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https://www.readbyqxmd.com/read/28446653/vagotomy-and-parkinson-disease-a-swedish-register-based-matched-cohort-study
#1
Bojing Liu, Fang Fang, Nancy L Pedersen, Annika Tillander, Jonas F Ludvigsson, Anders Ekbom, Per Svenningsson, Honglei Chen, Karin Wirdefeldt
OBJECTIVE: To examine whether vagotomy decreases the risk of Parkinson disease (PD). METHODS: Using data from nationwide Swedish registers, we conducted a matched-cohort study of 9,430 vagotomized patients (3,445 truncal and 5,978 selective) identified between 1970 and 2010 and 377,200 reference individuals from the general population individually matched to vagotomized patients by sex and year of birth with a 40:1 ratio. Participants were followed up from the date of vagotomy until PD diagnosis, death, emigration out of Sweden, or December 31, 2010, whichever occurred first...
April 26, 2017: Neurology
https://www.readbyqxmd.com/read/28436278/glaucoma-correlates-with-increased-risk-of-parkinson-s-disease-in-the-elderly-a-national-based-cohort-study-in-taiwan
#2
Shih-Wei Lai, Cheng-Li Lin, Kuan-Fu Liao
BACKGROUND/OBJECTIVE: Very little is known about the association between glaucoma and Parkinson's disease in the elderly. The objective of this study was to determine whether glaucoma is associated with Parkinson's disease in older people in Taiwan. METHODS: A retrospective cohort study was conducted to analyze the Taiwan National Health Insurance Program database from 2000 to 2010. We included 4,330 subjects aged 65 years or older with newly diagnosed glaucoma as the glaucoma group, and 17,000 randomly selected subjects without a glaucoma diagnosis as the non-glaucoma group...
April 22, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28428905/deep-brain-stimulation-target-selection-in-an-advanced-parkinson-s-disease-patient-with-significant-tremor-and-comorbid-depression
#3
Amar S Patel
CLINICAL VIGNETTE: A 67-year-old female with advanced Parkinson's disease (PD), medically refractory tremor, and a history of significant depression presented for evaluation of deep brain stimulation (DBS) candidacy. CLINICAL DILEMMA: Traditionally, the subthalamic nucleus (STN) has been preferred over the globus pallidus interna (GPi) as a DBS target for PD patients with levodopa-responsive fluctuations in rigidity and akinesia, for whom tremor is also a significant source of impairment...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28425238/depression-and-parkinson-disease-prevalence-temporal-relationship-and-determinants
#4
Hale Yapici Eser, Hatice Ayşe Bora, Aslı Kuruoğlu
BACKGROUND/AIM: Comorbidity of depression in Parkinson disease (PD) is a major factor that changes patients' quality of life. However, the neurobiological and sociodemographic risk factors for this comorbidity are not well studied. In this study, we aimed to define the prevalence, temporal relationship, and psychosocial and clinical determinants of depression comorbid with PD. MATERIALS AND METHODS: Fifty-five PD patients were evaluated with SCID, a data form that assessed sociodemographic and PD-related variables, UPDRS III, HAM-D, HAM-A, MMSE, and the Apathy Evaluation Scale...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28419289/parkinson-s-disease-patient-and-general-practitioner-perspectives-on-the-role-of-primary-care
#5
Annette O A Plouvier, Tim C Olde Hartman, Clementine E M Verhulst, Bastiaan R Bloem, Chris van Weel, Antoine L M Lagro-Janssen
Background.: Specialized Parkinson's disease (PD) care offers advantages to patients. However, specialized health care providers may be unaware of patients' personal context and comorbidity, leading to conflicting treatment regimens. Patients may benefit from a more holistic approach. Objective.: To clarify the role community-dwelling PD patients see for general practitioners (GPs) in PD care and to clarify the role GPs see for themselves. Methods...
April 1, 2017: Family Practice
https://www.readbyqxmd.com/read/28416268/post-traumatic-stress-disorder-and-risk-of-parkinson-disease-a-nationwide-longitudinal-study
#6
Yee-Lam E Chan, Ya-Mei Bai, Ju-Wei Hsu, Kai-Lin Huang, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Tai-Long Pan, Tzeng-Ji Chen, Shih-Jen Tsai, Mu-Hong Chen
OBJECTIVE: Increasing evidence has suggested a relationship between post-traumatic stress disorder (PTSD) and neurodegenerative disorder, such as Alzheimer disease. The association between PTSD and Parkinson disease (PD), however, remains unclear. METHOD: Using the Taiwan National Health Insurance Research Database, 7,280 subjects (1,456 patients aged ≥45 years with PTSD and 5,824 age-/sex-matched individuals without PTSD) were enrolled between 2002 and 2009 and followed to the end of 2011...
March 23, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28416129/increase-in-parkinson-s-disease-related-mortality-among-males-in-northern-italy
#7
Ugo Fedeli, Elena Schievano
BACKGROUND: According to standard mortality statistics based on the underlying cause of death (UCOD), mortality from Parkinson's disease (PD) is increasing in most European countries. However, mortality trends are better investigated taking into account all the diseases reported in the death certificate (multiple causes of death approach, MCOD). METHODS: All deaths of residents in the Veneto Region (Northern Italy) aged≥45 years with any mention of PD were extracted from 2008 to 2015...
April 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28409063/a-practical-approach-to-detection-and-treatment-of-depression-in-parkinson-disease-and-dementia
#8
REVIEW
Zahra Goodarzi, Zahinoor Ismail
PURPOSE OF REVIEW: To review the available evidence for the detection and management of depression in Parkinson disease (PD) and dementia. RECENT FINDINGS: Depression is a common comorbidity in those with PD or dementia, and leads to increased morbidity. There are several available and accurate tools for the detection of depression in PD (e.g., Geriatric Depression Scale) and dementia (e.g., Cornell Scale for Depression in Dementia). Treatment of depression depends on patient preference, severity of depression, comorbidities, and available resources...
April 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/28405323/the-use-of-enteral-access-for-continuous-delivery-of-levodopa-carbidopa-in-patients-with-advanced-parkinson-s-disease
#9
Julian Cheron, Jacques Deviere, Frederic Supiot, Asuncion Ballarin, Pierre Eisendrath, Emmanuel Toussaint, Vincent Huberty, Carmen Musala, Daniel Blero, Arnaud Lemmers, André Van Gossum, Marianna Arvanitakis
BACKGROUND: Continuous delivery to the jejunum of levodopa-carbidopa is a promising therapy in patients with advanced Parkinson's disease, as it reduces motor fluctuation. Percutaneous endoscopic gastrostomy and jejunal tube (PEG-J) placement is a suitable option for this. However, studies focused in PEG-J management are lacking. OBJECTIVES: We report our experience regarding this technique, including technical success, adverse events and outcomes, in patients with advanced Parkinson's disease...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28401296/associations-of-specific-psychiatric-disorders-with-isolated-focal-dystonia-and-monogenic-and-idiopathic-parkinson-s-disease
#10
Susanne Steinlechner, Johann Hagenah, Hans-Jürgen Rumpf, Christian Meyer, Ulrich John, Tobias Bäumer, Norbert Brüggemann, Meike Kasten, Alexander Münchau, Christine Klein, Rebekka Lencer
Comorbidity of psychiatric disorders in patients with movement disorders is common. Often, psychiatric symptoms manifest before the onset of the movement disorder, thus not representing a mere reaction to its burden. How the disease mechanisms of psychiatric and movement disorders are related is still poorly understood. The aim of the present study was to compare prevalence rates of specific psychiatric disorders between different movement disorders including isolated focal dystonia (IFD, N = 91), monogenic Parkinson's disease (PD, N = 41), idiopathic PD (N = 45), and a sample from a Northern Germany general population (TACOS Study; N = 4075)...
April 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28397662/-perioperative-challenges-of-parkinson-s-disease
#11
Peter Søndergaard Thyrrestrup, Lyudmyla Horodyska
Parkinson's disease (PD) is a neurogenerative disease, which causes motoric disorders, and the risk of developing PD increases with age. There is an increasing number of persons above 60 years undergoing anaesthesia, and PD is becoming a common comorbidity. PD symptoms, delayed medicine administration or medical side effects can complicate anaesthesia. The importance of correct administration of PD medication administration must be emphasized to avoid complications. Optimized perioperative care can potentially prevent complicated and prolonged admission periods...
February 20, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28395086/regional-overlap-of-pathologies-in-lewy-body-disorders
#12
Martí Colom-Cadena, Oriol Grau-Rivera, Lluís Planellas, Catalina Cerquera, Estrella Morenas, Sergio Helgueta, Laia Muñoz, Jaime Kulisevsky, Maria Jose Martí, Eduard Tolosa, Jordi Clarimon, Alberto Lleó, Ellen Gelpi
Lewy body disorders (LBD) are common neurodegenerative diseases characterized by the presence of aggregated α-synuclein in Lewy bodies and Lewy neurites in the central and peripheral nervous systems. The brains of patients with LBD often display other comorbid pathologies, i.e. insoluble tau, β-amyloid aggregates, TAR DNA-binding protein 43 (TDP-43) deposits, and argyrophilic grain disease (AGD). The incidence and physiological relevance of these concurrent pathological findings remain controversial. We performed a semiquantitative detailed mapping of α-synuclein, tau, β-amyloid (Aβ), TDP-43, and AGD pathologies in 17 areas in 63 LBD cases (44 with Parkinson disease [PD], 28 with dementia, and 19 with dementia with Lewy bodies)...
March 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28389758/comparison-of-outcomes-of-operative-versus-non-operative-treatment-of-acetabular-fractures-in-the-elderly-and-severely-comorbid-patient
#13
Kempland C Walley, P T Appleton, E K Rodriguez
BACKGROUND: Acetabular fractures in the elderly and severely comorbid patient can be associated with high morbidity and mortality; however, differences in outcomes of acute ORIF versus non-operative care of acetabular fractures in a subgroup of elderly (>75 years) and/or severely comorbid younger patients (>65) remain unclear. PATIENTS AND METHODS: A retrospective review of 243 patients who sustained an acetabular fracture between April 2005 and November 2014 was performed...
April 7, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28387438/the-cognitive-footprint-of-psychiatric-and-neurological-conditions-cross-sectional-study-in-the-uk-biobank-cohort
#14
B Cullen, D J Smith, I J Deary, J J Evans, J P Pell
OBJECTIVE: We aimed to quantify the prevalence of cognitive impairment in adults with a history of mood disorder, schizophrenia, multiple sclerosis or Parkinson's disease, within a large general population cohort. METHOD: Cross-sectional study using UK Biobank data (n = 502 642). Psychiatric and neurological exposure status was ascertained via self-reported diagnoses, hospital records and questionnaires. Impairment on reasoning, reaction time and memory tests was defined with reference to a single unexposed comparison group...
April 7, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28376692/neuroversion-using-electroconvulsive-therapy-as-a-bridge-to-deep-brain-stimulation-implantation
#15
Nolan R Williams, Greg Sahlem, Jaspreet Pannu, Istvan Takacs, Baron Short, Gonzalo Revuelta, Mark S George
Parkinson's disease (PD) is a movement disorder with significant neuropsychiatric comorbidities. Electroconvulsive therapy (ECT) is effective in treating these neuropsychiatric symptoms; however, clinicians are reluctant to use ECT in patients with deep brain stimulation (DBS) implantations for fear of damaging the device, as well as potential cognitive side effects. Right unilateral ultra-brief pulse (RUL UBP) ECT has a more favorable cognitive side-effect profile yet has never been reported in PD patients with DBS implants...
February 2017: Neurocase
https://www.readbyqxmd.com/read/28376127/the-doc-screen-feasible-and-valid-screening-for-depression-obstructive-sleep-apnea-osa-and-cognitive-impairment-in-stroke-prevention-clinics
#16
Richard H Swartz, Megan L Cayley, Krista L Lanctôt, Brian J Murray, Ashley Cohen, Kevin E Thorpe, Michelle N Sicard, Karen Lien, Demetrios J Sahlas, Nathan Herrmann
BACKGROUND: Post-stroke Depression, Obstructive sleep apnea (OSA) and Cognitive impairment ("DOC") are associated with greater mortality, worse recovery and poorer quality of life. Best practice recommendations endorse routine screening for each condition; yet, all are under-assessed, diagnosed and treated. We seek to determine the feasibility and validity of an integrated tool ("DOC" screen) to identify stroke clinic patients at high-risk of depression, OSA, and cognitive impairment...
2017: PloS One
https://www.readbyqxmd.com/read/28350821/neuropathological-diagnoses-and-clinical-correlates-in-older-adults-in-brazil-a-cross-sectional-study
#17
Claudia K Suemoto, Renata E L Ferretti-Rebustini, Roberta D Rodriguez, Renata E P Leite, Luciana Soterio, Sonia M D Brucki, Raphael R Spera, Tarcila M Cippiciani, Jose M Farfel, Alexandre Chiavegatto Filho, Michel Satya Naslavsky, Mayana Zatz, Carlos A Pasqualucci, Wilson Jacob-Filho, Ricardo Nitrini, Lea T Grinberg
BACKGROUND: Clinicopathological studies are important in determining the brain lesions underlying dementia. Although almost 60% of individuals with dementia live in developing countries, few clinicopathological studies focus on these individuals. We investigated the frequency of neurodegenerative and vascular-related neuropathological lesions in 1,092 Brazilian admixed older adults, their correlation with cognitive and neuropsychiatric symptoms, and the accuracy of dementia subtype diagnosis...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28343366/motor-learning-in-animal-models-of-parkinson-s-disease-aberrant-synaptic-plasticity-in-the-motor-cortex
#18
REVIEW
Tonghui Xu, Shaofang Wang, Rupa R Lalchandani, Jun B Ding
In Parkinson's disease (PD), dopamine depletion causes major changes in the brain, resulting in the typical cardinal motor features of the disease. PD neuropathology has been restricted to postmortem examinations, which are limited to only a single time of PD progression. Models of PD in which dopamine tone in the brain is chemically or physically disrupted are valuable tools in understanding the mechanisms of the disease. The basal ganglia have been well studied in the context of PD, and circuit changes in response to dopamine loss have been linked to the motor dysfunctions in PD...
April 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28339122/mortality-risk-in-a-nationwide-cohort-of-individuals-with-tic-disorders-and-with-tourette-syndrome
#19
Sandra M Meier, Søren Dalsgaard, Preben B Mortensen, James F Leckman, Kerstin J Plessen
BACKGROUND: Few studies have investigated mortality risk in individuals with tic disorders. METHODS: We thus measured the risk of premature death in individuals with tic disorders and with Tourette syndrome in a prospective cohort study with 80 million person-years of follow-up. We estimated mortality rate ratios and adjusted for calendar year, age, sex, urbanicity, maternal and paternal age, and psychiatric disorders to compare individuals with and without tic disorders...
April 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28329183/remote-traumatic-brain-injury-is-associated-with-motor-dysfunction-in-older-military-veterans
#20
Raquel C Gardner, Carrie B Peltz, Kimbra Kenney, Kenneth E Covinsky, Ramon Diaz-Arrastia, Kristine Yaffe
Background: Traumatic brain injury (TBI) has been identified as a risk factor for Parkinson's disease (PD). Motor dysfunction among TBI-exposed elders without PD has not been well characterized. We sought to determine whether remote TBI is a risk factor for motor dysfunction on exam and functionally relevant motor dysfunction in day-to-day life among independently living elders without PD. Methods: This is a cross-sectional cohort study of independently living retired military veterans aged 50 or older with (n = 78) and without (n = 85) prior TBI-all without diagnosed PD...
January 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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