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Methotrexate intraocular

Stephen J Balevic, C Egla Rabinovich
Uveitis refers to the presence of intraocular inflammation, and as a strict definition compromises the iris and ciliary body anteriorly and the choroid posteriorly (the uvea). Untreated, uveitis can lead to visual loss or blindness. The etiology of uveitis can include both infectious and noninfectious (usually immune-mediated) causes, the latter of which are often mediated predominantly by Th1 CD4(+) T-cells that secrete proinflammatory cytokines. Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine involved in the pathogenesis of uveitis, which at high concentrations can cause excess inflammation and tissue damage...
2016: Drug Design, Development and Therapy
Ama Sadaka, Robert A Sisk, James M Osher, Okan Toygar, Melinda K Duncan, Christopher D Riemann
PURPOSE: The purpose of this study was to evaluate intravitreal methotrexate infusion (IMI) during pars plana vitrectomy (PPV) for retinal detachment in patients with high risk for the development of proliferative vitreoretinopathy (PVR). METHODS: Patients presenting with severe recurrent PVR with tractional retinal detachment and/or a history of severe ocular inflammation were treated with IMI. Clinical outcomes were determined from a retrospective medical chart review...
2016: Clinical Ophthalmology
Sayaka Akaike, Koju Kamoi, Mari Tezuka, Daisuke Tomizawa, Ryoichi Yoshimura, Masatoshi Takagi, Kyoko Ohno-Matsui
BACKGROUND: Myeloid/NK cell precursor acute leukemia (MNKL) is a rare type of leukemia, and ocular complications have not previously been reported. We now report a patient with MNKL who developed intraocular infiltrates during follow-up. METHODS AND RESULTS: A 13-year-old boy diagnosed with MNKL developed left eye pain 3 months after starting treatment. Examination of the left eye revealed a visual acuity of counting fingers at 20 cm, ciliary hyperemia, small corneal keratic precipitates, hypopyon, grade 4 vitreous opacities, and an obscured fundus...
September 2016: Medicine (Baltimore)
Damien Guindolet, Pascal Dureau, Céline Terrada, Catherine Edelson, Amandine Barjol, Georges Caputo, Phuc LeHoang, Bahram Bodaghi
PURPOSE: To evaluate the evolution of chronic uveitis in children undergoing cataract surgery with primary intraocular lens (IOL) implantation. METHODS: Twelve children with chronic uveitis underwent cataract surgery with primary posterior chamber intraocular lens (IOL) implantation. RESULTS: Fourteen eyes were implanted with a foldable hydrophobic acrylic IOL. The mean follow-up was 35.39 months (8.72-69.57). The mean BCDVA before surgery and at the end of follow-up was 1...
September 6, 2016: Ocular Immunology and Inflammation
James R Singer, Archana K Nigalye, Mary T Champion, Matthew J Welch
PURPOSE: To report the successful treatment of a 78-year-old woman with bilateral mantle cell lymphoma involving the optic nerves. Chemotherapy initially was administered in the form of intravitreal methotrexate (MTX) monotherapy and was subsequently combined with systemic ibrutinib. METHODS: Retrospective case report. The diagnosis of CD5-negative mantle cell lymphoma was confirmed via immunohistopathological analysis of an axillary lymph node. Serial ophthalmologic examinations in conjunction with fluorescein angiography, fundus photography, and spectral domain optical coherence tomography were used to assess the treatment response...
August 12, 2016: Retinal Cases & Brief Reports
Khawla Abusamra, Merih Oray, Nazanin Ebrahimiadib, Stacey Lee, Stephen Anesi, C Stephen Foster
PURPOSE: To describe clinical manifestations, diagnostic approaches, therapy, and outcomes of biopsy-proven intraocular lymphoma. METHODS: Review of tertiary referral center records between 2005 and 2015. RESULTS: A total of 51 eyes of 26 patients were included; mean age of onset was 60.42 years. Common ocular complaints included floaters (42%) and blurred vision (35%); 62% of patients had ocular and central nervous system involvement; 11% had systemic lymphoma; and 27% had only ocular involvement...
July 20, 2016: Ocular Immunology and Inflammation
Hiroki Akiyama, Hiroshi Takase, Fumito Kubo, Tohru Miki, Masahide Yamamoto, Makoto Tomita, Manabu Mochizuki, Osamu Miura, Ayako Arai
In order to prevent central nervous system (CNS) involvement and improve the prognosis of primary intraocular lymphoma (PIOL), we prospectively evaluated the efficacy of combined therapy using intravitreal methotrexate (MTX) and systemic high-dose MTX on treatment-naïve PIOL. Patients with newly diagnosed PIOL whose lymphoma was limited to the eyes were enrolled. The patients were treated with weekly intravitreal MTX until the ocular lesions were resolved, followed by five cycles of systemic high-dose MTX (3...
October 2016: Cancer Science
O F Tropinskaya, E R Vetlova, N K Serova, A V Golanov, N A Fil'chenkova
AIM: The aim of the study was to define indications for stereotactic radiotherapy (SRT) of primary intraocular lymphoma (PIOL) and to evaluate the SRT efficacy and toxicity level. MATERIAL AND METHODS: Twelve immunocompetent patients with PIOL associated with primary CNS lymphoma underwent SRT of the affected eye/both eyes area. Three patients underwent repeated SRT due to PIOL recurrence. RESULTS: An improvement in visual acuity occurred in 6 patients...
2016: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Chiaki Oe, Miki Hiraoka, Sachie Tanaka, Hiroshi Ohguro
Acute retinal necrosis (ARN) is a rapidly progressive and severe retinitis resulting in a poor visual outcome. Infections caused by herpes viruses such as herpes simplex virus (HSV) types 1 and 2 or the varicella zoster virus (VZV) are known to be implicated in the development of ARN. In the present study, an 80-year-old female with ARN was examined. She had been affected with rheumatoid arthritis and had taken methotrexate for over 10 years. Her right eye showed clinical features of ARN, and her left eye showed mild retinitis...
January 2016: Case Reports in Ophthalmology
Soumyarwit Manna, Rupak K Banerjee, James J Augsburger, Marwan F Al-Rjoub, Zelia M Correa
Our group has developed a biodegradable drug delivery device (micro-implant) for long-term slow intraocular release of methotrexate (MTX) that can be implanted in the peripheral vitreous. The purpose of this study was to assess the position of the implanted devices and the status of the adjacent vitreous and peripheral retina over time using B-scan ocular ultrasonography (US). In each of the eight New Zealand rabbits used in this study, a chitosan (CS) and poly-lactic acid (PLA)-based micro-implant containing approximately 400 μg of MTX and a placebo micro-implant without MTX were inserted into the peripheral vitreous of the right and left eyes, respective, employing minimally invasive surgery...
July 2016: Experimental Eye Research
Beata Szostakiewicz-Grabek, Maria Juszkiewicz-Borowiec, Dorota Krasowska
Drugs with side effects affecting vision are often used in the treatment of skin disorders. The study evaluated principal groups of medicines which may negatively influence vision and the eye itself. Antimalaric drugs may cause a number of disorders of vision and a diagnosed retinophaty is an absolute contraindication. Retinoids often cause a dry eye condition, which results in intolerance to wearing contact lenses. They can also be a cause of poor nightly vision. Psoralens, used in photochemotherapy, can penetrate to the frontal part of the eye, inducing clouding of the lens and cataract...
April 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Vanesa Calvo-Río, Ricardo Blanco, Montserrat Santos-Gómez, Esteban Rubio-Romero, Miguel Cordero-Coma, Adela Gallego-Flores, Raúl Veroz, Ignacio Torre, Félix Francisco Hernández, Antonio Atanes, Javier Loricera, M C González-Vela, Natalia Palmou, José L Hernández, Miguel A González-Gay
OBJECTIVE: To assess the efficacy of golimumab (GLM) in refractory uveitis associated to spondyloarthritis (SpA). METHODS: Multicenter study of SpA-related uveitis refractory to at least 1 immunosuppressive drug. The main outcome variables were degree of anterior and posterior chamber inflammation, visual acuity, and macular thickness. RESULTS: A total of 15 patients (13 men/2 women; 18 affected eyes; mean age 39 ± 6 years) were evaluated...
August 2016: Seminars in Arthritis and Rheumatism
Sarakshi Mahajan, Raje Nijhawan, Aravind Rajwanshi, Samendra Karkhur, Samyak Mulkutar, Mohit Dogra, Vivek Lal, Vishali Gupta, Amod Gupta
PURPOSE: Primary vitreoretinal lymphomas (PVRL) pose a major diagnostic challenge, especially in the countries with a high prevalence of infectious variety of uveitis. The present study aims to report the clinical characteristics and diagnostic difficulties in patients with PVRL in an Indian Population. METHODS: Retrospective chart reviews of 12 patients with a diagnosis of PVRL. RESULTS: The study included 6 men and 6 women, with a mean age of 55...
March 22, 2016: Ocular Immunology and Inflammation
Florence Chaput, Radgonde Amer, Edoardo Baglivo, Valerie Touitou, Alexandra Kozyreff, Dominique Bron, Bahram Bodaghi, Phuc LeHoang, Chris Bergstrom, Hans E Grossniklaus, Chi-Chao Chan, Jacob Pe'er, Laure E Caspers
PURPOSE: To report on the clinical data of seven patients with T-cell intraocular lymphoma (IOL). METHODS: Retrospective case series. RESULTS: Seven immunocompetent patients, 12 eyes, 6 women, with T-cell-IOL were included from five countries. Mean age was 53.5 years (range: 25-82). Four patients had systemic-ocular lymphoma, two had CNS-ocular lymphoma, and one had systemic-CNS- ocular lymphoma. Vitritis was the most frequent clinical sign, followed by anterior uveitis and serous retinal detachment...
March 22, 2016: Ocular Immunology and Inflammation
Neslihan Sevimli, Remzi Karadag, Ercan Madenci, Huseyin Bayramlar, Pinar Arslan, Ayse Ocal, Yasar Dag
PURPOSE: To evaluate the ocular findings in patients with rheumatoid arthritis (RA) treated with disease-modifying antirheumatic drugs (DMARDs) such as methotrexate (MTX) or MTX with biological agents. METHODS: One hundred and twelve eyes of 56 patients with RA and treated with MTX or MTX with biological agents were included in the study. Patients were divided into two groups using DMARDs only (group 1) and patients using DMARDs and biologic agents together (group 2)...
March 2017: Cutaneous and Ocular Toxicology
Silvia Monsalvo, Cristina Serrano, Elena Prieto, Guillermo Fernández-Sanz, Maria-Camino Puente, Maria Rodriguez-Pinilla, Aranzazu Garcia Raso, Pilar Llamas, Raul Cordoba
BACKGROUND The uveitis masquerade syndromes (UMS) are a group of ocular diseases that may mimic chronic intraocular inflammation. Many malignant entities such as non-Hodgkin's lymphomas may masquerade as uveitis. We report a case of an HIV-positive patient with masquerade syndrome presenting unilateral uveitis. CASE REPORT 45-year-old Caucasian man with a diagnosis of diffuse large B-cell lymphoma (DLBCL). The patient was diagnosed by a biopsy of an abdominal mass which showed fragments of gastric mucosa with diffuse growth of neoplastic cells...
February 9, 2016: Cytometry. Part B, Clinical Cytometry
Seul Lee, Moon Jin Kim, Jin Seok Kim, Sung Yong Oh, Seok Jin Kim, Yoon Hyung Kwon, In Young Chung, Jung Hun Kang, Deok-Hwan Yang, Hye Jin Kang, Dok Hyun Yoon, Won Seog Kim, Hyo-Jin Kim, Cheolwon Suh
BACKGROUND: Intraocular lymphoma (IOL) is a rare malignant lymphoma that most closely resembles a diffuse large B-cell lymphoma, and it is a subtype of primary central nervous system lymphoma (PCNSL). IOL is located inside the eye in the retina, uvea, and/or optic nerve. We retrospectively analyzed IOL patient data to identify treatment patterns and survival rates in Korea. METHODS: Cytological confirmation for a diagnosis of IOL was performed for all patients. The clinical data collected from medical records included Ann Arbor stage, International Prognostic Index, performance status, date of diagnosis, treatment modality and response, date of relapse, and date of last follow-up...
December 2015: Blood Research
Wei-Li Ma, Hsin-An Hou, Ya-Jui Hsu, Yin-Kai Chen, Jih-Luh Tang, Woei Tsay, Po-Ting Yeh, Chung-May Yang, Chang-Ping Lin, Hwei-Fang Tien
A standard treatment for patients with primary intraocular lymphoma (PIOL) remains unclear. This study retrospectively analyzed the clinical features and outcomes of 19 patients with PIOL who were treated with a first-line therapy comprising combined intravenous high-dose methotrexate and intravitreal methotrexate between January 2003 and December 2013. Thirteen (68.4 %) patients were female, and the median age at diagnosis was 57 (39-77 years). Diagnoses were based on the identification of abnormal lymphoid cells in vitreous fluid...
March 2016: Annals of Hematology
Martha E Ryan, Jessica G Shantha, Hans E Grossniklaus, Steven Yeh
Intraocular lymphoma is considered a uveitis masquerade syndrome and may rarely present with features resembling a necrotizing viral retinitis. The authors report a secondary vitreoretinal lymphoma presenting in this fashion, which was treated with a unique combination of intravitreal methotrexate and rituximab.
November 2015: Ophthalmic Surgery, Lasers & Imaging Retina
Chan Yoon Cheah, Sarah Milgrom, Dai Chihara, Dan S Gombos, Chelsea C Pinnix, Bouthaina S Dabaja, Nathan H Fowler
BACKGROUND: Primary intraocular lymphoma is a rare variant of primary CNS lymphoma for which the optimum treatment strategy remains unknown. METHODS: We performed a retrospective single-center study including patients who underwent uniform management from October 2007 in which patients were offered sequential rituximab, methotrexate, procarbazine, and vincristine (R-MPV) followed by binocular radiotherapy and consolidative high-dose cytarabine. RESULTS: Eleven patients with median age 66 years (range, 48-72) were included...
April 2016: Neuro-oncology
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