Ohlerth, Inés Carrera, Jacqueline Mauch, Nelly Spielmann, Regula Bettschart-Wolfensberger, Markus Weiss
BACKGROUND: Hypotension (HT) and/or hypocapnia (HC) are frequent complications occurring during pediatric anesthesia and may cause cerebral injury in the developing brain. AIM: The aim of this study is to investigate the effects of HT and/or HC on perfusion and metabolism in the developing brain. METHODS: Twenty-eight piglets were randomly allocated to four groups: control (C), HT, HC, and hypotension and hyocapnia (HTC). Anesthesia was induced and maintained using sevoflurane...
September 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27252647/in-alzheimer-s-disease-6-month-treatment-with-glp-1-analog-prevents-decline-of-brain-glucose-metabolism-randomized-placebo-controlled-double-blind-clinical-trial
#15
Michael Gejl, Albert Gjedde, Lærke Egefjord, Arne Møller, Søren B Hansen, Kim Vang, Anders Rodell, Hans Brændgaard, Hanne Gottrup, Anna Schacht, Niels Møller, Birgitte Brock, Jørgen Rungby
In animal models, the incretin hormone GLP-1 affects Alzheimer's disease (AD). We hypothesized that treatment with GLP-1 or an analog of GLP-1 would prevent accumulation of Aβ and raise, or prevent decline of, glucose metabolism (CMRglc) in AD. In this 26-week trial, we randomized 38 patients with AD to treatment with the GLP-1 analog liraglutide (n = 18), or placebo (n = 20). We measured Aβ load in brain with tracer [(11)C]PIB (PIB), CMRglc with [(18)F]FDG (FDG), and cognition with the WMS-IV scale (ClinicalTrials...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27248706/alteration-of-the-intra-and-cross-hemisphere-posterior-default-mode-network-in-frontal-lobe-glioma-patients
#16
Haosu Zhang, Yonghong Shi, Chengjun Yao, Weijun Tang, Demin Yao, Chenxi Zhang, Manning Wang, Jinsong Wu, Zhijian Song
Patients with frontal lobe gliomas often experience neurocognitive dysfunctions before surgery, which affects the default mode network (DMN) to different degrees. This study quantitatively analyzed this effect from the perspective of cerebral hemispheric functional connectivity (FC). We collected resting-state fMRI data from 20 frontal lobe glioma patients before treatment and 20 healthy controls. All of the patients and controls were right-handed. After pre-processing the images, FC maps were built from the seed defined in the left or right posterior cingulate cortex (PCC) to the target regions determined in the left or right temporal-parietal junction (TPJ), respectively...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27224930/synaptic-proteins-predict-cognitive-decline-in-alzheimer-s-disease-and%C3%A2-lewy-body-dementia
#17
Erika Bereczki, Paul T Francis, David Howlett, Joana B Pereira, Kina Höglund, Anna Bogstedt, Angel Cedazo-Minguez, Jean-Ha Baek, Tibor Hortobágyi, Johannes Attems, Clive Ballard, Dag Aarsland
INTRODUCTION: Our objective was to compare the levels of three synaptic proteins involved in different steps of the synaptic transmission: Rab3A, SNAP25, and neurogranin, in three common forms of dementia: Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia. METHODS: A total of 129 postmortem human brain samples were analyzed in brain regional specific manner exploring their associations with morphologic changes and cognitive decline...
May 22, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/27203600/lateralized-resting-state-functional-brain-network-organization-changes-in-heart-failure
#18
Bumhee Park, Bhaswati Roy, Mary A Woo, Jose A Palomares, Gregg C Fonarow, Ronald M Harper, Rajesh Kumar
Heart failure (HF) patients show brain injury in autonomic, affective, and cognitive sites, which can change resting-state functional connectivity (FC), potentially altering overall functional brain network organization. However, the status of such connectivity or functional organization is unknown in HF. Determination of that status was the aim here, and we examined region-to-region FC and brain network topological properties across the whole-brain in 27 HF patients compared to 53 controls with resting-state functional MRI procedures...
2016: PloS One
https://www.readbyqxmd.com/read/27178661/chronic-pain-disrupts-the-reward-circuitry-in-multiple-sclerosis
#19
Daniela Seixas, Jacqueline Palace, Irene Tracey
Pain commonly affects multiple sclerosis (MS) patients, and has the potential to become chronic and burden an already damaged central nervous system. Imaging studies are providing insights into brain restructuring associated with chronic pain and different chronic pain conditions seem to evoke distinct plasticity patterns. Our objective was to study the structural and functional brain changes of chronic neuropathic pain of MS. Employing structural and resting functional magnetic resonance imaging we compared MS patients with chronic central pain with MS patients without pain matched with respect to age, gender, subtype and duration of MS and disability...
August 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27165581/dengue-fever-with-diffuse-cerebral-hemorrhages-subdural-hematoma-and-cranial-diabetes-insipidus
#20
Nayomi Shermila Jayasinghe, Eranga Thalagala, Milanka Wattegama, Kanapathipillai Thirumavalavan
BACKGROUND: Neurological manifestations in dengue fever occur in <1 % of the patients and known to be due to multisystem dysfunction secondary to vascular leakage. Occurrence of wide spread cerebral haemorrhages with subdural hematoma during the leakage phase without profound thrombocytopenia and occurrence of cranial diabetes insipidus are extremely rare and had not been reported in published literature earlier, thus we report the first case. CASE PRESENTATION: A 24 year old previously healthy lady was admitted on third day of fever with thrombocytopenia...
2016: BMC Research Notes
keyword
keyword
63618
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"