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Peripheral blood and atherosclerosis

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https://www.readbyqxmd.com/read/29116138/vascular-endothelial-growth-factor-signaling-requires-glycine-to-promote-angiogenesis
#1
Dongqing Guo, Colin E Murdoch, Hao Xu, Hui Shi, Dayue Darrel Duan, Asif Ahmed, Yuchun Gu
Peripheral vascular occlusive disease (PVOD) is a common manifestation of atherosclerosis, and it has a high rate of morbidity. Therapeutic angiogenesis would re-establish blood perfusion and rescue ischemic tissue. Vascular endothelial growth factor (VEGF) induces angiogenesis and can potentially be used to treat ischemic diseases, yet in clinical trials VEGF has not fulfilled its full potential with side effects. Whether amino acids promote angiogenesis and the molecular mechanisms are largely unknown. Here we showed that (1) Glycine significantly promoted angiogenesis both in vitro and in vivo and effectively protected mitochondrial function...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29107690/effects-of-oral-and-subcutaneous-administration-of-hsp60-on-myeloid-derived-suppressor-cells-and-atherosclerosis-in-apoe-mice
#2
Yingying Hu, Zhuyue Chen, Lili Jiang, Feng Chen, Runming Jin, Longxian Cheng
HSP60 has been proved to be closely related to atherosclerosis due to its antigenicity. To determine this antigenicity effect, the ApoE-/- mice were fed with western-type diet and HSP60 was administrated orally or subcutaneously (SC) for potential vaccine against atherosclerosis. Here, we observed the ApoE-/- mice with oral HSP60 administration group showed a significant reduction in plaque size at the aortic root; accompanied by increased MSDCs (CD11b(+)Gr1(+)) in peripheral blood and spleen which was mostly composed of M-MDSCs (CD11b(+)LY6G(-)LY6C(high)), and increased plasma IL-10 and splenic Foxp3, Arg1, iNOS mRNA as well as decreased plasma IFN-γ and splenic T-bet mRNA compared to control group...
October 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29105622/the-effects-of-t-helper-17-and-regulatory-t-cells-on-patients-with-carotid-atherosclerosis
#3
Bo Wang, Xiaopeng Wang, Huifang Sun, Lili Hu, Jianbo Gao
This study was aimed to observe the level of T helper 17 (Th17) cells and CD4(+) CD25(+) Foxp(3+) regulatory T cells (Tregs) and their related factors in carotid atherosclerosis (AS) patients and AS model rats to explore the influence of Th17 on the pathological process of AS and its specific mechanism. 60 cases with AS in our hospital from July 2012 to July 2014 were recruited for this study as the observation group, and 40 healthy people who came to the hospital for a physical examination were the control group...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29104625/high-expression-of-long-chain-acyl-coenzyme-a-synthetase-1-in-peripheral-blood-may-be-a-molecular-marker-for-assessing-the-risk-of-acute-myocardial-infarction
#4
Liping Yang, Yushuang Yang, Daoyuan Si, Kaiyao Shi, Dongna Liu, Heyu Meng, Fanbo Meng
The current study aimed to investigate whether the increased expression of long chain acyl-coenzymeA synthetase 1 (ACSL1) in peripheral blood leukocytes (PBL) may be a molecular marker for the genetic evaluation of acute myocardial infarction (AMI). The mechanism of action of ACSL1 in the pathogenesis of AMI was also investigated. A total of 75 patients with AMI and 70 individuals without coronary heart disease were selected to participate in the present study. The demographic and clinical information of the enrolled subjects was recorded...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29104039/increased-levels-of-interleukin-22-in-thoracic-aorta-and-plasma-from-patients-with-acute-thoracic-aortic-dissection
#5
Jing Ye, Menglong Wang, Huimin Jiang, Qingwei Ji, Ying Huang, Jianfang Liu, Tao Zeng, Yao Xu, Zhen Wang, Yingzhong Lin, Jun Wan
BACKGROUND: Interleukin (IL)-22 plays important roles in the development of arterial disease, including atherosclerosis and hypertension. However, the relationship between IL-22 and acute thoracic aortic dissection (TAD) remains unknown. METHODS: Blood samples were collected from patients with chest pain who underwent computed tomography angiography of the thoracic aorta but had no known preoperative diagnosis of coronary artery disease, peripheral artery disease, arthritis, and/or membranous nephropathy...
November 3, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29096843/h-e-l-p-apheresis-exerts-long-term-effects-on-the-capacity-of-circulating-proangiogenic-cells
#6
Jan Sradnick, Sergey Tselmin, Andrea Wagner, Ulrich Julius, Vladimir Todorov, Christian Hugo, Bernd Hohenstein
BACKGROUND: Severe forms of mono- and polygenetic hypercholesterolemia as well as elevated Lipoprotein (a) (LP(a)) with progressing cardiovascular (CV) disease are indication for lipoprotein apheresis (LA) in Germany. Many studies investigated pleiotropic effects of LA that might contribute to beneficial effects in advanced atherosclerosis. The present study aimed at investigating the potential role of Proangiogenic Cells (PAC) in patients with new onset or chronic LA using the heparin induced extracorporeal LDL-precipitation (H...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29096828/analysis-of-circulating-mirnas-in-patients-with-familial-hypercholesterolaemia-treated-by-ldl-lp-a-apheresis
#7
Dana Dlouha, Milan Blaha, Vladimir Blaha, Ilona Fatorova, Jaroslav A Hubacek, Petr Stavek, Vera Lanska, Alena Parikova, Jan Pitha
BACKGROUND: LDL/Lp(a) apheresis therapy is a well-established method of aggressively lowering LDL and Lp(a). Recently, miRNAs have been discussed as markers of vascular status including atherosclerosis. MiRNAs inhibit post-transcriptional processes through RNA duplex formation resulting in gene silencing or regulation of gene expression. MATERIALS AND METHODS: We measured a profile of 175 plasma-circulating miRNAs using pre-defined Serum/Plasma Focus Human microRNA PCR Panels in pooled samples of 11 subjects with familial hypercholesterolaemia under long-term apheresis treatment...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29089753/high-prevalence-of-copd-in-atherosclerosis-patients
#8
Izabela Tuleta, Tarik Farrag, Laura Busse, Carmen Pizarro, Christian Schaefer, Simon Pingel, Georg Nickenig, Dirk Skowasch, Nadjib Schahab
Atherosclerosis and COPD are both systemic inflammatory diseases that may influence each other. The aim of the present study was to determine the prevalence of COPD in patients with cerebral and/or peripheral artery disease and to assess factors associated with the presence of COPD. Following the diagnosis of cerebral and/or peripheral artery disease by means of duplex sonography, 166 consecutive patients underwent body plethysmography with capillary blood gas analysis. Thereafter, blood tests with determination of different parameters such as lipid profile, inflammatory and coagulation markers were conducted in remaining 136 patients who fulfilled inclusion criteria of the study...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29077145/rosuvastatin-promotes-the-differentiation-of-peripheral-blood-monocytes-into-m2-macrophages-in-patients-with-atherosclerosis-by-activating-ppar-%C3%AE
#9
T Zhang, B Shao, G-A Liu
OBJECTIVE: To evaluate M2 marker changes in human circulating monocytes before and after rosuvastatin treatment, and to investigate the effects of rosuvastatin on the differentiation of monocytes into M2 macrophages by activating peroxisome proliferator-activated receptor-γ (PPAR-γ). PATIENTS AND METHODS: A total of 20 patients was administrated with rosuvastatin. The human peripheral blood mononuclear cells (PBMCs) were extracted by Ficoll-Hypaque density gradient centrifugation method...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29070768/effect-of-growth-hormone-replacement-therapy-on-plasma-diacron-reactive-oxygen-metabolites-and-endothelial-function-in-japanese-patients-the-great-clinical-study
#10
Kunihiro Suzuki, Kazunori Yanagi, Masanori Shimizu, Sho Wakamatsu, Takafumi Niitani, Soichiro Hosonuma, Masaaki Sagara, Yoshimasa Aso
Patients with growth hormone deficiency (GHD) have an increased risk of atherosclerosis and vascular mortality. Evidence suggests that endothelial dysfunction is involved in all stages of atherogenesis. This study examined the effect of growth hormone (GH) replacement therapy on diacron-reactive oxygen metabolites (d-ROMs) and endothelial function in Japanese patients with GHD, using peripheral arterial tonometry. This was an open-label, prospective, case-control study. Nine patients with GHD who had not previously received any GH replacement therapy were enrolled...
October 25, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29058952/increased-arterial-stiffness-in-children-with-congenital-heart-disease
#11
Anna-Luisa Häcker, Barbara Reiner, Renate Oberhoffer, Alfred Hager, Peter Ewert, Jan Müller
Objective Central systolic blood pressure (SBP) is a measure of arterial stiffness and strongly associated with atherosclerosis and end-organ damage. It is a stronger predictor of cardiovascular events and all-cause mortality than peripheral SBP. In particular, for children with congenital heart disease, a higher central SBP might impose a greater threat of cardiac damage. The aim of the study was to analyse and compare central SBP in children with congenital heart disease and in healthy counterparts. Patients and methods Central SBP was measured using an oscillometric method in 417 children (38...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29046295/free-circulating-active-elastase-contributes-to-chronic-inflammation-in-hemodialysis-patients
#12
Eman Khatib-Massalha, Regina Michelis, Beny Trabelcy, Yoram Gerchman, Batya Kristal, Amiram Ariel, Shifra Sela
Atherosclerosis and cardiovascular complications are prevalent among patients undergoing chronic hemodialysis (HD). In this population, peripheral polymorphonuclear leukocytes (PMNLs) are primed, releasing pro-inflammatory mediators, such as elastase. Elastase is normally inhibited by a specific inhibitor, avoiding undesirable degradation of cellular and extracellular components. This study tested the hypothesis that in states of non-infectious inflammation, elastase is released by PMNLs and acts in an uncontrolled manner to inflict vascular damage...
October 18, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29042132/low-very-low-density-lipoprotein-cholesterol-but-high-very-low-density-lipoprotein-receptor-mrna-expression-in-peripheral-white-blood-cells-an-atherogenic-phenotype-for-atherosclerosis-in-a-community-based-population
#13
Fan Zhao, Yue Qi, Jing Liu, Wei Wang, Wuxiang Xie, Jiayi Sun, Jun Liu, Yongchen Hao, Miao Wang, Yan Li, Dong Zhao
Very low-density lipoprotein cholesterol (VLDL-C), via binding very low-density lipoprotein receptor (VLDLR), can induce the development of atherosclerosis. Besides monocytes, VLDLR expression is detected in various peripheral white blood cells (WBCs), yet its underlying role remains unclear. We thereby aimed to test the hypothesis that VLDLR in all types of peripheral WBCs may be involved in the association between VLDL-C and atherosclerosis. VLDLR mRNA expression in peripheral WBC and plasma VLDL-C levels were measured in 747 participants from a community-based study...
August 31, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29030224/transfer-molded-wrappable-microneedle-meshes-for-perivascular-drug-delivery
#14
JiYong Lee, Dae-Hyun Kim, Kang Ju Lee, Il Ho Seo, Seung Hyun Park, Eui Hwa Jang, Youngjoo Park, Young-Nam Youn, WonHyoung Ryu
After surgical procedures such as coronary/peripheral bypass grafting or endarterectomy for the treatment of organ ischemia derived from atherosclerosis, intimal hyperplasia (IH) which leads to restenosis or occlusion at the site of graft anastomosis frequently occurs. In order to inhibit IH caused by abnormal growth of smooth muscle cells (SMCs) in tunica media, various perivascular drug delivery devices are reported for delivery of anti-proliferation drugs into vascular tissue. However, there still remain conflicting requirements such as local and unidirectional delivery vs device porosity, and conformal tight device installation vs pulsatile expansion and constriction of blood vessels...
October 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29021277/cardiometabolic-risk-variables-in-preadolescent-children-a-factor-analysis
#15
Lee Stoner, Mark Weatherall, Paula Skidmore, Nicholas Castro, Sally Lark, James Faulkner, Michelle A Williams
BACKGROUND: Atherosclerosis begins during preadolescence and is occurring at an accelerated rate. This acceleration has been linked to poor lifestyle behaviors and subsequent cardiometabolic complications. Although the clustering of cardiometabolic risk factors has been recognized for over 2 decades, previous studies in children have predominantly examined the relationships between atherosclerosis and individual cardiometabolic risk factors or have grouped together preadolescent and adolescent children...
October 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29020391/association-between-mitochondrial-dna-copy-number-and-sudden-cardiac-death-findings-from-the-atherosclerosis-risk-in-communities-study-aric
#16
Yiyi Zhang, Eliseo Guallar, Foram N Ashar, Ryan J Longchamps, Christina A Castellani, John Lane, Megan L Grove, Josef Coresh, Nona Sotoodehnia, Leonard Ilkhanoff, Eric Boerwinkle, Nathan Pankratz, Dan E Arking
Aims: Sudden cardiac death (SCD) is a major public health burden. Mitochondrial dysfunction has been implicated in a wide range of cardiovascular diseases including cardiomyopathy, heart failure, and arrhythmias, but it is unknown if it also contributes to SCD risk. We sought to examine the prospective association between mtDNA copy number (mtDNA-CN), a surrogate marker of mitochondrial function, and SCD risk. Methods and results: We measured baseline mtDNA-CN in 11 093 participants from the Atherosclerosis Risk in Communities (ARIC) study...
June 30, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29017439/the-expression-of-pdcd4-in-patients-with-missed-abortion-and-its-clinical-significance
#17
Yue Li, Xihong Liu, Yingshun Sun, Yanping Liu, Lu Wan, Lining Zhang, Zhenghui Fang, Zengtao Wei, Xiaoyan Wang
Missed abortion is a special form of spontaneous abortion and its incidence shows a rising trend. Immunological factor is one of the most common reasons. Tumor suppressor gene programmed cell death 4 ( PDCD4) also participates in some immune-mediated inflammation, such as atherosclerosis, and so on, but the role of PDCD4 in missed abortion remains unclear. Here, the expression of PDCD4 was detected in decidual and chorionic tissues, as well as peripheral blood mononuclear cells from patients with missed abortion and healthy controls using quantitative real-time polymerase chain reaction (qRT-PCR), Western blot, and immunohistochemistry...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29017166/the-role-of-the-mineralocorticoid-receptor-in-inflammation-focus-on-kidney-and-vasculature
#18
Zachary Belden, Jeffrey A Deiuliis, Mirela Dobre, Sanjay Rajagopalan
BACKGROUND: The remarkable success of clinical trials in mineralocorticoid receptor (MR) inhibition in heart failure has driven research on the physiological and pathological role(s) of nonepithelial MR expression. MR is widely expressed in the cardiovascular system and is a major determinant of endothelial function, smooth muscle tone, vascular remodeling, fibrosis, and blood pressure. An important new dimension is the appreciation of the role MR plays in immune cells and target organ damage in the heart, kidney and vasculature, and in the development of insulin resistance...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28973724/atherosclerosis-analysis-of-the-enos-t786c-gene-polymorphism
#19
A M Barbosa, K S F Silva, M H Lagares, D A Rodrigues, I R da Costa, M P Morais, J V M Martins, R S Mascarenhas, F L Campedelli, K K V O Moura
The coronary arteriosclerotic disease is the most common cardiovascular disease. Atherosclerosis affects large- and medium-sized arteries leading to severe thrombosis or artery stenosis that could evolve to myocardial infarction, ischemic stroke, ischemic injury of kidneys and intestines, and several other life-threatening clinical manifestations. Nitric oxide has been shown to be a promising therapeutic agent against cardiovascular diseases. The eNOS gene assumes several important functions, including regulation of vascular tone and regional blood flow, the suppression of vascular smooth muscle cell proliferation, and modulation of leukocyte-endothelium interactions...
September 21, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28950166/leukocyte-telomere-length-and-cardiovascular-disease-in-african-americans-the-jackson-heart-study
#20
Stanford Mwasongwe, Yan Gao, Michael Griswold, James G Wilson, Abraham Aviv, Alexander P Reiner, Laura M Raffield
BACKGROUND AND AIMS: In European descent populations, shorter leukocyte telomere length (LTL) has been associated with subclinical atherosclerosis, cardiovascular disease (CVD), and mortality, while longer LTL has been associated with greater left ventricular hypertrophy. We evaluated the relationship of LTL with subclinical cardiovascular disease indices and incident clinical events and mortality in African Americans (AAs). METHODS: Analyses were restricted to 2518 participants of the Jackson Heart Study (JHS) with LTL measured by Southern blot in baseline blood samples...
November 2017: Atherosclerosis
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