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https://www.readbyqxmd.com/read/29752303/typical-features-of-parkinson-disease-and-diagnostic-challenges-with-microdeletion-22q11-2
#1
Erik Boot, Nancy J Butcher, Sean Udow, Connie Marras, Kin Y Mok, Satoshi Kaneko, Matthew J Barrett, Paolo Prontera, Brian D Berman, Mario Masellis, Boris Dufournet, Karine Nguyen, Perrine Charles, Eugénie Mutez, Teodor Danaila, Aurélia Jacquette, Olivier Colin, Sophie Drapier, Michel Borg, Ania M Fiksinski, Elfi Vergaelen, Ann Swillen, Annick Vogels, Annika Plate, Claudia Perandones, Thomas Gasser, Kristien Clerinx, Frédéric Bourdain, Kelly Mills, Nigel M Williams, Nicholas W Wood, Jan Booij, Anthony E Lang, Anne S Bassett
OBJECTIVE: To delineate the natural history, diagnosis, and treatment response of Parkinson disease (PD) in individuals with 22q11.2 deletion syndrome (22q11.2DS), and to determine if these patients differ from those with idiopathic PD. METHODS: In this international observational study, we characterized the clinical and neuroimaging features of 45 individuals with 22q11.2DS and PD (mean follow-up 7.5 ± 4.1 years). RESULTS: 22q11.2DS PD had a typical male excess (32 male, 71...
May 11, 2018: Neurology
https://www.readbyqxmd.com/read/29747712/remote-delivery-of-psychological-interventions-for-parkinson-s-disease
#2
Caitlin Swalwell, Nancy A Pachana, Nadeeka N Dissanayaka
ABSTRACTObjective:Over two-thirds of Parkinson's disease (PD) patients experience comorbid neuropsychiatric symptoms, which adversely impact their quality of life and often require intervention. There is a preference for non-pharmacological, psychological approaches in addressing these symptoms. Given mobility limitations, travel burden, and cost, accessibility to psychological treatment can be problematic in this population. There has been a recent shift toward delivering care via telehealth in PD. Accordingly, this review aimed to examine remotely delivered psychological interventions for PD patients...
May 11, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29743207/use-of-medical-care-biases-associations-between-parkinson-disease-and-other-medical-conditions
#3
Anat Gross, Brad A Racette, Alejandra Camacho-Soto, Umber Dube, Susan Searles Nielsen
OBJECTIVE: To examine how use of medical care biases the well-established associations between Parkinson disease (PD) and smoking, smoking-related cancers, and selected positively associated comorbidities. METHODS: We conducted a population-based, case-control study of 89,790 incident PD cases and 118,095 randomly selected controls, all Medicare beneficiaries aged 66 to 90 years. We ascertained PD and other medical conditions using ICD-9-CM codes from comprehensive claims data for the 5 years before PD diagnosis/reference...
May 9, 2018: Neurology
https://www.readbyqxmd.com/read/29740928/incidence-timing-and-impact-of-comorbidity-on-second-hip-fracture-a-population-based-study
#4
Lara Harvey, Barbara Toson, Rebecca Mitchell, Henry Brodaty, Brian Draper, Jacqueline Close
BACKGROUND: To quantify the incidence and timing of second hip fracture, and to evaluate the relative impact of comorbidities on risk of second hip fracture. METHODS: Hospitalization records for individuals aged ≥65, admitted to a New South Wales hospital for fall-related hip fracture between 1 January 2005 and 31 December 2009 were linked. Comorbidities were identified from the records using a 1-year look-back period. To calculate second hip fracture rates, individuals were followed until death, fracture or end of study period (31 December 2012)...
May 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29728904/high-angular-resolution-diffusion-imaging-correlates-of-depression-in-parkinson-s-disease-a-connectometry-study
#5
Farzaneh Ghazi Sherbaf, Kaveh Same, Mohammad Hadi Aarabi
Depression is a significant disabling feature in Parkinson's disease (PD). However, the neuropathology of this comorbidity is still unclear. In fact, few studies have tried to elucidate the neural correlates of depression in PD and have mostly examined specific regions of interest. In this study, we applied diffusion MRI connectometry, a powerful complementary approach to investigate alterations in whole white matter pathways regarding the severity of depressive symptoms. Using a multiple regression model, the correlation of severity of depressive symptoms assessed by the Hospital Anxiety and Depression Scale (HADS) with white matter connectivity was surveyed in 27 non-demented PD patients related to 26 age, sex, and educational level-matched healthy subjects...
May 4, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29724602/emergence-of-non-motor-fluctuations-with-reference-to-motor-fluctuations-in-parkinson-s-disease
#6
Aryun Kim, Han-Joon Kim, Chae Won Shin, Ahro Kim, Yoon Kim, Mihee Jang, Yu Jin Jung, Woong-Woo Lee, Hyeyoung Park, Beomseok Jeon
INTRODUCTION: Non-motor fluctuations (NMF) and motor fluctuations (MF) are frequent in patients with Parkinson's disease (PD) with long-term medical treatment. We aimed to examine the timing of the emergence of NMF with reference to MF in a prospective cohort of patients with PD without symptom fluctuations. METHODS: A total of 334 patients with PD who had neither MF nor NMF were recruited. The exclusion criteria included a Mini-Mental State Examination score of less than 26 points at baseline and an alternative diagnosis or significant comorbidity during follow-up...
April 19, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29705686/addiction-vulnerability-trait-impacts-complex-movement-control-evidence-from-sign-trackers
#7
Aaron Kucinski, Cindy Lustig, Martin Sarter
Cognitive-motivational vulnerability traits are associated with increased risk for substance addiction and relapse. Sign-tracking (ST) behavior in rats is associated with poor attentional control, mediated by an unresponsive basal forebrain cholinergic system, and an increased risk for substance addiction/relapse. A separate literature links poor attentional control and cholinergic losses to increased fall risk in Parkinson's disease. Here we tested the hypothesis that the relatively inferior attentional control of STs extends to complex movement control and a propensity for falls...
April 26, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29686832/patterns-and-predictors-of-depression-treatment-among-older-adults-with-parkinson-s-disease-and-depression-in-ambulatory-care-settings-in-the-united-states
#8
Sandipan Bhattacharjee, Nina Vadiei, Lisa Goldstone, Ziyad Alrabiah, Scott J Sherman
Little is known regarding depression treatment patterns and predictors among older adults with comorbid Parkinson's disease and depression (dPD) in the United States (US). The objective of this study was to assess the patterns and predictors of depression treatment among older adults with dPD in the US. We adopted a cross-sectional study design by pooling multiple-year data (2005-2011) from the National Ambulatory Medical Care Survey (NAMCS) and the outpatient department of the National Hospital Ambulatory Medical Care Survey (NHAMCS)...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29669907/mild-tbi-and-risk-of-parkinson-disease-a-chronic-effects-of-neurotrauma-consortium-study
#9
Raquel C Gardner, Amy L Byers, Deborah E Barnes, Yixia Li, John Boscardin, Kristine Yaffe
OBJECTIVE: Our aim was to assess risk of Parkinson disease (PD) following traumatic brain injury (TBI), including specifically mild TBI (mTBI), among care recipients in the Veterans Health Administration. METHODS: In this retrospective cohort study, we identified all patients with a TBI diagnosis in Veterans Health Administration databases from October 2002 to September 2014 and age-matched 1:1 to a random sample of patients without TBI. All patients were aged 18 years and older without PD or dementia at baseline...
April 18, 2018: Neurology
https://www.readbyqxmd.com/read/29668839/prognostic-factors-of-functional-outcome-after-hip-fracture-surgery-a-systematic-review
#10
K J Sheehan, L Williamson, J Alexander, C Filliter, B Sobolev, P Guy, L M Bearne, C Sackley
Objective: this systematic review aimed to identify immutable and modifiable prognostic factors of functional outcomes and their proposed mechanism after hip fracture surgery. Design: systematic search of MEDLINE, Embase, CINAHL, PEDRO, OpenGrey and ClinicalTrials.gov for observational studies of prognostic factors of functional outcome after hip fracture among surgically treated adults with mean age of 65 years and older. Study selection, quality assessment, and data extraction were completed independently by two reviewers...
April 12, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29625874/peripheral-neuropathy-is-associated-with-more-frequent-falls-in-parkinson-s-disease
#11
Mélanie L Beaulieu, Martijn L T M Müller, Nicolaas I Bohnen
INTRODUCTION: Peripheral neuropathy is a common condition in the elderly that can affect balance and gait. Postural imbalance and gait difficulties in Parkinson's disease (PD), therefore, may stem not only from the primary neurodegenerative process but also from age-related medical comorbidities. Elucidation of the effects of peripheral neuropathy on these difficulties in PD is important to provide more targeted and effective therapy. The purpose of this study was to investigate the association between lower-limb peripheral neuropathy and falls and gait performance in PD while accounting for disease-specific factors...
April 3, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29623597/coping-mediates-the-relationship-between-sense-of-coherence-and-mental-quality-of-life-in-patients-with-chronic-illness-a-cross-sectional-study
#12
Marja-Leena Kristofferzon, Maria Engström, Annika Nilsson
PURPOSE: The aim of the present study was to investigate relationships between sense of coherence, emotion-focused coping, problem-focused coping, coping efficiency, and mental quality of life (QoL) in patients with chronic illness. A model based on Lazarus' and Folkman's stress and coping theory tested the specific hypothesis: Sense of coherence has a direct and indirect effect on mental QoL mediated by emotion-focused coping, problem-focused coping, and coping efficiency in serial adjusted for age, gender, educational level, comorbidity, and economic status...
April 5, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29610690/comorbid-normal-pressure-hydrocephalus-with-parkinsonism-a-clinical-challenge-and-call-for-awareness
#13
A Cucca, M C Biagioni, K Sharma, J Golomb, R M Gilbert, A Di Rocco, J E Fleisher
Idiopathic normal pressure hydrocephalus (iNPH) is the most common cause of hydrocephalus in adults. The diagnosis may be challenging, requiring collaborative efforts between different specialists. According to the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders, iNPH should be considered in the differential of any unexplained gait failure with insidious onset. Recognizing iNPH can be even more difficult in the presence of comorbid neurologic disorders. Among these, idiopathic Parkinson's disease (PD) is one of the major neurologic causes of gait dysfunction in the elderly...
2018: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29603405/short-and-long-term-cost-and-utilization-of-health-care-resources-in-parkinson-s-disease-in-the-uk
#14
Sharada Weir, Mihail Samnaliev, Tzu-Chun Kuo, Travis S Tierney, Silke Walleser Autiero, Rod S Taylor, Anette Schrag
BACKGROUND: There is currently no robust long-term data on costs of treating patients with Parkinson's disease. The objective of this study was to report levels of health care utilization and associated costs in the 10 years after diagnosis among PD patients in the United Kingdom. METHODS: We undertook a retrospective population-based cohort study using linked data from the UK Clinical Practice Research Datalink and Hospital Episode Statistics databases. Total health care costs of PD patients were compared with those of a control group of patients without PD selected using 1:1 propensity score matching based on age, sex, and comorbidity...
March 30, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29602843/dementia-and-vagotomy-in-taiwan-a-population-based-cohort-study
#15
Shih-Yi Lin, Cheng-Li Lin, I-Kuan Wang, Cheng-Chieh Lin, Chih-Hsueh Lin, Wu-Huei Hsu, Chia-Hung Kao
OBJECTIVE: Truncal vagotomy is associated with a decreased risk of subsequent Parkinson disease (PD), although the effect of vagotomy on dementia is unclear. In response, we investigated the risk of dementia in patients who underwent vagotomy. SETTING: Population-based cohort study. PARTICIPANTS: A total of 155 944 patients who underwent vagotomy (vagotomy cohort) and 155 944 age-matched, sex-matched and comorbidity-matched controls (non-vagotomy cohort) were identified between 2000 and 2011...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29599930/does-antipsychotic-drug-use-increase-the-risk-of-long-term-mortality-a-systematic-review-and-meta-analysis-of-observational-studies
#16
Chunsong Yang, Zilong Hao, Jinhui Tian, Wei Zhang, Wenting Li, Ling-Li Zhang, Fujian Song
Antipsychotics (AP) are widely used to treat schizophrenia and other psychiatric disorders. However, the association between the AP use and mortality risk is controversial. We searched PubMed, EMBASE, MEDLINE, PsycINFO, CINAHL, the Cochrane Library and four Chinese databases from inception to June 2016. All observational cohort or case-control studies reporting data on mortality outcomes in individuals exposed to AP drugs were included. This systematic review included 68 studies involving 4,812,370 participants...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29571869/prevalence-of-functional-psychogenic-parkinsonism-in-two-swiss-movement-disorders-clinics-and-review-of-the-literature
#17
Giulia Frasca Polara, Vanessa Fleury, Jon Stone, Anita Barbey, Pierre R Burkhard, François Vingerhoets, Selma Aybek
BACKGROUND: Functional parkinsonism (FP) is considered rare but no studies have looked at its frequency. Case series have described high rates of comorbidity with Parkinson's disease (PD), suggesting a possible association between these conditions. OBJECTIVES: To study the prevalence, epidemiology and clinical features of FP and its association with PD. METHODS: We conducted a cross-sectional population-based prevalence study as well as a chart review of cases who received a diagnosis of FP over a 10-year-period in two movement disorder clinics in Switzerland...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29569562/a-new-tool-to-adapt-the-treatment-of-parkinson-s-disease-patients-in-nursing-homes
#18
Christian Geny, Claudia Verna, Alexia Arifi, Ernestine Ferreira, Choukri Boubakri, Hubert Blain
Parkinson's disease (PD) is a common condition in nursing home (NH) residents. The primary treatment for Parkinson's disease is levodopa therapy to relieve motor symptoms and maximize physical function. Non-motor symptoms are highly prevalent in NH residents with Parkinson's disease and dramatically decrease quality of life. Choices in drug treatment need to take into account the complex interactions between aging, comorbidity and non-motor symptoms. Optimal management requires expertise and cooperative effort from prescribing neurologists and nursing home health professionals...
March 1, 2018: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/29569399/identification-of-clinically-relevant-phenotypes-in-patients-with-ebstein-anomaly
#19
Rodrigo Cabrera, Marta Catalina Miranda-Fernández, Victor Manuel Huertas-Quiñones, Marisol Carreño, Ivonne Pineda, Carlos M Restrepo, Claudia Tamar Silva, Rossi Quero, Juan David Cano, Diana Carolina Manrique, Camila Camacho, Sebastián Tabares, Alberto García, Néstor Sandoval, Karen Julieth Moreno Medina, Rodolfo José Dennis Verano
BACKGROUND: Ebstein anomaly (EA) is a heterogeneous congenital heart defect (CHD), frequently accompanied by diverse cardiac and extracardiac comorbidities, resulting in a wide range of clinical outcomes. HYPOTHESIS: Phenotypic characterization of EA patients has the potential to identify variables that influence prognosis and subgroups with distinct contributing factors. METHODS: A comprehensive cross-sectional phenotypic characterization of 147 EA patients from one of the main referral institutions for CHD in Colombia was carried out...
March 22, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29560834/comparison-of-structural-connectivity-in-parkinson-s-disease-with-depressive-symptoms-versus-non-depressed-a-diffusion-mri-connectometry-study
#20
Mina Ansari, Sahand Adib Moradi, Farzaneh Ghazi Sherbaf, Abozar Hedayatnia, Mohammad Hadi Aarabi
OBJECTIVE: Research on psychobiological markers of Parkinson's disease (PD) remains a hot topic. Non-motor symptoms such as depression and REM sleep behavior disorder (RBD) each attribute to a particular neurodegenerative cluster in PD, and might enlighten the way for early prediction/detection of PD. The neuropathology of mood disturbances remains unclear. In fact, a few studies have investigated depression using diffusion magnetic resonance imaging (diffusion MRI). METHOD: Diffusion MRI of PD patients without comorbid RBD was used to assess whether microstructural abnormalities are detectable in the brain of 40 PD patients with depression compared to 19 patients without depression...
March 21, 2018: International Psychogeriatrics
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