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Degenerative scoliosis

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https://www.readbyqxmd.com/read/28039556/microrna-15b-silencing-inhibits-il-1%C3%AE-induced-extracellular-matrix-degradation-by-targeting-smad3-in-human-nucleus-pulposus-cells
#1
Liang Kang, Cao Yang, Huipeng Yin, Kangcheng Zhao, Wei Liu, Wenbin Hua, Kun Wang, Yu Song, Ji Tu, Shuai Li, Rongjin Luo, Yukun Zhang
OBJECTIVES: To determine the role of microRNA-15b (miR-15b) in interleukin-1 beta (IL-1β)-induced extracellular matrix (ECM) degradation in the nucleus pulposus (NP). RESULTS: MiR-15b was up-regulated in degenerative NP tissues and in IL-1β-stimulated NP cells, as compared to the levels in normal controls (normal tissue specimens from patients with idiopathic scoliosis). Bioinformatics and luciferase activity analyses showed that mothers against decapentaplegic homolog 3 (SMAD3), a key mediator of the transforming growth factor-β signaling pathway, was directly targeted by miR-15b...
December 30, 2016: Biotechnology Letters
https://www.readbyqxmd.com/read/28017875/correlation-between-radiographic-parameters-and-functional-scores-in-degenerative-lumbar-and-thoracolumbar-scoliosis
#2
Simon Jérémy, Longis Pierre-Marie, Passuti Norbert
INTRODUCTION: Adult scoliosis is a condition in which the spinal deformity occurs because of degeneration. Although various studies have agreed on the importance of restoring the sagittal balance, few have evaluated the relationship between functional scores and radiological parameters. The primary objective of this retrospective study was to demonstrate the correlation between radiographic parameters and functional outcomes in adult patients with lumbar or thoracolumbar degenerative scoliosis...
December 22, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27986245/the-optimal-treatment-for-symptomatic-neurogenic-claudication-or-radiculopathy-in-the-presence-of-mild-degenerative-scoliosis-remains-unclear
#3
Jason W Savage
No abstract text is available yet for this article.
January 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27978906/-clinical-effects-of-different-methods-of-the-proximal-fusion-for-long-segmental-lumbar-vertebrae-fusion-in-treatment-of-degenerative-lumbar-scoliosis
#4
Y Y Xu, J W Tian, Q H Zhao, S H Dong, S G Wang, J Sun
Objective: To explored the clinical effects of different methods of the proximal fusion for long segmental lumbar vertebrae fusion in treatment of degenerative lumbar scoliosis(DLS). Methods: From January 2007 to March 2014 fifty-five cases of DLS treated by the posterior proximal fusion of long segmental lumbar vertebrae fusion were analyzed in Department of Orthopaedics, Shanghai general Hospital of Nanjing Medical University (35)HuaiAn The First Hospital Affiliated to Nanjing Medical University(20). According to various upper instrumented vertebra(UIV) the patients were divided into Group A(upper horizontal vertebra, UHV, n=17), Group B (upper natural vertebra, UNV n=18 ), and Group C(upper end vertebra, UEV, n=20)...
December 6, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27927493/why-do-patients-seek-a-spine-surgeon
#5
Roy Norris, Timothy Garvey, Robert Winter
STUDY DESIGN: Retrospective review of chief complaints (CCs) of patients seeking care at a specialty spine clinic with the diagnosis of degenerative scoliosis or lumbar stenosis. OBJECTIVES: The purpose of the study was to ascertain why patients seek care from spine surgeons. Specifically, we asked whether pain or deformity was more common. Secondarily, we studied the correlation of progressive curve magnitude with perceived functionality. BACKGROUND: Scant research is available on what leads a patient to be seen in a clinic...
September 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927490/results-of-the-scoliosis-research-society-morbidity-and-mortality-database-2009-2012-a-report-from-the-morbidity-and-mortality-committee
#6
Douglas C Burton, Brandon B Carlson, Howard M Place, Jonathan E Fuller, Kathy Blanke, Robert Cho, Kai-Ming Fu, Aruna Ganju, Robert Heary, Jose A Herrera-Soto, A Noelle Larson, William F Lavelle, Ian W Nelson, Alejo Vernengo-Lezica, Joseph M Verska
INTRODUCTION: Members of the Scoliosis Research Society are required to annually submit complication data regarding deaths, visual acuity loss, neurological deficit and infection (2012-1st year for this measure) for all deformity operations performed. The purpose of this study is to report the 2012 results and the differences in these complications from the years 2009-2012. METHODS: The SRS M&M database is a self-reported complications registry of deformity operations performed by the members...
September 2016: Spine Deformity
https://www.readbyqxmd.com/read/27896687/evaluation-of-the-influences-of-various-force-magnitudes-and-configurations-on-scoliotic-curve-correction-using-finite-element-analysis
#7
Mohammad Taghi Karimi, Mohammad Hossein Ebrahimi, Ali Mohammadi, Anthony McGarry
Scoliosis is a lateral curvature in the normally straight vertical line of the spine, and the curvature can be moderate to severe. Different treatment can be used based on severity and age of subjects, but most common treatment for this disease is using orthosis. To design orthosis types of force arrangement can be varied, from transverse loads to vertical loads or combination of them. But it is not well introduced how orthoses control scoliotic curve and how to achieve the maximum correction based on force configurations and magnitude...
November 28, 2016: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/27890439/a-japanese-nationwide-multicenter-survey-on-perioperative-complications-of-corrective-fusion-for-elderly-patients-with-adult-spinal-deformity
#8
Yu Yamato, Yukihiro Matsuyama, Kazuhiro Hasegawa, Yoichi Aota, Tsutomu Akazawa, Takahiro Iida, Kazumasa Ueyama, Koki Uno, Tokumi Kanemura, Noriaki Kawakami, Toshiaki Kotani, Masashi Takaso, Jun Takahashi, Masato Tanaka, Hiroshi Taneichi, Taichi Tsuji, Hideo Hosoe, Joji Mochida, Takachika Shimizu, Ikuho Yonezawa, Kota Watanabe, Morio Matsumoto
BACKGROUND: Recently, corrective fusion surgery for patients with adult spinal deformity (ASD) has become common in Japan. This study aimed to clarify the status of surgeries for ASD in Japan, focusing on perioperative complications. A nationwide multicenter survey gathering information on surgically treated ASD patients was conducted by the committee for Adult Spinal Deformity of the Japanese Scoliosis Society. METHODS: This study was a review of retrospectively collected data from 18 spine scoliosis centers belonging to the Japanese Scoliosis Society...
November 24, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27888418/suppression-of-mtor-signaling-pathway-promotes-bone-marrow-mesenchymal-stem-cells-differentiation-into-osteoblast-in-degenerative-scoliosis-in-vivo-and-in-vitro
#9
Yu Wang, Xiao-Dong Yi, Chun-De Li
To investigate the role of mTOR signaling pathway in bone marrow mesenchymal stem cells (BMSCs) differentiation into osteoblast in degenerative scoliosis (DS). The rat model of DS was established. Thirty-two Sprague-Dawley (SD) rats were selected and divided into the normal control group, the positive control group (normal rats injected with rapamycin), the negative control group (DS rats injected with PBS) and the experiment group (DS rats injected with rapamycin). H&E staining was performed to observe the osteogenesis of scoliosis...
November 25, 2016: Molecular Biology Reports
https://www.readbyqxmd.com/read/27857857/predictive-parameters-for-the-antecedent-development-of-hip-pathology-associated-with-long-segment-fusions-to-the-pelvis-for-the-treatment-of-adult-spinal-deformity
#10
Merritt D Kinon, Rani Nasser, Jonathan P Nakhla, Owoicho Adogwa, Jessica R Moreno, Michael Harowicz, Terence Verla, Reza Yassari, Carlos A Bagley
BACKGROUND: The surgical treatment of adult scoliosis frequently involves long segment fusions across the lumbosacral joints that redistribute tremendous amounts of force to the remaining mobile spinal segments as well as to the pelvis and hip joints. Whether or not these forces increase the risk of femoral bone pathology remains unknown. The aim of this study is to determine the correlation between long segment spinal fusions to the pelvis and the antecedent development of degenerative hip pathologies as well as what predictive patient characteristics, if any, correlate with their development...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27852709/long-fusion-correction-of-degenerative-adult-spinal-deformity-and-the-selection-of-the-upper-or-lower-thoracic-region-as-the-site-of-proximal-instrumentation-a-systematic-review-and-meta-analysis
#11
Xin Fu, Xiao-Lei Sun, Jonathan A Harris, Sun-Ren Sheng, Hua-Zi Xu, Yong-Long Chi, Ai-Min Wu
OBJECTIVE: The aim of this study was to compare outcomes when the upper and lower thoracic regions were used as the site of proximal instrumentation to treat adult spinal deformity. METHODS: MEDLINE, Embase and Cochrane library searches were performed to identify studies that compared outcome measures when the upper and lower thoracic vertebrae (UTV and LTV, respectively) were used as the site of proximal instrumentation. The weighted mean difference (WMD) was calculated for continuous outcomes, and the relative risk (RR) was calculated for dichotomous outcomes...
November 15, 2016: BMJ Open
https://www.readbyqxmd.com/read/27847581/foreign-body-reaction-after-implantation-of-a-device-for-intervertebral-assisted-motion
#12
Jun-Yeong Seo, Kee-Yong Ha, Young-Hoon Kim, Joo-Hyun Ahn
The device for intervertebral assisted motion (DIAM) is a dynamic implant that consists of a silicone bumper enveloped by a polyethylene terephthalate (PET) fiber sack. Silicone and PET were used because of their biological inertness, but repetitive motion of the spine can cause wear on the implant nonetheless. The purpose of this study is to report a case of foreign body reaction (FBR) against a DIAM. A 72-year-old female patient presented with lower back pain and both legs radiating pain. She had undergone DIAM implantation at L4-5 for spinal stenosis 5 years previously...
November 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27817139/three-dimensional-reconstruction-using-stereoradiography-for-evaluating-adult-spinal-deformity-a-reproducibility-study
#13
Emmanuelle Ferrero, Renaud Lafage, Shaleen Vira, Pierre-Yves Rohan, Jonathan Oren, Edward Delsole, Pierre Guigui, Frank Schwab, Virginie Lafage, Wafa Skalli
PURPOSE: In addition to the sagittal alignment, impact of transverse plane parameters (TPP) and rotatory subluxation on patients reported outcomes were highlighted. One of the hypotheses for genesis of degenerative scoliosis is disc degeneration with increased axial vertebral (AVR) and intervertebral rotation (AIR). Therefore, TPP analysis at early stage of the scoliosis seems of particular interest. This study aims at assessing reliability of tridimensional (3D) reconstructions of adult spinal deformity (ASD) patients...
November 5, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27716016/posterior-corrective-surgery-with-a-multilevel-transforaminal-lumbar-interbody-fusion-and-a-rod-rotation-maneuver-for-patients-with-degenerative-lumbar-kyphoscoliosis
#14
Akira Matsumura, Takashi Namikawa, Minori Kato, Tomonori Ozaki, Yusuke Hori, Noriaki Hidaka, Hiroaki Nakamura
The purpose of this study was to assess the clinical results of posterior corrective surgery using a multilevel transforaminal lumbar interbody fusion (TLIF) with a rod rotation (RR) and to evaluate the segmental corrective effect of a TLIF using CT imaging. The medical records of 15 consecutive patients with degenerative lumbar kyphoscoliosis (DLKS) who had undergone posterior spinal corrective surgery using a multilevel TLIF with an RR technique and who had a minimum follow-up of 2 years were retrospectively reviewed...
October 7, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27707614/extreme-lateral-interbody-fusion-relieves-symptoms-of-spinal-stenosis-and-low-grade-spondylolisthesis-by-indirect-decompression-in-complex-patients
#15
Erlick A C Pereira, Mohammad Farwana, Khai S Lam
Spinal stenosis and low-grade spondylolisthesis produce symptoms of neural compression that can be treated with extreme lateral lumbar interbody fusion (XLIF) via indirect decompression. This study aimed to investigate whether the restoration of disc dimensions would relieve symptoms of radiculopathy, claudication and back pain. In this retrospective study, patients undergoing XLIF surgery for relief of radicular symptoms or degenerative disc disease were included. Radiologically proven changes were used to assess the modes of degeneration...
January 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27693731/the-influence-of-subgroup-diagnosis-on-radiographic-and-clinical-outcomes-after-lumbar-fusion-for-degenerative-disc-disorders-revisited-a-systematic-review-of-the-literature
#16
REVIEW
Amandeep Bhalla, Andrew J Schoenfeld, Jaiben George, Michael Moghimi, Christopher M Bono
BACKGROUND CONTEXT: Understanding the influence of preoperative diagnosis on outcomes for lumbar fusion surgery improves the quality of research and outcomes data, and helps guide treatment decisions. PURPOSE: We sought to perform a systematic review of the literature published between 2000 and 2014 regarding lumbar fusion outcomes for degenerative disorders. An assessment of the influence of subgroup diagnosis on outcomes as well as the quality of this body of literature was performed...
January 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27683705/minimally-invasive-surgery-in-adult-degenerative-scoliosis-a-systematic-review-and-meta-analysis-of-decompression-anterior-lateral-and-posterior-lumbar-approaches
#17
Kevin Phan, Ya Ruth Huo, Jarred A Hogan, Joshua Xu, Alexander Dunn, Samuel K Cho, Ralph J Mobbs, Patrick McKenna, Trichy Rajagopal, Farhaan Altaf
BACKGROUND: Minimally invasive approaches for the treatment of adult degenerative scoliosis have been increasingly implemented. However, little data exists regarding the safety and complication profiles of minimally invasive lumbar interbody fusion (LIF) for adult degenerative scoliosis. This study aimed to greater understand different minimally invasive surgical approaches for adult degenerative scoliosis with respect to clinical outcomes, changes in radiographic measurements, and complication profiles via meta-analytical techniques...
June 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/27683674/lumbar-interbody-fusion-techniques-indications-and-comparison-of-interbody-fusion-options-including-plif-tlif-mi-tlif-olif-atp-llif-and-alif
#18
REVIEW
Ralph J Mobbs, Kevin Phan, Greg Malham, Kevin Seex, Prashanth J Rao
Degenerative disc and facet joint disease of the lumbar spine is common in the ageing population, and is one of the most frequent causes of disability. Lumbar spondylosis may result in mechanical back pain, radicular and claudicant symptoms, reduced mobility and poor quality of life. Surgical interbody fusion of degenerative levels is an effective treatment option to stabilize the painful motion segment, and may provide indirect decompression of the neural elements, restore lordosis and correct deformity. The surgical options for interbody fusion of the lumbar spine include: posterior lumbar interbody fusion (PLIF), transforaminal lumbar interbody fusion (TLIF), minimally invasive transforaminal lumbar interbody fusion (MI-TLIF), oblique lumbar interbody fusion/anterior to psoas (OLIF/ATP), lateral lumbar interbody fusion (LLIF) and anterior lumbar interbody fusion (ALIF)...
December 2015: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/27652200/sagittal-balance-correction-in-lateral-interbody-fusion-for-degenerative-scoliosis
#19
Daniel J Blizzard, Michael A Gallizzi, Charles Sheets, Benjamin T Smith, Robert E Isaacs, Megan Eure, Christopher R Brown
BACKGROUND: Sagittal balance restoration has been shown to be an important determinant of outcomes in corrective surgery for degenerative scoliosis. Lateral interbody fusion (LIF) is a less-invasive technique which permits the placement of a high lordosis interbody cage without risks associated with traditional anterior or transforaminal interbody techniques. Studies have shown improvement in lumbar lordosis following LIF, but only one other study has assessed sagittal balance in this population...
2016: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/27648110/case-study-the-use-of-massage-therapy-to-relieve-chronic-low-back-pain
#20
Laura Allen
OBJECTIVES: To study the effects of massage on chronic low-back pain in a patient with four different diagnoses: osteoarthritis, scoliosis, spinal stenosis, and degenerative disc disease. The patient's goal was to cut down on the amount of pain medication he takes. METHODS: A 63-year-old man with chronic back pain received four massages across a twenty-day period. Progress was recorded using the Oswestry Low Back Pain Scale, as he self-reported on levels of pain and interference with his activities of daily living...
September 2016: International Journal of Therapeutic Massage & Bodywork
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