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https://www.readbyqxmd.com/read/28494095/comparison-of-192-ir-169-yb-and-60-co-high-dose-rate-brachytherapy-sources-for-skin-cancer-treatment
#1
Habib Safigholi, Ali S Meigooni, William Y Song
PURPOSE: To evaluate the possibility of utilizing the high-dose rate (HDR) (169) Yb and (60) Co sources, in addition to (192) Ir, for the treatment of skin malignancies with conical applicators. METHODS: Monte Carlo (MC) simulations were used to benchmark the dosimetric parameters of single (169) Yb (4140), (60) Co (Co0.A86), and (192) Ir (mHDR-V2) brachytherapy sources in a water phantom and compared their results against published data. A standard conical tungsten alloy Leipzig-style applicator (Stand...
May 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28494012/fabrication-of-malleable-three-dimensional-printed-customized-bolus-using-three-dimensional-scanner
#2
Jae Won Park, Se An Oh, Ji Woon Yea, Min Kyu Kang
A three-dimensional (3D)-printed customized bolus (3D bolus) can be used for radiotherapy application to irregular surfaces. However, bolus fabrication based on computed tomography (CT) scans is complicated and also delivers unwanted irradiation. Consequently, we fabricated a bolus using a 3D scanner and evaluated its efficacy. The head of an Alderson Rando phantom was scanned with a 3D scanner. The 3D surface data were exported and reconstructed with Geomagic Design X software. A 3D bolus of 5-mm thickness designed to fit onto the nose was printed with the use of rubber-like printing material, and a radiotherapy plan was developed...
2017: PloS One
https://www.readbyqxmd.com/read/28488446/plasma-protein-hematologic-and-blood-chemistry-changes-in-african-grey-parrots-psittacus-erithacus-experimentally-infected-with-bornavirus
#3
Charlotte Högemann, Rüdiger Richter, Rüdiger Korbel, Monika Rinder
Bornaviruses are considered to be the causative agent of proventricular dilatation disease (PDD) in psittacine birds. In order to detect hematological and blood chemistry changes during the development of PDD and a possible correlation with clinical symptoms and the virological status, six African grey parrots (Psittacus erithacus) were experimentally infected with parrot bornavirus genotype 4 (PaBV-4) by subcutaneous route. All six parrots developed clinical signs of varying extent and successful infection was confirmed in all the birds by seroconversion or detection of RNA of the PaBV-4 infection strain...
May 10, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28482948/survey-of-preventable-disaster-deaths-at-medical-institutions-in-areas-affected-by-the-great-east-japan-earthquake-retrospective-survey-of-medical-institutions-in-miyagi-prefecture
#4
Satoshi Yamanouchi, Hiroyuki Sasaki, Hisayoshi Kondo, Tomohiko Mase, Yasuhiro Otomo, Yuichi Koido, Shigeki Kushimoto
Introduction In 2015, the authors reported the results of a preliminary investigation of preventable disaster deaths (PDDs) at medical institutions in areas affected by the Great East Japan Earthquake (2011). This initial survey considered only disaster base hospitals (DBHs) and hospitals that had experienced at least 20 patient deaths in Miyagi Prefecture (Japan); therefore, hospitals that experienced fewer than 20 patient deaths were not investigated. This was an additional study to the previous survey to better reflect PDD at hospitals across the entire prefecture...
May 9, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28464517/long-term-dosimetric-stability-of-multiple-tomotherapy-delivery-systems
#5
Jennifer B Smilowitz, David Dunkerley, Patrick M Hill, Poonam Yadav, Mark W Geurts
The dosimetric stability of six TomoTherapy units was analyzed to investigate changes in performance over time and with system upgrades. Energy and output were tracked using monitor chamber signal, onboard megavoltage computed tomography (MVCT) detector profile, and external ion chamber measurements. The systems (and monitoring periods) include three Hi-Art (67, 61, and 65 mos.), two TomoHDA (31 and 26 mos.), and one Radixact unit (11 mos.), representing approximately 10 years of clinical use. The four newest systems use the Dose Control Stability (DCS) system and Fixed Target Linear Accelerator (linac) (FTL)...
May 2, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28462601/neonatal-factors-among-subjects-diagnosed-with-a-pervasive-developmental-disorder-in-the-us
#6
David A Geier, Janet K Kern, Mark R Geier
PURPOSE: Contradictory studies suggest that some neonatal factors may be associated with a pervasive developmental disorder (PDD) diagnosis, but limited data is available from longitudinal, prospective medical record assessments. MATERIALS AND METHODS: The present hypothesis-testing longitudinal, case-control study evaluated birth characteristics among cases diagnosed with a PDD in comparison to controls by examining prospectively collected automated medical records within the Vaccine Safety Datalink (VSD) database...
May 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28458525/rivastigmine-the-advantages-of-dual-inhibition-of-acetylcholinesterase-and-butyrylcholinesterase-and-its-role-in-subcortical-vascular-dementia-and-parkinson-s-disease-dementia
#7
REVIEW
Nagaendran Kandiah, Ming-Chyi Pai, Vorapun Senanarong, Irene Looi, Encarnita Ampil, Kyung Won Park, Ananda Krishna Karanam, Stephen Christopher
Several studies have demonstrated clinical benefits of sustained cholinesterase inhibition with rivastigmine in Alzheimer's disease (AD) and Parkinson's disease dementia (PDD). Unlike donepezil and galantamine that selectively inhibit acetylcholinesterase (AChE; EC 3.1.1.7), rivastigmine is a unique cholinesterase inhibitor with both AChE and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibitory activity. Rivastigmine is also available as transdermal patch that has been approved by the US Food and Drug Administration for the treatment of mild, moderate, and severe AD as well as mild-to-moderate PDD...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28454845/abnormalities-of-cortical-neural-synchronization-mechanisms-in-patients-with-dementia-due-to-alzheimer-s-and-lewy-body-diseases-an-eeg-study
#8
Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Cordone, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Flavio Nobili, Dario Arnaldi, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Georg Caravias, Heinrich Garn, Fabiola Sorpresi, Michela Pievani, Giovanni B Frisoni, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Erol Başar, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, Raffaella Franciotti, Maria Francesca De Pandis, Laura Bonanni
The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini-Mental State Evaluation score were not different between the patient groups...
April 5, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28450040/comparison-of-predictors-of-heart-failure-with-preserved-versus-reduced-ejection-fraction-in-a-multiracial-cohort-of-preclinical-left-ventricular-diastolic-dysfunction
#9
Lili Zhang, Jared J Liebelt, Nidhi Madan, Jian Shan, Cynthia C Taub
Preclinical diastolic dysfunction (PDD) is a well-known but poorly understood risk factor for heart failure. We aimed to investigate risk factors contributing to progression of PDD to heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). Patients with echocardiogram from 2003 to 2008 with left ventricular ejection fraction ≥50%, grade I diastolic dysfunction, and free of clinical heart failure were included. The end point was incident HFpEF or HFrEF...
June 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28444840/topas-simulation-of-the-mevion-s250-compact-proton-therapy-unit
#10
Michael Prusator, Salahuddin Ahmad, Yong Chen
As proton therapy becomes increasingly popular, so does the need for Monte Carlo simulation studies involving accurate beam line modeling of proton treatment units. In this study, the 24 beam configurations of the Mevion S250 proton therapy system installed recently at our institution were modeled using the TOolkit for PArticle Simulation (TOPAS) code. Pristine Bragg peak, spread out Bragg peak (SOBP), and lateral beam profile dose distributions were simulated and matched to the measurements taken during commissioning of the unit...
April 26, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28443736/brain-resting-state-functional-connectivity-is-preserved-under-sevoflurane-anesthesia-in-patients-with-pervasive-developmental-disorders-a-pilot-study
#11
Lakshmikumar Venkatraghavan, Suparna Bharadwaj, Vincent Wourms, Audrey Tan, Michael T Jurkiewicz, David J Mikulis, Adrian P Crawley
Functional connectivity studies play a huge role in understanding the relationship between the network connections and the behavioral phenotype of patients with pervasive developmental disorders (PDD). Some patients with PDD may not be able to tolerate the imaging procedure while they are awake, and, hence, they often need general anesthesia. General anesthesia is a confounding factor in functional imaging studies due to its effect on the functional connectivity. The objective of this study is to look at the resting-state functional connectivity (RS-FC) under sevoflurane anesthesia in patients with PDDs...
May 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28441649/home-based-physical-behavior-in-late-stage-parkinson-disease-dementia-differences-between-cognitive-subtypes
#12
Bernhard Cerff, Walter Maetzler, Patricia Sulzer, Malte Kampmeyer, Jos Prinzen, Markus A Hobert, Dominik Blum, Rob van Lummel, Silvia Del Din, Susanne Gräber, Daniela Berg, Inga Liepelt-Scarfone
BACKGROUND: For the early diagnosis of Parkinson disease dementia (PDD), objective home-based tools are needed to quantify even mild stages of dysfunction of the activities of daily living (ADL). OBJECTIVES: In this pilot study, home-based physical behavior was assessed to examine whether it is possible to distinguish mild cognitive impairment (PD-MCI) from PDD. METHODS: Fifty-five patients with mild to severe Parkinson disease (PD) participated in this cross-sectional study...
April 26, 2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/28438923/reduced-concentration-clavulanate-for-young-children-with-acute-otitis-media
#13
Alejandro Hoberman, Jack L Paradise, Howard E Rockette, Jong-Hyeon Jeong, Diana H Kearney, Sonika Bhatnagar, Timothy R Shope, Gysella Muñiz, Judith M Martin, Marcia Kurs-Lasky, Mary Ann Haralam, Marcia A Pope, Jennifer P Nagg, Wenchen Zhao, Mohammad Kowser Miah, Jan Beumer, Raman Venkataramanan, Nader Shaikh
Amoxicillin/clavulanate (A/C), is currently the most effective oral antimicrobial in treating children with acute otitis media (AOM), but standard dosage of 90/6.4 mg/kg/day commonly causes diarrhea. We examined whether an A/C formulation containing lower concentrations of clavulanate would result in less diarrhea, while maintaining plasma levels of amoxicillin and clavulanate adequate to eradicate middle-ear pathogens and achieve clinical success. We conducted an open-label study in children aged 6 to 23 months with AOM...
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28434243/-clinical-and-neuropathological-characteristics-of-dementia-with-lewy-bodies
#14
János Bencze, Viktória Simon, Erika Bereczki, Réka Majer, Gréta Varkoly, Balázs Murnyák, János Kálmán, Tibor Hortobágyi
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia. The accurate diagnosis is often possible only by neuropathological examination. The morphologic hallmarks are the presence of α-synuclein-rich Lewy bodies and Lewy neurites, identical to those seen in Parkinson's disease (PD) and Parkinson's disease dementia (PDD). Neurotransmitter deficits, synaptic and ubiquitin-proteasome system (UPS) dysfunction play major role in the pathomechanism. Characteristic symptoms are cognitive fluctuation, parkinsonism and visual hallucinations...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28433088/parental-age-and-offspring-psychopathology-in-the-philadelphia-neurodevelopmental-cohort
#15
Alison K Merikangas, Monica E Calkins, Warren B Bilker, Tyler M Moore, Ruben C Gur, Raquel E Gur
OBJECTIVE: Increasing evidence implicates advanced paternal age at offspring birth in neuropsychiatric disorders. Advanced maternal age has also been associated with schizophrenia and other neurodevelopmental disorders, whereas younger maternal age has been linked with behavioral disorders. Few studies have considered the specificity of the associations with respect to comorbidity. In addition, most prior studies have been conducted in clinical samples or registries that may reflect more severe forms of psychopathology...
May 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28430289/evidence-from-spatial-pattern-analysis-for-the-anatomical-spread-of-%C3%AE-synuclein-pathology-in-parkinson-s-disease-dementia
#16
Richard A Armstrong
<i>The objective of this study was to determine whether there is evidence from quantitative morphometry and spatial pattern analysis to support the hypothesis of anatomical spread of -synuclein in Parkinson's disease dementia (PDD). Hence, clustering of -synuclein-immunoreactive Lewy bodies (LB), Lewy neurites (LN), and Lewy grains (LG) was studied in -synuclein-immunolabeled sections of cortical and limbic regions in 12 cases of PDD. The data suggested that: (1) LB, LN, and LG occurred in clusters which in 63% of regions were regularly distributed parallel to the tissue boundary, (2) in approximately 30% of cortical regions, the estimated cluster size of LB, LN, and LG was within the size range of cellular columns associated with the cortico-cortical pathways, (3) regularly distributed clusters were present in anatomically connected regions, and (4) the clustering pattern was similar to that of prion protein (PrPsc) deposits in Creutzfeldt-Jacob disease (CJD)...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28429391/technical-note-direct-measurement-of-continuous-tmr-data-with-a-1d-tank-and-automated-couch-movements
#17
Nels C Knutson, Matthew C Schmidt, Matthew D Belley, Ngoc B Nguyen, H Harold Li, Erno Sajo, Michael J Price
PURPOSE: Real-time dynamic control of the linear accelerator, couch, and imaging parameters during radiation delivery was investigated as a novel technique for acquiring tissue maximum ratio (TMR) data. METHODS: TrueBeam Developer Mode (Varian Medical Systems, Palo Alto, CA, USA) was used to control the linear accelerator using the Extensible Markup Language (XML). A single XML file was used to dynamically manipulate the machine, couch, and imaging parameters during radiation delivery...
April 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28427153/comparison-between-proton-boron-fusion-therapy-pbft-and-boron-neutron-capture-therapy-bnct-a-monte-carlo-study
#18
Joo-Young Jung, Do-Kun Yoon, Brendan Barraclough, Heui Chang Lee, Tae Suk Suh, Bo Lu
The aim of this study is to compare between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT) and to analyze dose escalation using a Monte Carlo simulation. We simulated a proton beam passing through the water with a boron uptake region (BUR) in MCNPX. To estimate the interaction between neutrons/protons and borons by the alpha particle, the simulation yielded with a variation of the center of the BUR location and proton energies. The variation and influence about the alpha particle were observed from the percent depth dose (PDD) and cross-plane dose profile of both the neutron and proton beams...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413935/predictive-validity-of-the-k-sads-pl-2009-version-in-school-aged-and-adolescent-outpatients
#19
Håkan Jarbin, Markus Andersson, Maria Råstam, Tord Ivarsson
BACKGROUND: The schedule for affective disorders and schizophrenia for school-age children (K-SADS) is one of the most commonly used standardized diagnostic interviews in child and adolescent psychiatry. Validity studies are scarce, and limited to concurrent validity with other measures and clinical diagnoses. AIMS: To evaluate the K-SADS interview in an outpatient child and adolescent psychiatry (CAP) setting with a Longitudinal Expert All Data (LEAD) procedure...
May 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28413724/are-anti-ganglioside-antibodies-associated-with-proventricular-dilatation-disease-in-birds
#20
Jeann Leal de Araujo, Ian Tizard, Jianhua Guo, J Jill Heatley, Aline Rodrigues Hoffmann, Raquel R Rech
The identification of Parrot bornaviruses (PaBV) in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease, since not all infected birds develop clinical signs. Although the most accepted theory indicates that PaBV directly triggers an inflammatory response in this disease, another hypothesis suggests the disease is triggered by autoantibodies targeting neuronal gangliosides, and PDD might therefore resemble Guillain-Barré Syndrome (GBS) in its pathogenesis...
2017: PeerJ
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