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Pervasive Developmental disorder

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https://www.readbyqxmd.com/read/27899087/paradoxical-physiological-responses-to-propranolol-in-a-rett-syndrome-patient-a-case-report
#1
P J Santosh, L Bell, K Lievesley, J Singh, F Fiori
BACKGROUND: Rett Syndrome (RTT), caused by a loss-of-function in the epigenetic modulator: X-linked methyl-CpG binding protein 2 (MeCP2), is a pervasive neurological disorder characterized by compromised brain functions, anxiety, severe mental retardation, language and learning disabilities, repetitive stereotyped hand movements and developmental regression. An imbalance in the sympathetic and the parasympathetic nervous system (dysautonomia) and the resulting autonomic storms is a frequent occurrence in patients with RTT...
November 29, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27871641/longitudinal-course-of-bipolar-disorder-in-youth-with-high-functioning-autism-spectrum-disorder
#2
Xenia Borue, Carla Mazefsky, Brian T Rooks, Michael Strober, Martin B Keller, Heather Hower, Shirley Yen, Mary Kay Gill, Rasim S Diler, David A Axelson, Benjamin I Goldstein, Tina R Goldstein, Neal Ryan, Fangzi Liao, Jeffrey I Hunt, Daniel P Dickstein, Boris Birmaher
OBJECTIVE: To provide the first longitudinal characterization of mood and psychosocial functioning in youth with comorbid bipolar (BD) and autism spectrum (ASD) disorders. METHOD: The Course and Outcome of Bipolar Youth study followed 368 youth (aged 7-17 years) with DSM-IV bipolar I (BP-I), BP-II, or Not Otherwise Specified (NOS) for, on average, 9 years using the Longitudinal Interval Follow-up Evaluation. This subgroup analysis compared youth with and without ASD on clinical presentation, percentage of time with mood symptomatology, and psychosocial functioning...
December 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27868194/randomized-controlled-trial-of-vitamin-d-supplementation-in-children-with-autism-spectrum-disorder
#3
Khaled Saad, Ahmed A Abdel-Rahman, Yasser M Elserogy, Abdulrahman A Al-Atram, Amira A El-Houfey, Hisham A K Othman, Geir Bjørklund, Feiyong Jia, Mauricio A Urbina, Mohamed Gamil M Abo-Elela, Faisal-Alkhateeb Ahmad, Khaled A Abd El-Baseer, Ahmed E Ahmed, Ahmad M Abdel-Salam
BACKGROUND: Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children. METHODS: This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3-10 years)...
November 21, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27859986/effectiveness-of-1-1-speech-and-language-therapy-for-older-children-with-developmental-language-disorder
#4
Susan H Ebbels, Lisa Wright, Sally Brockbank, Caroline Godfrey, Catherine Harris, Hannah Leniston, Kate Neary, Hilary Nicoll, Lucy Nicoll, Jackie Scott, Nataša Marić
BACKGROUND: Evidence of the effectiveness of therapy for older children with (developmental) language disorder (DLD), and particularly those with receptive language impairments, is very limited. The few existing studies have focused on particular target areas, but none has looked at a whole area of a service. AIMS: To establish whether for students with (developmental) language disorder attending a specialist school, 1:1 intervention with an SLT during one school term improves performance on targeted areas, compared with untreated control areas...
November 18, 2016: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/27819277/the-transgenerational-inheritance-of-autism-like-phenotypes-in-mice-exposed-to-valproic-acid-during-pregnancy
#5
Chang Soon Choi, Edson Luck Gonzales, Ki Chan Kim, Sung Min Yang, Ji-Woon Kim, Darine Froy Mabunga, Jae Hoon Cheong, Seol-Heui Han, Geon Ho Bahn, Chan Young Shin
Autism spectrum disorder (ASD) is a heterogeneously pervasive developmental disorder in which various genetic and environmental factors are believed to underlie its development. Recently, epigenetics has been suggested as a novel concept for ASD aetiology with a proposition that epigenetic marks can be transgenerationally inherited. Based on this assumption of epigenetics, we investigated the transgenerational inheritance of ASD-like behaviours and their related synaptic changes in the VPA animal model of ASD...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27793367/behavioral-cognitive-and-motor-performance-and-physical-development-of-five-year-old-children-who-were-born-after-intracytoplasmic-sperm-injection-with-the-use-of-testicular-sperm
#6
Aukje M Meijerink, Liliana Ramos, Anjo J W M Janssen, Nienke M Maas-van Schaaijk, Andreas Meissner, Sjoerd Repping, Monique H Mochtar, Didi D M Braat, Kathrin Fleischer
OBJECTIVE: To evaluate at the age of 5 years the behavioral, cognitive, and motor performance and physical development of children born after testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI). DESIGN: A prospective longitudinal cohort study. SETTING: Two university medical centers. PATIENT(S): A total of 103 5-year-olds who were born after TESE-ICSI. INTERVENTION(S): The follow-up of the children was performed by questionnaires at birth and again at 1 year and at 4 years of age...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27789184/a-limited-survey-based-uncontrolled-follow-up-study-of-children-born-after-ooplasmic-transplantation-in-a-single-centre
#7
Serena H Chen, Claudia Pascale, Maria Jackson, Mary Ann Szvetecz, Jacques Cohen
Experimental ooplasmic transplantation from donor to recipient oocyte took place between 1996 and 2001 at Saint Barnabas Medical Center, USA. Indication for 33 patients was repeated implantation failure. Thirteen couples had 17 babies. One patient delivered twins from mixed ooplasmic and donor egg embryos. A limited survey-based follow-up study on the children is reported: 12 out of 13 parents completed a questionnaire on pregnancy, birth, health, academic performance and disclosure. Parents of a quadruplet did not participate...
October 24, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27747464/a-comparison-of-dsm-iv-tr-and-dsm-5-diagnostic-classifications-in-the-clinical-diagnosis-of-autistic-spectrum-disorder
#8
Ferhat Yaylaci, Suha Miral
Aim of this study was to compare children diagnosed with Pervasive Developmental Disorder (PDD) according to DSM-IV-TR and DSM-5 diagnostic systems. One hundred fifty children aged between 3 and 15 years diagnosed with PDD by DSM-IV-TR were included. PDD symptoms were reviewed through psychiatric assessment based on DSM-IV-TR and DSM-5 criteria. Clinical severity was determined using Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC). A statistically significant decrease (19.3 %) was detected in the diagnostic ratio with DSM-5...
October 17, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27721971/efficacy-of-atomoxetine-in-the-treatment-of-attention-deficit-hyperactivity-disorder-in-patients-with-common-comorbidities-in-children-adolescents-and-adults-a-review
#9
Shari L Hutchison, Jaswinder K Ghuman, Harinder S Ghuman, Irina Karpov, James M Schuster
Attention-deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed mental health disorders and is associated with higher incidence of comorbid oppositional or conduct, mood, anxiety, pervasive developmental, and substance-use disorders. Comorbid mental health conditions may alter the presence of symptoms and treatment of ADHD. Atomoxetine (ATX), a nonstimulant medication for the treatment of ADHD, may be prescribed for individuals with ADHD and comorbid conditions despite some risk for certain undesirable side effects and lower effectiveness for the treatment of ADHD than stimulants...
October 2016: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/27644917/-left-temporal-arachnoid-cyst-and-specific-learning-disorders-associated-with-pervasive-developmental-disorders-not-otherwise-specified-pdd-nos-contributions-of-an-integrative-neuropsychomotor-neuropsychological-psychopathological-and-neurosurgical-approach
#10
L Vaivre-Douret, A Boschi, M L Cuny, C Clouard, A Mosser, B Golse, A Philippe, M Bourgeois, N Boddaert, S Puget
: Left temporal arachnoid cyst and specific learning disorders associated with pervasive developmental disorders - not otherwise specified (PDD-NOS): contributions of an integrative neuro-psychomotor, neuropsychological, psychopathological and neurosurgical approach about a case report in a child (François). With DSM-IV and DSM-IV-TR, the terminology of pervasive developmental disorders (PDD) covers two main categories of infantile disorders: disorders of "strictly" autistic nature and pervasive developmental disorders - not otherwise specified (PDD-NOS)...
September 16, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27573986/electrophysiological-and-behavioral-outcomes-of-berard-auditory-integration-training-ait-in-children-with-autism-spectrum-disorder
#11
Estate M Sokhadze, Manuel F Casanova, Allan Tasman, Sally Brockett
Autism is a pervasive developmental disorder of childhood characterized by deficits in social interaction, language, and stereotyped behaviors along with a restricted range of interests. It is further marked by an inability to perceive and respond to social and emotional signals in a typical manner. This might due to the functional disconnectivity of networks important for specific aspects of social cognition and behavioral control resulting in deficits of sensory information integration. According to several recent theories sensory processing and integration abnormalities may play an important role in impairments of perception, cognition, and behavior in individuals with autism...
August 29, 2016: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/27566120/lack-of-gender-related-differences-in-childhood-onset-schizophrenia
#12
Anna E Ordóñez, Frances F Loeb, Xueping Zhou, Lorie Shora, Rebecca A Berman, Diane D Broadnax, Peter Gochman, Siyuan Liu, Judith L Rapoport
OBJECTIVE: Gender differences, including younger age of onset and greater premorbid deficits in men, have been reported in adult-onset schizophrenia. This study comprehensively evaluated gender differences in childhood-onset schizophrenia (COS), a rare variant of the disorder. METHOD: Demographic, premorbid, clinical, familial, and cognitive characteristics, presence of chromosomal abnormalities, and brain magnetic resonance imaging cortical volumes were evaluated in 133 patients with COS...
September 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27563293/autism-and-classical-eyeblink-conditioning-performance-changes-of-the-conditioned-response-related-to-autism-spectrum-disorder-diagnosis
#13
John P Welsh, Jeffrey T Oristaglio
Changes in the timing performance of conditioned responses (CRs) acquired during trace and delay eyeblink conditioning (EBC) are presented for diagnostic subgroups of children having autism spectrum disorder (ASD) aged 6-15 years. Children diagnosed with autistic disorder (AD) were analyzed separately from children diagnosed with either Asperger's syndrome or Pervasive developmental disorder (Asp/PDD) not otherwise specified and compared to an age- and IQ-matched group of children who were typically developing (TD)...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27556593/metformin-for-treatment-of-overweight-induced-by-atypical-antipsychotic-medication-in-young-people-with-autism-spectrum-disorder-a-randomized-clinical-trial
#14
Evdokia Anagnostou, Michael G Aman, Benjamin L Handen, Kevin B Sanders, Amy Shui, Jill A Hollway, Jessica Brian, L Eugene Arnold, Lucia Capano, Jessica A Hellings, Eric Butter, Deepali Mankad, Rameshwari Tumuluru, Jessica Kettel, Cassandra R Newsom, Stasia Hadjiyannakis, Naomi Peleg, Dina Odrobina, Sarah McAuliffe-Bellin, Pearl Zakroysky, Sarah Marler, Alexis Wagner, Taylor Wong, Eric A Macklin, Jeremy Veenstra-VanderWeele
IMPORTANCE: Atypical antipsychotic medications are indicated for the treatment of irritability and agitation symptoms in children with autism spectrum disorder (ASD). Unfortunately, these medications are associated with weight gain and metabolic complications that are especially troubling in children and with long-term use. OBJECTIVE: To evaluate the efficacy of metformin for weight gain associated with atypical antipsychotic medications in children and adolescents with ASD (defined in the protocol as DSM-IV diagnosis of autistic disorder, Asperger disorder, or pervasive developmental disorder not otherwise specified), aged 6 to 17 years...
September 1, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27526557/-dsm-5-and-autism-diagnostic-changes-and-clinical-implications-in-early-childhood
#15
REVIEW
Michal Faroy, Gal Meiri, Shoshana Arbelle
Autistic spectrum disorders (ASDs) are characterized by significant disability in interpersonal communication, social interactions and patterns of unusual behavior. In recent decades the worldwide prevalence of ASDs is rising almost exponentially, without a clear known etiological explanation. Until recently, ASDs were defined by the American Manual of Psychiatric Diagnoses: The DSM-IV-TR, under one conceptual umbrella of "Pervasive Developmental Disorders" (PDD). Under this category, there were five separate diagnoses...
May 2016: Harefuah
https://www.readbyqxmd.com/read/27511908/increased-risk-of-autism-development-in-children-whose-mothers-experienced-birth-complications-or-received-labor-and-delivery-drugs
#16
Melissa Smallwood, Ashley Sareen, Emma Baker, Rachel Hannusch, Eddy Kwessi, Tyisha Williams
Autism spectrum disorder (ASD) is a perplexing and pervasive developmental disorder characterized by social difficulties, communicative deficits, and repetitive behavior. The increased rate of ASD diagnosis has raised questions concerning the genetic and environmental factors contributing to the development of this disorder; meanwhile, the cause of ASD remains unknown. This study surveyed mothers of ASD and non-ASD children to determine possible effects of labor and delivery (L&D) drugs on the development of ASD...
August 2016: ASN Neuro
https://www.readbyqxmd.com/read/27504264/atypical-benign-partial-epilepsy-of-childhood-with-acquired-neurocognitive-lexical-semantic-and-autistic-spectrum-disorder
#17
Nicholas M Allen, Judith Conroy, Thierry Deonna, Dara McCreary, Paul McGettigan, Cathy Madigan, Imogen Carter, Sean Ennis, Sally A Lynch, Amre Shahwan, Mary D King
Atypical benign partial epilepsy (ABPE) of childhood or pseudo-Lennox syndrome is a form of idiopathic focal epilepsy characterized by multiple seizure types, focal and/or generalized epileptiform discharges, continuous spike-wave during sleep (CSWS), and sometimes reversible neurocognitive deficits. There are few reported cases of ABPE describing detailed correlative longitudinal follow-up of the various associated neurocognitive, language, social communicative, or motor deficits, in parallel with the epilepsy...
2016: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/27502533/impact-of-the-dsm-v-attention-deficit-hyperactivity-disorder-criteria-for-diagnosing-children-with-high-iq
#18
Therdpong Thongseiratch, Juthamas Worachotekamjorn
This study compared the number of attention deficit hyperactivity disorder (ADHD) cases defined by Diagnostic and Statistical Manual (DSM)-IV versus DSM-V criterion in children who have learning or behavioral problems with high IQ. The medical records of children ≤15 years of age who presented with learning or behavioral problems and underwent a Wechsler Intelligence Scale for Children (WISC)-III IQ test at the Pediatric Outpatient Clinic unit between 2010 and 2015 were reviewed. Information on DSM-IV and DSM-V criteria for ADHD were derived from computer-based medical records...
October 2016: Psychological Reports
https://www.readbyqxmd.com/read/27495376/proteomic-analysis-of-4-hydroxynonenal-and-nitrotyrosine-modified-proteins-in-rtt-fibroblasts
#19
Alessandra Pecorelli, Carlo Cervellati, Alessio Cortelazzo, Franco Cervellati, Claudia Sticozzi, Cristiana Mirasole, Roberto Guerranti, Alessandro Trentini, Lello Zolla, Vinno Savelli, Joussef Hayek, Giuseppe Valacchi
Rett syndrome (RTT) is a pervasive developmental disorder, primarily affecting girls with a prevalence of 1 in every 10,000 births. A clear etiological factor present in more than 90% of classical RTT cases is the mutation of the gene encoding methyl-CpG-binding protein 2 (MECP2). Recent work from our group was able to shown a systemic oxidative stress (OxS) in these patients that correlates with the gravity of the clinical features. Using freshly isolated skin fibroblasts from RTT patients and healthy subjects, we have performed a two-dimensional gel electrophoresis in order to evidence the oxidative modifications of proteins with special focus on the formation of protein adducts with 4-hydroxynonenal (4-HNE PAs) - a major secondary product of lipid peroxidation - and Nitrotyrosine, a marker derived from the biochemical interaction of nitric oxide (NO) or nitric oxide-derived secondary products with reactive oxygen species (ROS)...
August 2, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27477199/social-preference-and-glutamatergic-dysfunction-underappreciated-prerequisites-for-social-dysfunction-in-schizophrenia
#20
REVIEW
Junghee Lee, Michael F Green
Impaired social functioning is pervasive in schizophrenia. Unfortunately, existing treatments have limited efficacy, and possible psychological or neurobiological mechanisms underlying social dysfunction in this disorder remain obscure. Here, we evaluate whether social preference, one key aspect of social processing that has been largely overlooked in schizophrenia research, and N-methyl-d-aspartate receptor (NMDAR) dysfunction can provide insights into the mechanism underlying social dysfunction in schizophrenia...
September 2016: Trends in Neurosciences
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